Establishment of a serum thyroid stimulating hormone (TSH) reference interval in healthy adults. The importance of environmental factors, including thyroid antibodies

Clinical Chemistry and Laboratory Medicine

Volumn 42, Issue 7, 2004, Pages 824-832

  Jensen, Esther ^a   Petersen, Per Hyltoft ^a,b   Blaabjerg, Ole ^a   Hansen, Pia Skov ^a,c   Brix, Thomas H ^a   Kyvik, Kirsten Ohm ^c   Hegedüs, Laszlo ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF BERGEN   (Norway)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Partitioning of subgroups; Rankit plot; Reference interval; Serum thyroid stimulating hormone (TSH); Thyro globulin antibodies (Tgab); Thyroid peroxidase antibodies (TPOab); TSH receptor antibodies (TSHRab)

Indexed keywords

THYROGLOBULIN ANTIBODY; THYROID ANTIBODY; THYROID PEROXIDASE ANTIBODY; THYROTROPIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD CHEMISTRY; BLOOD SAMPLING; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONFIDENCE INTERVAL; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FEMALE; GOITER; GROUPS BY AGE; HUMAN; IODINE DEFICIENCY; MALE; NORMAL DISTRIBUTION; POPULATION DISTRIBUTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RADIORECEPTOR ASSAY; REFERENCE VALUE; RISK FACTOR; SEX DIFFERENCE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; THYROTROPIN BLOOD LEVEL; VALIDATION PROCESS;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AUTOANTIBODIES; FAMILY HEALTH; FEMALE; HUMANS; IODIDE PEROXIDASE; MALE; MIDDLE AGED; NORMAL DISTRIBUTION; REFERENCE VALUES; RISK FACTORS; SEX FACTORS; THYROGLOBULIN; THYROID DISEASES; THYROTROPIN;

EID: 4344595728     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2004.136     Document Type: Article

References (33)

