Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release

Immunity

Volumn 42, Issue 4, 2015, Pages 640-653

  Dagvadorj, Jargalsaikhan ^a   Shimada, Kenichi ^a   Chen, Shuang ^a   Jones, Heather D ^a   Tumurkhuu, Gantsetseg ^a   Zhang, Wenxuan ^a   Wawrowsky, Kolja A ^a   Crother, Timothy R ^a   Arditi, Moshe ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; CD14 ANTIGEN; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; PURINERGIC P2X7 RECEPTOR; VASCULAR ENDOTHELIAL CADHERIN; CADHERIN; CALCIUM; PROTEIN PRECURSOR;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD VESSEL PERMEABILITY; BONE MARROW CELL; CALCIUM DEPLETION; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL ACTIVATION; CELL DEATH; CLINICAL ASSESSMENT; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; FLOW CYTOMETRY; LUNG ALVEOLUS MACROPHAGE; LUNG HOMOGENATE; LUNG LAVAGE; LUNG PARENCHYMA; MACROPHAGE CULTURE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; CAPILLARY PERMEABILITY; CHEMICALLY INDUCED; DRUG EFFECTS; ENDOTRACHEAL INTUBATION; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; LUNG; METABOLISM; NECROSIS; PATHOLOGY; TRANSGENIC MOUSE;

ACUTE LUNG INJURY; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIGENS, CD14; CADHERINS; CALCIUM; CAPILLARY PERMEABILITY; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INTERLEUKIN-1ALPHA; INTUBATION, INTRATRACHEAL; LIPOPOLYSACCHARIDES; LUNG; MACROPHAGES, ALVEOLAR; MICE; MICE, TRANSGENIC; NECROSIS; NEUTROPHIL INFILTRATION; NEUTROPHILS; PROTEIN PRECURSORS; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84928208468     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.03.007     Document Type: Article

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