Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

Pharmaceutical Biology

Volumn 50, Issue 8, 2012, Pages 1019-1025

  Mariee, Amr D ^a,b   Abd Allah, Gamil M ^a   El Beshbishy, Hesham A ^a,b  

^a Al Azhar University   (Egypt)

^b TAIBAH UNIVERSITY   (Saudi Arabia)

Author keywords

Hypercholesterolemia; Liver; Nitric oxide; Quercetin; Rat

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE; QUERCETIN; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DRUG MECHANISM; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HYPERCHOLESTEROLEMIA; LIPID LIVER LEVEL; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; CHOLESTEROL; CHOLESTEROL, DIETARY; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; GLUTATHIONE; HYPERCHOLESTEROLEMIA; LIPID PEROXIDES; LIVER; MALE; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

ANIMALIA; RATTUS;

EID: 84863643862     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.655424     Document Type: Article

References (51)

1. Aebi H. (1974). Catalase. In: Bergmeyer, HU (Ed.). Methods of Enzymatic Analysis. New York: Academic Press. pp 674-684.
2. Amin KA, Abd El-Twab TM. (2009). Oxidative markers, nitric oxide and homocysteine alteration in hypercholesterolimic rats: Role of atorvastatine and cinnamon. Int J Clin Exp Med, 2, 254-265.
3. Arafa HM. (2005). Curcumin attenuates diet-induced hypercholesterolemia in rats. Med Sci Monit, 11, BR228-BR234.
4. Barua RS, Ambrose JA, Srivastava S, DeVoe MC, Eales-Reynolds LJ. (2003). Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: An in vitro demonstration in human coronary artery endothelial cells. Circulation, 107, 2342-2347.
5. Beynen AC, Lemmens AG, Katan MB, De Bruijne JJ, Van Zutphen LF. (1987). Cholesterol metabolism and esterases in four strains of rats with differential cholesterolemic responses to a highcholesterol, high-cholate diet. Comp Biochem Physiol, B, 87, 41-48.
6. Coskun O, Kanter M, Korkmaz A, Oter S. (2005). Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res, 51, 117-123.
7. Eccleston HB, Andringa KK, Betancourt AM, King AL, Mantena SK, Swain TM, Tinsley HN, Nolte RN, Nagy TR, Abrams GA, Bailey SM. (2011). Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice. Antioxid Redox Signal, 15, 447-459.
8. Egert S, Boesch-Saadatmandi C, Wolffram S, Rimbach G, Müller MJ. (2010). Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J Nutr, 140, 278-284.
9. Ellman GL. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys, 82, 70-77.
10. Ferreira Ede S, Silva MA, Demonte A, Neves VA. (2011). Soy β-conglycinin (7S globulin) reduces plasma and liver cholesterol in rats fed hypercholesterolemic diet. J Med Food, 14, 94-100.
11. Feron O, Dessy C, Moniotte S, Desager JP, Balligand JL. (1999). Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J Clin Invest, 103, 897-905.
12. Fillios LC, Andrus SB, Mann GV, Stare FJ. (1956). Experimental production of gross atherosclerosis in the rat. J Exper Med 104, 539-552.
13. Fossati P, Prencipe L. (1982). Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem, 28, 2077-2080.
14. Friedewald WT, Levy RI, Fredrickson DS. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem, 18, 499-502.
15. Fungwe TV, Cagen L, Wilcox HG, Heimberg M. (1992). Regulation of hepatic secretion of very low density lipoprotein by dietary cholesterol. J Lipid Res, 33, 179-191.
16. Gnoni GV, Paglialonga G, Siculella L. (2009). Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cells. Eur J Clin Invest, 39, 761-768.
17. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. (1982). Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem, 126, 131-138.
18. Halim AB, el-Ahmady O, Hassab-Allah S, Abdel-Galil F, Hafez Y, Darwish A. (1997). Biochemical effect of antioxidants on lipids and liver function in experimentally-induced liver damage. Ann Clin Biochem, 34 (Pt 6), 656-663.
19. Hu MY, Li YL, Jiang CH, Liu ZQ, Qu SL, Huang YM. (2008). Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a high-fat diet in rabbits. Nutrition, 24, 1030-1038.
20. Igarashi K, Ohmuma M. (1995). Effects of isorhamnetin, rhamnetin, and quercetin on the concentrations of cholesterol and lipoperoxide in the serum and liver and on the blood and liver antioxidative enzyme activities of rats. Biosci Biotechnol Biochem, 59, 595-601.
21. Inukai N, Uchida M, Miyazaki Y, Suzuki T, Yoshikawa H, Tanaka K, Morita H, Takizawa T. (2010). Nitric oxide production and its contribution to hepatocyte proliferation in normal juvenile rats. J Vet Med Sci, 72, 861-867.
22. Kajikawa S, Imada K, Takeuchi T, Shimizu Y, Kawashima A, Harada T, Mizuguchi K. (2011). Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet. Dig Dis Sci, 56, 1065-1074.
23. Kamada C, da Silva EL, Ohnishi-Kameyama M, Moon JH, Terao J. (2005). Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit. Free Radic Res, 39, 185-194.
