메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

ATM kinase sustains HER2 tumorigenicity in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEAT SHOCK PROTEIN 90; PROTEIN KINASE B; ATM PROTEIN, HUMAN; ERBB2 PROTEIN, HUMAN;

EID: 84928041749     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7886     Document Type: Article
Times cited : (55)

References (49)
  • 1
    • 84875423827 scopus 로고    scopus 로고
    • The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
    • Shiloh, Y. & Ziv, Y. The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 14, 197-210 (2013).
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 197-210
    • Shiloh, Y.1    Ziv, Y.2
  • 2
    • 38449117827 scopus 로고    scopus 로고
    • Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia
    • Lavin, M. F., Gueven, N., Bottle, S. & Gatti, R. A. Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia. Br. Med. Bull. 81-82, 129-147 (2007).
    • (2007) Br. Med. Bull. , vol.81-82 , pp. 129-147
    • Lavin, M.F.1    Gueven, N.2    Bottle, S.3    Gatti, R.A.4
  • 3
    • 33645072212 scopus 로고    scopus 로고
    • ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: The DSB connection
    • Matei, I. R., Guidos, C. J. & Danska, J. S. ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: The DSB connection. Immunol. Rev. 209, 142-158 (2006).
    • (2006) Immunol. Rev. , vol.209 , pp. 142-158
    • Matei, I.R.1    Guidos, C.J.2    Danska, J.S.3
  • 4
    • 1242285050 scopus 로고    scopus 로고
    • ATM gene and lymphoid malignancies
    • Gumy-Pause, F., Wacker, P. & Sappino, A. P. ATM gene and lymphoid malignancies. Leukemia 18, 238-242 (2004).
    • (2004) Leukemia , vol.18 , pp. 238-242
    • Gumy-Pause, F.1    Wacker, P.2    Sappino, A.P.3
  • 5
    • 0034946243 scopus 로고    scopus 로고
    • Ataxia telangiectasia gene mutations in leukaemia and lymphoma
    • Boultwood, J. Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J. Clin. Pathol. 54, 512-516 (2001).
    • (2001) J. Clin. Pathol. , vol.54 , pp. 512-516
    • Boultwood, J.1
  • 6
    • 0023244806 scopus 로고
    • Breast and other cancers in families with ataxia telangiectasia
    • Swift, M., Reitnauer, P. J., Morrell, D. & Chase, C. L. Breast and other cancers in families with ataxia telangiectasia. N. Engl. J. Med. 316, 1289-1294 (1987).
    • (1987) N. Engl. J. Med. , vol.316 , pp. 1289-1294
    • Swift, M.1    Reitnauer, P.J.2    Morrell, D.3    Chase, C.L.4
  • 7
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer
    • Lavin, M. F. Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 9, 759-769 (2008).
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 8
    • 20544474516 scopus 로고    scopus 로고
    • Cancer risks and mortality in heterozygous ATM mutation carriers
    • Thompson, D. et al. Cancer risks and mortality in heterozygous ATM mutation carriers. J. Natl Cancer Inst. 97, 813-822 (2005).
    • (2005) J. Natl Cancer Inst. , vol.97 , pp. 813-822
    • Thompson, D.1
  • 9
    • 33744995360 scopus 로고    scopus 로고
    • The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer
    • Stredrick, D. L. et al. The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer. Hum. Mutat. 27, 538-544 (2006).
    • (2006) Hum. Mutat. , vol.27 , pp. 538-544
    • Stredrick, D.L.1
  • 10
    • 80053100604 scopus 로고    scopus 로고
    • Rare variants in the ATM gene and risk of breast cancer
    • Goldgar, D. E. et al. Rare variants in the ATM gene and risk of breast cancer. Breast Cancer Res. 13, R73 (2011).
    • (2011) Breast Cancer Res. , vol.13 , pp. 73
    • Goldgar, D.E.1
  • 11
    • 33746491583 scopus 로고    scopus 로고
    • ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
    • Renwick, A. et al. ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat. Genet. 38, 873-875 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 873-875
    • Renwick, A.1
  • 12
    • 0029821651 scopus 로고    scopus 로고
    • Dual roles of ATM in the cellular response to radiation and in cell growth control
    • Xu, Y. & Baltimore, D. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10, 2401-2410 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 2401-2410
    • Xu, Y.1    Baltimore, D.2
  • 13
    • 0033662156 scopus 로고    scopus 로고
    • Partecipation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
    • Yang, D.-Q. & Kastan, M. B. Partecipation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat. Cell Biol. 2, 893-898 (2000).
    • (2000) Nat. Cell Biol. , vol.2 , pp. 893-898
    • Yang, D.-Q.1    Kastan, M.B.2
  • 14
    • 70350238489 scopus 로고    scopus 로고
    • Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
    • Golding, S. E. et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol. Cancer Ther. 10, 2894-2902 (2009).
