Stage i of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia

Cancer

Volumn 119, Issue 14, 2013, Pages 2611-2619

  Kantarjian, Hagop M ^a   Martinelli, Giovanni ^b   Jabbour, Elias J ^a   Quintás Cardama, Alfonso ^a   Ando, Kiyoshi ^c   Bay, Jacques Olivier ^d   Wei, Andrew ^e   Gröpper, Stefanie ^f   Papayannidis, Cristina ^b   Owen, Kate ^g   Pike, Laura ^g   Schmitt, Nicola ^g   Stockman, Paul K ^g   Giagounidis, Aristoteles ^f  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c TOKAI UNIVERSITY HOSPITAL   (Japan)

^d UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^e MONASH UNIVERSITY   (Australia)

^f MARIEN HOSPITAL DÜSSELDORF   (Germany)

^g ASTRAZENECA   (United Kingdom)

Author keywords

acute myeloid leukemia; AZD1152; barasertib; low dose cytosine arabinoside

Indexed keywords

BARASERTIB; CYTARABINE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE KIDNEY FAILURE; ADULT; AGED; ALOPECIA; ARTICLE; ASTHENIA; BACKACHE; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER SURVIVAL; CELLULITIS; CHEMOTHERAPY INDUCED ANEMIA; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; CHILL; COMPARATIVE EFFECTIVENESS; CONSTIPATION; CONTROLLED STUDY; DECREASED APPETITE; DIARRHEA; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG ERUPTION; DRUG FATALITY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; ELDERLY CARE; EPISTAXIS; EXTRAVASATION; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FEVER; FOLLOW UP; HUMAN; HYPOKALEMIA; HYPONATREMIA; HYPOXIA; INFECTIOUS ARTHRITIS; INSOMNIA; KIDNEY FAILURE; LEUKOPENIA; LOBAR PNEUMONIA; LOW DRUG DOSE; LUNG MYCOSIS; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MUCOSA INFLAMMATION; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PERIPHERAL EDEMA; PHARYNGITIS; PHASE 1 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEPSIS; STOMATITIS; SURVIVAL TIME; THROMBOCYTOPENIA;

ACUTE MYELOID LEUKEMIA; AZD1152; BARASERTIB; LOW-DOSE CYTOSINE ARABINOSIDE;

AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CYTARABINE; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LEUKEMIA, MYELOID, ACUTE; MALE; NEUTROPENIA; ORGANOPHOSPHATES; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; STOMATITIS; TREATMENT OUTCOME;

EID: 84879644165     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.28113     Document Type: Article

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