-
1
-
-
84875423827
-
The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
-
Shiloh, Y. & Ziv, Y. The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 14, 197-210 (2013).
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 197-210
-
-
Shiloh, Y.1
Ziv, Y.2
-
2
-
-
38449117827
-
Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia
-
Lavin, M. F., Gueven, N., Bottle, S. & Gatti, R. A. Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia. Br. Med. Bull. 81-82, 129-147 (2007).
-
(2007)
Br. Med. Bull.
, vol.81-82
, pp. 129-147
-
-
Lavin, M.F.1
Gueven, N.2
Bottle, S.3
Gatti, R.A.4
-
3
-
-
33645072212
-
ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: The DSB connection
-
Matei, I. R., Guidos, C. J. & Danska, J. S. ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: The DSB connection. Immunol. Rev. 209, 142-158 (2006).
-
(2006)
Immunol. Rev.
, vol.209
, pp. 142-158
-
-
Matei, I.R.1
Guidos, C.J.2
Danska, J.S.3
-
4
-
-
1242285050
-
ATM gene and lymphoid malignancies
-
Gumy-Pause, F., Wacker, P. & Sappino, A. P. ATM gene and lymphoid malignancies. Leukemia 18, 238-242 (2004).
-
(2004)
Leukemia
, vol.18
, pp. 238-242
-
-
Gumy-Pause, F.1
Wacker, P.2
Sappino, A.P.3
-
5
-
-
0034946243
-
Ataxia telangiectasia gene mutations in leukaemia and lymphoma
-
Boultwood, J. Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J. Clin. Pathol. 54, 512-516 (2001).
-
(2001)
J. Clin. Pathol.
, vol.54
, pp. 512-516
-
-
Boultwood, J.1
-
6
-
-
0023244806
-
Breast and other cancers in families with ataxia telangiectasia
-
Swift, M., Reitnauer, P. J., Morrell, D. & Chase, C. L. Breast and other cancers in families with ataxia telangiectasia. N. Engl. J. Med. 316, 1289-1294 (1987).
-
(1987)
N. Engl. J. Med.
, vol.316
, pp. 1289-1294
-
-
Swift, M.1
Reitnauer, P.J.2
Morrell, D.3
Chase, C.L.4
-
7
-
-
52449114574
-
Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer
-
Lavin, M. F. Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 9, 759-769 (2008).
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 759-769
-
-
Lavin, M.F.1
-
8
-
-
20544474516
-
Cancer risks and mortality in heterozygous ATM mutation carriers
-
Thompson, D. et al. Cancer risks and mortality in heterozygous ATM mutation carriers. J. Natl Cancer Inst. 97, 813-822 (2005).
-
(2005)
J. Natl Cancer Inst.
, vol.97
, pp. 813-822
-
-
Thompson, D.1
-
9
-
-
33744995360
-
The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer
-
Stredrick, D. L. et al. The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer. Hum. Mutat. 27, 538-544 (2006).
-
(2006)
Hum. Mutat.
, vol.27
, pp. 538-544
-
-
Stredrick, D.L.1
-
10
-
-
80053100604
-
Rare variants in the ATM gene and risk of breast cancer
-
Goldgar, D. E. et al. Rare variants in the ATM gene and risk of breast cancer. Breast Cancer Res. 13, R73 (2011).
-
(2011)
Breast Cancer Res.
, vol.13
, pp. 73
-
-
Goldgar, D.E.1
-
11
-
-
33746491583
-
ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
-
Renwick, A. et al. ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat. Genet. 38, 873-875 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 873-875
-
-
Renwick, A.1
-
12
-
-
0029821651
-
Dual roles of ATM in the cellular response to radiation and in cell growth control
-
Xu, Y. & Baltimore, D. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10, 2401-2410 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 2401-2410
-
-
Xu, Y.1
Baltimore, D.2
-
13
-
-
0033662156
-
Partecipation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
-
Yang, D.-Q. & Kastan, M. B. Partecipation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat. Cell Biol. 2, 893-898 (2000).
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 893-898
-
-
Yang, D.-Q.1
Kastan, M.B.2
-
14
-
-
70350238489
-
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
-
Golding, S. E. et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol. Cancer Ther. 10, 2894-2902 (2009).
-
(2009)
Mol. Cancer Ther.
, vol.10
, pp. 2894-2902
-
-
Golding, S.E.1
-
15
-
-
79955420135
-
Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer
-
De Bacco, F. et al. Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J. Natl Cancer Inst. 103, 645-661 (2011).
