-
1
-
-
3042722258
-
Tryptophan hydroxylase-2 controls brain serotonin synthesis
-
Zhang, X., Beaulieu, J. M., Sotnikova, T. D., Gainetdinov, R. R. & Caron, M. G. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305, 217 (2004).
-
(2004)
Science
, vol.305
, pp. 217
-
-
Zhang, X.1
Beaulieu, J.M.2
Sotnikova, T.D.3
Gainetdinov, R.R.4
Caron, M.G.5
-
2
-
-
33846347644
-
The serotonin signaling system: From basic understanding to drug development for functional GI disorders
-
Gershon, M. D. & Tack, J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132, 397-414 (2007).
-
(2007)
Gastroenterology
, vol.132
, pp. 397-414
-
-
Gershon, M.D.1
Tack, J.2
-
3
-
-
0029885161
-
Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract
-
Wade, P. R. et al. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J. Neurosci. 16, 2352-2364 (1996).
-
(1996)
J. Neurosci.
, vol.16
, pp. 2352-2364
-
-
Wade, P.R.1
-
4
-
-
0013957950
-
Location of sites of 5-hydroxytryptamine storage and metabolism by radioautography
-
Gershon, M. D. & Ross, L. L. Location of sites of 5-hydroxytryptamine storage and metabolism by radioautography. J. Physiol. 186, 477-492 (1966).
-
(1966)
J. Physiol.
, vol.186
, pp. 477-492
-
-
Gershon, M.D.1
Ross, L.L.2
-
5
-
-
35548988366
-
Serotonin and the orchestration of energy balance
-
Tecott, L. H. Serotonin and the orchestration of energy balance. Cell. Metab. 6, 352-361 (2007).
-
(2007)
Cell. Metab.
, vol.6
, pp. 352-361
-
-
Tecott, L.H.1
-
6
-
-
84890109255
-
Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis
-
Berglund, E. D. et al. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J. Clin. Invest. 123, 5061 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 5061
-
-
Berglund, E.D.1
-
7
-
-
0031721271
-
Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
-
Nonogaki, K., Strack, A. M., Dallman, M. F. & Tecott, L. H. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med. 4, 1152-1156 (1998).
-
(1998)
Nat. Med.
, vol.4
, pp. 1152-1156
-
-
Nonogaki, K.1
Strack, A.M.2
Dallman, M.F.3
Tecott, L.H.4
-
8
-
-
79961180328
-
Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels
-
Sohn, J. W. et al. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron 71, 488-497 (2011).
-
(2011)
Neuron
, vol.71
, pp. 488-497
-
-
Sohn, J.W.1
-
9
-
-
0017284150
-
Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine
-
Breisch, S. T., Zemlan, F. P. & Hoebel, B. G. Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine. Science 192, 382-385 (1976).
-
(1976)
Science
, vol.192
, pp. 382-385
-
-
Breisch, S.T.1
Zemlan, F.P.2
Hoebel, B.G.3
-
10
-
-
54849404294
-
Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants
-
Savelieva, K. V. et al. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS ONE 3, e3301 (2008).
-
(2008)
PLoS ONE
, vol.3
, pp. e3301
-
-
Savelieva, K.V.1
-
11
-
-
38649099407
-
Targeting the murine serotonin transporter: Insights into human neurobiology
-
Murphy, D. L. & Lesch, K. P. Targeting the murine serotonin transporter: insights into human neurobiology. Nat. Rev. Neurosci. 9, 85-96 (2008).
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 85-96
-
-
Murphy, D.L.1
Lesch, K.P.2
-
12
-
-
78149305142
-
Antidepressants and body weight: A comprehensive review and meta-analysis
-
Serretti, A. & Mandelli, L. Antidepressants and body weight: a comprehensive review and meta-analysis. J. Clin. Psychiatry 71, 1259-1272 (2010).
-
(2010)
J. Clin. Psychiatry
, vol.71
, pp. 1259-1272
-
-
Serretti, A.1
Mandelli, L.2
-
13
-
-
0013986153
-
p-Chlorophenylalanine: A specific depletor of brain serotonin
-
Koe, B. K. & Weissman, A. p-Chlorophenylalanine: a specific depletor of brain serotonin. J. Pharmacol. Exp. Ther. 154, 499-516 (1966).
-
(1966)
J. Pharmacol. Exp. Ther.
, vol.154
, pp. 499-516
-
-
Koe, B.K.1
Weissman, A.2
-
14
-
-
41149162741
-
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract
-
Liu, Q. et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J. Pharmacol. Exp. Ther. 325, 47-55 (2008).
