Oxidative stress, DNA damage and apoptosis in male infertility: A clinical approach

BJU International

Volumn 95, Issue 4, 2005, Pages 503-507

  Agarwal, Ashok ^a   Said, Tamer M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Antioxidants; Male infertility; Reactive oxygen species; Sperm preservation

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETYLCARNITINE; ACETYLCYSTEINE; ALKYLATING AGENT; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CARNITINE; CASPASE; DNA FRAGMENT; ESSENTIAL FATTY ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; PENTOXIFYLLINE; REACTIVE OXYGEN METABOLITE; RETINOL; SPHINGOSINE 1 PHOSPHATE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ASTHENOSPERMIA; AZOOSPERMIA; CHEMOLUMINESCENCE; CLINICAL FEATURE; CRYOPRESERVATION; DNA DAMAGE; DRUG INDUCED DISEASE; FERTILIZATION IN VITRO; HUMAN; IDIOPATHIC DISEASE; INTRACYTOPLASMIC SPERM INJECTION; INTRAUTERINE INSEMINATION; MALE; MALE GENITAL TRACT INFECTION; MALE INFERTILITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGNOSIS; RADIATION INJURY; RISK FACTOR; SEMEN ANALYSIS; SHORT SURVEY; SMOKING; SPERM PRESERVATION; SYSTEMATIC REVIEW; VARICOCELE; Y CHROMOSOME;

ANTIOXIDANTS; APOPTOSIS; CRYOPRESERVATION; DNA DAMAGE; HUMANS; INFERTILITY, MALE; INSEMINATION, ARTIFICIAL; MALE; OLIGOSPERMIA; OXIDATIVE STRESS; PROGNOSIS; REACTIVE OXYGEN SPECIES; SPERMATOZOA; VARICOCELE;

EID: 14644430470     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2005.05328.x     Document Type: Short Survey

References (30)

1. Said T, Paasch U, Glander H, Agarwal A. Role of caspases in male infertility. Hum Reprod Update 2004; 10: 39-51
2. Agarwal A, Said T. Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update 2003; 9: 331-45
3. Pasqualotto F, Sharma R, Kobayashi H, Nelson D, Thomas A Jr, Agarwal A. Oxidative stress in normospermic men undergoing infertility evaluation. J Androl 2001; 73: 459-64
4. Evenson D, Jost L, Corzett M, Balhorn R. Characteristics of human sperm chromatin structure following an episode of influenza and high fever: a case study. J Androl 2000; 21: 739-46
5. Kodama H, Yamaguchi R, Fukuda J, Kasai H, Tanaka T. Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients. Fertil Steril 1997; 68: 519-24
6. Barbieri E, Hidalgo M, Venegas A, Smith R, Lissi E. Varicocele-associated decrease in antioxidant defenses. J Androl 1999; 20: 713-7
7. Saleh R, Agarwal A, Sharma R, Said T. Sikka S, Thomas A Jr. Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertil Steril 2003; 80: 1431-6
8. Aitken R. The Amoroso lecture. The human spermatozoon - a cell in crisis? J Reprod Fertil 1999; 115: 1-7
9. Aziz N, Saleh R, Sharma R et al. Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity index. Fertil Steril 2004; 81: 349-54
10. Saleh A, Agarwal A. Oxidative stress and male infertility: from research bench to clinical practice. J Androl 2002; 23: 737-52
11. Weng S, Taylor S, Morshedi M et al. Caspase activity and apoptotic markers in ejaculated human sperm. Mol Hum Reprod 2002; 8: 984-91
12. Tesarik J, Greco E, Cohen-Bacrie P, Mendoza C. Germ cell apoptosis in men with complete and incomplete spermiogenesis failure. Mol Hum Reprod 1998; 4: 757-62
13. Kobayashi H, Larson K, Sharma R et al. DNA damage in cancer patients before treatment as measured by the sperm chromatin structure assay. Fertil Steril 2001; 75: 469-75
14. Saleh R, Agarwal A, Sharma R, Nelson D, Thomas AJ. Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study. Fertil Steril 2002; 78: 491-9
15. Potts R, Newbury C, Smith G, Notarianni L, Jefferies T. Sperm chromatin damage associated with male smoking. Mutation Res 1999; 423: 103-11
16. Aitken R, Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction 2001; 122: 497-506
17. Sharma R, Said T, Agarwal A. Sperm DNA damage and its clinical relevance in assessing reproductive outcome. Asian J Androl 2004; 6: 139-48
18. Evenson DP, Jost LK, Marshall D et al. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod 1999; 14: 1039-49
19. Kobayashi H, Gil-Guzman E, Mahran A et al. Quality control of reactive oxygen species measurement by luminol-dependent chemiluminescence assay. J Androl 2001; 22: 568-74
20. Said T, Kattal N, Sharma R et al. Enhanced chemiluminescence assay vs colorimetric assay for measurement of the total antioxidant capacity of human seminal plasma. J Androl 2003; 24: 676-80
21. Evenson D, Larson K, Jost L. Sperm chromatin structure assay. its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 2002; 23: 25-43
22. Agarwal A, Nallella K, Allamaneni S, Said T. Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod Biomedicine Online 2004; 8: 616-27
23. Suomalainen L, Hakala J, Pentikainen V et al. Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. J Clin Endocrinol Metab 2003; 88: 5572-9
24. Erkkila K, Hirvonen V, Wuokko E, Parvinen M, Dunkel L. N-acetyl-L-cysteine inhibits apoptosis in human male germ cells in vitro. J Clin Endocrinol Metab 1998; 83: 2523-31
25. Oeda T, Henkel R, Ohmori H, Schill WB. Scavenging effect of N-acetyl-L-cysteine against reactive oxygen species in human semen: a possible therapeutic modality for male factor infertility? Andrologia 1997; 29: 125-31
26. Carrell D, Wilcox A, Lowy L et al. Elevated sperm chromosome aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss. Obstet Gynecol 2003; 101: 1229-35
27. Steele E, McClure N, Maxwell R, Lewis S. A comparison of DNA damage in testicular and proximal epididymal spermatozoa in obstructive azoospermia. Mol Hum Reprod 1999; 5: 831-5
28. Wang A, Zhang H, Ikemoto I, Anderson D, Loughlin K. Reactive oxygen species generation by seminal cells during cryopreservation. Urology 1997; 49: 921-5
29. Emiliani S, Van den Bergh M, Vannin A, Biramane J, Verdoodt M, Englert Y. Evidence of reduced single-stranded testicular sperm DNA from obstructive azoospermic men after three days of in vitro culture. Hum Reprod 2001; 16: 1200-3
30. Zollner U, Zollner K, Dietl J, Steck T. Semen sample collection enhances the implantation rate following ICSI in patients with severe oligoathenteratozoospermia. Hum Reprod 2001; 16: 1110-4