Synthesis of 1(2H)-isoquinolones by the nickel-catalyzed denitrogenative alkyne insertion of 1,2,3-benzotriazin-4(3H)-ones

Organic Letters

Volumn 10, Issue 14, 2008, Pages 3085-3088

  Miura, Tomoya ^a   Yamauchi, Motoshi ^a   Murakami, Masahiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE; BENZENE DERIVATIVE; ISOQUINOLINE DERIVATIVE; NICKEL; TRIAZINE DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; STEREOISOMERISM; SYNTHESIS;

ALKYNES; BENZENE DERIVATIVES; CATALYSIS; ISOQUINOLINES; MOLECULAR STRUCTURE; NICKEL; STEREOISOMERISM; TRIAZINES;

EID: 52049100181     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol8010826     Document Type: Article

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28. The benzotriazinone 1g was recovered.
29. See the Supporting Information for details.
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37. 3 (85:15), DPPPen (92: 8), DPEphos (88:12), XANTPHOS (93:7).
38. 3 as the ligand. For example, the reaction of 1-phenylprop-1-yne using dppf required heating at 80°C in toluene, giving inferior regioselectivity of 65:35.