-
1
-
-
84879385334
-
CGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
-
Ablasser A., Goldeck M., Cavlar T., Deimling T., Witte G., Röhl I., Hopfner K.P., Ludwig J., Hornung V. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 2013, 498:380-384.
-
(2013)
Nature
, vol.498
, pp. 380-384
-
-
Ablasser, A.1
Goldeck, M.2
Cavlar, T.3
Deimling, T.4
Witte, G.5
Röhl, I.6
Hopfner, K.P.7
Ludwig, J.8
Hornung, V.9
-
2
-
-
14244272868
-
PHENIX: building new software for automated crystallographic structure determination
-
Adams P.D., Grosse-Kunstleve R.W., Hung L.W., Ioerger T.R., McCoy A.J., Moriarty N.W., Read R.J., Sacchettini J.C., Sauter N.K., Terwilliger T.C. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D Biol. Crystallogr. 2002, 58:1948-1954.
-
(2002)
Acta Crystallogr. D Biol. Crystallogr.
, vol.58
, pp. 1948-1954
-
-
Adams, P.D.1
Grosse-Kunstleve, R.W.2
Hung, L.W.3
Ioerger, T.R.4
McCoy, A.J.5
Moriarty, N.W.6
Read, R.J.7
Sacchettini, J.C.8
Sauter, N.K.9
Terwilliger, T.C.10
-
3
-
-
9244225713
-
Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine
-
Batey R.T., Gilbert S.D., Montange R.K. Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine. Nature 2004, 432:411-415.
-
(2004)
Nature
, vol.432
, pp. 411-415
-
-
Batey, R.T.1
Gilbert, S.D.2
Montange, R.K.3
-
4
-
-
80054966913
-
STING is a direct innate immune sensor of cyclic di-GMP
-
Burdette D.L., Monroe K.M., Sotelo-Troha K., Iwig J.S., Eckert B., Hyodo M., Hayakawa Y., Vance R.E. STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011, 478:515-518.
-
(2011)
Nature
, vol.478
, pp. 515-518
-
-
Burdette, D.L.1
Monroe, K.M.2
Sotelo-Troha, K.3
Iwig, J.S.4
Eckert, B.5
Hyodo, M.6
Hayakawa, Y.7
Vance, R.E.8
-
5
-
-
84899131835
-
The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling
-
Cai X., Chiu Y.H., Chen Z.J. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol. Cell 2014, 54:289-296.
-
(2014)
Mol. Cell
, vol.54
, pp. 289-296
-
-
Cai, X.1
Chiu, Y.H.2
Chen, Z.J.3
-
6
-
-
84883425402
-
Cyclic dinucleotides and the innate immune response
-
Danilchanka O., Mekalanos J.J. Cyclic dinucleotides and the innate immune response. Cell 2013, 154:962-970.
-
(2013)
Cell
, vol.154
, pp. 962-970
-
-
Danilchanka, O.1
Mekalanos, J.J.2
-
7
-
-
84859754930
-
Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence
-
Davies B.W., Bogard R.W., Young T.S., Mekalanos J.J. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence. Cell 2012, 149:358-370.
-
(2012)
Cell
, vol.149
, pp. 358-370
-
-
Davies, B.W.1
Bogard, R.W.2
Young, T.S.3
Mekalanos, J.J.4
-
8
-
-
84878572947
-
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
-
Diner E.J., Burdette D.L., Wilson S.C., Monroe K.M., Kellenberger C.A., Hyodo M., Hayakawa Y., Hammond M.C., Vance R.E. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 2013, 3:1355-1361.
-
(2013)
Cell Rep.
, vol.3
, pp. 1355-1361
-
-
Diner, E.J.1
Burdette, D.L.2
Wilson, S.C.3
Monroe, K.M.4
Kellenberger, C.A.5
Hyodo, M.6
Hayakawa, Y.7
Hammond, M.C.8
Vance, R.E.9
-
9
-
-
58149138753
-
A structural basis for the recognition of 2'-deoxyguanosine by the purine riboswitch
-
Edwards A.L., Batey R.T. A structural basis for the recognition of 2'-deoxyguanosine by the purine riboswitch. J.Mol. Biol. 2009, 385:938-948.
