Routes of allergic sensitization and myeloid cell IKKβ differentially regulate antibody responses and allergic airway inflammation in male and female mice

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Bonnegarde Bernard, Astrid ^a,b   Jee, Junbae ^a   Fial, Michael J ^a   Steiner, Haley ^a   DiBartola, Stephanie ^a   Davis, Ian C ^a   Cormet Boyaka, Estelle ^a   Tomé, Daniel ^b   Boyaka, Prosper N ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b AGROPARISTECH   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; EOSINOPHIL PEROXIDASE; EOTAXIN; GAMMA INTERFERON; I KAPPA B KINASE BETA; IMMUNOGLOBULIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2C; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 2; OVALBUMIN; UNCLASSIFIED DRUG; ALLERGEN; CYTOKINE; I KAPPA B KINASE; MESSENGER RNA;

ADMINISTRATION OF DRUGS, FOOD AND CHEMICALS; ADULT; ALLERGIC AIRWAY INFLAMMATION; ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CELL COUNT; CONTROLLED STUDY; CYTOKINE RELEASE; EOSINOPHIL; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; LUNG COMPLIANCE; LUNG RESISTANCE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; ORAL SENSITIZATION; PARENTERAL SENSITIZATION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; TH2 CELL; ANIMAL; ANTIBODY PRODUCTION; BONE MARROW CELL; C57BL MOUSE; COMPARATIVE STUDY; DRUG ADMINISTRATION ROUTE; GENETICS; IMMUNOLOGY; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ALLERGENS; ANIMALS; ANTIBODY FORMATION; BLOTTING, WESTERN; CHOLERA TOXIN; CYTOKINES; DRUG ADMINISTRATION ROUTES; FEMALE; I-KAPPA B KINASE; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED C57BL; MYELOID CELLS; OVALBUMIN; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84899803627     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092307     Document Type: Article

References (32)

