Quercetin impairs the reproductive potential of neonatal male rats

International Journal of Pharmaceutical Sciences Review and Research

Volumn 31, Issue 2, 2015, Pages 31-39

  ElMazoudy, Reda H ^a,b   Mohamed, Nema A ^a   El Massry, Azza A ^a   Abdelsadek, Fatma R ^a  

^a Alexandria University Faculty Of Science   (Egypt)

^b IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

Neonatal rats; Quercetin; Semen analysis; Sex hormones

Indexed keywords

CATALASE; FOLLITROPIN; LIPID; LUTEINIZING HORMONE; MALONALDEHYDE; QUERCETIN; SUPEROXIDE DISMUTASE; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CELL VIABILITY; CONTROLLED STUDY; HEALTH STATUS; HISTOPATHOLOGY; HORMONE DETERMINATION; HYPOLIPEMIA; INTERSTITIUM; LD 50; MALE; MALE INFERTILITY; NEWBORN; NONHUMAN; ORGAN WEIGHT; RAT; REPRODUCTIVE SUCCESS; SEMEN ANALYSIS; SEMINIFEROUS TUBULE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY;

EID: 84928182238     PISSN: 0976044X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Annapurna A, Reddy CS, Akondi RB, Rao SR, Cardioprotective actions of two bioflavonoids, quercetin and rutin, in experimental myocardial infarction in both normal and streptozotocin induced type I diabetic rats, J Pharm Pharmacol, 61, 2009, 1365-1374.
2. D'Archivio M, Filesi C, Vari R, Scazzocchio B, Masella R, Bioavailability of the polyphenols: Status and controversies, Int J Mol Sci, 11, 2010, 1321-1342.
3. Tang SN, Singh C, Nall D, Meeker D, Shankar S, Srivastava RK, The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelialemesenchymal transition, J Mol Signal, 5, 2010, 14.
4. Jia YD, Lin JX, Mi YL, Quercetin attenuates cadmium-induced oxidative damage and apoptosis in granulosa cells from chicken ovarian follicles, Reprod Toxicol, 31, 2011, 477-485.
5. Reid MB. Free radicals and muscle fatigue: of ROS, canaries, and the IOC. Free Radic. Biol. Med., 44, 2008, 169-179.
6. Mariee AD, Abd-Allah GM, El-Beshbishy HA, Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats, Pharmaceutical Biology, 50(8), 2012, 1019-1025.
7. Seo HS, Ju JH, Jang K, Shin I, Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor alpha-negative breast cells, Nutr Res, 31, 2011, 139-146.
8. Wang P, Zhang K, Zhang Q, Effects of quercetin on the apoptosis of the human gastric carcinoma cells, Toxicology in Vitro, 26(2), 2012, 221-228.
9. Shih YL, Liu HC, Chen C S, Hsu CH, Pan MH, Chang HW, Chang CH, Shrilatha B, Muralidhara, Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences, J Reprod Toxicol, 23(4), 2007, 578-587.
10. Huang JJ, Liu X, Wang XQ, Yang LH, Qi DS, Yao RQ, Effects of quercetin on the learning and memory ability of neonatal rats with hypoxic-ischemic brain damage, Zhongguo Dang Dai Er Ke Za Zhi, 146, 2012, 454-457.
11. Bhutada P, Mundhada Y, Bansod K, Bhutada C, Tawari S, Dixit P, Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats, Neurobiol Learn Mem, 94, 2010, 293-302.
12. Haleagrahara N, Siew CJ, Mitra NK, Kumari M, Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum, Neurosci Lett, 500, 2011, 139-143.
13. Jedlinska-Krakowska M, Bomba G, Jakubowski K, Rotkiewicz T, Jana B, Penkowski A, Impact of oxidative stress and supplementation with vitamins E and C on testes morphology in rats, J Reprod Dev, 52, 2006, 203-209.
14. Shrilatha B, Muralidhara, Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences, J Reprod Toxicol, 23(4), 2007, 578-587.
15. Sullivan M, Follis RH, Jr & Hilgartner M, Toxicology of podophyllin, Proc Soc exp Biol Med, 77, 1951, 269-272.
16. Roeschlau P, Bernt E, Gruber NJ, Serum cholesterol determination Procedure, Clin Biochem, 12, 1974, 403-403.
