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Volumn 30, Issue 5, 2015, Pages 898-905

The excess risk of major osteoporotic fractures in hypothyroidism is driven by cumulative hyperthyroid as opposed to hypothyroid time: An observational register-based time-resolved cohort analysis

Author keywords

Epidemiology; Fracture risk assessment; Hypothyroidism; Osteoporosis; Thyroxine

Indexed keywords

PREDNISOLONE; THYROTROPIN; THYROXINE;

EID: 84927709161     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2416     Document Type: Article
Times cited : (79)

References (43)
  • 1
    • 33646035188 scopus 로고    scopus 로고
    • Quality of life in patients with benign thyroid disorders. A review
    • Watt T, Groenvold M, Rasmussen AK, et al. Quality of life in patients with benign thyroid disorders. A review. Eur J Endocrinol 2006; 154 4 501-10.
    • (2006) Eur J Endocrinol , vol.154 , Issue.4 , pp. 501-510
    • Watt, T.1    Groenvold, M.2    Rasmussen, A.K.3
  • 2
    • 84907638318 scopus 로고    scopus 로고
    • The Thyroid-Related Quality of Life Measure ThyPRO has good responsiveness and ability to detect relevant treatment effects
    • Watt T, Cramon P, Hegedüs L, et al. The Thyroid-Related Quality of Life Measure ThyPRO has good responsiveness and ability to detect relevant treatment effects. J Clin Endocrinol Metab 2014; 99 (10): 3708-17.
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.10 , pp. 3708-3717
    • Watt, T.1    Cramon, P.2    Hegedüs, L.3
  • 3
    • 84884174438 scopus 로고    scopus 로고
    • Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. A nationwide register study
    • Thvilum M, Brandt F, Almind D, Christensen K, Brix TH, Hegedüs L,. Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. A nationwide register study. PLoS One 2013; 8 (9): e75789.
    • (2013) PLoS One , vol.8 , Issue.9 , pp. e75789
    • Thvilum, M.1    Brandt, F.2    Almind, D.3    Christensen, K.4    Brix, T.H.5    Hegedüs, L.6
  • 4
    • 84899477139 scopus 로고    scopus 로고
    • Increased psychiatric morbidity before and after the diagnosis of hypothyroidism: A nationwide register study
    • Thvilum M, Brandt F, Almind D, Christensen K, Brix TH, Hegedüs L,. Increased psychiatric morbidity before and after the diagnosis of hypothyroidism: a nationwide register study. Thyroid 2014; 24 (5): 802-8.
    • (2014) Thyroid , vol.24 , Issue.5 , pp. 802-808
    • Thvilum, M.1    Brandt, F.2    Almind, D.3    Christensen, K.4    Brix, T.H.5    Hegedüs, L.6
  • 5
    • 84907201182 scopus 로고    scopus 로고
    • Hypothyroidism is a predictor of disability pension and loss of labor market income: A Danish register-based study
    • Thvilum M, Brandt F, Brix TH, Hegedüs L,. Hypothyroidism is a predictor of disability pension and loss of labor market income: a Danish register-based study. J Clin Endocrinol Metab 2014; 99 (9): 3129-35.
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.9 , pp. 3129-3135
    • Thvilum, M.1    Brandt, F.2    Brix, T.H.3    Hegedüs, L.4
  • 6
    • 84874920936 scopus 로고    scopus 로고
    • Excess mortality in patients diagnosed with hypothyroidism: A nationwide cohort study of singletons and twins
    • Thvilum M, Brandt F, Almind D, Christensen K, Hegedüs L, Brix TH,. Excess mortality in patients diagnosed with hypothyroidism: a nationwide cohort study of singletons and twins. J Clin Endocrinol Metab 2013; 98 (3): 1069-75.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.3 , pp. 1069-1075
    • Thvilum, M.1    Brandt, F.2    Almind, D.3    Christensen, K.4    Hegedüs, L.5    Brix, T.H.6
  • 9
    • 34248594569 scopus 로고    scopus 로고
    • Severe skeletal dysplasia caused by undiagnosed hypothyroidism
    • Hüffmeier U, Tietze HU, Rauch A,. Severe skeletal dysplasia caused by undiagnosed hypothyroidism. Eur J Med Genet 2007; 50: 209-15.
    • (2007) Eur J Med Genet , vol.50 , pp. 209-215
    • Hüffmeier, U.1    Tietze, H.U.2    Rauch, A.3
  • 11
    • 58149277137 scopus 로고    scopus 로고
    • Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes
    • Vestergaard P, Rejnmark L, Mosekilde L,. Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes. Calcif Tissue Int 2009; 84 (1): 45-55.
    • (2009) Calcif Tissue Int , vol.84 , Issue.1 , pp. 45-55
    • Vestergaard, P.1    Rejnmark, L.2    Mosekilde, L.3
  • 13
    • 77954946030 scopus 로고    scopus 로고
    • Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women
    • Murphy E, Glüer CC, Reid DM, et al. Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women. J Clin Endocrinol Metab 2010; 95 (7): 3173-81.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.7 , pp. 3173-3181
    • Murphy, E.1    Glüer, C.C.2    Reid, D.M.3
  • 14
    • 84906351598 scopus 로고    scopus 로고
    • Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures - The OPENTHYRO Register Cohort
    • Abrahamsen B, Jørgensen HL, Laulund AS, Nybo M, Brix TH, Hegedüs L,. Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures-the OPENTHYRO Register Cohort. J Bone Miner Res 2014; 29 (9): 2040-50.
    • (2014) J Bone Miner Res , vol.29 , Issue.9 , pp. 2040-2050
    • Abrahamsen, B.1    Jørgensen, H.L.2    Laulund, A.S.3    Nybo, M.4    Brix, T.H.5    Hegedüs, L.6
  • 15
    • 84883729865 scopus 로고    scopus 로고
    • Clinical review: A review of the clinical consequences of variation in thyroid function within the reference range
    • Taylor PN, Razvi S, Pearce SH, Dayan CM,. Clinical review: a review of the clinical consequences of variation in thyroid function within the reference range. J Clin Endocrinol Metab 2013; 98 (9): 3562-71.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.9 , pp. 3562-3571
    • Taylor, P.N.1    Razvi, S.2    Pearce, S.H.3    Dayan, C.M.4
  • 16
    • 79957783533 scopus 로고    scopus 로고
    • Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass
    • Roef G, Lapauw B, Goemaere S, et al. Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass. Eur J Endocrinol 2011; 164 (6): 1027-34.
    • (2011) Eur J Endocrinol , vol.164 , Issue.6 , pp. 1027-1034
    • Roef, G.1    Lapauw, B.2    Goemaere, S.3
  • 17
    • 0037059953 scopus 로고    scopus 로고
    • Levothyroxine treatment and occurrence of fracture of the hip
    • Sheppard MC, Holder R, Franklyn JA,. Levothyroxine treatment and occurrence of fracture of the hip. Arch Intern Med 2002; 162 (3): 338-43.
    • (2002) Arch Intern Med , vol.162 , Issue.3 , pp. 338-343
    • Sheppard, M.C.1    Holder, R.2    Franklyn, J.A.3
  • 18
    • 78649682543 scopus 로고    scopus 로고
    • Subclinical thyroid dysfunction and incident hip fracture in older adults
    • Lee JS, Buzková P, Fink HA, Vu J, Carbone L, Chen Z, et al. Subclinical thyroid dysfunction and incident hip fracture in older adults. Arch Intern Med 2010; 170 (21): 1876-83.
