Prevalence of mixed pathologies in the aging brain

Alzheimer's Research and Therapy

Volumn 6, Issue 9, 2014, Pages

  Rahimi, Jasmin ^a   Kovacs, Gabor G ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ARGYROPHILIC GRAIN DISEASE; BRAIN DISEASE; COGNITIVE DEFECT; COHORT ANALYSIS; CORTICOBASAL DEGENERATION; DIFFUSE LEWY BODY DISEASE; HIPPOCAMPAL SCLEROSIS; HUMAN; IMMUNOHISTOCHEMISTRY; LEWY BODY; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; REVIEW; SHY DRAGER SYNDROME; TAUOPATHY; TDP 43 PROTEINOPATHY; VASCULAR DISEASE;

EID: 84927938618     PISSN: None     EISSN: 17589193     Source Type: Journal    
DOI: 10.1186/s13195-014-0082-1     Document Type: Review

References (94)

1. Abbott A: Dementia: a problem for our age. Nature 2011, 475:S2-S4.
2. Kovacs GG, Botond G, Budka H: Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics. Acta Neuropathol 2010, 119:389-408.
3. Kovacs GG, Budka H: Current concepts of neuropathological diagnostics in practice: neurodegenerative diseases. Clin Neuropathol 2010, 29:271-288.
4. Ahmed Z, Bigio EH, Budka H, Dickson DW, Ferrer I, Ghetti B, Giaccone G, Hatanpaa KJ, Holton JL, Josephs KA, Powers J, Spina S, Takahashi H, White CL 3rd, Revesz T, Kovacs GG: Globular glial tauopathies (GGT): consensus recommendations. Acta Neuropathol 2013, 126:537-544.
5. Kovacs GG, Milenkovic I, Wohrer A, Hoftberger R, Gelpi E, Haberler C, Hönigschnabl S, Reiner-Concin A, Heinzl H, Jungwirth S, Krampla W, Fischer P, Budka H: Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series. Acta Neuropathol 2013, 126:365-384.
6. Kovacs GG, Molnar K, Laszlo L, Strobel T, Botond G, Honigschnabl S, Reiner-Concin A, Palkovits M, Fischer P, Budka H: A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol 2011, 122:205-222.
7. Rademakers R, Neumann M, Mackenzie IR: Advances in understanding the molecular basis of frontotemporal dementia. Nat Rev Neurol 2012, 8:423-434.
8. Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IR: FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain 2011, 134:2595-2609.
9. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 41:479-486.
10. Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259.
11. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K: Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 2006, 112:389-404.
12. Ball M, Braak H, Coleman P, Dickson D, Duyckaerts C, Gambetti P, Hansen L, Hyman B, Jellinger K, Markesbery W, Perl D, Powers J, Trojanowski JW, Wisniewski H, Phelps C, Khachaturian Z: Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 1997, 18:S1-S2.
13. Thal DR, Rub U, Orantes M, Braak H: Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology 2002, 58:1791-1800.
14. Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, Trojanowski JQ, Vinters HV, Montine TJ: National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement 2012, 8:1-13.
15. Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, Hyman BT: National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol 2012, 123:1-11.
16. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E: Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003, 24:197-211.
17. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, et al: Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005, 65:1863-1872.
18. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, de Vos RA, Wilcock GK, Jellinger KA, Perry RH: Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996, 47:1113-1124.
19. McKeith IG, Perry EK, Perry RH: Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy Bodies. Neurology 1999, 53:902-905.
20. Alafuzoff I, Ince PG, Arzberger T, Al-Sarraj S, Bell J, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Parchi P, Parkkinen L, Patsouris E, Roggendorf W, Rozemuller A, Stadelmann-Nessler C, Streichenberger N, Thal DR, Kretzschmar H: Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium. Acta Neuropathol 2009, 117:635-652.
21. Zaccai J, Brayne C, McKeith I, Matthews F, Ince PG: Patterns and stages of alpha-synucleinopathy: relevance in a population-based cohort. Neurology 2008, 70:1042-1048.
