Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures - The OPENTHYRO register cohort

Journal of Bone and Mineral Research

Volumn 29, Issue 9, 2014, Pages 2040-2050

  Abrahamsen, Bo ^a,b   Jørgensen, Henrik L ^c   Laulund, Anne Sofie ^d   Nybo, Mads ^d   Brix, Thomas H ^d   Hegedüs, Laszlo ^d  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Endocrine pathways; Epidemiology; Fracture risk assessment; Health Services Research; Osteoporosis

Indexed keywords

THYROTROPIN;

ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE DURATION; EUTHYROIDISM; FEMALE; FOLLOW UP; FRAGILITY FRACTURE; HIGH RISK PATIENT; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTOR VARIABLE; RISK ASSESSMENT; THYROTOXICOSIS; THYROTROPIN BLOOD LEVEL; ADOLESCENT; BLOOD; COMPLICATION; DENMARK; DOSE RESPONSE; GENERAL PRACTICE; HOSPITAL; INCIDENCE; MIDDLE AGED; OSTEOPOROTIC FRACTURES; PROPORTIONAL HAZARDS MODEL; REFERENCE VALUE; REGISTER; STATISTICS AND NUMERICAL DATA; SURVIVAL; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; COHORT STUDIES; DENMARK; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENERAL PRACTICE; HOSPITALS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; OSTEOPOROTIC FRACTURES; PROPORTIONAL HAZARDS MODELS; REFERENCE VALUES; REGISTRIES; SURVIVAL ANALYSIS; THYROTOXICOSIS; THYROTROPIN; YOUNG ADULT;

EID: 84906351598     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2244     Document Type: Article

References (43)

