Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase

Biochemical Journal

Volumn 351, Issue 3, 2000, Pages 811-816

  Gomis, R R ^a   Ferrer, J C ^a   Guinovart, J J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Adenovirus; Glucose; Hepatocyte; Liver metabolism

Indexed keywords

GLUCOKINASE; GLYCOGEN; GLYCOGEN SYNTHASE;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME STRUCTURE; GLYCOGEN SYNTHESIS; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

ADENOVIRIDAE; ANIMALS; GENE EXPRESSION REGULATION, VIRAL; GLUCOKINASE; GLYCOGEN SYNTHASE; HEPATOCYTES; LACTIC ACID; LIVER GLYCOGEN; MALE; RATS; RATS, WISTAR;

EID: 0034329627     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510811     Document Type: Article

References (29)

1. The disposal of an oral glucose load in healthy subjects. A quantitative study
2. Novel aspects of the regulation of glycogen storage
3. Control of glycogen synthesis is shared between glucose transport and glycogen synthase in skeletal muscle fibers
4. The primary structure of rat liver glycogen synthase deduced by cDNA cloning. Absence of phosphorylation sites 1a and 1b
5. Glucose induces the translocation of glycogen synthase to the cell cortex in rat hepatocytes
6. Muscle glycogen synthase translocates from the cell nucleus to the cystosol in response to glucose
7. Metabolic engineering with recombinant adenoviruses
8. Use of recombinant adenovirus for metabolic engineering of mammalian cells
9. Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase
10. Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose
11. A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes
12. D-Glucose-6-phosphate and D-fructose-6-phosphate
13. Uridine-5'-diphosphoglucose
14. L-(+)-Lactate determination with lactate dehydrogenase and NAD
15. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
16. The glucose-phosphorylating capacity of liver as measured by three independent assays. Implications for the mechanism of hepatic glycogen synthesis
17. 14C-glucose
18. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
19. Overexpression of muscle glycogen phosphorylase in cultured human muscle fibers causes increased glucose consumption and nonoxidative disposal
20. Increased glycogen accumulation in transgenic mice overexpressing glycogen synthase in skeletal muscle
21. Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms
22. The role of glucose 6-phosphate in the control of glycogen synthase
23. Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase
24. Metabolic impact of adenovirus-mediated overexpression of the glucose-6-phosphatase catalytic subunit in hepatocytes
25. Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin
26. Stimulation of glycogen synthesis and lipogenesis by glutamine in isolated rat hepatocytes
27. Cell swelling and glycogen metabolism in hepatocytes from fasted rats
28. Liver glucose transporter: A basolateral protein in hepatocytes and intestine and kidney cells
29. Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes