ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation

Journal of Bone and Mineral Research

Volumn 30, Issue 5, 2015, Pages 765-774

  Chen, Zhijun ^a   Yue, Susan X ^a   Zhou, Guang ^a,b   Greenfield, Edward M ^a   Murakami, Shunichi ^a,b,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c Kawasaki Medical School   (Japan)

Author keywords

Endochondral ossification; ERK; Hypertrophic chondrocytes; Metachondromatosis; Terminal differentiation

Indexed keywords

COLLAGENASE 3; EARLY GROWTH RESPONSE FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOPONTIN; PROTEIN TYROSINE PHOSPHATASE SHP 2; TRANSCRIPTION FACTOR RUNX2; VON WILLEBRAND FACTOR; BIOLOGICAL MARKER; CRE RECOMBINASE; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, MOUSE; EGR2 PROTEIN, MOUSE; INTEGRASE; OSTERIX PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE GROWTH; BONE LENGTH; CARTILAGE CELL; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CHONDROLYSIS; CHONDROSARCOMA CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENCHONDRAL OSSIFICATION; ENCHONDROMA; GROWTH PLATE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; NICK END LABELING; NONHUMAN; OSSIFICATION; OSTEOCLASTOGENESIS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSIENT TRANSFECTION; ANIMAL; BONE DEVELOPMENT; BONE MINERALIZATION; CHONDROCYTE; CHONDROGENESIS; ENZYME ACTIVATION; ENZYMOLOGY; GENE DELETION; HYPERTROPHY; KNOCKOUT MOUSE; METABOLISM; OSTEOBLAST; PATHOLOGY; TRANSGENE;

ANIMALS; BIOMARKERS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CHONDROCYTES; CHONDROGENESIS; EARLY GROWTH RESPONSE PROTEIN 1; EARLY GROWTH RESPONSE PROTEIN 2; ENZYME ACTIVATION; GENE DELETION; HYPERTROPHY; IN SITU HYBRIDIZATION; INTEGRASES; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OSTEOBLASTS; OSTEOGENESIS; TRANSCRIPTION FACTORS; TRANSGENES;

EID: 84927778827     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2409     Document Type: Article

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