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.325
, pp. 47-55
-
-
Liu, Q.1
-
15
-
-
49649105198
-
5-Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue
-
Uchida-Kitajima, S. et al. 5-Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue. FEBS Lett. 582, 3037-3044 (2008).
-
(2008)
FEBS Lett.
, vol.582
, pp. 3037-3044
-
-
Uchida-Kitajima, S.1
-
16
-
-
0026635582
-
Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients
-
Mann, J. J. et al. Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch. Gen. Psychiatry 49, 442-446 (1992).
-
(1992)
Arch. Gen. Psychiatry
, vol.49
, pp. 442-446
-
-
Mann, J.J.1
-
17
-
-
84871451681
-
Gut-derived serotonin is a multifunctional determinant to fasting adaptation
-
Sumara, G., Sumara, O., Kim, J. K. & Karsenty, G. Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab. 16, 588-600 (2012).
-
(2012)
Cell Metab.
, vol.16
, pp. 588-600
-
-
Sumara, G.1
Sumara, O.2
Kim, J.K.3
Karsenty, G.4
-
18
-
-
77957364237
-
Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5
-
Kinoshita, M. et al. Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. Mol. Endocrinol. 24, 1978-1987 (2010).
-
(2010)
Mol. Endocrinol.
, vol.24
, pp. 1978-1987
-
-
Kinoshita, M.1
-
19
-
-
79955039894
-
Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation
-
Stunes, A. et al. Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation. Diabetes Obes. Metab. 13, 551-558 (2011).
-
(2011)
Diabetes Obes. Metab.
, vol.13
, pp. 551-558
-
-
Stunes, A.1
-
20
-
-
0021322138
-
Thermogenic mechanisms in brown fat
-
Nicholls, D. G. & Locke, R. M. Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 1-64 (1984).
-
(1984)
Physiol. Rev.
, vol.64
, pp. 1-64
-
-
Nicholls, D.G.1
Locke, R.M.2
-
21
-
-
84864287504
-
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
-
Wu, J. et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150, 366-376 (2012).
-
(2012)
Cell
, vol.150
, pp. 366-376
-
-
Wu, J.1
-
22
-
-
78650945931
-
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
-
Seale, P. et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J. Clin. Invest. 121, 96-105 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 96-105
-
-
Seale, P.1
-
23
-
-
0025997336
-
Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel
-
Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M. & Julius, D. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science 254, 432-437 (1991).
-
(1991)
Science
, vol.254
, pp. 432-437
-
-
Maricq, A.V.1
Peterson, A.S.2
Brake, A.J.3
Myers, R.M.4
Julius, D.5
-
24
-
-
0024474475
-
5-HT3 receptors are membrane ion channels
-
Derkach, V., Surprenant, A. & North, R. A. 5-HT3 receptors are membrane ion channels. Nature 339, 706-709 (1989).
-
(1989)
Nature
, vol.339
, pp. 706-709
-
-
Derkach, V.1
Surprenant, A.2
North, R.A.3
-
25
-
-
84888310803
-
Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy
-
Ohara-Imaizumi, M. et al. Serotonin regulates glucose-stimulated insulin secretion from pancreatic b cells during pregnancy. Proc. Natl Acad. Sci. 110, 19420-19425 (2013).
-
(2013)
Proc. Natl Acad. Sci.
, vol.110
, pp. 19420-19425
-
-
Ohara-Imaizumi, M.1
-
26
-
-
84921697003
-
Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state
-
Kim, K. et al. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology 156, 444-452 (2014).
-
(2014)
Endocrinology
, vol.156
, pp. 444-452
-
-
Kim, K.1
-
27
-
-
0142025121
-
Association studies of genetic polymorphisms in central obesity: A critical review
-
Rosmond, R. Association studies of genetic polymorphisms in central obesity: a critical review. Int. J. Obes. 27, 1141-1151 (2003).
-
(2003)
Int. J. Obes.
, vol.27
, pp. 1141-1151
-
-
Rosmond, R.1
-
28
-
-
84875049510
-
Genetic variations in the serotoninergic system contribute to body-mass index in Chinese adolescents
-
Chen, C. et al. Genetic variations in the serotoninergic system contribute to body-mass index in Chinese adolescents. PLoS ONE 8, e58717 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e58717
-
-
Chen, C.1
-
29
-
-
84899896600
-
Genetic association analysis of 30 genes related to obesity in a European American population
-
Li, P. et al. Genetic association analysis of 30 genes related to obesity in a European American population. Int. J. Obes. 38, 724-729 (2014).