-
(2011)
J. Natl Cancer Inst.
, vol.103
, pp. 645-661
-
-
De Bacco, F.1
-
16
-
-
45449097412
-
ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells
-
Halaby, M. J., Hibma, J. C., He, J. & Yang, D. Q. ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells. Cell Signal. 20, 1555-1563 (2008).
-
(2008)
Cell Signal.
, vol.20
, pp. 1555-1563
-
-
Halaby, M.J.1
Hibma, J.C.2
He, J.3
Yang, D.Q.4
-
17
-
-
20044390541
-
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
-
Viniegra, J. G. et al. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J. Biol. Chem. 280, 4029-4036 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4029-4036
-
-
Viniegra, J.G.1
-
18
-
-
78649231611
-
MTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1a
-
Cam, H., Easton, J., High, A. & Houghton, P. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1a. Mol. Cell 40, 509-520 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 509-520
-
-
Cam, H.1
Easton, J.2
High, A.3
Houghton, P.4
-
19
-
-
84864701748
-
Pathological neoangiogenesis depends on oxidative stress regulation by ATM
-
Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T. & Kubota, Y. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat. Med. 18, 1208-1216 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 1208-1216
-
-
Okuno, Y.1
Nakamura-Ishizu, A.2
Otsu, K.3
Suda, T.4
Kubota, Y.5
-
20
-
-
84856893251
-
Mitochondrial dysfunction in ataxia-telangiectasia
-
Valentin-Vega, Y. A. et al. Mitochondrial dysfunction in ataxia-telangiectasia. Blood 119, 1490-1500 (2012).
-
(2012)
Blood
, vol.119
, pp. 1490-1500
-
-
Valentin-Vega, Y.A.1
-
21
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon, D. J. et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707-712 (1989).
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
-
22
-
-
78649390831
-
Treatment of HER2-overexpressing breast cancer
-
Baselga, J. Treatment of HER2-overexpressing breast cancer. Ann. Oncol. 21 Suppl 7, vii36-vii40 (2010).
-
(2010)
Ann. Oncol.
, vol.21
, pp. 36-40
-
-
Baselga, J.1
-
23
-
-
33745828702
-
EGF-ERBB signalling: Towards the systems level
-
Citri, A. & Yarden, Y. EGF-ERBB signalling: Towards the systems level. Nat. Rev. Mol. Cell Biol. 7, 505-516 (2006).
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 505-516
-
-
Citri, A.1
Yarden, Y.2
-
24
-
-
34547854801
-
The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
-
Moasser, M. M. The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 26, 6469-6487 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 6469-6487
-
-
Moasser, M.M.1
-
25
-
-
0023196582
-
ErbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells
-
Di Fiore, P. P. et al. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 237, 178-182 (1987).
-
(1987)
Science
, vol.237
, pp. 178-182
-
-
Di Fiore, P.P.1
-
26
-
-
0023430930
-
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells
-
Hudziak, R. M., Schlessinger, J. & Ullrich, A. Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc. Natl Acad. Sci. USA 84, 7159-7163 (1987).
-
(1987)
Proc. Natl Acad. Sci. USA
, vol.84
, pp. 7159-7163
-
-
Hudziak, R.M.1
Schlessinger, J.2
Ullrich, A.3
-
27
-
-
77649247825
-
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation
-
Reddy, J. P. et al. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc. Natl Acad. Sci. USA 107, 3728-3733 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 3728-3733
-
-
Reddy, J.P.1
-
28
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003).
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
29
-
-
36949005417
-
DNA damage signalling guards against activated oncogenes and tumour progression
-
Bartek, J., Bartkova, J. & Lukas, J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 26, 7773-7779 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 7773-7779
-
-
Bartek, J.1
Bartkova, J.2
Lukas, J.3
-
30
-
-
77951169413
-
ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells
-
Haenssen, K. K. et al. ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells. J. Cell Sci. 123, 1373-1382 (2010).
-
(2010)
J. Cell Sci.
, vol.123
, pp. 1373-1382
-
-
Haenssen, K.K.1
-
31
-
-
0032479871
-
Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice
-
Boggio, K. et al. Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J. Exp. Med. 188, 589-596 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 589-596
-
-
Boggio, K.1
-
32
-
-
1942431966
-
The achilles heel of ErbB-2/HER2: Regulation by the Hsp90 chaperone machine and potential for pharmacological intervention
-
Citri, A., Kochupurakkal, B. S. & Yarden, Y. The achilles heel of ErbB-2/HER2: Regulation by the Hsp90 chaperone machine and potential for pharmacological intervention. Cell Cycle 3, 51-60 (2004).