24. Kim JH, Park SH, Bae SS, Hong KW, Kim YD, Park KP, Choi BT, Shin HK. (2011). Combinatorial effect of probucol and cilostazol in focal ischemic mice with hypercholesterolemia. J Pharmacol Exp Ther, 338, 451-457.
25. Korou LM, Agrogiannis G, Pantopoulou A, Vlachos IS, Iliopoulos D, Karatzas T, Perrea DN. (2010). Comparative antilipidemic effect of N-acetylcysteine and sesame oil administration in diet-induced hypercholesterolemic mice. Lipids Health Dis, 9, 23.
26. Kumar SA, Sudhahar V, Varalakshmi P. (2006). Protective role of eicosapentaenoate-lipoate (EPA-LA) derivative in combating oxidative hepatocellular injury in hypercholesterolemic atherogenesis. Atherosclerosis, 189, 115-122.
27. Lee KH, Park E, Lee HJ, Kim MO, Cha YJ, Kim JM, Lee H, Shin MJ. (2011). Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers. Nutr Res Pract, 5, 28-33.
28. López-Revuelta A, Sánchez-Gallego JI, Hernández- Hernández A, Sánchez-Yagüe J, Llanillo M. (2006). Membrane cholesterol contents influence the protective effects of quercetin and rutin in erythrocytes damaged by oxidative stress. Chem Biol Interact, 161, 79-91.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem, 193, 265-275.
30. Mahley RW, Holcombe KS. (1977). Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat. J Lipid Res, 18, 314-324.
31. McCord JM, Fridovich I. (1969). Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem, 244, 6049-6055.
32. Mihara M, Uchiyama M. (1978). Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem, 86, 271-278.
33. Monte MJ, Jimenez R. (1993). Effects of a hypercholesterolaemiainducing diet on biliary electrolytes and lipid secretion in the rat. Int J Exp Pathol, 74, 203-210.
34. Morales AI, Vicente-Sánchez C, Jerkic M, Santiago JM, Sánchez-González PD, Pérez-Barriocanal F, López-Novoa JM. (2006). Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicol Appl Pharmacol, 210, 128-135.
35. Nepal S, Malik S, Sharma AK, Bharti S, Kumar N, Siddiqui KM, Bhatia J, Kumari S, Arya DS. (2011). Abresham ameliorates dyslipidemia, hepatic steatosis and hypertension in high-fat diet fed rats by repressing oxidative stress, TNF-α and normalizing NO production. Exp Toxicol Pathol.
36. Ohta Y, Kongo M, Kishikawa T. (2003). Melatonin exerts a therapeutic effect on cholestatic liver injury in rats with bile duct ligation. J Pineal Res, 34, 119-126.
37. Perez-Vizcaino F, Duarte J. (2010). Flavonols and cardiovascular disease. Mol Aspects Med, 31, 478-494.
38. Prasad K, Kalra J. (1993). Oxygen free radicals and hypercholesterolemic atherosclerosis: Effect of vitamin E. Am Heart J, 125, 958-973.
39. Reitman S, Frankel S. (1957). A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol, 28, 56-63.
40. Roeschlau P, Bernt E, Gruber W. (1974). Enzymatic determination of total cholesterol in serum. Z Klin Chem Klin Biochem, 12, 226.
41. Romero M, Jiménez R, Hurtado B, Moreno JM, Rodríguez- Gómez I, López-Sepúlveda R, Zarzuelo A, Pérez-Vizcaino F, Tamargo J, Vargas F, Duarte J. (2010). Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats. Eur J Pharmacol, 627, 242-250.
42. Scheuer H, Gwinner W, Hohbach J, Gröne EF, Brandes RP, Malle E, Olbricht CJ, Walli AK, Gröne HJ. (2000). Oxidant stress in hyperlipidemia-induced renal damage. Am J Physiol Renal Physiol, 278, F63-F74.
43. Sithisarn P, Supabphol R, Gritsanapan W. (2006). Comparison of free radical scavenging activity of Siamese neem tree (Azadirachta indica A. Juss var. siamensis Valeton) leaf extracts prepared by different methods of extraction. Med Princ Pract, 15, 219-222.
44. Teitz NN. (1987). Assay for gamma glutamyl transpeptidase activity in serum. In: Fundamentals of Clinical Chemistry, third edition. Philadelphia: W.B. Saunders /Co. p. 391.
45. Vessal M, Hemmati M, Vasei M. (2003). Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol, 135C, 357-364.
46. Vicente-Sánchez C, Egido J, Sánchez-González PD, Pérez-Barriocanal F, López-Novoa JM, Morales AI. (2008). Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity. Food Chem Toxicol, 46, 2279-2287.
47. Warnick GR, Benderson J, Albers JJ. (1982). Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-densitylipoprotein cholesterol. Clin Chem, 28, 1379-1388.
48. Yamamoto Y, Oue E. (2006). Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet. Biosci Biotechnol Biochem, 70, 933-939.
49. Yang RL, Li W, Shi YH, Le GW. (2008). Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: A microarray analysis. Nutrition, 24, 582-588.
50. Zhao L, Wu J, Wang Y, Yang J, Wei J, Gao W, Guo C. (2011). Cholesterol metabolism is modulated by quercetin in rats. J Agric Food Chem, 59, 1104-1108.
51. Zou JG, Wang ZR, Huang YZ, Cao KJ, Wu JM. (2003). Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. Int J Mol Med, 11, 317-320.