Subclinical thyroid dysfunction and incident hip fracture in older adults

Archives of Internal Medicine

Volumn 170, Issue 21, 2010, Pages 1876-1883

  Lee, Jennifer S ^a   Bůžková, Petra ^b   Fink, Howard A ^c   Vu, Joseph ^a   Carbone, Laura ^d   Chen, Zhao ^e   Cauley, Jane ^f   Bauer, Doug C ^g   Cappola, Anne R ^h   Robbins, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e UNIVERSITY OF ARIZONA   (United States)

^f UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BONE METABOLISM; CONFIDENCE INTERVAL; DISEASE ASSOCIATION; EUTHYROIDISM; FEMALE; HAZARD RATIO; HIGH RISK PATIENT; HIP FRACTURE; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; THYROID DISEASE;

AGED; FEMALE; FOLLOW-UP STUDIES; HIP FRACTURES; HUMANS; HYPERTHYROIDISM; HYPOTHYROIDISM; INCIDENCE; MALE; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; SEX DISTRIBUTION; THYROTROPIN; UNITED STATES;

EID: 78649682543     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2010.424     Document Type: Article

References (37)

1. Cummings SR, Nevitt MC, Browner WS, et al; Study of Osteoporotic Fractures Research Group. Risk factors for hip fracture in white women. N Engl J Med. 1995;332(12):767-773.
2. von Recklinghausen FC. Die Fibrose oder deformirende Ostitis die Osteomalacie und die osteoplastische Carcinose. In: Reimer G, ed. Festschrift Rudolpf Virchow. Berlin, Germany; 1891:1-89.
3. Helfand M; US Preventive Services Task Force. Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2004;140(2):128-141.
4. Tunbridge WM, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: the Whickham Survey. Clin Endocrinol (Oxf ). 1977;7(6):481-493. (Pubitemid 8235965)
5. Uzzan B, Campos J, Cucherat M, Nony P, Boissel JP, Perret GY. Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis. J Clin Endocrinol Metab. 1996;81(12):4278-4289. (Pubitemid 26412030)
6. Faber J, Galløe AM. Changes in bone mass during prolonged subclinical hyperthyroidism due to L-thyroxine treatment: a meta-analysis. Eur J Endocrinol. 1994;130(4):350-356. (Pubitemid 24135720)
7. Bauer DC, Ettinger B, Nevitt MC, Stone KL; Study of Osteoporotic Fractures Research Group. Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann Intern Med. 2001;134(7):561-568.
8. Abe E, Marians RC, Yu W, et al. TSH is a negative regulator of skeletal remodeling. Cell. 2003;115(2):151-162.
9. Novack DV. TSH, the bone suppressing hormone. Cell. 2003;115(2):129-130.
10. Toft AD. Clinical practice: subclinical hyperthyroidism. N Engl J Med. 2001;345(7):512-516.
11. Lakatos P. Thyroid hormones: beneficial or deleterious for bone? Calcif Tissue Int. 2003;73(3):205-209.
12. Bertoli A, Fusco A, Andreoli A, et al. Effect of subclinical hypothyroidism and obesity on whole-body and regional bone mineral content. Horm Res. 2002;57(3-4):79-84.
13. Galliford TM, Murphy E, Williams AJ, Bassett JH, Williams GR. Effects of thyroid status on bone metabolism: a primary role for thyroid stimulating hormone or thyroid hormone? Minerva Endocrinol. 2005;30(4):237-246.
14. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008;29(1):76-131.
15. Col NF, Surks MI, Daniels GH. Subclinical thyroid disease: clinical applications. JAMA. 2004;291(2):239-243.
16. Surks MI, Ortiz E, Daniels GH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004;291(2):228-238.
17. Morris MS. The association between serum thyroid-stimulating hormone in its reference range and bone status in postmenopausal American women. Bone. 2007;40(4):1128-1134.
18. Schuit SC, van der Klift M, Weel AE, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004;34(1):195-202.
19. Fried LP, Borhani NO, Enright P, et al. The Cardiovascular Health Study: design and rationale. Ann Epidemiol. 1991;1(3):263-276.
20. Cappola AR, Fried LP, Arnold AM, et al. Thyroid status, cardiovascular risk, and mortality in older adults. JAMA. 2006;295(9):1033-1041. (Pubitemid 43313719)
21. Fried LP, Tangen CM, Walston J, et al; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146-M156.
22. Taylor HL, Jacobs DR Jr, Schucker B, Knudsen J, Leon AS, Debacker G. A questionnaire for the assessment of leisure time physical activities. J Chronic Dis. 1978;31(12):741-755. (Pubitemid 9140316)
23. Agresti A, Coull BA. Approximate is better than "exact" for interval estimation of binomial proportions. Am Stat. 1998;52(2):119-126.
24. Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika. 1994;81(3):515-526.
25. Gharib H. Review: available evidence does not support a benefit for thyroid hormone replacement in adults with subclinical hypothyroidism. ACP J Club. 2008;148(1):6.
26. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT; American Association of Clinical Endocrinologists/American Thyroid Association/Endocrine Society. Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. Endocr Pract. 2004;10(6):497-501.
27. Lewis CE, Ewing SK, Taylor BC, et al; Osteoporotic Fractures in Men (MrOS) Study Research Group. Predictors of non-spine fracture in elderly men: the MrOS study. J Bone Miner Res. 2007;22(2):211-219.
28. Abe E, Sun L, Mechanick J, et al. Bone loss in thyroid disease: role of low TSH and high thyroid hormone. Ann N Y Acad Sci. November 2007;1116:383-391.
29. Hase H, Ando T, Eldeiry L, et al. TNFα mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci U S A. 2006;103(34):12849-12854. (Pubitemid 44298650)
30. Vassart G, Dumont JE. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992;13(3):596-611.
31. Bassett JH,Williams GR. The molecular actions of thyroid hormone in bone. Trends Endocrinol Metab. 2003;14(8):356-364.
32. Williams GR. Does serum TSH level have thyroid hormone independent effects on bone turnover? Nat Clin Pract Endocrinol Metab. 2009;5(1):10-11.
33. Bassett JH, Williams AJ, Murphy E, et al. A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism. Mol Endocrinol. 2008;22(2):501-512.
34. Sampath TK, Simic P, Sendak R, et al. Thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats. J Bone Miner Res. 2007;22(6):849-859.
35. Sun L, Vukicevic S, Baliram R, et al. Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci U S A. 2008;105(11):4289-4294.
36. Somwaru LL, Arnold AM, Joshi N, Fried LP, Cappola AR. High frequency of and factors associated with thyroid hormone over-replacement and under-replacement inmen and women aged 65 and over. J Clin Endocrinol Metab. 2009;94(4):1342-1345.
37. Carbone L, Buzkova P, Fink HA, et al. Hip fractures and heart failure: findings from the Cardiovascular Health Study. Eur Heart J. 2010;31(1):77-84.