-
(2009)
J.Mol. Biol.
, vol.385
, pp. 938-948
-
-
Edwards, A.L.1
Batey, R.T.2
-
11
-
-
84956899552
-
An RNA tertiary switch by modifying how helices are tethered
-
Ganser L.R., Mustoe A.M., Al-Hashimi H.M. An RNA tertiary switch by modifying how helices are tethered. Genome Biol. 2014, 15:425.
-
(2014)
Genome Biol.
, vol.15
, pp. 425
-
-
Ganser, L.R.1
Mustoe, A.M.2
Al-Hashimi, H.M.3
-
12
-
-
84906311591
-
Structural insights into recognition of c-di-AMP by the ydaO riboswitch
-
Gao A., Serganov A. Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nat. Chem. Biol. 2014, 10:787-792.
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 787-792
-
-
Gao, A.1
Serganov, A.2
-
13
-
-
84878309796
-
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
-
Gao P., Ascano M., Wu Y., Barchet W., Gaffney B.L., Zillinger T., Serganov A.A., Liu Y., Jones R.A., Hartmann G., et al. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 2013, 153:1094-1107.
-
(2013)
Cell
, vol.153
, pp. 1094-1107
-
-
Gao, P.1
Ascano, M.2
Wu, Y.3
Barchet, W.4
Gaffney, B.L.5
Zillinger, T.6
Serganov, A.A.7
Liu, Y.8
Jones, R.A.9
Hartmann, G.10
-
14
-
-
84868270751
-
Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities
-
Gray P.M., Forrest G., Wisniewski T., Porter G., Freed D.C., DeMartino J.A., Zaller D.M., Guo Z., Leone J., Fu T.M., Vora K.A. Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities. Cell. Immunol. 2012, 278:113-119.
-
(2012)
Cell. Immunol.
, vol.278
, pp. 113-119
-
-
Gray, P.M.1
Forrest, G.2
Wisniewski, T.3
Porter, G.4
Freed, D.C.5
DeMartino, J.A.6
Zaller, D.M.7
Guo, Z.8
Leone, J.9
Fu, T.M.10
Vora, K.A.11
-
15
-
-
63049137897
-
Principles of c-di-GMP signalling in bacteria
-
Hengge R. Principles of c-di-GMP signalling in bacteria. Nat. Rev. Microbiol. 2009, 7:263-273.
-
(2009)
Nat. Rev. Microbiol.
, vol.7
, pp. 263-273
-
-
Hengge, R.1
-
16
-
-
84905123345
-
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
-
Hornung V., Hartmann R., Ablasser A., Hopfner K.P. OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids. Nat. Rev. Immunol. 2014, 14:521-528.
-
(2014)
Nat. Rev. Immunol.
, vol.14
, pp. 521-528
-
-
Hornung, V.1
Hartmann, R.2
Ablasser, A.3
Hopfner, K.P.4
-
17
-
-
53349178089
-
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Ishikawa H., Barber G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008, 455:674-678.
-
(2008)
Nature
, vol.455
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
18
-
-
84911391431
-
Crystal structure of a c-di-AMP riboswitch reveals an internally pseudo-dimeric RNA
-
Jones C.P., Ferré-D'Amaré A.R. Crystal structure of a c-di-AMP riboswitch reveals an internally pseudo-dimeric RNA. EMBO J. 2014, 33:2692-2703.
-
(2014)
EMBO J.
, vol.33
, pp. 2692-2703
-
-
Jones, C.P.1
Ferré-D'Amaré, A.R.2
-
19
-
-
84875784381
-
RNA-based fluorescent biosensors for live cell imaging of second messengers cyclic di-GMP and cyclic AMP-GMP
-
Kellenberger C.A., Wilson S.C., Sales-Lee J., Hammond M.C. RNA-based fluorescent biosensors for live cell imaging of second messengers cyclic di-GMP and cyclic AMP-GMP. J.Am. Chem. Soc. 2013, 135:4906-4909.