    • (2010) Arch Intern Med , vol.170 , Issue.21 , pp. 1876-1883
    • Lee, J.S.1    Buzková, P.2    Fink, H.A.3    Vu, J.4    Carbone, L.5    Chen, Z.6
  • 19
    • 79955668280 scopus 로고    scopus 로고
    • Levothyroxine dose,risk of fractures in older adults: Nested case-control study
    • Turner MR, Camacho X, Fischer HD, et al. Levothyroxine dose,risk of fractures in older adults: nested case-control study. BMJ 2011; 342: d2238.
    • (2011) BMJ , vol.342 , pp. d2238
    • Turner, M.R.1    Camacho, X.2    Fischer, H.D.3
  • 20
    • 84905459162 scopus 로고    scopus 로고
    • Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: The Cardiovascular Health Study
    • Garin MC, Arnold AM, Lee JS, Robbins J, Cappola AR,. Subclinical thyroid dysfunction and hip fracture and bone mineral density in older adults: the Cardiovascular Health Study. J Clin Endocrinol Metab 2014: 20141051.
    • (2014) J Clin Endocrinol Metab , pp. 20141051
    • Garin, M.C.1    Arnold, A.M.2    Lee, J.S.3    Robbins, J.4    Cappola, A.R.5
  • 21
    • 15144344551 scopus 로고    scopus 로고
    • The Danish prescription registries
    • Gaist D, Sørensen HT, Hallas J,. The Danish prescription registries. Dan Med Bull 1997; 44 (4): 445-8.
    • (1997) Dan Med Bull , vol.44 , Issue.4 , pp. 445-448
    • Gaist, D.1    Sørensen, H.T.2    Hallas, J.3
  • 22
    • 72449208662 scopus 로고    scopus 로고
    • From relative risk to absolute fracture risk calculation: The FRAX algorithm
    • 15442241
    • McCloskey EV, Johansson H, Oden A, Kanis JA,. From relative risk to absolute fracture risk calculation: the FRAX algorithm. Curr Osteoporos Rep 2009; 7 (1544-2241): 77-83.
    • (2009) Curr Osteoporos Rep , vol.7 , pp. 77-83
    • McCloskey, E.V.1    Johansson, H.2    Oden, A.3    Kanis, J.A.4
  • 23
    • 4344595728 scopus 로고    scopus 로고
    • Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies
    • Jensen E, Hyltoft Petersen P, et al. Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies. Clin Chem Lab Med 2004; 42 (7): 824-32.
    • (2004) Clin Chem Lab Med , vol.42 , Issue.7 , pp. 824-832
    • Jensen, E.1    Hyltoft Petersen, P.2
  • 24
    • 36549033449 scopus 로고    scopus 로고
    • High-trauma fractures, low bone mineral density in older women, men
    • Mackey DC, Lui L-Y., Cawthon PM, et al. High-trauma fractures, low bone mineral density in older women, men. JAMA 2007; 298 (20): 2381-8.
    • (2007) JAMA , vol.298 , Issue.20 , pp. 2381-2388
    • Mackey, D.C.1    Lui, L.-Y.2    Cawthon, P.M.3
  • 25
    • 3242747632 scopus 로고    scopus 로고
    • The validity of self-reported fractures among Danish female nurses: Comparison with fractures registered in the Danish National Hospital Register
    • Hundrup YA, Hoidrup S, Obel EB, Rasmussen NK,. The validity of self-reported fractures among Danish female nurses: comparison with fractures registered in the Danish National Hospital Register. Scand J Public Health 2004; 32: 136-43.
    • (2004) Scand J Public Health , vol.32 , pp. 136-143
    • Hundrup, Y.A.1    Hoidrup, S.2    Obel, E.B.3    Rasmussen, N.K.4
  • 26
    • 27744568384 scopus 로고    scopus 로고
    • Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
    • Quan H, Sundararajan V, Halfon P, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 2005; 43: 1130-9.
