Alzheimer and vascular neuropathological changes associated with different cognitive states in a non-demented sample

Journal of Alzheimer's Disease

Volumn 29, Issue 2, 2012, Pages 309-318

  Stephan, Blossom C M ^a   Matthews, Fiona E ^a   Ma, Brandy ^a   Muniz, Graciela ^a   Hunter, Sally ^a   Davis, Daniel ^a   McKeith, Ian G ^b   Foster, Gill ^c   Ince, Paul G ^c   Brayne, Carol ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Aging; Alzheimer's disease; cognitive impairment; neuropathology; vascular pathology

Indexed keywords

APOLIPOPROTEIN E;

AGED; AGING; ALZHEIMER DISEASE; ANGINA PECTORIS; ARTICLE; AUTOPSY; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; COMORBIDITY; DEMENTIA; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENOTYPE; HEALTH STATUS; HEART INFARCTION; HUMAN; HYPERTENSION; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; RISK FACTOR; STROKE;

EID: 84859382993     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110518     Document Type: Article

References (48)

1. Tyas SL, Snowdon DA, Desrosiers MF, Riley KP, Markesbery WR (2007) Healthy ageing in the Nun Study: Definition and neuropathologic correlates. Age Ageing 36, 650-655. (Pubitemid 350258975)
2. Galvin JE, Powlishta KK, Wilkins K, McKeel DW Jr, Xiong C, Grant E, Storandt M, Morris JC (2005) Predictors of pre-clinical Alzheimer disease and dementia: A clinicopathologic study. Arch Neurol 62, 758-765. (Pubitemid 40656091)
3. Bouras C, Hof PR, Morrison JH (1993) Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes. Neurosci Lett 153, 131-135. (Pubitemid 23147053)
4. Neuropathology Group of the Medical Research Council Cognitive Function Ageing Study (2001) Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 357, 169-175.
5. Morris JC, Storandt M, McKeel DW Jr, Rubin EH, Price JL, Grant EA, Berg L (1996) Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymp-tomatic and very mild Alzheimer's disease. Neurology 46, 707-719.
6. Price JL, Morris JC (1999) Tangles and plaques in nonde-mented aging and "preclinical" Alzheimer's disease. Ann Neurol 45, 358-368. (Pubitemid 29120041)
7. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, the Medical Research Council Cognitive Function and Ageing S (2009) Age, neuropathology, and dementia. N Engl J Med 360, 2302-2309.
8. Kok E, Haikonen S, Luoto T, Huhtala H, Goebeler S, Haa-pasalo H, Karhunen PJ (2009) Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age. Ann Neurol 65, 650-657.
9. Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS (2006) The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: A longitudinal cohort study. Lancet Neurol 5, 406-412.
10. Bennett DAM, Wilson RSP, Schneider JAM, Evans DAM, Mendes de Leon CFP, Arnold SEM, Barnes LLP, Bienias JLS (2003) Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology 60, 1909-1915.
11. Tyas SL, Salazar JC, Snowdon DA, Desrosiers MF, Riley KP, Mendiondo MS, Kryscio RJ (2007) Transitions to mild cognitive impairments, dementia, and death: Findings from the Nun Study. Am J Epidemiol 165, 1231-1238. (Pubitemid 47234333)
12. Haroutunian V, Hoffman LB, Beeri MS (2009) Is there a neu-ropathology difference between mild cognitive impairment and dementia? Dialogues Clin Neurosci 11, 171-179.
13. Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR (2006) Neuropathologic substrate of mild cognitive impairment. Arch Neurol 63, 38-46. (Pubitemid 43063860)
14. Folstein M, Folstein S, McHugh PR (1975) Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician. J Psychiatric Res 12, 189-198.
15. Stephan BCM, Savva GM, Brayne C, Bond J, McKeith IG, Matthews FE, the Medical Research Council Cognitive Function, Ageing S (2010) Optimizing mild cognitive impairment for discriminating dementia risk in the general older population. Am J Geriatric Psych 18, 662-673.
16. Busse A, Bischkopf J, Riedel-Heller SG, Angermeyer MC (2003) Mild cognitive impairment1: Prevalence and predictive validity according to current approaches. Acta Neurol Scand 108, 71-81. (Pubitemid 36920654)
17. MRC CFAS (1998) MRC CFAS Medical Research Council Cognitive Function and Ageing Study Group: Cognitive function and dementia in six areas of England and Wales: The distribution of MMSE. Psychol Med 28, 319-335.
18. Copeland JR, Dewey ME, Griffiths-Jones HM (1986) A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychol Med 16, 89-99. (Pubitemid 16130410)
19. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, Belle Gv, Berg L, participating Cn (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479-486.
20. Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG (2004) Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. Neuropathol Appl Neurobiol 30, 385-395. (Pubitemid 39120300)
21. Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT, Ince PG, on behalf of the MRC Cognitive Function, Ageing Neuropathology Study Group (2006) White matter lesions in an unselected cohort of the elderly: Molecular pathology suggests origin from chronic hypoperfusion injury. Stroke 37, 1391-1398. (Pubitemid 44305715)
22. Scheltens P, Barkhof F, Leys D, Pruvo JP, Nauta JJ, Verm-ersch P, Steinling M, Valk J (1993) A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 114, 7-12. (Pubitemid 23025201)
23. Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P (2009) Epidemiological pathology of dementia: Attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med 6, e1000180.
24. Nicoll JA, Burnett C, Love S, Graham DI, Dewar D, Ironside JW, Stewart J, Vinters HV (1997) High frequency of apolipoprotein E epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy. Ann Neurol 41, 716-721. (Pubitemid 27249176)
25. Price JL (1993) The relationship between tangle and plaque formation during healthy aging and mild dementia. Neurobiol Aging 14, 661-663. (Pubitemid 23347911)
26. Haroutunian V, Perl DP, Purohit DP, Marin D, Khan K, Lantz M, Davis KL, Mohs RC (1998) Regional Distribution of Neuritic Plaques in the Nondemented Elderly and Subjects With Very Mild Alzheimer Disease. Arch Neurol 55, 1185-1191. (Pubitemid 28427489)
27. Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Renbing X, Peck A (1988) Clinical, pathological, and neu-rochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23, 138-144. (Pubitemid 18081451)
28. Schmitt FA, Davis DG, Wekstein DR, Smith CD, Ashford JW, Markesbery WR (2000) "Preclinical" AD revisited: Neu-ropathology of cognitively normal older adults. Neurology55, 370-376. (Pubitemid 30654797)
29. Kazee AM, Eskin TA, Lapham LW, Gabriel KR, McDaniel KD, Hamill RW (1993) Clinicopathologic correlates in Alzheimer disease: Assessment of clinical and pathologic diagnostic criteria. Alzheimer Dis Assoc Disord 7, 152-164. (Pubitemid 23276027)
30. Jicha GA, Parisi JE, Dickson DW, Johnson K, Cha R, Ivnik RJ, Tangalos EG, Boeve BF, Knopman DS, Braak H, Petersen RC (2006) Neuropathologic outcome of mild cognitive impair-ment following progression to clinical dementia. Arch Neurol 63, 674-681.
31. Price JL, McKeel DW Jr, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC (2009) Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging 30, 1026-1036.
32. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS (2006) Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 66, 1837-1844. (Pubitemid 44049813)
33. Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Davis DG, Poduska JW, Patel E, Mendiondo MS, Markesbery WR (2010) Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol 20, 66-79.
34. Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Han-ninen T, Laakso MP, Hallikainen M, Vanhanen M, Nissinen A, Helkala EL, Vainio P, Vanninen R, Partanen K, Soini-nen H (2004) Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging 25, 303-310. (Pubitemid 38220965)
35. Gomez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH, Hyman BT (1996) Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer"s Disease. J Neurosci 16, 4491-4500. (Pubitemid 26243044)
36. Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW, Morris JC (2001) Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch Neurol 58, 1395-1402. (Pubitemid 32845990)
37. West MJ, Kawas CH, Stewart WF, Rudow GL, Troncoso JC (2004) Hippocampal neurons in pre-clinical Alzheimer's disease. Neurobiol Aging 25, 1205-1212. (Pubitemid 39094023)
38. Longstreth WT Jr, Sonnen JA, Koepsell TD, Kukull WA, Larson EB, Montine TJ (2009) Associations between microinfarcts and other macroscopic vascularfindingsonneu-ropathologic examination in 2 databases.Alzheimer Dis Assoc Disord 23, 291-294.
39. Gold G, Kovari E, Herrmann FR, Canuto A, Hof PR, Michel J-P, Bouras C, Giannakopoulos P (2005) Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke 36, 1184-1188. (Pubitemid 40798736)
40. Kovari E, Gold G, Herrmann FR, Canuto A, Hof PR, Michel J-P, Bouras C, Giannakopoulos P (2004) Cortical microin-farcts and demyelination significantly affect cognitioninbrain aging. Stroke 35, 410-414. (Pubitemid 38174421)
41. Sonnen JA, Larson EB, Haneuse S, Woltjer R, Li G, Crane PK, Craft S, Montine TJ (2009) Neuropathology in the adult changes in thought study: A review. J Alzheimers Dis 18, 703-711.
42. White L, Petrovitch H, Hardman J, Nelson J, Davis DG, Ross GW, Masaki K, Launer L, Markesbery WR (2002) Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci 977, 9-23. (Pubitemid 35418132)
43. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR (1997) Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 277, 813-817. (Pubitemid 27111317)
44. Bennett DA, Schneider JA, Bienias JL, Evans DA, Wilson RS (2005) Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 64, 834-841. (Pubitemid 40316322)
45. Silbert LC, Nelson C, Howieson DB, Moore MM, Kaye JA (2008) Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline. Neurology 71, 108-113.
46. Soderlund H, Nilsson LG, Berger K, Breteler MM, Dufouil C, Fuhrer R, Giampaoli S, Hofman A, Pajak A, de Ridder M, Sans S, Schmidt R, Launer LJ (2006) Cerebral changes on MRI and cognitive function: The CASCADE study.Neurobiol Aging 27, 16-23. (Pubitemid 41627945)
47. Murray ME, Senjem ML, Petersen RC, Hollman JH, Preboske GM, Weigand SD, Knopman DS, Ferman TJ, Dickson DW, Jack CR Jr (2010) Functional impact of white matter hyperin-tensities in cognitively normal elderly subjects. Arch Neurol 67, 1379-1385.
48. Schneider JA, Arvanitakis Z, Bang W, Bennett DA (2007) Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69, 2197-2204. (Pubitemid 350294674)