1. Whitacre CC (2001) Sex differences in autoimmune disease. Nat Immunol 2: 777-780.
2. Rhodes L, Moorman JE, Redd SC (2005) Sex differences in asthma prevalence and other disease characteristics in eight states. J Asthma 42: 777-782. (Pubitemid 41759194)
3. Beery TA (2003) Sex differences in infection and sepsis. Crit Care Nurs Clin North Am 15: 55-62.
4. Tedeschi SK, Bermas B, Costenbader KH (2013) Sexual disparities in the incidence and course of SLE and RA. Clin Immunol.
5. Barnes PJ (2008) Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8: 183-192.
6. Vancza EM, Galdanes K, Gunnison A, Hatch G, Gordon T (2009) Age, strain, and gender as factors for increased sensitivity of the mouse lung to inhaled ozone. Toxicol Sci 107: 535-543.
7. Fagan JK, Scheff PA, Hryhorczuk D, Ramakrishnan V, Ross M, et al. (2001) Prevalence of asthma and other allergic diseases in an adolescent population: association with gender and race. Ann Allergy Asthma Immunol 86: 177-184. (Pubitemid 32167842)
8. Hansen JS, Alberg T, Rasmussen H, Lovik M, Nygaard UC (2011) Determinants of experimental allergic responses: interactions between allergen dose, sex and age. Scand J Immunol 73: 554-567.
9. Carey MA, Card JW, Voltz JW, Germolec DR, Korach KS, et al. (2007) The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies. Am J Physiol Lung Cell Mol Physiol 293: L272-278. (Pubitemid 47205005)
10. Repa A, Wild C, Hufnagl K, Winkler B, Bohle B, et al. (2004) Influence of the route of sensitization on local and systemic immune responses in a murine model of type I allergy. Clin Exp Immunol 137: 12-18. (Pubitemid 38869772)
11. Bonnegarde-Bernard A, Jee J, Fial MJ, Aeffner F, Cormet-Boyaka E, et al. (2013) IKKbeta in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites. Mucosal Immunol.
12. Fischer R, McGhee JR, Vu HL, Atkinson TP, Jackson RJ, et al. (2005) Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy. Am J Pathol 167: 1621-1630. (Pubitemid 41713315)
13. Oyoshi MK, Elkhal A, Scott JE, Wurbel MA, Hornick JL, et al. (2011) Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin. J Clin Invest 121: 2210-2220.
14. Huvenne W, Callebaut I, Plantinga M, Vanoirbeek JA, Krysko O, et al. (2010) Staphylococcus aureus enterotoxin B facilitates allergic sensitization in experimental asthma. Clin Exp Allergy 40: 1079-1090.
15. Ganeshan K, Neilsen CV, Hadsaitong A, Schleimer RP, Luo X, et al. (2009) Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. J Allergy Clin Immunol 123: 231-238 e234.
16. Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27: 693-733.
17. Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, et al. (2007) NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130: 918-931. (Pubitemid 47332565)
18. Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA (2001) Possible new role for NF-kappaB in the resolution of inflammation. Nat Med 7: 1291-1297. (Pubitemid 34007932)
19. O'Connor MF, Motivala SJ, Valladares EM, Olmstead R, Irwin MR (2007) Sex differences in monocyte expression of IL-6: role of autonomic mechanisms. Am J Physiol Regul Integr Comp Physiol 293: R145-151. (Pubitemid 47096572)
20. Massaro GD, Mortola JP, Massaro D (1995) Sexual dimorphism in the architecture of the lung's gas-exchange region. Proc Natl Acad Sci U S A 92: 1105-1107.
21. Reinhard C, Eder G, Fuchs H, Ziesenis A, Heyder J, et al. (2002) Inbred strain variation in lung function. Mamm Genome 13: 429-437. (Pubitemid 34809898)
22. Wills-Karp M, Ewart SL (1997) The genetics of allergen-induced airway hyperresponsiveness in mice. Am J Respir Crit Care Med 156: S89-96. (Pubitemid 27449319)
23. Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, et al. (2009) Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflamm Res 58: 845-854.
24. Zosky GR, Larcombe AN, White OJ, Burchell JT, von Garnier C, et al. (2009) Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways. Am J Physiol Lung Cell Mol Physiol 297: L373-379.
25. Marinaro M, Staats HF, Hiroi T, Jackson RJ, Coste M, et al. (1995) Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol 155: 4621-4629.
26. Melgert BN, Postma DS, Kuipers I, Geerlings M, Luinge MA, et al. (2005) Female mice are more susceptible to the development of allergic airway inflammation than male mice. Clin Exp Allergy 35: 1496-1503.
27. Card JW, Carey MA, Bradbury JA, DeGraff LM, Morgan DL, et al. (2006) Gender differences in murine airway responsiveness and lipopolysaccharide- induced inflammation. J Immunol 177: 621-630. (Pubitemid 43939176)
28. Seymour BW, Friebertshauser KE, Peake JL, Pinkerton KE, Coffman RL, et al. (2002) Gender differences in the allergic response of mice neonatally exposed to environmental tobacco smoke. Dev Immunol 9: 47-54. (Pubitemid 35014196)
29. Takeda M, Tanabe M, Ito W, Ueki S, Konnno Y, et al. (2013) Gender difference in allergic airway remodelling and immunoglobulin production in mouse model of asthma. Respirology 18: 797-806.
30. Adler A, Cieslewicz G, Irvin CG (2004) Unrestrained plethysmography is an unreliable measure of airway responsiveness in BALB/c and C57BL/6 mice. J Appl Physiol 97: 286-292. (Pubitemid 38802530)
31. Corteling R, Trifilieff A (2004) Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment. BMC Pharmacol 4: 4.
32. Mine Y, Yang M (2007) Epitope characterization of ovalbumin in BALB/c mice using different entry routes. Biochim Biophys Acta 1774: 200-212. (Pubitemid 46205493)