Synthesis and enzymatic studies of bisubstrate analogues for farnesyl diphosphate synthase

Journal of Organic Chemistry

Volumn 80, Issue 8, 2015, Pages 3902-3913

  Ramamoorthy, Gurusankar ^a   Pugh, Mark L ^a,d   Tian, Bo Xue ^b,c   Phan, Richard M ^a,e   Perez, Lawrence B ^a,f   Jacobson, Matthew P ^b,c   Poulter, C Dale ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BRIGHAM YOUNG UNIVERSITY IDAHO   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^f US Army Dugway Proving Ground   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAINS; FUNCTIONAL GROUPS; REGIOSELECTIVITY;

CATALYTIC EFFICIENCIES; CHAIN ELONGATION REACTION; CONFORMATIONAL SPACE; FARNESYL DIPHOSPHATE; FARNESYL DIPHOSPHATE SYNTHASE; HOMOALLYLIC ALCOHOL; ISOPENTENYL DIPHOSPHATE; SEVEN-MEMBERED RINGS;

COMPENSATION (PERSONNEL);

ALCOHOL DERIVATIVE; DIMETHYLALLYL DIPHOSPHATE; GERANYL DIPHOSPHATE; GERANYLTRANSFERASE; HYDROGEN; PYROPHOSPHATE; PYROPHOSPHORIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 3-METHYL-3-BUTEN-1-OL; BUTANOL; FARNESYL DIPHOSPHATE; ISOPRENOID PHOSPHATE; QUATERNARY AMMONIUM DERIVATIVE; SESQUITERPENE; TRIS(TETRA-N-BUTYLAMMONIUM)HYDROGEN DIPHOSPHATE;

ALKYLATION; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CYCLIZATION; ELECTROPHILICITY; ELIMINATION REACTION; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SUBSTRATE; ENZYME SYNTHESIS; MOLECULAR DOCKING; MUTAGENESIS; PROTON NUCLEAR MAGNETIC RESONANCE; STEADY STATE; STEREOCHEMISTRY; CHEMISTRY; ENZYME SPECIFICITY; SYNTHESIS;

BUTANOLS; CATALYSIS; CYCLIZATION; GERANYLTRANSTRANSFERASE; POLYISOPRENYL PHOSPHATES; QUATERNARY AMMONIUM COMPOUNDS; SESQUITERPENES; SUBSTRATE SPECIFICITY;

EID: 84928139339     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/acs.joc.5b00202     Document Type: Article

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