메뉴 건너뛰기




Volumn 38, Issue 7, 2014, Pages 751-755

Prognostic value of TP53 gene mutations in myelodysplastic syndromes and acute myeloid leukemia treated with azacitidine

Author keywords

Acute myeloblastic leukemia; Azacitidine; Myelodysplastic syndromes; Prognostic factor; TP53 mutation

Indexed keywords

AZACITIDINE; PROTEIN P53;

EID: 84902086132     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2014.03.012     Document Type: Article
Times cited : (135)

References (29)
  • 1
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
    • Fenaux P., Mufti G.J., Hellstrom-Lindberg E., Santini V., Finelli C., Giagounidis A., et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009, 10:223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Finelli, C.5    Giagounidis, A.6
  • 2
    • 77449149371 scopus 로고    scopus 로고
    • DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
    • Shen L., Kantarjian H., Guo Y., Lin E., Shan J., Huang X., et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol 2010, 28:605-613.
    • (2010) J Clin Oncol , vol.28 , pp. 605-613
    • Shen, L.1    Kantarjian, H.2    Guo, Y.3    Lin, E.4    Shan, J.5    Huang, X.6
  • 3
    • 79960207573 scopus 로고    scopus 로고
    • Prognostic significance of monosomal karyotype in higher risk myelodysplastic syndrome treated with azacitidine
    • Itzykson R., Thepot S., Eclache V., Quesnel B., Dreyfus F., Beyne-Rauzy O., et al. Prognostic significance of monosomal karyotype in higher risk myelodysplastic syndrome treated with azacitidine. Leukemia 2011, 25:1207-1209.
    • (2011) Leukemia , vol.25 , pp. 1207-1209
    • Itzykson, R.1    Thepot, S.2    Eclache, V.3    Quesnel, B.4    Dreyfus, F.5    Beyne-Rauzy, O.6
  • 4
    • 78650172030 scopus 로고    scopus 로고
    • Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine
    • Itzykson R., Thépot S., Quesnel B., Dreyfus F., Beyne-Rauzy O., Turlure P., et al. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine. Blood 2011, 117:403-411.
    • (2011) Blood , vol.117 , pp. 403-411
    • Itzykson, R.1    Thépot, S.2    Quesnel, B.3    Dreyfus, F.4    Beyne-Rauzy, O.5    Turlure, P.6
  • 5
    • 84871063591 scopus 로고    scopus 로고
    • The revised IPSS is a powerful tool to evaluate the outcome of MDS patients treated with azacitidine: the GFM experience
    • Lamarque M., Raynaud S., Itzykson R., Thepot S., Quesnel B., Dreyfus F., et al. The revised IPSS is a powerful tool to evaluate the outcome of MDS patients treated with azacitidine: the GFM experience. Blood 2012, 120:5084-5085.
    • (2012) Blood , vol.120 , pp. 5084-5085
    • Lamarque, M.1    Raynaud, S.2    Itzykson, R.3    Thepot, S.4    Quesnel, B.5    Dreyfus, F.6
  • 6
    • 79960229916 scopus 로고    scopus 로고
    • Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
    • Itzykson R., Kosmider O., Cluzeau T., Mansat-De Mas V., Dreyfus F., Beyne-Rauzy O., et al. Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia 2011, 25:1147-1152.
    • (2011) Leukemia , vol.25 , pp. 1147-1152
    • Itzykson, R.1    Kosmider, O.2    Cluzeau, T.3    Mansat-De Mas, V.4    Dreyfus, F.5    Beyne-Rauzy, O.6
  • 10
    • 49349140725 scopus 로고    scopus 로고
    • Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
    • Haferlach C., Dicker F., Herholz H., Schnittger S., Kern W., Haferlach T. Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. Leukemia 2008, 22:1539-1541.
    • (2008) Leukemia , vol.22 , pp. 1539-1541
    • Haferlach, C.1    Dicker, F.2    Herholz, H.3    Schnittger, S.4    Kern, W.5    Haferlach, T.6
  • 11
    • 79952164235 scopus 로고    scopus 로고
    • Unraveling the molecular pathophysiology of myelodysplastic syndromes
    • Bejar R., Levine R., Ebert B.L. Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol 2011, 29:504-515.
    • (2011) J Clin Oncol , vol.29 , pp. 504-515
    • Bejar, R.1    Levine, R.2    Ebert, B.L.3
  • 13
    • 84873995626 scopus 로고    scopus 로고
    • TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis
    • Kulasekararaj A.G., Smith A.E., Mian S.A., Mohamedali A.M., Krishnamurthy P., Lea N.C., et al. TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis. Br J Haematol 2013, 160:660-672.
    • (2013) Br J Haematol , vol.160 , pp. 660-672
    • Kulasekararaj, A.G.1    Smith, A.E.2    Mian, S.A.3    Mohamedali, A.M.4    Krishnamurthy, P.5    Lea, N.C.6
  • 14
    • 79956291339 scopus 로고    scopus 로고
    • TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression
