Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis

Molecular and Cellular Biology

Volumn 29, Issue 21, 2009, Pages 5843-5857

  Matsushita, Takehiko ^a   Yuk, Yu Chan ^a   Kawanami, Aya ^a   Balmes, Gener ^b   Landreth, Gary E ^a   Murakami, Shunichi ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOCLAST DIFFERENTIATION FACTOR; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEFECT; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL SPECIFICITY; CHONDROPATHY; CONTROLLED STUDY; EMBRYO; ENZYME INACTIVATION; GROWTH PLATE; LIMB MALFORMATION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PERICHONDRIUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BASE PAIRING; BONE AND BONES; CELL DIFFERENTIATION; CHONDROCYTES; CHONDROGENESIS; CHORISTOMA; ENZYME ACTIVATION; GROWTH PLATE; HOMEODOMAIN PROTEINS; LIMB DEFORMITIES, CONGENITAL; MAP KINASE KINASE 1; MESODERM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUTATION; OSTEOBLASTS; OSTEOCHONDRODYSPLASIAS; OSTEOCLASTS; OSTEOGENESIS; PROMOTER REGIONS, GENETIC; RANK LIGAND;

EID: 70350536355     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01549-08     Document Type: Article

References (51)

1. Banerjee, C., J. L. Stein, A. J. Van Wijnen, B. Frenkel, J. B. Lian, and G. S. Stein. 1996. Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site. Endocrinology 137:1991-2000. (Pubitemid 26139694)
2. Bentires-Alj, M., M. I. Kontaridis, and B. G. Neel. 2006. Stops along the RAS pathway in human genetic disease. Nat. Med. 12:283-285.
3. Boyce, B. F., and L. Xing. 2008. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch. Biochem. Biophys. 473:139-146.
4. Chuderland, D., and R. Seger. 2005. Protein-protein interactions in the regulation of the extracellular signal-regulated kinase. Mol. Biotechnol. 29:57-74.
5. Colnot, C. 2005. Cellular and molecular interactions regulating skeletogenesis. J. Cell. Biochem. 95:688-697.
6. Cox, W. G., and V. L. Singer. 1999. A high-resolution, fluorescence-based method for localization of endogenous alkaline phosphatase activity. J. Histochem. Cytochem. 47:1443-1456.
7. Day, T. F., X. Guo, L. Garrett-Beal, and Y. Yang. 2005. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev. Cell 8:739-750.
8. Ding, Q., W. Xia, J. C. Liu, J. Y. Yang, D. F. Lee, J. Xia, G. Bartholomeusz, Y. Li, Y. Pan, Z. Li, R. C. Bargou, J. Qin, C. C. Lai, F. J. Tsai, C. H. Tsai, and M. C. Hung. 2005. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol. Cell 19:159-170. (Pubitemid 41019664)
9. Eferl, R., A. Hoebertz, A. F. Schilling, M. Rath, F. Karreth, L. Kenner, M. Amling, and E. F. Wagner. 2004. The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J. 23:2789-2799. (Pubitemid 39013551)
10. Filgueira, L. 2004. Fluorescence-based staining for tartrate-resistant acidic phosphatase (TRAP) in osteoclasts. J. Histochem. Cytochem. 52:411-414.
11. Ge, C., G. Xiao, D. Jiang, and R. T. Franceschi. 2007. Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J. Cell Biol. 176:709-718. (Pubitemid 46333984)
12. Hill, T. P., D. Spater, M. M. Taketo, W. Birchmeier, and C. Hartmann. 2005. Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev. Cell 8:727-738.
13. Hunziker, E. B. 1994. Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc. Res. Tech. 28:505-519.
14. Ibrahimi, O. A., E. S. Chiu, J. G. McCarthy, and M. Mohammadi. 2005. Understanding the molecular basis of Apert syndrome. Plast. Reconstr. Surg. 115:264-270.
15. Jochum, W., J. P. David, C. Elliott, A. Wutz, H. Plenk, Jr., K. Matsuo, and E. F. Wagner. 2000. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat. Med. 6:980-984.
16. Kim, N., P. R. Odgren, D. K. Kim, S. C. Marks, Jr., and Y. Choi. 2000. Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc. Natl. Acad. Sci. USA 97:10905-10910.
17. Kondoh, K., S. Torii, and E. Nishida. 2005. Control of MAP kinase signaling to the nucleus. Chromosoma 114:86-91. (Pubitemid 41030971)
18. Kyriakis, J. M., H. App, X. F. Zhang, P. Banerjee, D. L. Brautigan, U. R. Rapp, and J. Avruch. 1992. Raf-1 activates MAP kinase-kinase. Nature 358:417-421.
19. Leclerc, N., T. Noh, A. Khokhar, E. Smith, and B. Frenkel. 2005. Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer. Arthritis Rheum. 52:929-939. (Pubitemid 40365117)
20. Levi, G., P. Topilko, S. Schneider-Maunoury, M. Lasagna, S. Mantero, R. Cancedda, and P. Charnay. 1996. Defective bone formation in Krox-20 mutant mice. Development 122:113-120. (Pubitemid 26038423)
21. Logan, M., J. F. Martin, A. Nagy, C. Lobe, E. N. Olson, and C. J. Tabin. 2002. Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33:77-80. (Pubitemid 34651279)
22. Long, F., U. I. Chung, S. Ohba, J. McMahon, H. M. Kronenberg, and A. P. McMahon. 2004. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131:1309-1318. (Pubitemid 38443885)
23. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
24. Martin, J. F., and E. N. Olson. 2000. Identification of a prx1 limb enhancer. Genesis 26:225-229.
25. Masuyama, R., I. Stockmans, S. Torrekens, R. Van Looveren, C. Maes, P. Carmeliet, R. Bouillon, and G. Carmeliet. 2006. Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J. Clin. Investig. 116:3150-3159.
26. McCabe, L. R., M. Kockx, J. Lian, J. Stein, and G. Stein. 1995. Selective expression of fos- and jun-related genes during osteoblast proliferation and differentiation. Exp. Cell Res. 218:255-262.
27. Miller, J., A. Horner, T. Stacy, C. Lowrey, J. B. Lian, G. Stein, G. H. Nuckolls, and N. A. Speck. 2002. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. Nat. Genet. 32:645-649.
28. Murakami, S., G. Balmes, S. McKinney, Z. Zhang, D. Givol, and B. de Crombrugghe. 2004. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev. 18:290-305. (Pubitemid 38199254)
29. Nakashima, K., X. Zhou, G. Kunkel, Z. Zhang, J. M. Deng, R. R. Behringer, and B. de Crombrugghe. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29. (Pubitemid 34137009)
30. Opperman, L. A. 2000. Cranial sutures as intramembranous bone growth sites. Dev. Dyn. 219:472-485.
31. Ornitz, D. M., and P. J. Marie. 2002. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev. 16:1446-1465.
32. Ovchinnikov, D. A., J. M. Deng, G. Ogunrinu, and R. R. Behringer. 2000. Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 26:145-146. (Pubitemid 30158102)
33. Provot, S., G. Nachtrab, J. Paruch, A. P. Chen, A. Silva, and H. M. Kronenberg. 2008. A-Raf and B-Raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes. Mol. Cell. Biol. 28:344-357.
34. Rodda, S. J., and A. P. McMahon. 2006. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133:3231-3244.
35. Samuels, I. S., J. C. Karlo, A. N. Faruzzi, K. Pickering, K. Herrup, J. D. Sweatt, S. C. Saitta, and G. E. Landreth. 2008. Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J. Neurosci. 28:6983-6995.
36. Seger, R., and E. G. Krebs. 1995. The MAPK signaling cascade. FASEB J. 9:726-735.
37. Selcher, J. C., T. Nekrasova, R. Paylor, G. E. Landreth, and J. D. Sweatt. 2001. Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn. Mem. 8:11-19.
38. Shapiro, I. M., C. S. Adams, T. Freeman, and V. Srinivas. 2005. Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Res. C 75:330-339.
39. Shukla, V., X. Coumoul, R. H. Wang, H. S. Kim, and C. X. Deng. 2007. RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat. Genet. 39:1145-1150.
40. Smith, J. A., C. E. Poteet-Smith, K. Malarkey, and T. W. Sturgill. 1999. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J. Biol. Chem. 274:2893-2898.
41. Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21:70-71.
42. Trivier, E., D. De Cesare, S. Jacquot, S. Pannetier, E. Zackai, I. Young, J. L. Mandel, P. Sassone-Corsi, and A. Hanauer. 1996. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature 384:567-570. (Pubitemid 26415934)
43. Xiao, G., D. Jiang, P. Thomas, M. D. Benson, K. Guan, G. Karsenty, and R. T. Franceschi. 2000. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J. Biol. Chem. 275:4453-4459.
44. Yang, X., K. Matsuda, P. Bialek, S. Jacquot, H. C. Masuoka, T. Schinke, L. Li, S. Brancorsini, P. Sassone-Corsi, T. M. Townes, A. Hanauer, and G. Karsenty. 2004. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell 117:387-398. (Pubitemid 38534544)
45. Yasuda, H., N. Shima, N. Nakagawa, K. Yamaguchi, M. Kinosaki, S. Mochizuki, A. Tomoyasu, K. Yano, M. Goto, A. Murakami, E. Tsuda, T. Morinaga, K. Higashio, N. Udagawa, N. Takahashi, and T. Suda. 1998. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis- inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA 95:3597-3602.
46. Yoon, S., and R. Seger. 2006. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24:21-44. (Pubitemid 43108774)
47. Yoshida, C. A., T. Furuichi, T. Fujita, R. Fukuyama, N. Kanatani, S. Kobayashi, M. Satake, K. Takada, and T. Komori. 2002. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat. Genet. 32:633-638.
48. Yoshida, C. A., H. Yamamoto, T. Fujita, T. Furuichi, K. Ito, K. Inoue, K. Yamana, A. Zanma, K. Takada, Y. Ito, and T. Komori. 2004. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 18:952-963.
49. Zelzer, E., D. J. Glotzer, C. Hartmann, D. Thomas, N. Fukai, S. Soker, and B. R. Olsen. 2001. Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech. Dev. 106:97-106.
50. Zhao, Y., C. Bjorbaek, and D. E. Moller. 1996. Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. J. Biol. Chem. 271:29773-29779.
51. Zheng, Q., G. Zhou, R. Morello, Y. Chen, X. Garcia-Rojas, and B. Lee. 2003. Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J. Cell Biol. 162:833-842. (Pubitemid 37087723)