17. Wahlefeld GI, Determination with lactate dehydrogenase and NAD. In: H. U. Bergmeyer (Ed.), Methods of enzymatic analysis, New York: Verlag Chemie-Academic Press, 1974, 1464-1472.
18. Burstein M, Scholnick HR, Morfin R, Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions [Review], J Lipid Res, 11, 1970, 583-595.
19. Bablok W, A General Regression Procedure for Method Transformation, J Clin Chem Clin Biochem, 26, 1988, 783-790.
20. Beastall GH, Ferguson KM, O'Reilly DSJ, Seth J, Sheridan B, Assays for follicle stimulating hormone and luteinizing hormone: guidelines for the provision of a clinical biochemistry service, Ann Clin Biochem, 24, 1987, 246-262.
21. Feng R, He W, Ochi H, A new murine oxidative stress model associated with Senescence, Mech Ageing Dev, 122, 2001, 547-559.
22. Türk G, Atesxsxahin A, Sönmez M, Yüce A, Çeribasxı AO, Lycopene protects against cyclosporine A-induced testicular toxicity in rats, Theriogenology, 67, 2007, 778-785.
23. Sönmez M, Gaffari T, Abdurrauf Y, The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats, Theriogenology, 63(7), 2005, 2063-2072.
24. Okamura M, Watanabe T, Kashida Y, Machida N, Mitsumori K, Possible mechanisms underlying the testicular toxicity of oxfendazole in rats, Toxicol Pathol, 32, 2004, 1-8.
25. Eliasson R, Supravital staining of human spermatozoa, Fertil Steril, 28, 1977, 1257.
26. Mukherjee KL, Routine biochemical tests and histological techniques, In: Mukherjee K, editor, Medical laboratory technology, New Delhi: Tata McGraw-Hill Publishing Company Limited, 2003, 1124-1190.
27. Ruiz MJ, Fernández M, Picó Y, Mañes J, Asensi M, Carda C, Asensio G, Estrela JM, Dietary Administration of High Doses of Pterostilbene and Quercetin to Mice Is Not, Toxic J Agric Food Chem, 57(8), 2009, 3180-3186.
28. Aydin B, Quercetin Prevents Methotrexate-induced Hepatotoxicity without Interfering Methotrexate Metabolizing Enzymes in Liver of Mice, Journal of Applied Biological Sciences, 52, 2011, 75-80.
29. Selvakumar K, Senthamilselvan B, Sekaran S, Firdous A B, Gunasekaran K, and Jagadeesan A, Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats, Journal of Biomarkers, 2013, 2012, 12 pages.
30. Taepongsorat L, Tangpraprutgul P, Kitana N, Malaivijitnond S, Stimulating effects of quercetin on sperm quality and reproductive organs in adult male rats, Asian J Androl, 10, 2008, 249-258.
31. Verma R, Lokendra K Darpesh G, Manish P, Tulsi M, and Suresh B, Evaluating the Ameliorative Potential of Quercetin against the Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats, Pulmonary Medicine, 2013, 2013, 10 pages.
32. Esmaeilzadeh F, Mohammadjavad HA, Omid HMH, Masoud M, Effect of quercetin supplementation on blood pressure in patients with a history of ischemic stroke, Technical Journal of Engineering and Applied Sciences TJEAS, 2013, 1963-1966.
33. Atef E, El-Baky A, Quercetin protective action on oxidative stress, Sorbitol insulin resistance and cells function in experimental diabetic rats, Int J Pharm Sci Res, 2, 2011, 11-8.
34. Mi Y, Zhang C, Taya K, Quercetin protects spermatogonial cells from 2, 4-d-induced oxidative damage in embryonic chickens, J Reprod Dev, 53, 2007, 749-754.
35. Jeong SM, Kang MJ, Choi HN, Kim JH, Kim JI, Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice, Nutr Res Pract, 6, 2012, 201-207.
36. Annapurna A, Ansari MA, Manjunath PM, Partial role of multiple pathways in infarct size limiting effect of quercetin and rutin against cerebral ischemia-reperfusion injury in rats, Eur Rev Med Pharmacol Sci, 17(4), 2013, 491-500.