-
(2014)
Int. J. Obes.
, vol.38
, pp. 724-729
-
-
Li, P.1
-
30
-
-
79955433960
-
Metabolomic analysis of livers and serum from high-fat diet induced obese mice
-
Kim, H.-J. et al. Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J. Proteome Res. 10, 722-731 (2010).
-
(2010)
J. Proteome Res.
, vol.10
, pp. 722-731
-
-
Kim, H.-J.1
-
31
-
-
81555204260
-
Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in mice
-
Haub, S. et al. Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in mice. J. Pharmacol. Exp. Ther. 339, 790-798 (2011).
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.339
, pp. 790-798
-
-
Haub, S.1
-
32
-
-
29344440496
-
The serotonin-1Dβ receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosa
-
Levitan, R. et al. The serotonin-1Dβ receptor gene and severity of obsessive-compulsive disorder in women with bulimia nervosa. Eur. Neuropsychopharmacol. 16, 1-6 (2006).
-
(2006)
Eur. Neuropsychopharmacol.
, vol.16
, pp. 1-6
-
-
Levitan, R.1
-
33
-
-
85047696533
-
The 5-HT2A-1438G/A polymorphism in anorexia nervosa: A combined analysis of 316 trios from six European centres
-
Gorwood, P. et al. The 5-HT2A-1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres. Mol. Psychiatry 7, 90-94 (2002).
-
(2002)
Mol. Psychiatry
, vol.7
, pp. 90-94
-
-
Gorwood, P.1
-
35
-
-
84923212941
-
Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis
-
Crane, J. D. et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat. Med. 21, 166-172 (2014).
-
(2014)
Nat. Med.
, vol.21
, pp. 166-172
-
-
Crane, J.D.1
-
36
-
-
0020647587
-
Alpha and beta-adrenergic mediation of membrane potential changes and metabolism in rat brown adipose tissue
-
Girardier, L. & Schneider-Picard, G. Alpha and beta-adrenergic mediation of membrane potential changes and metabolism in rat brown adipose tissue. J. Physiol. 335, 629-641 (1983).
-
(1983)
J. Physiol.
, vol.335
, pp. 629-641
-
-
Girardier, L.1
Schneider-Picard, G.2
-
37
-
-
56349162283
-
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
-
Yadav, V. K. et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135, 825-837 (2008).
-
(2008)
Cell
, vol.135
, pp. 825-837
-
-
Yadav, V.K.1
-
38
-
-
79952155359
-
Transcriptional control of adipose lipid handling by IRF4
-
Eguchi, J. et al. Transcriptional control of adipose lipid handling by IRF4 Cell Metab. 13, 249-259 (2011).
-
(2011)
Cell Metab.
, vol.13
, pp. 249-259
-
-
Eguchi, J.1
-
39
-
-
0035793045
-
Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes
-
Imai, T. et al. Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proc. Natl Acad. Sci. USA 98, 224-288 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 224-288
-
-
Imai, T.1
-
40
-
-
33646124709
-
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
-
Uldry, M. et al. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 3, 333-341 (2006).
-
(2006)
Cell Metab.
, vol.3
, pp. 333-341
-
-
Uldry, M.1
-
41
-
-
0033521022
-
β3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes
-
Klein, J. et al. β3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J. Biol. Chem. 274, 34795-34802 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34795-34802
-
-
Klein, J.1
-
42
-
-
0036078412
-
Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice
-
Bernal-Mizrachi, C. et al. Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arterioscler. Thromb. Vasc. Biol. 22, 961-968 (2002).
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 961-968
-
-
Bernal-Mizrachi, C.1
-
44
-
-
84870352895
-
Functional imaging of brown fat in mice with 18F-FDG micro-PET/CT
-
Wang, X., Minze, L. & Shi, Z. Functional imaging of brown fat in mice with 18F-FDG micro-PET/CT. J. Vis. Exp. 69, e4060 (2011).
-
(2011)
J. Vis. Exp.
, vol.69
, pp. e4060
-
-
Wang, X.1
Minze, L.2
Shi, Z.3
-
45
-
-
79955536573
-
Carnitine is necessary to maintain the phenotype and function of brown adipose tissue
-
Ozaki, K., Sano, T., Tsuji, N., Matsuura, T. & Narama, I. Carnitine is necessary to maintain the phenotype and function of brown adipose tissue. Lab. Invest. 91, 704-710 (2011).
-
(2011)
Lab. Invest.
, vol.91
, pp. 704-710
-
-
Ozaki, K.1
Sano, T.2
Tsuji, N.3
Matsuura, T.4
Narama, I.5
|