-
1
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling, T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (2007).
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
-
2
-
-
85047688293
-
The bigger picture of FTO-the first GWAS-identified obesity gene
-
Loos, R. J. & Yeo, G. S. The bigger picture of FTO-the first GWAS-identified obesity gene. Nat. Rev Endocrinol. 10, 51-61 (2014).
-
(2014)
Nat. Rev Endocrinol.
, vol.10
, pp. 51-61
-
-
Loos, R.J.1
Yeo, G.S.2
-
3
-
-
79960895140
-
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
-
Kilpelainen, T. O. et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat. Genet. 43, 753-760 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 753-760
-
-
Kilpelainen, T.O.1
-
4
-
-
64549158008
-
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
-
Renstrom, F. et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum. Mol. Genet. 18, 1489-1496 (2009).
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 1489-1496
-
-
Renstrom, F.1
-
5
-
-
51649128621
-
Obesity associated genetic variation in FTO is associated with diminished satiety
-
Wardle, J. et al. Obesity associated genetic variation in FTO is associated with diminished satiety. J. Clin. Endocrinol. Metab. 93, 3640-3643 (2008).
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 3640-3643
-
-
Wardle, J.1
-
6
-
-
84863684047
-
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
-
Fox, C. S. et al. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet. 8, e1002695 (2012).
-
(2012)
PLoS Genet.
, vol.8
, pp. e1002695
-
-
Fox, C.S.1
-
7
-
-
67349211789
-
Inactivation of the FTO gene protects from obesity
-
Fischer, J. et al. Inactivation of the FTO gene protects from obesity. Nature 458, 894-898 (2009).
-
(2009)
Nature
, vol.458
, pp. 894-898
-
-
Fischer, J.1
-
8
-
-
84873520661
-
Adult onset global loss of the FTO gene alters body composition and metabolism in the mouse
-
McMurray, F. et al. Adult onset global loss of the FTO gene alters body composition and metabolism in the mouse. PLoS Genet. 9, e1003166 (2013).
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003166
-
-
McMurray, F.1
-
9
-
-
78649512744
-
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice
-
Gao, X. et al. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS ONE 5, e14005 (2010).
-
(2010)
PLoS ONE
, vol.5
, pp. e14005
-
-
Gao, X.1
-
10
-
-
70149100469
-
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene
-
Church, C. et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 5, e1000599 (2009).
-
(2009)
PLoS Genet.
, vol.5
, pp. e1000599
-
-
Church, C.1
-
11
-
-
78649459183
-
Overexpression of FTO leads to increased food intake and results in obesity
-
Church, C. et al. Overexpression of FTO leads to increased food intake and results in obesity. Nat. Genet. 42, 1086-1092 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 1086-1092
-
-
Church, C.1
-
12
-
-
84897855294
-
Obesity-associated variants within FTO form long-range functional connections with IRX3
-
Smemo, S. et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 507, 371-375 (2014).
-
(2014)
Nature
, vol.507
, pp. 371-375
-
-
Smemo, S.1
-
13
-
-
84899900892
-
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice
-
Stratigopoulos, G. et al. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab. 19, 767-779 (2014).
-
(2014)
Cell Metab.
, vol.19
, pp. 767-779
-
-
Stratigopoulos, G.1
-
14
-
-
84881257670
-
A link between FTO, ghrelin, and impaired brain food-cue responsivity
-
Karra, E. et al. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J. Clin. Invest. 123, 3539-3551 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3539-3551
-
-
Karra, E.1
-
15
-
-
77955981202
-
The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels
-
Berulava, T. & Horsthemke, B. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur. J. Hum. Genet. 18, 1054-1056 (2010).
-
(2010)
Eur. J. Hum. Genet.
, vol.18
, pp. 1054-1056
-
-
Berulava, T.1
Horsthemke, B.2
-
16
-
-
67649875640
-
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations
-
Boissel, S. et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am. J. Hum. Genet. 85, 106-111 (2009).
-
(2009)
Am. J. Hum. Genet.
, vol.85
, pp. 106-111
-
-
Boissel, S.1
-
17
-
-
36749041363
-
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
-
Gerken, T. et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 1469-1472 (2007).
-
(2007)
Science
, vol.318
, pp. 1469-1472
-
-
Gerken, T.1
-
18
-
-
54849381000
-
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
-
Jia, G. et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 582, 3313-3319 (2008).
-
(2008)
FEBS Lett.
, vol.582
, pp. 3313-3319
-
-
Jia, G.1
-
19
-
-
81355146483
-
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
-
Jia, G. et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7, 885-887 (2011).
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 885-887
-
-
Jia, G.1
-
20
-
-
84862649489
-
Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons
-
Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell 149, 1635-1646 (2012).
-
(2012)
Cell
, vol.149
, pp. 1635-1646
-
-
Meyer, K.D.1
-
21
-
-
84860779086
-
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
-
Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485, 201-206 (2012).