-
(2013)
J.Am. Chem. Soc.
, vol.135
, pp. 4906-4909
-
-
Kellenberger, C.A.1
Wilson, S.C.2
Sales-Lee, J.3
Hammond, M.C.4
-
20
-
-
84928570713
-
GEMM-I riboswitches from Geobacter sense the bacterial second messenger cyclic AMP-GMP
-
Published online April 6, 2015
-
Kellenberger C.A., Wilson S.C., Hickey S.F., Gonzalez T.L., Su Y., Hallberg Z.F., Brewer T.F., Iavarone A.T., Carlson H.K., Hsieh Y.-F., Hammond M.C. GEMM-I riboswitches from Geobacter sense the bacterial second messenger cyclic AMP-GMP. Proc. Natl. Acad. Sci. 2015, Published online April 6, 2015. 10.1073/pnas.1419328112.
-
(2015)
Proc. Natl. Acad. Sci.
-
-
Kellenberger, C.A.1
Wilson, S.C.2
Hickey, S.F.3
Gonzalez, T.L.4
Su, Y.5
Hallberg, Z.F.6
Brewer, T.F.7
Iavarone, A.T.8
Carlson, H.K.9
Hsieh, Y.-F.10
Hammond, M.C.11
-
21
-
-
36048942754
-
Guanine riboswitch variants from Mesoplasma florum selectively recognize 2'-deoxyguanosine
-
Kim J.N., Roth A., Breaker R.R. Guanine riboswitch variants from Mesoplasma florum selectively recognize 2'-deoxyguanosine. Proc. Natl. Acad. Sci. USA 2007, 104:16092-16097.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 16092-16097
-
-
Kim, J.N.1
Roth, A.2
Breaker, R.R.3
-
22
-
-
84880522115
-
Anticancer flavonoids are mouse-selective STING agonists
-
Kim S., Li L., Maliga Z., Yin Q., Wu H., Mitchison T.J. Anticancer flavonoids are mouse-selective STING agonists. ACS Chem. Biol. 2013, 8:1396-1401.
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 1396-1401
-
-
Kim, S.1
Li, L.2
Maliga, Z.3
Yin, Q.4
Wu, H.5
Mitchison, T.J.6
-
23
-
-
84891899586
-
Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acids
-
Kimsey I., Al-Hashimi H.M. Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acids. Curr. Opin. Struct. Biol. 2014, 24:72-80.
-
(2014)
Curr. Opin. Struct. Biol.
, vol.24
, pp. 72-80
-
-
Kimsey, I.1
Al-Hashimi, H.M.2
-
24
-
-
71449123530
-
Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch
-
Kulshina N., Baird N.J., Ferré-D'Amaré A.R. Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch. Nat. Struct. Mol. Biol. 2009, 16:1212-1217.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 1212-1217
-
-
Kulshina, N.1
Baird, N.J.2
Ferré-D'Amaré, A.R.3
-
25
-
-
77955630859
-
An allosteric self-splicing ribozyme triggered by a bacterial second messenger
-
Lee E.R., Baker J.L., Weinberg Z., Sudarsan N., Breaker R.R. An allosteric self-splicing ribozyme triggered by a bacterial second messenger. Science 2010, 329:845-848.
-
(2010)
Science
, vol.329
, pp. 845-848
-
-
Lee, E.R.1
Baker, J.L.2
Weinberg, Z.3
Sudarsan, N.4
Breaker, R.R.5
-
26
-
-
84887997976
-
Riboswitches in eubacteria sense the second messenger c-di-AMP
-
Nelson J.W., Sudarsan N., Furukawa K., Weinberg Z., Wang J.X., Breaker R.R. Riboswitches in eubacteria sense the second messenger c-di-AMP. Nat. Chem. Biol. 2013, 9:834-839.
