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Volumn , Issue 19, 2007, Pages 1966-1968

Tandem C-C coupling - Intramolecular acetylenic Schmidt reaction under Pd/C-Cu catalysis

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; COPPER; HETEROCYCLIC COMPOUND; ISOQUINOLINE DERIVATIVE; PALLADIUM;

EID: 34250895132     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b617823e     Document Type: Article
Times cited : (44)

References (31)
  • 25
    • 34250901757 scopus 로고    scopus 로고
    • 3;
    • Formation of 10-12% of dimeric product was observed when arylalkynes were used
  • 28
    • 0037100307 scopus 로고    scopus 로고
    • In an alternative mechanism, intermediate A adds HPdI to generate two vinyl palladium intermediates. Intramolecular azide addition to the double bond generates two triazines. Loss of nitrogen results in two aziridines. The aziridines then open to give vinyl palladium intermediates corresponding to the five- and six-membered ring products that finally afford 3 and 4 in the presence of triethylamine (which perhaps acts as a reducing agent). For intramolecular cycloaddition of an azide across a double bond leading to an aziridine, see:
    • N. Briet M. H. Brookes R. J. Davenport F. C. A. Galvin P. J. Gilbert S. R. Mack V. Sabin Tetrahedron 2002 58 5761
    • (2002) Tetrahedron , vol.58 , pp. 5761
    • Briet, N.1    Brookes, M.H.2    Davenport, R.J.3    Galvin, F.C.A.4    Gilbert, P.J.5    Mack, S.R.6    Sabin, V.7
  • 30
    • 0035926427 scopus 로고    scopus 로고
    • 50 of 28.32 on a tested panel of cancer cell lines [e.g. HT29 (colon), H460 (lung), LoVo (colon)] (see Electronic Supplementary Information) For in vitro antitumour activity of compounds 3m-n against various cell lines, see:
    • G. Broggini L. Garanti G. Molteni T. Pilati Tetrahedron: Asymmetry 2001 12 1201
    • (2001) Tetrahedron: Asymmetry , vol.12 , pp. 1201
    • Broggini, G.1    Garanti, L.2    Molteni, G.3    Pilati, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.