A prospective study of thyroid function, bone loss, and fractures in older men: The MrOS study

Journal of Bone and Mineral Research

Volumn 28, Issue 3, 2013, Pages 472-479

  Waring, Avantika C ^a   Harrison, Stephanie ^b   Fink, Howard A ^c   Samuels, Mary H ^d   Cawthon, Peggy M ^b   Zmuda, Joseph M ^e   Orwoll, Eric S ^d   Bauer, Douglas C ^f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BONE DENSITY; FRACTURE; MEN; OSTEOPOROSIS; THYROID FUNCTION

Indexed keywords

THYROTROPIN;

AGED; ALCOHOL CONSUMPTION; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; FOLLOW UP; FRACTURE; FREE THYROXINE INDEX; HIP FRACTURE; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; MALE; OSTEOLYSIS; PHYSICAL ACTIVITY; PROSPECTIVE STUDY; RACE; REVIEW; SMOKING; THYROID FUNCTION;

ABSORPTIOMETRY, PHOTON; AGED; FRACTURES, BONE; HUMANS; MALE; OSTEOPOROSIS; PROSPECTIVE STUDIES; THYROID FUNCTION TESTS; THYROID HORMONES;

EID: 84873966807     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1774     Document Type: Review

References (40)

1. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM., Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 1995; 332 (12): 767-73.
2. El Hadidy el HM, Ghonaim M, El Gawad S, El Atta MA., Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men. BMC Endocr Disord. 2011; 11: 15.
3. Bauer DC, Ettinger B, Nevitt MC, Stone KL., Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann Intern Med. 2001; 134 (7): 561-8.
4. Lee JS, Buzkova P, Fink HA, Vu J, Carbone L, Chen Z, Cauley J, Bauer DC, Cappola AR, Robbins J., Subclinical thyroid dysfunction and incident hip fracture in older adults. Arch Intern Med. 2010; 170 (21): 1876-83.
5. van der Deure WM, Uitterlinden AG, Hofman A, Rivadeneira F, Pols HA, Peeters RP, Visser TJ., Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study. Clin Endocrinol (Oxf). 2008; 68 (2): 175-81.
6. Murphy E, Gluer CC, Reid DM, Felsenberg D, Roux C, Eastell R, Williams GR., Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women. J Clin Endocrinol Metab. 2010; 95 (7): 3173-81.
7. Mazziotti G, Porcelli T, Patelli I, Vescovi PP, Giustina A., Serum TSH values and risk of vertebral fractures in euthyroid post-menopausal women with low bone mineral density. Bone. 2010; 46 (3): 747-51.
8. Grimnes G, Emaus N, Joakimsen RM, Figenschau Y, Jorde R., The relationship between serum TSH and bone mineral density in men and postmenopausal women: the Tromso study. Thyroid. 2008; 18 (11): 1147-55.
9. Kim BJ, Lee SH, Bae SJ, Kim HK, Choe JW, Kim HY, Koh JM, Kim GS., The association between serum thyrotropin (TSH) levels and bone mineral density in healthy euthyroid men. Clin Endocrinol (Oxf). 2010; 73 (3): 396-403.
10. Roef G, Lapauw B, Goemaere S, Zmierczak H, Fiers T, Kaufman JM, Taes Y., Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass. Eur J Endocrinol. 2011; 164 (6): 1027-34.
11. Melton LJ 3rd, Chrischilles EA, Cooper C, Lane AW, Riggs BL., Perspective. How many women have osteoporosis?. J Bone Miner Res. 1992; 7 (9): 1005-10.
12. Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR., Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA. 2009; 301 (5): 513-21.
13. Parle JV, Franklyn JA, Cross KW, Jones SC, Sheppard MC., Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol (Oxf). 1991; 34 (1): 77-83.
14. Bensenor IM, Lotufo PA, Menezes PR, Scazufca M., Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH). BMC Public Health. 2010; 10: 298.
15. Blank JB, Cawthon PM, Carrion-Petersen ML, Harper L, Johnson JP, Mitson E, Delay RR., Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials. 2005; 26 (5): 557-68.
16. Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K., Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study-a large observational study of the determinants of fracture in older men. Contemp Clin Trials. 2005; 26 (5): 569-85.
17. Prentice RL., On the design of synthetic case-control studies. Biometrics. 1986; 42 (2): 301-10.
18. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ., Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291 (2): 228-38.
19. Cauley JA, Blackwell T, Zmuda JM, Fullman RL, Ensrud KE, Stone KL, Barrett-Connor E, Orwoll ES., Correlates of trabecular and cortical volumetric bone mineral density at the femoral neck and lumbar spine: the osteoporotic fractures in men study (MrOS). J Bone Miner Res. 2010; 25 (9): 1958-71.
20. Washburn RA, Smith KW, Jette AM, Janney CA., The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol. 1993; 46 (2): 153-62.
21. Mackey DC, Lui LY, Cawthon PM, Bauer DC, Nevitt MC, Cauley JA, Hillier TA, Lewis CE, Barrett-Connor E, Cummings SR., High-trauma fractures and low bone mineral density in older women and men. JAMA. 2007; 298 (20): 2381-8.
22. Pahor M, Chrischilles EA, Guralnik JM, Brown SL, Wallace RB, Carbonin P., Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol. 1994; 10 (4): 405-11.
23. Barlow WE, Ichikawa L, Rosner D, Izumi S., Analysis of case-cohort designs. J Clin Epidemiol. 1999; 52 (12): 1165-72.
24. Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SH., The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis. J Clin Endocrinol Metab. 2008; 93 (8): 2998-3007.
25. Mariotti S., Mild hypothyroidism and ischemic heart disease: is age the answer?. J Clin Endocrinol Metab. 2008; 93 (8): 2969-71.
26. Vestergaard P, Mosekilde L., Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients. Thyroid. 2002; 12 (5): 411-9.
27. Greenspan SL, Greenspan FS., The effect of thyroid hormone on skeletal integrity. Ann Intern Med. 1999; 130 (9): 750-8.
28. Schneider R, Reiners C., The effect of levothyroxine therapy on bone mineral density: a systematic review of the literature. Exp Clin Endocrinol Diabetes. 2003; 111 (8): 455-70.
29. Mosekilde L, Melsen F., A tetracycline-based histomorphometric evaluation of bone resorption and bone turnover in hyperthyroidism and hyperparathyroidism. Acta Med Scand. 1978; 204 (1-2): 97-102.
30. Harvey RD, McHardy KC, Reid IW, Paterson F, Bewsher PD, Duncan A, Robins SP., Measurement of bone collagen degradation in hyperthyroidism and during thyroxine replacement therapy using pyridinium cross-links as specific urinary markers. J Clin Endocrinol Metab. 1991; 72 (6): 1189-94.
31. Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, Davies TF, Zaidi M., TSH is a negative regulator of skeletal remodeling. Cell. 2003; 115 (2): 151-62.
32. Sun L, Vukicevic S, Baliram R, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah K, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M., Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci U S A. 2008; 105 (11): 4289-94.
33. Flynn RW, Bonellie SR, Jung RT, MacDonald TM, Morris AD, Leese GP., Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy. J Clin Endocrinol Metab. 2010; 95 (1): 186-93.
34. Lewis CE, Ewing SK, Taylor BC, Shikany JM, Fink HA, Ensrud KE, Barrett-Connor E, Cummings SR, Orwoll E., Predictors of non-spine fracture in elderly men: the MrOS study. J Bone Miner Res. 2007; 22 (2): 211-9.
35. Huber G, Staub JJ, Meier C, Mitrache C, Guglielmetti M, Huber P, Braverman LE., Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies. J Clin Endocrinol Metab. 2002; 87 (7): 3221-6.
36. Diez JJ, Iglesias P., Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure. J Clin Endocrinol Metab. 2004; 89 (10): 4890-7.
37. Rosario PW., Natural history of subclinical hyperthyroidism in elderly patients with TSH between 0.1 and 0.4 mIU/l: a prospective study. Clin Endocrinol (Oxf). 2010; 72 (5): 685-8.
38. Das G, Ojewuyi TA, Baglioni P, Geen J, Premawardhana LD, Okosieme OE., Serum thyrotrophin at baseline predicts the natural course of subclinical hyperthyroidism. Clin Endocrinol (Oxf). 2012; 77 (1): 146-51.
39. Berry SD, Ngo L, Samelson EJ, Kiel DP., Competing risk of death: an important consideration in studies of older adults. J Am Geriatr Soc. 2010; 58 (4): 783-7.
40. Biondi B, Cooper DS., The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008; 29 (1): 76-131.