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 834-839
-
-
Nelson, J.W.1
Sudarsan, N.2
Furukawa, K.3
Weinberg, Z.4
Wang, J.X.5
Breaker, R.R.6
-
27
-
-
84928789631
-
Control of bacterial exoelectrogenesis by c-AMP-GMP
-
Published online April 6, 2015
-
Nelson J.W., Sudarsan N., Phillips G.E., Stav S., Lünse C.E., McCown P.J., Breaker R.R. Control of bacterial exoelectrogenesis by c-AMP-GMP. Proc. Natl. Acad. Sci. 2015, Published online April 6, 2015. 10.1073/pnas.1419264112.
-
(2015)
Proc. Natl. Acad. Sci.
-
-
Nelson, J.W.1
Sudarsan, N.2
Phillips, G.E.3
Stav, S.4
Lünse, C.E.5
McCown, P.J.6
Breaker, R.R.7
-
28
-
-
65649131534
-
Preparation and crystallization of riboswitch-ligand complexes
-
Pikovskaya O., Serganov A.A., Polonskaia A., Serganov A., Patel D.J. Preparation and crystallization of riboswitch-ligand complexes. Methods Mol. Biol. 2009, 540:115-128.
-
(2009)
Methods Mol. Biol.
, vol.540
, pp. 115-128
-
-
Pikovskaya, O.1
Serganov, A.A.2
Polonskaia, A.3
Serganov, A.4
Patel, D.J.5
-
29
-
-
80052967464
-
Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch
-
Pikovskaya O., Polonskaia A., Patel D.J., Serganov A. Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch. Nat. Chem. Biol. 2011, 7:748-755.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 748-755
-
-
Pikovskaya, O.1
Polonskaia, A.2
Patel, D.J.3
Serganov, A.4
-
30
-
-
84906313473
-
C-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets
-
Ren A., Patel D.J. c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets. Nat. Chem. Biol. 2014, 10:780-786.
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 780-786
-
-
Ren, A.1
Patel, D.J.2
-
31
-
-
84874914744
-
Cyclic di-GMP: the first 25 years of a universal bacterial second messenger
-
Römling U., Galperin M.Y., Gomelsky M. Cyclic di-GMP: the first 25 years of a universal bacterial second messenger. Microbiol. Mol. Biol. Rev. 2013, 77:1-52.
-
(2013)
Microbiol. Mol. Biol. Rev.
, vol.77
, pp. 1-52
-
-
Römling, U.1
Galperin, M.Y.2
Gomelsky, M.3
-
32
-
-
84872543206
-
A decade of riboswitches
-
Serganov A., Nudler E. A decade of riboswitches. Cell 2013, 152:17-24.
-
(2013)
Cell
, vol.152
, pp. 17-24
-
-
Serganov, A.1
Nudler, E.2
-
33
-
-
10644250950
-
Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs
-
Serganov A., Yuan Y.R., Pikovskaya O., Polonskaia A., Malinina L., Phan A.T., Hobartner C., Micura R., Breaker R.R., Patel D.J. Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem. Biol. 2004, 11:1729-1741.
-
(2004)
Chem. Biol.
, vol.11
, pp. 1729-1741
-
-
Serganov, A.1
Yuan, Y.R.2
Pikovskaya, O.3
Polonskaia, A.4
Malinina, L.5
Phan, A.T.6
Hobartner, C.7
Micura, R.8
Breaker, R.R.9
Patel, D.J.10
-
34
-
-
33745635350
-
Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch
-
Serganov A., Polonskaia A., Phan A.T., Breaker R.R., Patel D.J. Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch. Nature 2006, 441:1167-1171.
-
(2006)
Nature
, vol.441
, pp. 1167-1171
-
-
Serganov, A.1
Polonskaia, A.2
Phan, A.T.3
Breaker, R.R.4
Patel, D.J.5
-
35
-
-
84920512700
-
Role of tautomerism in RNA biochemistry
-
Singh V., Fedeles B.I., Essigmann J.M. Role of tautomerism in RNA biochemistry. RNA 2015, 21:1-13.