22. Jellinger KA: The enigma of mixed dementia. Alzheimers Dement 2007, 3:40-53.
23. Kovacs GG, Alafuzoff I, Al-Sarraj S, Arzberger T, Bogdanovic N, Capellari S, Ferrer I, Gelpi E, Kovari V, Kretzschmar H, Nagy Z, Parchi P, Seilhean D, Soininen H, Troakes C, Budka H: Mixed brain pathologies in dementia: the BrainNet Europe consortium experience. Dement Geriatr Cogn Disord 2008, 26:343-350.
24. Armstrong RA, Lantos PL, Cairns NJ: Overlap between neurodegenerative disorders. Neuropathology 2005, 25: 111-124.
25. Nelson PT, Smith CD, Abner EL, Wilfred BJ, Wang WX, Neltner JH, Baker M, Fardo DW, Kryscio RJ, Scheff SW, Jicha GA, Jellinger KA, Van Eldik LJ, Schmitt FA: Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease. Acta Neuropathol 2013, 126:161-177.
26. MacQueen KM, McLellan E, Metzger DS, Kegeles S, Strauss RP, Scotti R, Blanchard L, Trotter RT 2nd: What is community? An evidence-based definition for participatory public health. Am J Public Health 2001, 91:1929-1938.
27. Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA: The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis 2009, 18:691-701.
28. Jack CR Jr, Holtzman DM: Biomarker modeling of Alzheimer's disease. Neuron 2013, 80:1347-1358.
29. Jellinger KA, Attems J: Prevalence of dementia disorders in the oldest-old: an autopsy study. Acta Neuropathol 2010, 119:421-433.
30. Dawe RJ, Bennett DA, Schneider JA, Arfanakis K: Neuropathologic correlates of hippocampal atrophy in the elderly: a clinical, pathologic, postmortem MRI study. PLoS One 2011, 6:e26286.
31. Bennett DA, Schneider JA, Buchman AS, Mendes de Leon C, Bienias JL, Wilson RS: The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology 2005, 25:163-175.
32. Schneider JA, Arvanitakis Z, Yu L, Boyle PA, Leurgans SE, Bennett DA: Cognitive impairment, decline and fluctuations in older communitydwelling subjects with Lewy bodies. Brain 2012, 135:3005-3014.
33. Schneider JA, Arvanitakis Z, Leurgans SE, Bennett DA: The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol 2009, 66:200-208.
34. Bennett DA, Schneider JA, Arvanitakis Z, Wilson RS: Overview and findings from the religious orders study. Curr Alzheimer Res 2012, 9:628-645.
35. Wilson RS, Yu L, Trojanowski JQ, Chen EY, Boyle PA, Bennett DA, Schneider JA: TDP-43 pathology, cognitive decline, and dementia in old age. JAMA Neurol 2013, 70:1418-1424.
36. Keage HA, Ince PG, Matthews FE, Wharton SB, McKeith IG, Brayne C, MRC CFAS and CC75C: Impact of less common and 'disregarded' neurodegenerative pathologies on dementia burden in a populationbased cohort. J Alzheimers Dis 2012, 28:485-493.
37. Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P: Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med 2009, 6:e1000180.
38. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study: Age, neuropathology, and dementia. N Engl J Med 2009, 360: 2302-2309.
39. Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG, Medical Research Council Cognitive Function and Aging Study: Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience. J Alzheimers Dis 2011, 25:359-372.
40. Brayne C, Richardson K, Matthews FE, Fleming J, Hunter S, Xuereb JH, Paykel E, Mukaetova-Ladinska EB, Huppert FA, O'Sullivan A, Dening T: Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75 s cohort (CC75C) study. J Alzheimers Dis 2009, 18:645-658.
41. Polvikoski TM, van Straaten EC, Barkhof F, Sulkava R, Aronen HJ, Niinisto L, Oinas M, Scheltens P, Erkinjuntti T, Kalaria RN: Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old. Neurology 2010, 75:2071-2078.
42. Oinas M, Polvikoski T, Sulkava R, Myllykangas L, Juva K, Notkola IL, Rastas S, Niinisto L, Kalimo H, Paetau A: Neuropathologic findings of dementia with lewy bodies (DLB) in a population-based Vantaa 85+ study. J Alzheimers Dis 2009, 18:677-689.
