Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study

Journal of Alzheimer's Disease

Volumn 18, Issue 3, 2009, Pages 645-658

  Brayne, Carol ^a   Richardson, Kathryn ^a   Matthews, Fiona E ^a   Fleming, Jane ^a   Hunter, Sally ^a   Xuereb, John H ^b   Paykel, Eugene ^b   Mukaetova Ladinska, Elizabeta B ^c   Huppert, Felicia A ^b   O'Sullivan, Angela ^b   Dening, Tom ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d FULBOURN HOSPITAL   (United Kingdom)

Author keywords

Alzheimer's disease; Cohort study; Dementia; Neuropathology; Old age; Vascular dementia

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAIN ATROPHY; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH CERTIFICATE; DEMENTIA; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIFFUSE LEWY BODY DISEASE; DISEASE REGISTRY; ENTORHINAL CORTEX; FEMALE; HEALTH STATUS; HEALTH SURVEY; HIPPOCAMPUS; HUMAN; LEWY BODY; MAJOR CLINICAL STUDY; MALE; MIXED DEPRESSION AND DEMENTIA; MULTIINFARCT DEMENTIA; MULTIVARIATE ANALYSIS; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; POPULATION RESEARCH; PRIORITY JOURNAL; RETROSPECTIVE STUDY; UNITED KINGDOM; WHITE MATTER;

EID: 75149173859     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2009-1182     Document Type: Article

References (34)

1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M(2005) Global prevalence of dementia: a Delphi consensus study. Lancet 366, 2112-2117.
2. Zaccai J, Ince P, Brayne C (2006) Population-based neuropathological studies of dementia: design, methods and areas of investigation-a systematic review. BMC Neurol 6, 2.
3. Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ (2007) Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol 62, 406-413.
4. Polvikoski T, Sulkava R, Myllykangas L, Notkola IL, Niinisto L, Verkkoniemi A, Kainulainen K, Kontula K, Perez-Tur J, Hardy J, Haltia M (2001) Prevalence of Alzheimer's disease in very elderly people: a prospective neuropathological study. Neurology 56, 1690-1696.
5. Xuereb JH, Brayne C, Dufouil C, Gertz H, Wischik C, Harrington C, Mukaetova-Ladinska E, McGee MA, O'Sullivan A, O'Connor D, Paykel ES, Huppert FA (2000) Neuropathological findings in the very old. Results from the first 101 brains of a population-based longitudinal study of dementing disorders. Ann N Y Acad Sci 903, 490-496.
6. White L, Petrovitch H, Hardman J, Nelson J, Davis DG, Ross GW, Masaki K, Launer L, MarkesberyWR(2002) Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci 977, 9-23. (Pubitemid 35418132)
7. Schneider JA, Arvanitakis Z, Bang W, Bennett DA (2007) Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69, 2197-2204.
8. (2001) Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 357, 169-175.
9. Bigler ED, Lowry CM, Kerr B, Tate DF, Hessel CD, Earl HD, Miller MJ, Rice SA, Smith KH, Tschanz JT,Welsh-Bohmer K, Plassman B, Victoroff J (2003) Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging. Neuropsychology 17, 339-352.
10. Haroutunian V, Schnaider-Beeri M, Schmeidler J, Wysocki M, Purohit DP, Perl DP, Libow LS, Lesser GT, Maroukian M, GrossmanHT(2008) Role of the neuropathology ofAlzheimer disease in dementia in the oldest-old. Arch Neurol 65, 1211-1217.
11. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, for the Medical Research Council Cognitive Function and Ageing Study (2009) Age, neuropathology, and dementia. N Engl J Med 360, 2302-2309.
12. Brayne C, Huppert F, Paykel E, Gill C (1992) The Cambridge Project for Later Life: design and preliminary results. Neuroepidemiology 11 Suppl 1, 71-75.
13. Fleming J, Zhao E, O'Connor DW, Pollitt PA, Brayne C (2007) Cohort profile: the Cambridge City over-75s Cohort (CC75C). Int J Epidemiol 36, 40-46.
14. Roth M, TymE, Mountjoy CQ, Huppert FA, Hendrie H,Verma S, Goddard R (1986) CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 149, 698-709.
15. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
16. American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR), American Psychiatric Association, Washington, DC.
17. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
18. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65, 1863-1872.
19. Beardsall L, Barkley C, O'Sullivan A (1992) The response of elderly community residents to request for brain donation: An interim report. Int J Geriatr Psychiatry 7, 199-201.
20. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479-486.
21. Braak H, Braak E (1995) Staging of Alzheimer's diseaserelated neurofibrillary changes. Neurobiol Aging 16, 271-278; discussion 278-284.
22. Brayne C, Gao L, Dewey M, Matthews FE (2006) Dementia before death in ageing societies-the promise of prevention and the reality. PLoS Med 3, e397.
23. Brayne C, Gill C, Paykel ES, Huppert F, O'Connor DW(1995) Cognitive decline in an elderly population-a two wave study of change. Psychol Med 25, 673-683.
24. Apostolova LG, Mosconi L, Thompson PM, Green AE, Hwang KS, Ramirez A, Mistur R, Tsui WH, de Leon MJ (2008) Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiol Aging, in press.
25. Dickson DW, Davies P, Bevona C, Van Hoeven KH, Factor SM, Grober E, Aronson MK, Crystal HA (1994) Hippocampal sclerosis: a common pathological feature of dementia in very old (< or = 80 years of age) humans. Acta Neuropathol 88, 212-221.
26. Wakisaka Y, Furuta A, Tanizaki Y, Kiyohara Y, Iida M, Iwaki T (2003) Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study. Acta Neuropathol 106, 374-382. (Pubitemid 37265318)
27. Prins ND, van Dijk EJ, den Heijer T, Vermeer SE, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM (2004) Cerebral white matter lesions and the risk of dementia. Arch Neurol 61, 1531-1534.
28. Sitoh YY, Sahadevan S (2004) Clinical significance of cerebral white matter lesions in older Asians with suspected dementia. Age Ageing 33, 67-71.
29. Gold G, Kovari E, Hof PR, Bouras C, Giannakopoulos P (2007) Sorting out the clinical consequences of ischemic lesions in brain aging: a clinicopathological approach. J Neurol Sci 257, 17-22.
30. Troncoso JC, Zonderman AB, Resnick SM, Crain B, Pletnikova O, O'Brien RJ (2008) Effect of infarcts on dementia in the Baltimore longitudinal study of aging. Ann Neurol 64, 168-176.
31. Jellinger KA (2008) The pathology of vascular dementia: a critical update. J Alzheimers Dis 14, 107-123.
32. Olichney JM, Hansen LA, Lee JH, Hofstetter CR, Katzman R, Thal LJ (2000) Relationship between severe amyloid angiopathy, apolipoprotein E genotype, and vascular lesions in Alzheimer's disease. Ann N Y Acad Sci 903, 138-143.
33. Imhof A, Kovari E, von Gunten A, Gold G, Rivara CB, Herrmann FR, Hof PR, Bouras C, Giannakopoulos P (2007) Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm? J Neurol Sci 257, 72-79.
34. Castellani RJ, Lee HG, Zhu X, Perry G, Smith MA (2008) Alzheimer disease pathology as a host response. JNeuropathol Exp Neurol 67, 523-531.