    • (2005) Med Care , vol.43 , pp. 1130-1139
    • Quan, H.1    Sundararajan, V.2    Halfon, P.3
  • 28
    • 84873966807 scopus 로고    scopus 로고
    • Osteoporotic Fractures in Men (MrOS) Study. A prospective study of thyroid function, bone loss, and fractures in older men: The MrOS study
    • Waring AC, Harrison S, Fink HA, et al. Osteoporotic Fractures in Men (MrOS) Study. A prospective study of thyroid function, bone loss, and fractures in older men: the MrOS study. J Bone Miner Res 2013; 28 (3): 472-9.
    • (2013) J Bone Miner Res , vol.28 , Issue.3 , pp. 472-479
    • Waring, A.C.1    Harrison, S.2    Fink, H.A.3
  • 29
    • 75149179019 scopus 로고    scopus 로고
    • Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy
    • Flynn RW, Bonellie SR, Jung RT, MacDonald TM, Morris AD, Leese GP,. Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy. J Clin Endocrinol Metab 2010; 95 (1): 186-93.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.1 , pp. 186-193
    • Flynn, R.W.1    Bonellie, S.R.2    Jung, R.T.3    Macdonald, T.M.4    Morris, A.D.5    Leese, G.P.6
  • 30
    • 2342509616 scopus 로고    scopus 로고
    • The interrelationships between thyroid dysfunction and hypogonadism in men and boys
    • Meikle AW,. The interrelationships between thyroid dysfunction and hypogonadism in men and boys. Thyroid 2004; Suppl 1: S17-25.
    • (2004) Thyroid , pp. S17-S25
    • Meikle, A.W.1
  • 31
    • 0036283611 scopus 로고    scopus 로고
    • Clinical review 144: Estrogen and the male skeleton
    • Khosla S, Melton LJ, III., Riggs BL,. Clinical review 144: estrogen and the male skeleton. J Clin Endocrinol Metab 2002; 87 (4): 1443-50.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.4 , pp. 1443-1450
    • Khosla, S.1    Melton, L.J.2    Riggs, B.L.3
  • 32
    • 38449089727 scopus 로고    scopus 로고
    • Secretion of testicular steroids and gonadotrophins in hypothyroidism
    • Kumar a, Mohanty BP, Rani L,. Secretion of testicular steroids and gonadotrophins in hypothyroidism. Andrologia 2007; 39 (6): 253-60.
    • (2007) Andrologia , vol.39 , Issue.6 , pp. 253-260
    • Kumar, A.1    Mohanty, B.P.2    Rani, L.3
  • 33
    • 76149126990 scopus 로고    scopus 로고
    • Endocrine aspects of obstructive sleep apnea
    • Attal P, Chanson P,. Endocrine aspects of obstructive sleep apnea. J Clin Endocrinol Metab 2010; 95 (2): 483-95.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.2 , pp. 483-495
    • Attal, P.1    Chanson, P.2
  • 35
    • 0033535435 scopus 로고    scopus 로고
    • Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group
    • Whooley MA, Kip KE, Cauley JA, Ensrud KE, Nevitt MC, Browner WS,. Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group. Arch Intern Med 1999; 159: 484-90.
    • (1999) Arch Intern Med , vol.159 , pp. 484-490
    • Whooley, M.A.1    Kip, K.E.2    Cauley, J.A.3    Ensrud, K.E.4    Nevitt, M.C.5    Browner, W.S.6
  • 36
    • 84896289651 scopus 로고    scopus 로고
    • Low bone mineral density is related to high physiological levels of free thyroxine in peri-menopausal women
    • Van Rijn LE, Pop VJ, Williams GR,. Low bone mineral density is related to high physiological levels of free thyroxine in peri-menopausal women. Eur J Endocrinol 2014; 170 (3): 461-8.
