Isoquinolinone synthesis by SNAr reaction: A versatile route to imidazo[4,5-h]isoquinolin-9-ones

Tetrahedron Letters

Volumn 43, Issue 42, 2002, Pages 7553-7556

  Snow, Roger J ^a   Butz, Tanja ^a   Hammach, Abdelhakim ^a   Kapadia, Suresh ^a   Morwick, Tina M ^a   Prokopowicz III, Anthony S ^a   Takahashi, Hidenori ^a   Tan, Jonathan D ^a   Tschantz, Matt A ^a   Wang, Xiao Jun ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DICHLORO 3 NITROBENZONITRILE; AMINE; CHLORINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; NITRILE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

EID: 18644386512     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)01802-6     Document Type: Article

References (9)

1. Snow R.J., Cardozo M.G., Morwick T.M., Busacca C.A., Dong Y., Eckner R.J., Jacober S., Jakes S., Kapadia S., Lukas S., Panzenbeck M., Peet G.W., Peterson J.D., Prokopowicz A.S. III, Sellati R., Tolbert R.M., Tschantz M.A., Moss N. J. Med. Chem. 45:2002;3394-3405.
2. Wu M.-J., Chang L.-J., Wei L.-M., Lin C.-F. Tetrahedron. 55:1999;13193-13200.
3. Sakamoto T., Miura N., Kondo Y., Yamanaka H. Chem. Pharm. Bull. 34:1986;2760-2765.
4. Brun E.M., Gil S., Mestres R., Parra M. Synthesis. 2000;273-280.
5. Fisher L.E., Muchowski J.M., Clark R.D. J. Org. Chem. 57:1992;2700-2705.
6. Bois-Choussy M., Beugelmans R. Synthesis. 1981;729-731.
7. Sommer M.B., Bergtrup M., Bogeso P. J. Org. Chem. 55:1990;4817-4821.
8. Capps D.B., Dunbar J., Kesten S.R., Shillis J., Werbel L.M., Plowman J., Ward D.L. J. Med. Chem. 35:1992;4770-4778.
9. Goldberg, D. R.; Butz, T.; Cardozo, M. G.; Eckner, R. J.; Hammach, A.; Huang, J.; Jakes, S.; Kapadia, S.; Kashem, M.; Lukas, S.; Morwick, T. M.; Moss, N.; Panzenbeck, M.; Patel, U.; Pav, S.; Peet, G. W.; Peterson, J. D.; Prokopowicz, A. S., III; Snow, R. J.; Sellati, R.; Takahashi, H.; Tan, J.; Tschantz, M. A.; Wang, X.; Wang, Y.; Wolak, J.; Xiong, P. J. Med. Chem., submitted.