-
(2012)
Nature
, vol.485
, pp. 201-206
-
-
Dominissini, D.1
-
22
-
-
84920273757
-
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
-
Zhao, X. et al. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 24, 1403-1419 (2014).
-
(2014)
Cell Res.
, vol.24
, pp. 1403-1419
-
-
Zhao, X.1
-
23
-
-
42949102733
-
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
-
Wahlen, K., Sjolin, E. & Hoffstedt, J. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. J. Lipid Res. 49, 607-611 (2008).
-
(2008)
J. Lipid Res.
, vol.49
, pp. 607-611
-
-
Wahlen, K.1
Sjolin, E.2
Hoffstedt, J.3
-
24
-
-
78650959240
-
Regulation of FTO and FTM expression during human preadipocyte differentiation
-
Tews, D., Fischer-Posovszky, P. & Wabitsch, M. Regulation of FTO and FTM expression during human preadipocyte differentiation. Horm. Metab. Res. 43, 17-21 (2011).
-
(2011)
Horm. Metab. Res.
, vol.43
, pp. 17-21
-
-
Tews, D.1
Fischer-Posovszky, P.2
Wabitsch, M.3
-
25
-
-
42249105698
-
Crucial roles of D-type cyclins in the early stage of adipocyte differentiation
-
Hishida, T., Naito, K., Osada, S., Nishizuka, M. & Imagawa, M. Crucial roles of D-type cyclins in the early stage of adipocyte differentiation. Biochem. Biophys. Res. Commun. 370, 289-294 (2008).
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.370
, pp. 289-294
-
-
Hishida, T.1
Naito, K.2
Osada, S.3
Nishizuka, M.4
Imagawa, M.5
-
26
-
-
84887502374
-
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
-
Wang, Q. A., Tao, C., Gupta, R. K. & Scherer, P. E. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 19, 1338-1344 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 1338-1344
-
-
Wang, Q.A.1
Tao, C.2
Gupta, R.K.3
Scherer, P.E.4
-
27
-
-
84861872697
-
Adipogenesis: From stem cell to adipocyte
-
Tang, Q. Q. & Lane, M. D. Adipogenesis: from stem cell to adipocyte. Annu. Rev. Biochem. 81, 715-736 (2012).
-
(2012)
Annu. Rev. Biochem.
, vol.81
, pp. 715-736
-
-
Tang, Q.Q.1
Lane, M.D.2
-
28
-
-
0037422569
-
Mitotic clonal expansio: A synchronous process required for adipogenesis
-
Tang, Q. Q., Otto, T. C. & Lane, M. D. Mitotic clonal expansio: a synchronous process required for adipogenesis. Proc. Natl Acad. Sci. USA 100, 44-49 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 44-49
-
-
Tang, Q.Q.1
Otto, T.C.2
Lane, M.D.3
-
29
-
-
0037417875
-
CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis
-
Tang, Q. Q., Otto, T. C. & Lane, M. D. CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc. Natl Acad. Sci. USA 100, 850-855 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 850-855
-
-
Tang, Q.Q.1
Otto, T.C.2
Lane, M.D.3
-
30
-
-
0346458703
-
Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes
-
Zhang, J. W., Tang, Q. Q., Vinson, C. & Lane, M. D. Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc. Natl Acad. Sci. USA 101, 43-47 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 43-47
-
-
Zhang, J.W.1
Tang, Q.Q.2
Vinson, C.3
Lane, M.D.4
-
31
-
-
7644229528
-
ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis
-
Rochford, J. J. et al. ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Mol. Cell Biol. 24, 9863-9872 (2004).
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 9863-9872
-
-
Rochford, J.J.1
-
32
-
-
77958150921
-
The obesity-associated Fto gene is a transcriptional coactivator
-
Wu, Q., Saunders, R. A., Szkudlarek-Mikho, M., Serna Ide, L. & Chin, K. V. The obesity-associated Fto gene is a transcriptional coactivator. Biochem. Biophys. Res. Commun. 401, 390-395 (2010).
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.401
, pp. 390-395
-
-
Wu, Q.1
Saunders, R.A.2
Szkudlarek-Mikho, M.3
Serna Ide, L.4
Chin, K.V.5
-
33
-
-
84895878932
-
Runx1t1 (Runt-related transcription factor 1; translocated to, 1) epigenetically regulates the proliferation and nitric oxide production of microglia
-
Baby, N., Li, Y., Ling, E. A., Lu, J. & Dheen, S. T. Runx1t1 (Runt-related transcription factor 1; translocated to, 1) epigenetically regulates the proliferation and nitric oxide production of microglia. PLoS ONE 9, e89326 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e89326
-
-
Baby, N.1
Li, Y.2
Ling, E.A.3
Lu, J.4
Dheen, S.T.5
-
34
-
-
63549114784
-
Hypertrophy and/or hyperplasia: Dynamics of adipose tissue growth
-
Jo, J. et al. Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth. PLoS Comput. Biol. 5, e1000324 (2009).
-
(2009)
PLoS Comput. Biol.
, vol.5
, pp. e1000324
-
-
Jo, J.1
|