    • (2009) Mol. Cancer Ther. , vol.10 , pp. 2894-2902
    • Golding, S.E.1
  • 15
    • 79955420135 scopus 로고    scopus 로고
    • Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer
    • De Bacco, F. et al. Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J. Natl Cancer Inst. 103, 645-661 (2011).
    • (2011) J. Natl Cancer Inst. , vol.103 , pp. 645-661
    • De Bacco, F.1
  • 16
    • 45449097412 scopus 로고    scopus 로고
    • ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells
    • Halaby, M. J., Hibma, J. C., He, J. & Yang, D. Q. ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells. Cell Signal. 20, 1555-1563 (2008).
    • (2008) Cell Signal. , vol.20 , pp. 1555-1563
    • Halaby, M.J.1    Hibma, J.C.2    He, J.3    Yang, D.Q.4
  • 17
    • 20044390541 scopus 로고    scopus 로고
    • Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
    • Viniegra, J. G. et al. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J. Biol. Chem. 280, 4029-4036 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 4029-4036
    • Viniegra, J.G.1
  • 18
    • 78649231611 scopus 로고    scopus 로고
    • MTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1a
    • Cam, H., Easton, J., High, A. & Houghton, P. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1a. Mol. Cell 40, 509-520 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 509-520
    • Cam, H.1    Easton, J.2    High, A.3    Houghton, P.4
  • 19
    • 84864701748 scopus 로고    scopus 로고
    • Pathological neoangiogenesis depends on oxidative stress regulation by ATM
    • Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T. & Kubota, Y. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat. Med. 18, 1208-1216 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1208-1216
    • Okuno, Y.1    Nakamura-Ishizu, A.2    Otsu, K.3    Suda, T.4    Kubota, Y.5
  • 20
    • 84856893251 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in ataxia-telangiectasia
    • Valentin-Vega, Y. A. et al. Mitochondrial dysfunction in ataxia-telangiectasia. Blood 119, 1490-1500 (2012).
    • (2012) Blood , vol.119 , pp. 1490-1500
    • Valentin-Vega, Y.A.1
  • 21
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon, D. J. et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707-712 (1989).
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1
  • 22
    • 78649390831 scopus 로고    scopus 로고
    • Treatment of HER2-overexpressing breast cancer
    • Baselga, J. Treatment of HER2-overexpressing breast cancer. Ann. Oncol. 21 Suppl 7, vii36-vii40 (2010).
    • (2010) Ann. Oncol. , vol.21 , pp. 36-40
    • Baselga, J.1
  • 23
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: Towards the systems level
    • Citri, A. & Yarden, Y. EGF-ERBB signalling: Towards the systems level. Nat. Rev. Mol. Cell Biol. 7, 505-516 (2006).
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 24
    • 34547854801 scopus 로고    scopus 로고
    • The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
    • Moasser, M. M. The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 26, 6469-6487 (2007).
    • (2007) Oncogene , vol.26 , pp. 6469-6487
    • Moasser, M.M.1
  • 25
    • 0023196582 scopus 로고
    • ErbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells
    • Di Fiore, P. P. et al. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 237, 178-182 (1987).
    • (1987) Science , vol.237 , pp. 178-182
    • Di Fiore, P.P.1
  • 26
    • 0023430930 scopus 로고
    • Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells
    • Hudziak, R. M., Schlessinger, J. & Ullrich, A. Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc. Natl Acad. Sci. USA 84, 7159-7163 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 7159-7163
    • Hudziak, R.M.1    Schlessinger, J.2    Ullrich, A.3
  • 27
    • 77649247825 scopus 로고    scopus 로고
    • Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation
    • Reddy, J. P. et al. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc. Natl Acad. Sci. USA 107, 3728-3733 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 3728-3733
    • Reddy, J.P.1
  • 28
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003).
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 29
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek, J., Bartkova, J. & Lukas, J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 26, 7773-7779 (2007).
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 30
    • 77951169413 scopus 로고    scopus 로고
    • ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells
    • Haenssen, K. K. et al. ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells. J. Cell Sci. 123, 1373-1382 (2010).
    • (2010) J. Cell Sci. , vol.123 , pp. 1373-1382
    • Haenssen, K.K.1
  • 31
    • 0032479871 scopus 로고    scopus 로고
    • Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice
    • Boggio, K. et al. Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J. Exp. Med. 188, 589-596 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 589-596
    • Boggio, K.1
  • 32
    • 1942431966 scopus 로고    scopus 로고
    • The achilles heel of ErbB-2/HER2: Regulation by the Hsp90 chaperone machine and potential for pharmacological intervention
    • Citri, A., Kochupurakkal, B. S. & Yarden, Y. The achilles heel of ErbB-2/HER2: Regulation by the Hsp90 chaperone machine and potential for pharmacological intervention. Cell Cycle 3, 51-60 (2004).