43. Polvikoski T, Sulkava R, Myllykangas L, Notkola IL, Niinisto L, Verkkoniemi A, Kainulainen K, Kontula K, Perez-Tur J, Hardy J, Haltia M: Prevalence of Alzheimer's disease in very elderly people: a prospective neuropathological study. Neurology 2001, 56:1690-1696.
44. Fujimi K, Sasaki K, Noda K, Wakisaka Y, Tanizaki Y, Matsui Y, Sekita A, Iida M, Kiyohara Y, Kanba S, Iwaki T: Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: the Hisayama study. Brain Pathol 2008, 18:317-325.
45. Wakisaka Y, Furuta A, Tanizaki Y, Kiyohara Y, Iida M, Iwaki T: Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study. Acta Neuropathol 2003, 106:374-382.
46. Launer LJ, Hughes TM, White LR: Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study. Ann Neurol 2011, 70:774-780.
47. Launer LJ, Petrovitch H, Ross GW, Markesbery W, White LR: AD brain pathology: vascular origins? Results from the HAAS autopsy study. Neurobiol Aging 2008, 29:1587-1590.
48. White L, Small BJ, Petrovitch H, Ross GW, Masaki K, Abbott RD, Hardman J, Davis D, Nelson J, Markesbery W: Recent clinical-pathologic research on the causes of dementia in late life: update from the Honolulu-Asia Aging Study. J Geriatr Psychiatry Neurol 2005, 18:224-227.
49. Cholerton B, Larson EB, Baker LD, Craft S, Crane PK, Millard SP, Sonnen JA, Montine TJ: Neuropathologic correlates of cognition in a populationbased sample. J Alzheimers Dis 2013, 36: 699-709.
50. Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ: Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol 2007, 62:406-413.
51. Dolan D, Troncoso J, Resnick SM, Crain BJ, Zonderman AB, O'Brien RJ: Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing. Brain 2010, 133:2225-2231.
52. Troncoso JC, Zonderman AB, Resnick SM, Crain B, Pletnikova O, O'Brien RJ: Effect of infarcts on dementia in the Baltimore longitudinal study of aging. Ann Neurol 2008, 64:168-176.
53. Erten-Lyons D, Dodge HH, Woltjer R, Silbert LC, Howieson DB, Kramer P, Kaye JA: Neuropathologic basis of age-associated brain atrophy. JAMA Neurol 2013, 70:616-622.
54. Green MS, Kaye JA, Ball MJ: The Oregon brain aging study: neuropathology accompanying healthy aging in the oldest old. Neurology 2000, 54:105-113.
55. Robinson JL, Geser F, Corrada MM, Berlau DJ, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ: Neocortical and hippocampal amyloid-beta and tau measures associate with dementia in the oldest-old. Brain 2011, 134:3708-3715.
56. Alafuzoff I, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Braak H, Bugiani O, Del-Tredici K, Ferrer I, Gelpi E, Giaccone G, Graeber MB, Ince P, Kamphorst W, King A, Korkolopoulou P, Kovács GG, Larionov S, Meyronet D, Monoranu C, Parchi P, Patsouris E, Roggendorf W, Seilhean D, Tagliavini F, Stadelmann C, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H: Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain Pathol 2008, 18:484-496.
57. Alafuzoff I, Pikkarainen M, Al-Sarraj S, Arzberger T, Bell J, Bodi I, Bogdanovic N, Budka H, Bugiani O, Ferrer I, Gelpi E, Giaccone G, Graeber MB, Hauw JJ, Kamphorst W, King A, Kopp N, Korkolopoulou P, Kovács GG, Meyronet D, Parchi P, Patsouris E, Preusser M, Ravid R, Roggendorf W, Seilhean D, Streichenberger N, Thal DR, Kretzschmar H: Interlaboratory comparison of assessments of Alzheimer diseaserelated lesions: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol 2006, 65: 740-757.
58. Uchikado H, Lin WL, DeLucia MW, Dickson DW: Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy. J Neuropathol Exp Neurol 2006, 65:685-697.
59. Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Alafuzoff I: Consensus recommendations on pathologic changes in the hippocampus: a postmortem multicenter inter-rater study. J Neuropathol Exp Neurol 2013, 72:452-461.