37. Karampour NS, Ardeshir A, Hossein NV, Babak M, Mohsen R, Quercetin Preventive Effects on Theophylline-Induced Anomalies in Rat Embryo Jundishapur, J Nat Pharm Prod, 9(3), 2014, e17834.
38. Anjaneyulu M, Chopra K, Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats, Clinical and Experimental Pharmacology and Physiology, 31, 2004, 244-248.
39. Mira L, Fernandez MT, Santos M, Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity, Free Radical Res, 36, 2002, 1199-1208.
40. Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats, Free Radic Biol Med, 51, 2011, 1329-1336.
41. Gnoni GV, Paglialonga G, Siculella L, Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cells, Eur J Clin Invest, 39, 2009, 761-768.
42. Ricardo KFS, Oliveira TTd, Nagem TJ, Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton, Brazilian Arch Biol Technol, 44, 2001, 263-267.
43. Lee KH, Park E, Lee HJ, Kim MO, Cha YJ, Kim JM, Lee H, Shin MJ, Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers, Nutr Res Pract, 5, 2011, 28-33.
44. Krishnaveni M, Mirunalini S, Karthishwaran K, Dhamodharan G, Antidiabetic and antihyperlipidemic properties of Phyllanthus emblica Linn. (Euphorbiaceae) on streptozotocin induced diabetic rats, Pak J Nutr, 9, 2010, 43-51.
45. Khaki A, Fatemeh F, Mohammad N, Amir AK, Zahra G, Maryam G, Anti-oxidative effects of citro flavonoids on spermatogenesis in rat, African Journal of Pharmacy and Pharmacolog, 5(6), 2011, 721-725.
46. Ma Z, Hung Nguyen T, Hoa Huynh T, Tien Do P, Huynh H, Reduction of rat prostate weight by combined quercetinfinasteride treatment is associated with cell cycle deregulation, J Endocrinol, 181, 2004, 493-507.
47. Aravindakshan M, Chauhan PS, Sundaram K, Studies on germinal effects of quercetin, a naturally occurring flavonoid, Mutat Res, 144, 1985, 99-106.
48. Khanduja KL, Verma A, Bhardwaj A, Impairment of human sperm motility and viability by quercetin is independent of lipid peroxidation, Andrologia, 33, 2001, 277-281.
49. Maggiolini M, Bonofiglio D, Marsico S, Panno ML, Cenni B, Picard D, Estrogen receptor α mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells, Mol Pharmacol, 60, 2001, 595-602.
50. Robaszkiewicz A, Balcerczyk A, Bartosz G, Antioxidative and prooxidative effects of quercetin on A549 cells, Cell Biol Int, 31, 2007, 1245-1250.
51. Chandel A, Dhindsa S, Topiwala S, Chaudhuri A, Dandona P, Testosterone concentration in young patients with diabetes, Diabetes Care, 31(10), 2008, 2013-2017.
52. Mi Y, Zhang C, Protective effect of quercetin on Aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells, Toxicological Sciences, 88(2), 2005, 545-550.
53. Izawa H, Kohara M, Aizawa K, Suganuma H, Inakuma T, Watanabe G, Taya K, Sagai M, Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles. Biosci Biotechnol Biochem, 72, 2008, 1235-1241.
54. Hulethel M, Lunenfeld E, Regulation of spermatogenesis by paracrin/autocrine testicular factors, Asian J Androl, 6, 2004, 259-268.
55. Okamura A, Kamijima M, Shibata E, Ohtani K, Takagi K, Ueyama J, Watanabe Y, Omura M, Wang H, Ichihara G, Kondo T, Nakajima T, A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats, Toxicology, 213, 2005, 129-137.
56. Agarwal A, Said TM, Oxidative stress, DNA damage and apoptosis in male infertility: A clinical approach, BJU Int, 95, 2005, 503-507.
57. Oms-Oliu G, Odriozola-Serrano I, Soliva-Fortuny R, Martin-Bellosa O, Effects of high-intensity pulsed electric field processing conditions on lycopene, vitamin C and antioxidant capacity of watermelon juice, Food Chem, 115, 2009, 1312-1319.
58. Moridani MY, Pourahmad J, Bui H, Siraki A, O'Brien PJ, Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers, Free Radic Biol Med, 34, 2003, 245-253.