    • (2004) Cell Cycle , vol.3 , pp. 51-60
    • Citri, A.1    Kochupurakkal, B.S.2    Yarden, Y.3
  • 33
    • 0036225446 scopus 로고    scopus 로고
    • Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
    • Normanno, N. et al. Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth. Ann. Oncol. 13, 65-72 (2002).
    • (2002) Ann. Oncol. , vol.13 , pp. 65-72
    • Normanno, N.1
  • 34
    • 84884255642 scopus 로고    scopus 로고
    • Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis
    • Minami, T. et al. Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis. Sci. Rep. 3, 2669 (2013).
    • (2013) Sci. Rep. , vol.3 , pp. 2669
    • Minami, T.1
  • 35
    • 77953540958 scopus 로고    scopus 로고
    • HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
    • Weigelt, B., Lo, A. T., Park, C. C., Gray, J. W. & Bissell, M. J. HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res. Treat. 122, 35-43 (2010).
    • (2010) Breast Cancer Res. Treat. , vol.122 , pp. 35-43
    • Weigelt, B.1    Lo, A.T.2    Park, C.C.3    Gray, J.W.4    Bissell, M.J.5
  • 36
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • Shou, J. et al. Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J. Natl Cancer Inst. 96, 926-935 (2004).
    • (2004) J. Natl Cancer Inst. , vol.96 , pp. 926-935
    • Shou, J.1
  • 37
    • 38849091433 scopus 로고    scopus 로고
    • Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
    • Massarweh, S. et al. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res. 68, 826-833 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 826-833
    • Massarweh, S.1
  • 38
    • 77952576753 scopus 로고    scopus 로고
    • The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
    • Larsson, L. G. & Henriksson, M. A. The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy. Exp. Cell Res. 316, 1429-1437 (2010).
    • (2010) Exp. Cell Res. , vol.316 , pp. 1429-1437
    • Larsson, L.G.1    Henriksson, M.A.2
  • 39
    • 36448975490 scopus 로고    scopus 로고
    • Structure dynamics and functions of promyelocytic leukaemia nuclear bodies
    • Bernardi, R. & Pandolfi, P. P. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat. Rev. Mol. Cell Biol. 8, 1006-1016 (2007).
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 1006-1016
    • Bernardi, R.1    Pandolfi, P.P.2
  • 40
    • 84865959001 scopus 로고    scopus 로고
    • A metabolic prosurvival role for PML in breast cancer
    • Carracedo, A. et al. A metabolic prosurvival role for PML in breast cancer. J. Clin. Invest. 122, 3088-3100 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 3088-3100
    • Carracedo, A.1
  • 41
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • Matsuoka, S. et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166 (2007).
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1
  • 42
    • 33745186920 scopus 로고    scopus 로고
    • Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells
    • Biton, S. et al. Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells. J. Biol. Chem. 281, 17482-17491 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 17482-17491
    • Biton, S.1
  • 43
    • 84055184840 scopus 로고    scopus 로고
    • Oxygen sensing is impaired in ATM defective cells
    • Mongiardi, P. et al. Oxygen sensing is impaired in ATM defective cells. Cell Cycle 10, 4311-4320 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 4311-4320
    • Mongiardi, P.1
  • 44
    • 33845779054 scopus 로고    scopus 로고
    • ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells
    • Biton, S. et al. ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells. DNA Repair (Amst) 6, 128-134 (2007).
    • (2007) DNA Repair (Amst) , vol.6 , pp. 128-134
    • Biton, S.1
  • 45
    • 38549156012 scopus 로고    scopus 로고
    • Silencing the MET oncogene leads to regression of experimental tumors and metastases
    • Corso, S. et al. Silencing the MET oncogene leads to regression of experimental tumors and metastases. Oncogene 27, 684-693 (2008).
    • (2008) Oncogene , vol.27 , pp. 684-693
    • Corso, S.1
  • 46
    • 78651225884 scopus 로고    scopus 로고
    • The cooperation between hMena overexpression and HER2 signalling in breast cancer
    • Di Modugno, F. et al. The cooperation between hMena overexpression and HER2 signalling in breast cancer. PLoS ONE 5, e15852 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e15852
    • Di Modugno, F.1
  • 47
    • 38349087547 scopus 로고    scopus 로고
    • ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells
    • Stagni, V. et al. ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells. Blood 111, 829-837 (2008).
    • (2008) Blood , vol.111 , pp. 829-837
    • Stagni, V.1
  • 48
    • 80052693990 scopus 로고    scopus 로고
    • Abl interconnects oncogenic Met and p53 core pathways in cancer cells
    • Furlan, A. et al. Abl interconnects oncogenic Met and p53 core pathways in cancer cells. Cell Death Differ. 18, 1608-1616 (2011).
    • (2011) Cell Death Differ. , vol.18 , pp. 1608-1616
    • Furlan, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.