60. Fujishima M, Kiyohara Y: Incidence and risk factors of dementia in a defined elderly Japanese population: the Hisayama study. Ann NY Acad Sci 2002, 977:1-8.
61. Petrovitch H, Ross GW, Steinhorn SC, Abbott RD, Markesbery W, Davis D, Nelson J, Hardman J, Masaki K, Vogt MR, Launer L, White LR: AD lesions and infarcts in demented and non-demented Japanese-American men. Ann Neurol 2005, 57:98-103.
62. Schneider JA, Wilson RS, Cochran EJ, Bienias JL, Arnold SE, Evans DA, Bennett DA: Relation of cerebral infarctions to dementia and cognitive function in older persons. Neurology 2003, 60:1082-1088.
63. Stephan BC, Matthews FE, Ma B, Muniz G, Hunter S, Davis D, McKeith IG, Foster G, Ince PG, Brayne C: Alzheimer and vascular neuropathological changes associated with different cognitive States in a non-demented sample. J Alzheimers Dis 2012, 29:309-318.
64. White L, Petrovitch H, Hardman J, Nelson J, Davis DG, Ross GW, Masaki K, Launer L, Markesbery WR: Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann NY Acad Sci 2002, 977:9-23.
65. Alafuzoff I, Gelpi E, Al-Sarraj S, Arzberger T, Attems J, Bodi I, Bogdanovic N, Budka H, Bugiani O, Englund E, Ferrer I, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, Höftberger R, Ironside JW, Jellinger K, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Parchi P, Patsouris E, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, et al: The need to unify neuropathological assessments of vascular alterations in the ageing brain: multicentre survey by the BrainNet Europe consortium. Exp Gerontol 2012, 47:825-833.
66. Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Davis DG, Poduska JW, Patel E, Mendiondo MS, Markesbery WR: Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol 2010, 20: 66-79.
67. Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, et al: Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 2012, 71:362-381.
68. Riley KP, Snowdon DA, Markesbery WR: Alzheimer 's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol 2002, 51:567-577.
69. Boyle PA, Yu L, Wilson RS, Schneider JA, Bennett DA: Relation of neuropathology with cognitive decline among older persons without dementia. Front Aging Neurosci 2013, 5:50.
70. Dickson DW, Fujishiro H, DelleDonne A, Menke J, Ahmed Z, Klos KJ, Josephs KA, Frigerio R, Burnett M, Parisi JE, Ahlskog JE: Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathol 2008, 115:437-444.
71. Byford M, Brayne C, McKeith I, Chatfield M, Ince P, Matthews F: Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study. BMC Geriatr 2009, 9: 22.
72. Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, Perry RH, Trojanowski JQ, Mann DM, Lee VM: A harmonized classification system for FTLD-TDP pathology. Acta Neuropathol 2011, 122:111-113.
73. Schultz C, Ghebremedhin E, Del Tredici K, Rub U, Braak H: High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe. Neurobiol Aging 2004, 25:397-405.
74. Dugger BN, Hentz JG, Adler CH, Sabbagh MN, Shill HA, Jacobson S, Caviness JN, Belden C, Driver-Dunckley E, Davis KJ, Sue LI, Beach TG: Clinicopathological outcomes of prospectively followed normal elderly brain bank volunteers. J Neuropathol Exp Neurol 2014, 73:244-252.
75. Jellinger KA, Attems J: Is there pure vascular dementia in old age? J Neurol Sci 2010, 299:150-154.
76. Ahtiluoto S, Polvikoski T, Peltonen M, Solomon A, Tuomilehto J, Winblad B, Sulkava R, Kivipelto M: Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study. Neurology 2010, 75:1195-1202.
77. Jellinger KA: The pathology of 'vascular dementia': a critical update. J Alzheimers Dis 2008, 14:107-123.
78. Grinberg LT, Nitrini R, Suemoto CK, de Lucena Ferretti-Rebustini RE, Leite RE, Farfel JM, Santos E, de Andrade MP, Alho AT, Lima Mdo C, Oliveira KC, Tampellini E, Polichiso L, Santos GB, Rodriguez RD, Ueda K, Pasqualucci CA, Jacob-Filho W: Prevalence of dementia subtypes in a developing country: a clinicopathological study. Clinics (Sao Paulo) 2013, 68:1140-1145.
