Quercetin prevents methotrexate-induced hepatotoxicity without interfering methotrexate metabolizing enzymes in liver of mice

Journal of Applied Biological Sciences

Volumn 5, Issue 2, 2011, Pages 75-80

  Aydin, Birsen ^a  

^a AMASYA UNIVERSITY   (Turkey)

Author keywords

Drug metabolizing enzymes; Herb drug interactions; Methotrexate; Oxidative stress; Quercetin

Indexed keywords

MUS;

EID: 79960516752     PISSN: 13071130     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. McCune JS, Hatfield AJ, Blackburn AAR, Leith PO, Livingston RB, Ellis GK. 2004. Potential of chemotherapy-herb interactions in adult cancer patients. Support Care Cancer. 12: 454-462.
2. Yang AK, He SM, Liu L, Liu JP, Wei MQ, Zhou SF. 2010. Herbal interactions with anticancer drugs: mechanistic and clinical considerations. Curr Med Chem. 17:1635-78. Review.
3. Jahovic N, Cevik H, Sehirli AO, Yegen BC, Sener G. 2003. Melatonin prevents methotraxate- induced hepatorenal oxidative injury in rats. J Pineal Res. 34: 282-7.
4. Cetinkaya A, Bulbuloglu E, Kurutas EB, Kantarceken B. 2006. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Med Sci Monit. 12: 47-8.
5. Sener G, Eksioglu-Demiralp E, Cetiner M, Ercan F, Sirvanci S, Gedik N, Yegen BC. 2006. L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death. Cell Biol Toxicol. 22: 47-60.
6. Cetin A, Kaynar L, Kocyigit I, Hacioglu SK, Saraymen R, Ozturk A, Sari I, Sagdic O. 2008. Role of grape seed extract on methotrexate induced oxidative stress in rat liver. Am J Chinese Med. 36: 861-72.
7. Caetano NN, Campello AP, Carnieri EG, Kluppel ML, Oliveira MB. 1997. Effects of methotrexate (MX) on NAD (p) dehydrogenase of Hela cells: Malic enzymes, 2- oxolurterate and isocitrate dehydrogenases. Cell Biochem Funct. 15: 259-64.
8. Babiak RM, Campello AP, Carnieri EG, Oliveira MB. 1998. Methotrexate: Pentose cycle and oxidative stress. Cell Biochem Func. 16:283-93.
9. Pawlikowska-Pawlega B, Guszecki WI, Misiak LE, Gawron A. 2003. The study of the quercetin action on human erythrocyte membranes. Biochem Pharmacol. 66: 605-12.
10. Darwish HA, Mahdy A. 2009. Alpha-lipoic acid and quercetin protect against methotrexate induced-hepatotoxicity in rats. HealthMED. 3: 80-89.
11. Shanmugarajan TS, Prithwish N, Somasundaram I, Arunsundar M, Niladri M, Lavande JP, Ravichandiran V. 2008. Mitigation of azathioprine-induced oxidative hepatic injury by the flavonoid quercetin in wistar rats. Toxicol Mech Methods. 18: 653-60.
12. Mostafavi-Pour Z, Zal F, Monabati A, Vessal M. 2008. Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Hepatol Res. 38: 385-92.
13. Dias AS, Porawski M, Alonso M, Marroni N, Collado PS, González-Gallego J. 2005. Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J Nutr. 135: 299-304.
14. Genestier L, Paillot R, Quemeneur L, Izeradjene K, Revillard JP. 2000. Mechanisms of action of methotrexate. Int Immunopharmacol. 47: 247-57.
15. Sánchez-del-Campo L, Sáez-Ayala M, Chazarra S, Cabezas-Herrera J, Rodríguez-López JN. 2009. Binding of natural and synthetic polyphenols to human dihydrofolate reductase. Int J Mol Sci. 10: 5398-410.
16. Pirouzpanah S, Rashidi MR, Delazar A, Razavieh SV, Hamidi A. 2006. Inhibitory effects of Ruta graveolens L. extract on guinea pig liver aldehyde oxidase. Chem Pharm Bull (Tokyo). 54: 9-13.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ.1951. Protein measurement with the folin phenol reagent. J Biol Chem. 193, 265-75.
18. Aebi H. 1984. Catalase in vitro. Method Enzymol. 105:121-126.
19. Winterbourn CC, Hawkins RE, Brian M, Carrell RW. 1975. The estimation of red cell superoxide dismutase activity. J Lab Clin Med. 85: 337- 41.