1. Demers LM, Spencer CA. NACB: Laboratory support for the diagnosis and monitoring of thyroid disease. http://www.nacb.org/lmpg/thyroid_LMPG_Word.stm. Demers LM, Spencer CA. Laboratory Medicine Practice Guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 2003;13:3-126.
2. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 1977;7:481-93.
3. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 1995;43:55-68.
4. Hershman JM, Pekary AE, Berg L, Solomon DH, Sawin CT. Serum thyrotropin and thyroid hormone levels in elderly and middle-aged euthyroid persons. J Am Geriatr Soc 1993;41:823-8.
5. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1998 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489-99.
6. Franklyn JA, Ramsden DB, Sheppard MC. The influence of age and sex on tests of thyroid function. Ann Clin Biochem 1985;22:502-5.
7. Andersen S, Pedersen KM, Bruun NH, Laurberg P. Narrow individual variations in serum T4 and T3 in normal subjects: a clue to the understanding of subclinical thyroid disease. J Clin Endocrinol Metab 2002;87:1068-72.
8. Henny J, Petitclerc C, Fuentes-Arderiu X, Hyltoft Petersen P, Queraltó JM, Schiele F, et al. Need for revisiting the concept of reference values. Clin Chem Lab Med 2000;38:589-95.
9. Henny J, Petitclerc C, Fuentes-Arderiu X, Hyltoft Petersen P, Queraltó JM, Schiele F, et al. French translation: Réviser le concept de valeurs de référence: une né cessité. Ann Biol Clin (Paris) 2001;59:383-92.
10. Fuentes-Arderiu X, Mas-Serra R, Alumà-Trullàs A, Martí-Marcet MI, Dot-Bach D. Guideline for the production of multicentre physiological reference values using the same measurement system. A proposal of the Catalan Association for Clinical Laboratory Sciences. Clin Chem Lab Med 2004;42:778-782.
11. Pål Rustad. Nordic Reference Interval Project (NRIP). http://www.furst.no/norip/
12. Lahti A, Hyltoft Petersen P, Boyd JC, Fraser CG, Jørgensen N. Objective criteria for partitioning Gaussian-distributed reference values into subgroups. Clin Chem 2002;48:338-52.
13. Hyltoft Petersen P, Blaabjerg O. Principles for estimation of reference intervals. Ups J Med Sci 1994;99:307-13.
14. Lund E, Blaabjerg O, Blom M, Hyltoft Petersen P, Rahbek Nørgaard J, Uldall A, et al. Reference intervals for α 1-antitrypsin. Ups J Med Sci 1994;99:339-46.
15. Blaabjerg O, Nørgaard I, Blom M, Rahbek Nørgaard J, Hyltoft Petersen P, Gry H, et al. Reference Intervals based on a Danish population. Ups J Med Sci 1994;99:315-38.
16. Jørgensen LGM, Stahl M, Brandslund I, Hyltoft Petersen P, Borch-Johnsen K, de Fine Olivarius N. Plasma glucose reference interval in a low-risk population 2. Impact of the new WHO and ADA recommendations on diagnosis of diabetes mellitus. Scand J Clin Lab Invest 2001;61:181-90.
17. Skytthe A, Christensen K, Holm NV, Vaupel JW, Kyvik K. The Danish Twin Registry: 127 birth cohorts of twins. Twin Res 2002;5:352-7.
18. Kyvik KO, Christensen K, Skytthe A, Harvald B, Holm NV. The Danish Twin Register. Dan Med Bull 1996;43:467-70.
19. Hansen PS, Brix TH, Sørensen TIA, Kyvik KO, Hegedüs L. Major genetic influence on the regulation of the pituitary-thyroid axis. A study of healthy Danish twins. J Clin Endocrinol Metab 2004;89:1181-7.
20. Andersen S. Aquatic iodine, urinary iodine and thyroid function. PhD thesis. Aalborg University, Denmark, 2002.
21. Bliss CI. Statistics in biology. New York: McGraw-Hill, 1967:558 pp.
22. Hald A. Statistical theory with engineering applications. New York: John Wiley & Sons, Inc., 1952:783 pp.
23. Altman DG. Practical statistics for medical research. London-Glasgow-Weinheim-New York-Tokyo-Melbourne-Madras: Chapman & Hall, 1991:611 pp.
24. Gaines Das RE, Bristow AF. The second International Reference Preparation of Thyroid Stimulating Hormone, Human, for Immunoassay: calibration by bioassay and immunoassay in an international collaborative study. J Endocr 1985:104;367-79.
25. Brix TH, Kyvik KO, Hegedüs L. Validity of self-reported hyperthyroidism and hypothyroidism: comparison of self-reported questionnaire data with medical record review. Thyroid 2001;11:769-73.
26. Nielsen CH, Hegedüs L, Leslie RGQ. Autoantibodies in autoimmune thyroid disease promote immune complex formation with self antigens and increase B cell and CD4+ T cell proliferation in response to self antigens. Eur J Immunol 2004;34:263-72.
27. Andersen S, Petersen SB, Laurberg P. Iodine in drinking water in Denmark is bound in humic substances. Eur J Endocrinol 2002;147:663-70.
28. Pedersen KM, Laurberg P, Nøhr S, Jørgensen A, Andersen S. Iodine in drinking water varies by more than 100-fold in Denmark. Importance for iodine content of infant formulas. Eur J Endocrinol 1999;140:400-3.
29. Bülow I, Knudsen N, Jørgensen T, Perrild H, Ovesen L, Laurberg P. Large differences in incidences of overt hyper- and hypothyroidism associated with a small difference in iodine intake: a prospective comparative register-based population survey. J Clin Endocrinol Metab 2002;87:4462-9.
30. Bülow Pedersen I. On the importance of small differences in iodine intake for thyroid function. PhD thesis. Aalborg University, Denmark, 2002.
31. Knudsen N, Bülow I, Jørgensen T, Laurberg P, Ovesen L, Perrild H. Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status. Eur J Endocrinol 2000;143:485-91.
32. Van Coevorden A, Laurent E, Decoster C, Kerkhofs M, Neve P, van Cauter E, et al. Decreased basal and stimulated thyrotropin secretion in healthy elderly men. J Clin Endocrinol Metab 1989;69:177-85.
33. Andersen S, Bruun NH, Pedersen KM, Laurberg P. Biologic variation is important for interpretation of thyroid function tests. Thyroid 2003;13:1069-78.