79. Tanskanen M, Makela M, Myllykangas L, Notkola IL, Polvikoski T, Sulkava R, Kalimo H, Paetau A: Prevalence and severity of cerebral amyloid angiopathy: a population-based study on very elderly Finns (Vantaa 85+). Neuropathol Appl Neurobiol 2012, 38:329-336.
80. Tanskanen M, Makela M, Myllykangas L, Rastas S, Sulkava R, Paetau A: Intracerebral hemorrhage in the oldest old: a population-based study (Vantaa 85+). JAMA Neurol 2012, 3:103.
81. Thal DR, Ghebremedhin E, Rub U, Yamaguchi H, Del Tredici K, Braak H: Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2002, 61:282-293.
82. Tanskanen M, Kalaria RN, Notkola IL, Makela M, Polvikoski T, Myllykangas L, Sulkava R, Kalimo H, Paetau A, Scheltens P, Barkhof F, van Straaten E, Erkinjuntti T: Relationships between white matter hyperintensities, cerebral amyloid angiopathy and dementia in a population-based sample of the oldest old. Curr Alzheimer Res 2013, 10:1090-1097.
83. Erten-Lyons D, Woltjer R, Kaye J, Mattek N, Dodge HH, Green S, Tran H, Howieson DB, Wild K, Silbert LC: Neuropathologic basis of white matter hyperintensity accumulation with advanced age. Neurology 2013, 81:977-983.
84. Haller S, Kovari E, Herrmann FR, Cuvinciuc V, Tomm AM, Zulian GB, Lovblad KO, Giannakopoulos P, Bouras C: Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study. Acta Neuropathol Commun 2013, 1:14.
85. McAleese KE, Firbank M, Hunter D, Sun L, Hall R, Neal JW, Mann DM, Esiri M, Jellinger KA, O'Brien JT, Attems J: Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter. Neuropathol Appl Neurobiol 2013, 39:485-497.
86. Schneider JA, Arvanitakis Z, Bang W, Bennett DA: Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 2007, 69:2197-2204.
87. Gelber RP, Launer LJ, White LR: The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment. Curr Alzheimer Res 2012, 9:664-672.
88. Barker WW, Luis CA, Kashuba A, Luis M, Harwood DG, Loewenstein D, Waters C, Jimison P, Shepherd E, Sevush S, Graff-Radford N, Newland D, Todd M, Miller B, Gold M, Heilman K, Doty L, Goodman I, Robinson B, Pearl G, Dickson D, Duara R: Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis Assoc Disord 2002, 16:203-212.
89. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR: Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997, 277:813-817.
90. Murray ME, Cannon A, Graff-Radford NR, Liesinger AM, Rutherford NJ, Ross OA, Duara R, Carrasquillo MM, Rademakers R, Dickson DW: Differential clinicopathologic and genetic features of late-onset amnestic dementias. Acta Neuropathol 2014, 128:411-421.
91. Rauramaa T, Pikkarainen M, Englund E, Ince PG, Jellinger K, Paetau A, Alafuzoff I: TAR-DNA binding protein-43 and alterations in the hippocampus. J Neural Transm 2011, 118:683-689.
92. Josephs KA, Whitwell JL, Weigand SD, Murray ME, Tosakulwong N, Liesinger AM, Petrucelli L, Senjem ML, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Jack CR Jr, Parisi JE, Petersen RC, Dickson DW: TDP-43 is a key player in the clinical features associated with Alzheimer's disease. Acta Neuropathol 2014, [Epub ahead of print].
93. Arnold SJ, Dugger BN, Beach TG: TDP-43 deposition in prospectively followed, cognitively normal elderly individuals: correlation with argyrophilic grains but not other concomitant pathologies. Acta Neuropathol 2013, 126:51-57.
94. Boyle PA, Wilson RS, Yu L, Barr AM, Honer WG, Schneider JA, Bennett DA: Much of late life cognitive decline is not due to common neurodegenerative pathologies. Ann Neurol 2013, 74:478-489.