Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring

Journal of Hepatology

Volumn 62, Issue 5, 2015, Pages 1085-1091

  Karimi, Khalil ^a   Keßler, Timo ^a   Thiele, Kristin ^a   Ramisch, Katherina ^a   Erhardt, Annette ^a   Huebener, Peter ^a   Barikbin, Roja ^a   Arck, Petra ^a   Tiegs, Gisa ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Allergic inflammation; Eosinophil infiltration; Hematopoietic stem cells; Hepatotoxicity; Pregnancy immune adaptation

Indexed keywords

PARACETAMOL; ANALGESIC AGENT;

ADULT; ADULT ANIMAL; ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRILOBULAR NECROSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; EXPERIMENTAL ASTHMA; FEMALE; FETAL STEM CELL; FETUS; FETUS LIVER; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; LEUKOCYTE DIFFERENTIAL COUNT; LIVER CELL; LIVER INJURY; LIVER TOXICITY; LUNG DISEASE; LUNG PARENCHYMA; MALE; MARE; MOUSE; MOUSE MODEL; NECROSIS; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PREGNANCY OUTCOME; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROGENY; ADULT CHILD; ANIMAL; ASTHMA; DISEASE MODEL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; HUMAN; INFLAMMATION; LIVER; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; PREVENTION AND CONTROL; SEVERITY OF ILLNESS INDEX;

ACETAMINOPHEN; ADULT; ADULT CHILDREN; ANALGESICS, NON-NARCOTIC; ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; FEMALE; FETAL STEM CELLS; HUMANS; INFLAMMATION; LIVER; MALE; MICE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEVERITY OF ILLNESS INDEX;

EID: 84927797321     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.12.020     Document Type: Article

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