The effect of simvastatin treatment on proliferation and differentiation of neural stem cells after traumatic brain injury

Brain Research

Volumn 1602, Issue C, 2015, Pages 1-8

  Xie, Chuncheng ^a   Cong, Damin ^a,b   Wang, Xiujuan ^c   Wanga, Yuehua ^a   Liang, Hongsheng ^a   Zhang, Xiangtong ^a   Huang, Qi ^b  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c Heilongjiang Province Hospital   (China)

Author keywords

Neural stem cells; Notch signaling; Simvastatin; Traumatic brain injury

Indexed keywords

NESTIN; NOTCH1 RECEPTOR; SIMVASTATIN; NES PROTEIN, RAT; NEUROPROTECTIVE AGENT; NOTCH1 PROTEIN, RAT; SECRETASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRAUMATIC BRAIN INJURY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; BRAIN INJURIES; CELL CULTURE; CONVALESCENCE; DISEASE MODEL; DRUG EFFECTS; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; TIME; TREATMENT OUTCOME; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; BRAIN INJURIES; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; MALE; NESTIN; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; RATS, WISTAR; RECEPTOR, NOTCH1; RECOVERY OF FUNCTION; SIMVASTATIN; TIME FACTORS; TREATMENT OUTCOME;

EID: 84928005755     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.03.021     Document Type: Article

References (25)

1. Abrahamson, E.E., et al., 2009. Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels. Ann. Neurol. 66, 407-414.
2. Arumugam, T.V., et al., 2011. Evidence that gamma-secretasemediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol. Pharmacol. 80, 23-31.
3. Baliko, F., et al., 2007. Inhibition of notch signaling induces neural differentiation in Ewing sarcoma. Am. J. Pathol. 170, 1686-1694.
4. Cameron, H.A., et al., 1993. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 56, 337-344.
5. Devaraj, S., Chan, E., Jialal, I., 2006. Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome. J. Clin. Endocrinol. Metab. 91, 4489-4496.
6. Dixon, C.E., et al., 1991. A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Methods 39, 253-262.
7. Goldman, S., 2005. Stem and progenitor cell-based therapy of the human central nervous system. Nat. Biotechnol. 23, 862-871.
8. Kaplan, M.S., Bell, D.H., 1984. Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus. J. Neurosci. 4, 1429-1441.
9. Keilani, S., Sugaya, K., 2008. Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1. BMC Dev. Biol. 8, 69.
10. Kuhn, H.G., Dickinson-Anson, H., Gage, F.H., 1996. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027-2033.
11. Li, B., et al., 2009. Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury. Neurosurgery 65, 179-185.
12. Lois, C., Alvarez-Buylla, A., 1993. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc. Nat. Acad. Sci. U.S.A. 90, 2074-2077.
13. Lu, D., et al., 2007. Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J. Neurotrauma 24, 1132-1146.
14. Luskin, M.B., 1993. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11, 173-189.
15. Mahmood, A., et al., 2009. Long-term benefits after treatment of traumatic brain injury with simvastatin in rats. Neurosurgery 65, 187-191.
16. Posmantur, R., et al., 1997. A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. Neuroscience 77, 875-888.
17. Ramirez, C., et al., 2011. Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment. J. Alzheimers Dis. 24, 161-174.
18. Shimada, I.S., et al., 2011. Proliferating reactive astrocytes are regulated by Notch-1 in the peri-infarct area after stroke. Stroke 42, 3231-3237.
19. Shohami, E., Novikov, M., Bass, R., 1995. Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat. Brain Res. 674, 55-62.
20. VanDussen, K.L., et al., 2011. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 139, 488-497.
21. Wu, H., et al., 2008. Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. J. Neurosurg. 109, 691-698.
22. Wu, H., et al., 2009. Attenuation of astrogliosis and modulation of endothelial growth factor receptor in lipid rafts by simvastatin after traumatic brain injury. J. Neurosurg. 113, 591-597.
23. Wu, H., et al., 2011. Induction of angiogenesis and modulation of vascular endothelial growth factor receptor-2 by simvastatin after traumatic brain injury. Neurosurgery 68, 1363-1371.
24. Xu, J., et al., 2009. Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway. Am. J. Phys. 296, C535-C543.
25. Zacharek, A., et al., 2009. Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke 40, 254-260.