Acetaminophen and asthma

Paediatric Respiratory Reviews

Volumn 14, Issue 1, 2013, Pages 9-16

  Henderson, A John ^a   Shaheen, Seif O ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Acetaminophen; Asthma

Indexed keywords

ACETANILIDE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; PARACETAMOL; PHENACETIN;

ASTHMA; CASE CONTROL STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFICACY; DRUG LEGISLATION; DRUG MARKETING; DRUG RESEARCH; DRUG SAFETY; DRUG SENSITIVITY; FORCED EXPIRATORY VOLUME; GENE; GSTM1 GENE; GSTP1 GENE; GSTT1 GENE; HEALTH CARE POLICY; HUMAN; LONGITUDINAL STUDY; NAPQ1 GENE; NEPHROTOXICITY; NONHUMAN; OBSERVATIONAL STUDY; PEDIATRICS; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; PROGENY; PUBLIC HEALTH; REVIEW; UNITED KINGDOM; UNSPECIFIED SIDE EFFECT; WHEEZING;

ACETAMINOPHEN; ANTIPYRETICS; ASTHMA; FEMALE; HUMANS; INCIDENCE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; WORLD HEALTH;

EID: 84872680519     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2012.04.004     Document Type: Review

References (74)

1. Ellis F., Osborne C., Pack M. Paracetamol: a curriculum resource 2002, Royal Society of Chemistry, London.
2. Porter J.D., Robinson P.H., Glasgow J.F., Banks J.H., Hall S.M. Trends in the incidence of Reye's syndrome and the use of aspirin. Arch Dis Child 1990, 65:826-829.
3. Reye R.D., Morgan G., Baral J. Encephalopathy and Fatty Degeneration of the Viscera. A Disease Entity in Childhood. Lancet 1963, 2:749-752.
4. Collins E. Maternal and fetal effects of acetaminophen and salicylates in pregnancy. Obstet Gynecol 1981, 58(5 Suppl):57S-62S.
5. Bernal W. Changing patterns of causation and the use of transplantation in the United kingdom. Semin Liver Dis 2003, 23:227-237.
6. Sheen C.L., Dillon J.F., Bateman D.N., Simpson K.J., MacDonald T.M. Paracetamol pack size restriction: the impact on paracetamol poisoning and the over-the-counter supply of paracetamol, aspirin and ibuprofen. Pharmacoepidemiol Drug Saf 2002, 11:329-331.
7. Cooke R.A. Allergy in drug idiosyncracy. J Am Med Assoc 1919, 73:759-760.
8. Clarke C.A. Ashma from Aspirin. BMJ 1969, 1. 256.3.
9. Settipane R.A., Stevenson D.D. Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma. J Allergy Clin Immunol 1989, 84:26-33.
10. Fischer T.J., Guilfoile T.D., Kesarwala H.H., Winant J.G., Kearns G.L., Gartside P.S., et al. Adverse pulmonary responses to aspirin and acetaminophen in chronic childhood asthma. Pediatrics 1983, 71:313-318.
11. Varner A.E., Busse W.W., Lemanske R.F. Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma. Ann Allergy Asthma Immunol 1998, 81:347-351.
12. Shaheen S.O., Sterne J.A., Songhurst C.E., Burney P.G. Frequent paracetamol use and asthma in adults. Thorax 2000, 55:266-270.
13. Newson R.B., Shaheen S.O., Chinn S., Burney P.G. Paracetamol sales and atopic disease in children and adults: an ecological analysis. European Respiratory Journal 2000, 16:817-823.
14. Davey G., Berhane Y., Duncan P., ref-Adib G., Britton J., Venn A. Use of acetaminophen and the risk of self-reported allergic symptoms and skin sensitization in Butajira, Ethiopia. J Allergy Clin Immunol 2005, 116:863-868.
15. Thomsen S.F., Kyvik K.O., Skadhauge L., Steffensen I., Backer V. Intake of paracetamol and risk of asthma in adults. J Asthma 2008, 45:675-676.
16. Etminan M., Sadatsafavi M., Jafari S., Doyle-Waters M., Aminzadeh K., Fitzgerald J.M. Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis. Chest 2009, 136:1316-1323.
17. Shaheen S., Potts J., Gnatiuc L., Makowska J., Kowalski M.L., Joos G., et al. The relation between paracetamol use and asthma: a GA2LEN European case-control study. Eur Respir J 2008, 32:1231-1236.
18. McKeever T.M., Lewis S.A., Smit H.A., Burney P., Britton J.R., Cassano P.A. The association of acetaminophen, aspirin, and ibuprofen with respiratory disease and lung function. Am J Respir Crit Care Med 2005, 171:966-971.
19. Amberbir A., Medhin G., Hanlon C., Britton J., Venn A., Davey G. Frequent use of paracetamol and risk of allergic disease among women in an Ethiopian population. PLoS One 2011, 6:e22551.
20. Wong G.W., Leung T.F., Ma Y., Liu E.K., Yung E., Lai C.K. Symptoms of asthma and atopic disorders in preschool children: prevalence and risk factors. Clin Exp Allergy 2007, 37:174-179.
21. Cohet C., Cheng S., MacDonald C., Baker M., Foliaki S., Huntington N., et al. Infections, medication use, and the prevalence of symptoms of asthma, rhinitis, and eczema in childhood. J Epidemiol Community Health 2004, 58:852-857.
