Ethanol promotes saturated fatty acid-induced hepatoxicity through endoplasmic reticulum (ER) stress response

Chinese Journal of Natural Medicines

Volumn 13, Issue 4, 2015, Pages 250-256

  Yi, Hong Wei ^a,b   Ma, Yu Xiang ^b   Wang, Xiao Ning ^b   Wang, Cui Fen ^c   Lu, Jian ^a   Cao, Wei ^a   Wu, Xu Dong ^b  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c MARSHALL UNIVERSITY   (United States)

Author keywords

CHOP knockout; ER stress; Ethanol (EtOH); Liver toxicity; Palmitic acid (PA)

Indexed keywords

ALCOHOL; CASPASE 3; PALMITIC ACID; ACTIVATING TRANSCRIPTION FACTOR 4; DNA BINDING PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DYSLIPIDEMIA; ENDOPLASMIC RETICULUM STRESS; INFLAMMATION; LIPID DIET; LIPID LIVER LEVEL; LIPOTOXICITY; LIVER CELL; LIVER CELL DAMAGE; LIVER TOXICITY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; ADVERSE EFFECTS; ANIMAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; FATTY LIVER; GENE INACTIVATION; GENETICS; LIPID METABOLISM; LIVER; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TOXIC HEPATITIS; UNFOLDED PROTEIN RESPONSE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; CASPASE 3; DIET, HIGH-FAT; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; DYSLIPIDEMIAS; ENDOPLASMIC RETICULUM STRESS; ETHANOL; FATTY LIVER; GENE KNOCKOUT TECHNIQUES; HEPATOCYTES; LIPID METABOLISM; LIVER; MALE; MICE; PALMITIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84928031142     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(15)30011-X     Document Type: Article

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