    • (2014) Eur J Endocrinol , vol.170 , Issue.3 , pp. 461-468
    • Van Rijn, L.E.1    Pop, V.J.2    Williams, G.R.3
  • 37
    • 0025140523 scopus 로고
    • Accelerated bone loss in hypothyroid patients overtreated with L-thyroxine
    • Stall GM, Harris S, Sokoll LJ, Dawson-Hughes B,. Accelerated bone loss in hypothyroid patients overtreated with L-thyroxine. Ann Intern Med 1990; 113 (4): 265-9.
    • (1990) Ann Intern Med , vol.113 , Issue.4 , pp. 265-269
    • Stall, G.M.1    Harris, S.2    Sokoll, L.J.3    Dawson-Hughes, B.4
  • 38
    • 79951680455 scopus 로고    scopus 로고
    • Risk of femoral shaft and subtrochanteric fractures among users of bisphosphonates and raloxifene
    • Vestergaard P, Schwartz F, Rejnmark L, Mosekilde L,. Risk of femoral shaft and subtrochanteric fractures among users of bisphosphonates and raloxifene. Osteoporos Int 2011; 22 (3): 993-1001.
    • (2011) Osteoporos Int , vol.22 , Issue.3 , pp. 993-1001
    • Vestergaard, P.1    Schwartz, F.2    Rejnmark, L.3    Mosekilde, L.4
  • 39
    • 84879263040 scopus 로고    scopus 로고
    • Morbidity before and after the diagnosis of hyperthyroidism: A nationwide register-based study
    • Brandt F, Thvilum M, Almind D, et al. Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study. PLoS One 2013; 8 (6): e66711.
    • (2013) PLoS One , vol.8 , Issue.6 , pp. e66711
    • Brandt, F.1    Thvilum, M.2    Almind, D.3
  • 40
    • 84927723927 scopus 로고    scopus 로고
    • Hyperthyroidism and psychiatric morbidity. Evidence from a Danish nation-wide register study
    • Brandt F, Thvilum M, Almind D, et al. Hyperthyroidism and psychiatric morbidity. Evidence from a Danish nation-wide register study. Eur J Endocrinol 2013.
    • (2013) Eur J Endocrinol
    • Brandt, F.1    Thvilum, M.2    Almind, D.3
  • 41
    • 84868620920 scopus 로고    scopus 로고
    • Excess mortality in hyperthyroidism: The influence of preexisting comorbidity and genetic confounding: A Danish nationwide register-based cohort study of twins and singletons
    • Brandt F, Almind D, Christensen K, Green A, Brix TH, Hegedüs L,. Excess mortality in hyperthyroidism: the influence of preexisting comorbidity and genetic confounding: a Danish nationwide register-based cohort study of twins and singletons. J Clin Endocrinol Metab 2012; 97 (11): 4123-9.
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.11 , pp. 4123-4129
    • Brandt, F.1    Almind, D.2    Christensen, K.3    Green, A.4    Brix, T.H.5    Hegedüs, L.6
  • 42
    • 85016904324 scopus 로고    scopus 로고
    • Mechanisms of bone remodeling
    • Stovall D.W. ed. Hoboken, NJ: John Wiley & Sons, Ltd;. p
    • Shabestari M, Eriksen EF,. Mechanisms of bone remodeling. In:, Stovall DW, ed. Osteoporosis. Hoboken, NJ: John Wiley & Sons, Ltd; 2013. p. 31-45.
    • (2013) Osteoporosis , pp. 31-45
    • Shabestari, M.1    Eriksen, E.F.2
  • 43
    • 0019754282 scopus 로고
    • Effects of thyroid hormone(s) on mean wall thickness of trabecular bone packets
    • Kragstrup J, Melsen F, Mosekilde L., Effects of thyroid hormone(s) on mean wall thickness of trabecular bone packets. Metab Bone Dis Relat Res 1981; 3 (3): 181-5.
    • (1981) Metab Bone Dis Relat Res , vol.3 , Issue.3 , pp. 181-185
    • Kragstrup, J.1    Melsen, F.2    Mosekilde, L.3


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