22. Rodriguez Martinez C., Sossa M., Goss C.H. Factors associated with severe disease in a population of asthmatic children of Bogota, Colombia. J Asthma 2008, 45:141-147.
23. Sharma S.K., Banga A. Prevalence and risk factors for wheezing in children from rural areas of north India. Allergy Asthma Proc 2007, 28:647-653.
24. Tapiainen T., Dunder T., Mottonen M., Pokka T., Uhari M. Adolescents with asthma or atopic eczema have more febrile days in early childhood: a possible explanation for the connection between paracetamol and asthma?. J Allergy Clin Immunol 2010, 125:751-752.
25. Bush A. Asthma research: the real action is in children. Paediatr Respir Rev 2005, 6:101-110.
26. Barr R.G., Wentowski C.C., Curhan G.C., Somers S.C., Stampfer M.J., Schwartz J., et al. Prospective study of acetaminophen use and newly diagnosed asthma among women. Am J Respir Crit Care Med 2004, 169:836-841.
27. Marquis A., Strippoli M.P., Spycher B.D., Rebholz C.E., von der Weid N.X., Kuehni C.E. Paracetamol, nonsteroidal anti-inflammatory drugs, and risk of asthma in adult survivors of childhood cancer. J Allergy Clin Immunol 2011, 127:270-272.
28. Barr R.G., Kurth T., Stampfer M.J., Buring J.E., Hennekens C.H., Gaziano J.M. Aspirin and decreased adult-onset asthma: randomized comparisons from the physicians' health study. Am J Respir Crit Care Med 2007, 175:120-125.
29. Kurth T., Barr R.G., Gaziano J.M., Buring J.E. Randomised aspirin assignment and risk of adult-onset asthma in the Women's Health Study. Thorax 2008, 63:514-518.
30. Beasley R.W., Clayton T.O., Crane J., Lai C.K., Montefort S.R., Mutius E., et al. Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three. Am J Respir Crit Care Med 2011, 183:171-178.
31. Beasley R., Clayton T., Crane J., von Mutius E., Lai C.K., Montefort S., et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008, 372:1039-1048.
32. Del-Rio-Navarro B.E., Ito-Tsuchiya F.M., Berber A., Zepeda-Ortega B., Sienra-Monge J.J., Garcia-Almaraz R., et al. Study of the relationship between acetaminophen and asthma in Mexican children aged 6 to 7 years in 3 Mexican cities using ISAAC methodology. J Investig Allergol Clin Immunol 2008, 18:194-201.
33. Wickens K., Beasley R., Town I., Epton M., Pattemore P., Ingham T., et al. The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort. Clin Exp Allergy 2011, 41:399-406.
34. Rusconi F., Gagliardi L., Galassi C., Forastiere F., Brunetti L., La Grutta S., et al. Paracetamol and antibiotics in childhood and subsequent development of wheezing/asthma: association or causation?. Int J Epidemiol 2011, 40:662-667.
35. Shaheen S.O., Newson R.B., Ring S.M., Rose-Zerilli M.J., Holloway J.W., Henderson A.J. Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma. J Allergy Clin Immunol 2010, 126:1141-1148. e7.
36. Amberbir A., Medhin G., Alem A., Britton J., Davey G., Venn A. The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study. Am J Respir Crit Care Med 2011, 183:165-170.
37. Bakkeheim E., Mowinckel P., Carlsen K.H., Haland G., Carlsen K.C. Paracetamol in early infancy: the risk of childhood allergy and asthma. Acta Paediatr 2011, 100:90-96.
38. Lowe A.J., Carlin J.B., Bennett C.M., Hosking C.S., Allen K.J., Robertson C.F., et al. Paracetamol use in early life and asthma: prospective birth cohort study. BMJ 2010, 341:c4616.
39. Schnabel E., Heinrich J. Respiratory tract infections and not paracetamol medication during infancy are associated with asthma development in childhood. J Allergy Clin Immunol 2010, 126:1071-1073.
40. Shaheen S.O., Newson R.B., Smith G.D., Henderson A.J. Prenatal paracetamol exposure and asthma: further evidence against confounding. Int J Epidemiol 2010, 39:790-794.
41. McBride J.T. The association of acetaminophen and asthma prevalence and severity. Pediatrics 2011, 128:1181-1185.
42. Prymula R., Siegrist C.A., Chlibek R., Zemlickova H., Vackova M., Smetana J., et al. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet 2009, 374:1339-1350.
43. Shaheen S.O., Newson R.B., Sherriff A., Henderson A.J., Heron J.E., Burney P.G., et al. Paracetamol use in pregnancy and wheezing in early childhood. Thorax 2002, 57:958-963.
44. Shaheen S.O., Newson R.B., Henderson A.J., Headley J.E., Stratton F.D., Jones R.W., et al. Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. Clin Exp Allergy 2005, 35:18-25.