-
(2004)
Cell Cycle
, vol.3
, pp. 51-60
-
-
Citri, A.1
Kochupurakkal, B.S.2
Yarden, Y.3
-
33
-
-
0036225446
-
Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
-
Normanno, N. et al. Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth. Ann. Oncol. 13, 65-72 (2002).
-
(2002)
Ann. Oncol.
, vol.13
, pp. 65-72
-
-
Normanno, N.1
-
34
-
-
84884255642
-
Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis
-
Minami, T. et al. Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis. Sci. Rep. 3, 2669 (2013).
-
(2013)
Sci. Rep.
, vol.3
, pp. 2669
-
-
Minami, T.1
-
35
-
-
77953540958
-
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
-
Weigelt, B., Lo, A. T., Park, C. C., Gray, J. W. & Bissell, M. J. HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res. Treat. 122, 35-43 (2010).
-
(2010)
Breast Cancer Res. Treat.
, vol.122
, pp. 35-43
-
-
Weigelt, B.1
Lo, A.T.2
Park, C.C.3
Gray, J.W.4
Bissell, M.J.5
-
36
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
Shou, J. et al. Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J. Natl Cancer Inst. 96, 926-935 (2004).
-
(2004)
J. Natl Cancer Inst.
, vol.96
, pp. 926-935
-
-
Shou, J.1
-
37
-
-
38849091433
-
Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
-
Massarweh, S. et al. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res. 68, 826-833 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 826-833
-
-
Massarweh, S.1
-
38
-
-
77952576753
-
The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
-
Larsson, L. G. & Henriksson, M. A. The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy. Exp. Cell Res. 316, 1429-1437 (2010).
-
(2010)
Exp. Cell Res.
, vol.316
, pp. 1429-1437
-
-
Larsson, L.G.1
Henriksson, M.A.2
-
39
-
-
36448975490
-
Structure dynamics and functions of promyelocytic leukaemia nuclear bodies
-
Bernardi, R. & Pandolfi, P. P. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat. Rev. Mol. Cell Biol. 8, 1006-1016 (2007).
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 1006-1016
-
-
Bernardi, R.1
Pandolfi, P.P.2
-
40
-
-
84865959001
-
A metabolic prosurvival role for PML in breast cancer
-
Carracedo, A. et al. A metabolic prosurvival role for PML in breast cancer. J. Clin. Invest. 122, 3088-3100 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 3088-3100
-
-
Carracedo, A.1
-
41
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka, S. et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166 (2007).
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
-
42
-
-
33745186920
-
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells
-
Biton, S. et al. Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells. J. Biol. Chem. 281, 17482-17491 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 17482-17491
-
-
Biton, S.1
-
43
-
-
84055184840
-
Oxygen sensing is impaired in ATM defective cells
-
Mongiardi, P. et al. Oxygen sensing is impaired in ATM defective cells. Cell Cycle 10, 4311-4320 (2011).
-
(2011)
Cell Cycle
, vol.10
, pp. 4311-4320
-
-
Mongiardi, P.1
-
44
-
-
33845779054
-
ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells
-
Biton, S. et al. ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells. DNA Repair (Amst) 6, 128-134 (2007).
-
(2007)
DNA Repair (Amst)
, vol.6
, pp. 128-134
-
-
Biton, S.1
-
45
-
-
38549156012
-
Silencing the MET oncogene leads to regression of experimental tumors and metastases
-
Corso, S. et al. Silencing the MET oncogene leads to regression of experimental tumors and metastases. Oncogene 27, 684-693 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 684-693
-
-
Corso, S.1
-
46
-
-
78651225884
-
The cooperation between hMena overexpression and HER2 signalling in breast cancer
-
Di Modugno, F. et al. The cooperation between hMena overexpression and HER2 signalling in breast cancer. PLoS ONE 5, e15852 (2010).
-
(2010)
PLoS ONE
, vol.5
, pp. e15852
-
-
Di Modugno, F.1
-
47
-
-
38349087547
-
ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells
-
Stagni, V. et al. ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells. Blood 111, 829-837 (2008).
-
(2008)
Blood
, vol.111
, pp. 829-837
-
-
Stagni, V.1
-
48
-
-
80052693990
-
Abl interconnects oncogenic Met and p53 core pathways in cancer cells
-
Furlan, A. et al. Abl interconnects oncogenic Met and p53 core pathways in cancer cells. Cell Death Differ. 18, 1608-1616 (2011).
-
(2011)
Cell Death Differ.
, vol.18
, pp. 1608-1616
-
-
Furlan, A.1
|