-
(2015)
RNA
, vol.21
, pp. 1-13
-
-
Singh, V.1
Fedeles, B.I.2
Essigmann, J.M.3
-
36
-
-
71449108155
-
Structural basis of ligand binding by a c-di-GMP riboswitch
-
Smith K.D., Lipchock S.V., Ames T.D., Wang J., Breaker R.R., Strobel S.A. Structural basis of ligand binding by a c-di-GMP riboswitch. Nat. Struct. Mol. Biol. 2009, 16:1218-1223.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 1218-1223
-
-
Smith, K.D.1
Lipchock, S.V.2
Ames, T.D.3
Wang, J.4
Breaker, R.R.5
Strobel, S.A.6
-
37
-
-
77956021842
-
Structural and biochemical determinants of ligand binding by the c-di-GMP riboswitch
-
Smith K.D., Lipchock S.V., Livingston A.L., Shanahan C.A., Strobel S.A. Structural and biochemical determinants of ligand binding by the c-di-GMP riboswitch. Biochemistry 2010, 49:7351-7359.
-
(2010)
Biochemistry
, vol.49
, pp. 7351-7359
-
-
Smith, K.D.1
Lipchock, S.V.2
Livingston, A.L.3
Shanahan, C.A.4
Strobel, S.A.5
-
38
-
-
79956338019
-
Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches
-
Smith K.D., Shanahan C.A., Moore E.L., Simon A.C., Strobel S.A. Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches. Proc. Natl. Acad. Sci. USA 2011, 108:7757-7762.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 7757-7762
-
-
Smith, K.D.1
Shanahan, C.A.2
Moore, E.L.3
Simon, A.C.4
Strobel, S.A.5
-
39
-
-
47749152941
-
Riboswitches in eubacteria sense the second messenger cyclic di-GMP
-
Sudarsan N., Lee E.R., Weinberg Z., Moy R.H., Kim J.N., Link K.H., Breaker R.R. Riboswitches in eubacteria sense the second messenger cyclic di-GMP. Science 2008, 321:411-413.
-
(2008)
Science
, vol.321
, pp. 411-413
-
-
Sudarsan, N.1
Lee, E.R.2
Weinberg, Z.3
Moy, R.H.4
Kim, J.N.5
Link, K.H.6
Breaker, R.R.7
-
40
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
-
Sun L., Wu J., Du F., Chen X., Chen Z.J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013, 339:786-791.
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
41
-
-
33744469562
-
Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand
-
Thore S., Leibundgut M., Ban N. Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand. Science 2006, 312:1208-1211.
-
(2006)
Science
, vol.312
, pp. 1208-1211
-
-
Thore, S.1
Leibundgut, M.2
Ban, N.3
-
42
-
-
84904246134
-
Isostericity and tautomerism of base pairs in nucleic acids
-
Westhof E. Isostericity and tautomerism of base pairs in nucleic acids. FEBS Lett. 2014, 588:2464-2469.
-
(2014)
FEBS Lett.
, vol.588
, pp. 2464-2469
-
-
Westhof, E.1
-
43
-
-
84879589271
-
Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection
-
e00282-e13
-
Witte C.E., Whiteley A.T., Burke T.P., Sauer J.D., Portnoy D.A., Woodward J.J. Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection. MBio 2013, 4. e00282-e13.
-
(2013)
MBio
, vol.4
-
-
Witte, C.E.1
Whiteley, A.T.2
Burke, T.P.3
Sauer, J.D.4
Portnoy, D.A.5
Woodward, J.J.6
-
44
-
-
84873724533
-
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
-
Wu J., Sun L., Chen X., Du F., Shi H., Chen C., Chen Z.J. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 2013, 339:826-830.
-
(2013)
Science
, vol.339
, pp. 826-830
-
-
Wu, J.1
Sun, L.2
Chen, X.3
Du, F.4
Shi, H.5
Chen, C.6
Chen, Z.J.7
-
45
-
-
84880508067
-
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
-
Zhang X., Shi H., Wu J., Zhang X., Sun L., Chen C., Chen Z.J. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 2013, 51:226-235.
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(2013)
Mol. Cell
, vol.51
, pp. 226-235
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Zhang, X.1
Shi, H.2
Wu, J.3
Zhang, X.4
Sun, L.5
Chen, C.6
Chen, Z.J.7
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