45. Enomoto A., Itoh K., Nagayoshi E., Haruta J., Kimura T., O'Connor T., et al. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 2001, 59:169-177.
46. Chan K., Han X.D., Kan Y.W. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci U S A 2001, 98:4611-4616.
47. Egger M., Schneider M., Davey Smith G. Spurious precision? Meta-analysis of observational studies. BMJ 1998, 316:140-144.
48. Persky V., Piorkowski J., Hernandez E., Chavez N., Wagner-Cassanova C., Vergara C., et al. Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life. Ann Allergy Asthma Immunol 2008, 101:271-278.
49. Rebordosa C., Kogevinas M., Sorensen H.T., Olsen J. Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study. Int J Epidemiol 2008, 37:583-590.
50. Perzanowski M.S., Miller R.L., Tang D., Ali D., Garfinkel R.S., Chew G.L., et al. Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort. Thorax 2010, 65:118-123.
51. Garcia-Marcos L., Sanchez-Solis M., Perez-Fernandez V., Pastor-Vivero M.D., Mondejar-Lopez P., Valverde-Molina J. Is the effect of prenatal paracetamol exposure on wheezing in preschool children modified by asthma in the mother?. Int Arch Allergy Immunol 2009, 149:33-37.
52. Eyers S., Weatherall M., Jefferies S., Beasley R. Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis. Clin Exp Allergy 2011, 41:482-489.
53. Rebordosa C., Kogevinas M., Bech B.H., Sorensen H.T., Olsen J. Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes. Int J Epidemiol 2009, 38:706-714.
54. Goksor E., Thengilsdottir H., Alm B., Norvenius G., Wennergren G. Prenatal paracetamol exposure and risk of wheeze at preschool age. Acta Paediatr 2011, 100:1567-1571.
55. Kang E.M., Lundsberg L.S., Illuzzi J.L., Bracken M.B. Prenatal exposure to acetaminophen and asthma in children. Obstet Gynecol 2009, 114:1295-1306.
56. Bakkeheim E., Mowinckel P., Carlsen K.H., Haland G., Lodrup Carlsen K.C. Paracetamol in early infancy; the risk of childhood allergy and asthma. Acta Paediatr 2010.
57. Bisgaard H., Loland L., Holst K.K., Pipper C.B. Prenatal determinants of neonatal lung function in high-risk newborns. J Allergy Clin Immunol 2009, 123:651-657. 57 e1-4.
58. Chen T.C., Leviton A. Asthma and eczema in children born to women with migraine. Arch Neurol 1990, 47:1227-1230.
59. Kanabar D., Dale S., Rawat M. A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clin Ther 2007, 29:2716-2723.
60. Lesko S.M., Louik C., Vezina R.M., Mitchell A.A. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002, 109:E20.
61. Holgate S.T. The acetaminophen enigma in asthma. Am J Respir Crit Care Med 2011, 183:147-148.
62. Placke M.E., Wyand D.S., Cohen S.D. Extrahepatic lesions induced by acetaminophen in the mouse. Toxicol Pathol 1987, 15:381-387.
63. Chen T.S., Richie J.P., Lang C.A. Life span profiles of glutathione and acetaminophen detoxification. Drug Metab Dispos 1990, 18:882-887.
64. Micheli L., Cerretani D., Fiaschi A.I., Giorgi G., Romeo M.R., Runci F.M. Effect of acetaminophen on glutathione levels in rat testis and lung. Environ Health Perspect 1994, 102(Suppl 9):63-64.
65. Dimova S., Hoet P.H., Dinsdale D., Nemery B. Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro. Int J Biochem Cell Biol 2005, 37:1727-1737.
66. Peterson J.D., Herzenberg L.A., Vasquez K., Waltenbaugh C. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci U S A 1998, 95:3071-3076.
67. Nuttall S.L., Khan J.N., Thorpe G.H., Langford N., Kendall M.J. The impact of therapeutic doses of paracetamol on serum total antioxidant capacity. J Clin Pharm Ther 2003, 28:289-294.
68. Hinz B., Cheremina O., Brune K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 2008, 22:383-390.
69. Wallace J.L. Commonality of defensive roles of COX-2 in the lung and gut. Am J Pathol 2006, 168:1060-1063.
70. Nassini R., Materazzi S., Andre E., Sartiani L., Aldini G., Trevisani M., et al. Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J 2010, 24:4904-4916.
71. Levy G., Khanna N.N., Soda D.M., Tsuzuki O., Stern L. Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Pediatrics 1975, 55:818-825.
72. Rollins D.E., von Bahr C., Glaumann H., Moldeus P., Rane A. Acetaminophen: potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells. Science 1979, 205:1414-1416.
73. Shaheen S.O., Adcock I.M. The developmental origins of asthma: does epigenetics hold the key?. Am J Respir Crit Care Med 2009, 180:690-691.
74. Hitchler M.J., Domann F.E. An epigenetic perspective on the free radical theory of development. Free Radic Biol Med 2007, 43:1023-1036.