Unfractionated heparin attenuates lung vascular leak in a mouse model of sepsis:Role of RhoA/Rho kinase pathway

Thrombosis Research

Volumn 132, Issue 1, 2013, Pages

  Han, Jiali ^a   Ding, Renyu ^a   Zhao, Dongmei ^a   Zhang, Zhidan ^a   Ma, Xiaochun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

acute lung injury; RhoA; ROCK; sepsis; unfractionated heparin; vascular barrier function

Indexed keywords

HEPARIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; RHO KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION; HISTOPATHOLOGY; LUNG EDEMA; LUNG VASCULAR LEAK; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY VASCULAR DISEASE; SEPSIS;

ACUTE LUNG INJURY; ALI; LIPOPOLYSACCHARIDE; LPS; MLC; MYOSIN LIGHT-CHAIN; MYOSIN PHOSPHATASE TARGET SUBUNIT 1; MYPT1; REVERSE TRANSCRIBED-POLYMERASE CHAIN REACTION; RHO-KINASE; RHOA; ROCK; RT-PCR; SEPSIS; UFH; UNFRACTIONATED HEPARIN; VASCULAR BARRIER FUNCTION;

ANIMALS; ANTICOAGULANTS; CAPILLARY LEAK SYNDROME; CAPILLARY PERMEABILITY; DISEASE MODELS, ANIMAL; EDEMA; ENZYME ACTIVATION; HEPARIN; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED C57BL; RANDOM ALLOCATION; RHO-ASSOCIATED KINASES; SEPSIS; SIGNAL TRANSDUCTION;

EID: 84881312364     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.03.010     Document Type: Article

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