The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects

Journal of Immunology

Volumn 194, Issue 8, 2015, Pages 3873-3882

  Tian, Xiaoling ^a   Zhang, Anli ^a   Qiu, Chao ^a   Wang, Wei ^b   Yang, Yu ^a   Qiu, Chenli ^a   Liu, Aiping ^a   Zhu, Lingyan ^a   Yuan, Songhua ^a   Hu, Huiliang ^a   Wang, Wanhai ^a   Wei, Qiang ^b   Zhang, Xiaoyan ^a,c   Xu, Jianqing ^a,c  

^a FUDAN UNIVERSITY   (China)

^b INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

^c CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; GAMMA INTERFERON; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; PROGRAMMED DEATH 1 RECEPTOR; REGULATOR PROTEIN; UNCLASSIFIED DRUG; CD223 ANTIGEN; HLA ANTIGEN CLASS 2; LEUKOCYTE ANTIGEN; PDCD1 PROTEIN, HUMAN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DISEASE COURSE; EX VIVO STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOREGULATION; JURKAT CELL LINE; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RHESUS MONKEY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION; VIRUS LOAD; ANIMAL; GENE EXPRESSION REGULATION; HIV INFECTIONS; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY;

ADULT; ANIMALS; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HIV INFECTIONS; HUMANS; MACACA MULATTA; MALE; MIDDLE AGED; PROGRAMMED CELL DEATH 1 RECEPTOR;

EID: 84927665679     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402176     Document Type: Article

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