Isoquinolone synthesis through SNAr reaction of 2-halobenzonitriles with ketones followed by cyclization

Journal of Organic Chemistry

Volumn 80, Issue 8, 2015, Pages 3998-4002

  Mayo, Muhammad Shareef ^a   Yu, Xiaoqiang ^a   Feng, Xiujuan ^a   Yamamoto, Yoshinori ^a,b   Bao, Ming ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

KETONES; NITROGEN COMPOUNDS; SULFUR COMPOUNDS;

LEWIS ACID;

CYCLIZATION;

1,3,4,5 TETRAHYDROPHENANTHRIDIN 6(2H) ONE; 3 (2 FLUOROPHENYL)ISOQUINOLIN 1(2H) ONE; 3 (4 FLUOROPHENYL)ISOQUINOLIN 1(2H) ONE; 3 (4 IODOPHENYL)ISOQUINOLIN 1(2H) ONE; 3 (4 METHOXYPHENYL)ISOQUINOLIN 1(2H) ONE; 3 (NAPHTHALEN 1 YL)ISOQUINOLIN 1(2H) ONE; 3 (NAPHTHALEN 2 YL)ISOQUINOLIN 1(2H) ONE; 3 (O TOLYL)ISOQUINOLIN 1(2H) ONE; 3 (P TOLYL)ISOQUINOLIN 1(2H) ONE; 3 ETHYL 4 METHYLISOQUINOLIN 1(2H) ONE; 3 PHENYLISOQUINOLIN 1(2H) ONE; 3 [4 (TRIFLUOROMETHYL)PHENYL]ISOQUINOLIN 1(2H) ONE; 4 METHYL 3 PHENYLISOQUINOLIN 1(2H) ONE; 6 METHYL 3 PHENYLISOQUINOLIN 1(2H) ONE; 7 CHLORO 3 PHENYLISOQUINOLIN 1(2H) ONE; ANALGESIC AGENT; ANTIDEPRESSANT AGENT; ANTIULCER AGENT; BENZONITRILE; KETONE; LEWIS ACID; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG; ARGON; COPPER; HALOGENATED HYDROCARBON; NITRILE;

ARTICLE; CATALYST; CYCLIZATION; DRUG SYNTHESIS; ELECTRON; REACTION ANALYSIS; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

ARGON; CATALYSIS; COPPER; CYCLIZATION; HYDROCARBONS, HALOGENATED; KETONES; MOLECULAR STRUCTURE; NITRILES; QUINOLONES;

EID: 84928143213     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/acs.joc.5b00357     Document Type: Article

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