1. Watt T, Groenvold M, Rasmussen AK, et al. Quality of life in patients with benign thyroid disorders. A review. Eur J Endocrinol. 2006; 154 (4): 501-10.
2. Brandt F, Thvilum M, Almind D, et al. Morbidity before and after the diagnosis of hyperthyroidism: a nationwide register-based study. PLoS One. 2013; 8 (6): e66711.
3. Brandt F, Thvilum M, Almind D, et al. Hyperthyroidism and psychiatric morbidity. Evidence from a Danish nation-wide register study. Eur J Endocrinol. 2013; 170: 341-8.
4. Brandt F, Green A, Hegedüs L, Brix TH,. A critical review and meta-analysis of the association between overt hyperthyroidism and mortality. Eur J Endocrinol. 2011; 165 (4): 491-7.
5. Brandt F, Almind D, Christensen K, Green A, Brix TH, Hegedüs L,. Excess mortality in hyperthyroidism: the influence of preexisting comorbidity and genetic confounding: a danish nationwide register-based cohort study of twins and singletons. J Clin Endocrinol Metab. 2012; 97 (11): 4123-9.
6. Mosekilde L, Eriksen EF, Charles P,. Effects of thyroid hormones on bone and mineral metabolism. Endocrinol. Metab. Clin. North Am. 1990 Mar; 19 (1): 35-63.
7. Langdahl BL, Loft AG, Eriksen EF, Mosekilde L, Charles P, Gitte A,. Bone mass, bone turnover, calcium homeostasis, and body composition in surgically and radioiodine-treated former hyperthyroid patients. Thyroid. 1996 Jun; 6 (3): 169-75.
8. Gorka J, Taylor-Gjevre RM, Arnason T,. Metabolic and clinical consequences of hyperthyroidism on bone density. Int. J. Endocrinol. 2013 Jan; 2013 (3): 638727.
9. Mosekilde L, Melsen F,. A tetracycline-based histomorphometric evaluation of bone resorption and bone turnover in hyperthyroidism and hyperparathyroidism. Acta Med. Scand. 1978 Jan; 204 (1-2): 97-102.
10. Vestergaard P, Mosekilde L, Meta-analysis RA,. Hyperthyroidism, bone mineral, and fracture risk-a meta-analysis. Thyroid. 2003 Jun; 13 (6): 585-93.
11. Waring AC, Harrison S, Fink H a, et al. A prospective study of thyroid function, bone loss, and fractures in older men: The MrOS study. J. Bone Miner. Res. 2013 Mar; 28 (3): 472-9.
12. Nicholls JJ, Brassill MJ, Williams GR, Bassett JHD,. The skeletal consequences of thyrotoxicosis. J. Endocrinol. 2012 Jun; 213 (3): 209-21.
13. Aub JC, Bauer W, Heath C, Ropes M,. Studies of calcium and phosphorus metabolism: III. The effects of the thyroid hormone and thyroid disease. J. Clin. Invest. 1929 Apr; 7 (1): 97-137.
14. Murphy E, Glüer CC, Reid DM, et al. Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women. J. Clin. Endocrinol. Metab. 2010 Jul; 95 (7): 3173-81.
15. Bauer DC, Ettinger B, Nevitt MC, Stone KL,. Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann. Intern. Med. 2001 Apr 3; 134 (7): 561-8.
16. Gaist D, Sørensen HT, Hallas J,. The Danish prescription registries. Dan. Med. Bull. 1997 Sep; 44 (4): 445-8.
17. McCloskey EV, Johansson H, Oden A, Kanis JA,. From relative risk to absolute fracture risk calculation: the FRAX algorithm. CurrOsteoporosRep. 2009 Sep; 7 (1544-2241 (Electronic)): 77-83.
18. McCloskey EV, Johansson H, Oden A, Kanis JA,. From relative risk to absolute fracture risk calculation: the FRAX algorithm. Curr. Osteoporos. Rep. 2009 Sep; 7 (3): 77-83.
19. Mackey DC, Lui L-Y, Cawthon PM, et al. High-trauma fractures and low bone mineral density in older women and men. JAMA. 2007 Nov 28; 298 (20): 2381-8.
20. Hundrup YA, Hoidrup S, Obel EB, Rasmussen NK,. The validity of self-reported fractures among Danish female nurses: comparison with fractures registered in the Danish National Hospital Register. Scand J Public Heal. 2004; 32: 136-43.
21. Ryg J, Rejnmark L, Overgaard S, Brixen K, Vestergaard P,. Hip Fracture Patients at Risk of Second Hip Fracture-A Nationwide Population-Based Cohort Study of 169, 145 Cases During 1977-2001. J Bone Miner Res. 2009; 24 (7): 1299-307.
22. Abrahamsen B, Eiken P, Eastell R,. Proton Pump Inhibitor Use and the Antifracture Efficacy of Alendronate. Arch Intern Med. 2011 Jun 13; 171 (11): 998-1004.
23. Kannegaard PN, van der Mark S, Eiken P, Abrahamsen B,. Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival. Age Ageing. 2010 Mar; 39 (2): 203-9.
24. Quan H, Sundararajan V, Halfon P, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care. 2005 Nov;43; 1130-9.
25. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A,. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. JBone MinerRes. 2007 Mar; 22 (3): 465-75.
26. Borgström F, Lekander I, Ivergård M, et al. The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS) - quality of life during the first 4 months after fracture. Osteoporos. Int. 2013 Mar; 24 (3): 811-23.
27. Svedbom A, Hernlund E, Ivergård M, et al. Osteoporosis in the European Union: a compendium of country-specific reports. Arch. Osteoporos. 2013 Dec; 8 (1-2): 137.
28. Abrahamsen B, van Staa T, Ariely R, Olson M, Cooper C,. Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int. 2009 Oct;20; 1633-150.
29. Mosekilde L, Melsen F,. A Tetracycline-Based Histomorphometric Evaluation of Bone Resorption and Bone Turnover in Hyperthyroidism and Hyperparathyroidism. 1978; (1): 97-102.
30. Banse X, Devogelaer JP, Delloye C, Lafosse A, Holmyard D, Grynpas M,. Irreversible perforations in vertebral trabeculae ? J. Bone Miner. Res. 2003 Jul; 18 (7): 1247-53.
31. Faber J, Jensen IW, Petersen L, Nygaard B, Hegedüs L, Siersbaek-Nielsen K,. Normalization of serum thyrotrophin by means of radioiodine treatment in subclinical hyperthyroidism: effect on bone loss in postmenopausal women. Clin. Endocrinol. (Oxf). 1998 Mar; 48 (3): 285-90.
32. Langdahl BL, Loft a G, Eriksen EF, Mosekilde L, Charles P,. Bone mass, bone turnover, body composition, and calcium homeostasis in former hyperthyroid patients treated by combined medical therapy. Thyroid. 1996 Jun; 6 (3): 161-8.
33. Karga H, Papapetrou PD, Korakovouni A, Papandroulaki F, Polymeris A, Pampouras G,. Bone mineral density in hyperthyroidism. Clin. Endocrinol. (Oxf). 2004 Oct; 61 (4): 466-72.
34. Andersen TF, Madsen M, Jorgensen J, Mellemkjoer L, Olsen JH,. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull. 1999 Jun; 46: 263-8.
35. Vestergaard P, Schwartz F, Rejnmark L, Mosekilde L,. Risk of femoral shaft and subtrochanteric fractures among users of bisphosphonates and raloxifene. Osteoporos. Int. 2011 Mar; 22 (3): 993-1001.
36. Jørgensen NR, Schwarz P, Holme I, Henriksen BM, Petersen LJ, Backer V,. The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease: a cross sectional study. Respir. Med. 2007 Jan; 101 (1): 177-85.
37. Flynn RW, Bonellie SR, Jung RT, MacDonald TM, Morris AD, Leese GP,. Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy. J. Clin. Endocrinol. Metab. 2010 Jan; 95 (1): 186-93.
38. Kim DJ, Khang YH, Koh J-M, Shong YK, Kim GS,. Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women. Clin. Endocrinol. (Oxf). 2006 Jan; 64 (1): 86-90.
39. Morris MS,. The association between serum thyroid-stimulating hormone in its reference range and bone status in postmenopausal American women. Bone. 2007 Apr; 40 (4): 1128-34.
40. Van der Deure WM, Uitterlinden AG, Hofman A, et al. Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study. Clin. Endocrinol. (Oxf). 2008 Feb; 68 (2): 175-81.
41. Vestergaard P, Mosekilde L, Follow-up HAN,. Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients. Thyroid. 2002 May; 12 (5): 411-9.
42. Kanis JA, Johnell O, Oden A, de Laet C, Mellstrom D,. Epidemiology of Osteoporosis and Fracture in Men. CalcifTissue Int. 2004 Jun
43. Turner MR, Camacho X, Fischer HD, et al. Levothyroxine dose and risk of fractures in older adults: nested case-control study. BMJ. 2011 Apr 28; 342: d2238.