20. Lawrance RA and Burk RF. 1976. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun. 71: 52-958.
21. Moron MA, Depierre JW, Mannervick B. 1979. Levels of glutathione, glutathionereductase and glutathione S-transferase activities in rat lungand liver. Biochem Biophys Acta. 582: 67-78.
22. Imai Y, Ito A, and Sato R. 1966. Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J Biochem. 60 417-423.
23. Waxman DJ, Morrissey JJ, and LeBlanc GA. 1989. Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms. Endocrinology. 124: 2954-2966.
24. Omura T, Takesue S. 1970. A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes. J Biochem. 67: 249-257.
25. Mihara K, Sato R. 1972. Partial purification of cytochrome b5 reductase from rabbit liver microsomes with detergents and its properties. J Biochem. 71: 725-735.
26. Johns, DG. 1976. Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates. J Clin Invest. 46: 492-1505.
27. Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione S-transferases-the first step in mercapturic acid formation. J Biol Chem 249: 7130-7139.
28. Benson AM, Hunkeler MJ, Talalay P. 1980. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc Natl Acad Sci USA. 77: 5216-5220.
29. Wright JR, Colby HD and Miles PR. 1981. Cytosolic factors which affect microsomal lipid peroxidation in lung and liver. Arch Biochem Biophys. 206:296-304.
30. Suh JH, Shevni SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM. 2004. Decline in transcripitional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversed with lipoic acid. Proc Natl Acad Sci. 101: 3381-3386.
31. Sinet P M and Garba P.1981. Inactivation of the human Cu Zn SOD during exposure to O2 and H2O2. Arch Biochem Biophys. 212: 411-416.
32. Valerio LG Jr, Kepa JK, Pickwell GV, Quattrochi LC. 2001. Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 119: 49-57.
33. Rice-Evans C, Miller NJ and Paganga G. 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biol Med. 20: 933-956.
34. Lukienko PI, Bushma MI, Legon'kova LF, Abakimov GZ. 1985. Effect of folic acid and methotrexate on the function of the hydroxylating system and the cholesterol and phospholipid content in the liver microsomes of rats. Farmakol Toksikol. 48: 53-5.
35. Cheung RL, Lee C, Jones EJ, Riddick DS. 1996. Lack of effect of methotrexate on the expression of constitutive hepatic cytochromes P450 in the male rat. Xenobiotica. 26: 503-14.
36. Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. 2000. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis. J Clin Invest. 105: 1067-1075.
37. Siess MH, Vernevaut MF. 1982. The influence of food flavonoids on the activity of some hepatic microsomal monooxygenases in rats. Food Chem Toxicol. 20: 883-6.
38. Siess MH, Guillermic M, Le Bon AM, Suschetet M. 1989. Induction of monooxygenase and transferase activities in rat by dietary administration of flavonoids. Xenobiotica. 9: 1379-86.
39. Fischer, J. G., & Fisher, H. L. 2000. Supplementation with the flavonoid quercetin alters the activity of some antioxidant enzymes. J Am Diet Assoc. 100: (Suppl A11).
40. Uda Y, Price KR, Williamson G, Rhodes MJ. 1997. Induction of the anticarcinogenic marker enzyme, quinone reductase, in murine hepatoma cells in vitro by flavonoids. Cancer Lett. 120: 213-6.
41. Talalay P, Fahey JW, Holtzclaw D, Prestera T & Yuesheng Z. 1995. Chemoprotection against cancer by Phase 2 enzyme induction. Toxicol Lett. 82/83: 173-179.
42. Prestera T, Zhang Y, Spencer SR, Wilczak CA, Talalay P. 1993. The electrophile counterattack response: protection against neoplasia and toxicity. Adv Enzyme Regul. 33: 281-296.