    • Jädersten M., Saft L., Smith A., Kulasekararaj A., Pomplun S., Göhring G., et al. TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression. J Clin Oncol 2011, 29:1971-1979.
    • (2011) J Clin Oncol , vol.29 , pp. 1971-1979
    • Jädersten, M.1    Saft, L.2    Smith, A.3    Kulasekararaj, A.4    Pomplun, S.5    Göhring, G.6
  • 15
    • 0028575432 scopus 로고
    • Inactivation of the p53 gene in leukemias and myelodysplastic syndrome (MDS) with 17p monosomy
    • Preudhomme C., Vanrumbeke M., Lai J.L., Lepelley P., Wattel E., Fenaux P. Inactivation of the p53 gene in leukemias and myelodysplastic syndrome (MDS) with 17p monosomy. Leukemia 1994, 8:2241-2242.
    • (1994) Leukemia , vol.8 , pp. 2241-2242
    • Preudhomme, C.1    Vanrumbeke, M.2    Lai, J.L.3    Lepelley, P.4    Wattel, E.5    Fenaux, P.6
  • 16
    • 0028928283 scopus 로고
    • Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoïesis and a high incidence of P53 mutations
    • Lai J.L., Preudhomme C., Zandecki M., Flactif M., Vanrumbeke M., Lepelley P., et al. Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoïesis and a high incidence of P53 mutations. Leukemia 1995, 9:370-381.
    • (1995) Leukemia , vol.9 , pp. 370-381
    • Lai, J.L.1    Preudhomme, C.2    Zandecki, M.3    Flactif, M.4    Vanrumbeke, M.5    Lepelley, P.6
  • 17
    • 0032006824 scopus 로고    scopus 로고
    • 17p deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ
    • Soenen V., Preudhomme C., Roumier C., Daudignon A., Laï J.L., Fenaux P. 17p deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ. Blood 1998, 91:1008-1015.
    • (1998) Blood , vol.91 , pp. 1008-1015
    • Soenen, V.1    Preudhomme, C.2    Roumier, C.3    Daudignon, A.4    Laï, J.L.5    Fenaux, P.6
  • 18
    • 0028172868 scopus 로고
    • P53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • Wattel E., Preudhomme C., Hecquet B., Vanrumbeke M., Quesnel B., Dervite I., et al. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 1994, 84:3148-3157.
    • (1994) Blood , vol.84 , pp. 3148-3157
    • Wattel, E.1    Preudhomme, C.2    Hecquet, B.3    Vanrumbeke, M.4    Quesnel, B.5    Dervite, I.6
  • 19
    • 0029043805 scopus 로고
    • A simple P53 functional assay for screening cell lines, blood, and tumors
    • Flaman J.M., Frebourg T., Moreau V., Charbonnier F., Martin C., Chappuis P., et al. A simple P53 functional assay for screening cell lines, blood, and tumors. PNAS 1995, 92:3963-3967.
    • (1995) PNAS , vol.92 , pp. 3963-3967
    • Flaman, J.M.1    Frebourg, T.2    Moreau, V.3    Charbonnier, F.4    Martin, C.5    Chappuis, P.6
  • 20
    • 58349094961 scopus 로고    scopus 로고
    • High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors
    • Manié E., Vincent-Salomon A., Lehmann-Che J., Pierron G., Turpin E., Warcoin M., et al. High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors. Cancer Res 2009, 69:663-671.
    • (2009) Cancer Res , vol.69 , pp. 663-671
    • Manié, E.1    Vincent-Salomon, A.2    Lehmann-Che, J.3    Pierron, G.4    Turpin, E.5    Warcoin, M.6
  • 21
    • 83555166249 scopus 로고    scopus 로고
    • The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories
    • Kohlmann A., Klein H.-U., Weissmann S., Bresolin S., Chaplin T., Cuppens H., et al. The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories. Leukemia 2011, 25:1840-1848.
    • (2011) Leukemia , vol.25 , pp. 1840-1848
    • Kohlmann, A.1    Klein, H.-U.2    Weissmann, S.3    Bresolin, S.4    Chaplin, T.5    Cuppens, H.6
  • 22
    • 33749438404 scopus 로고    scopus 로고
    • Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
    • List A., Dewald G., Bennett J., Giagounidis A., Raza A., Feldman E., et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006, 355:1456-1465.
    • (2006) N Engl J Med , vol.355 , pp. 1456-1465
    • List, A.1    Dewald, G.2    Bennett, J.3    Giagounidis, A.4    Raza, A.5    Feldman, E.6
  • 23
    • 80053621748 scopus 로고    scopus 로고
    • A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with low-/intermediate-1-risk myelodysplastic syndromes with del5q
    • Fenaux P., Giagounidis A., Selleslag D., Beyne-Rauzy O., Mufti G., Mittelman M., et al. A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with low-/intermediate-1-risk myelodysplastic syndromes with del5q. Blood 2011, 118:3765-3776.
    • (2011) Blood , vol.118 , pp. 3765-3776
    • Fenaux, P.1    Giagounidis, A.2    Selleslag, D.3    Beyne-Rauzy, O.4    Mufti, G.5    Mittelman, M.6
  • 24
    • 84878924059 scopus 로고    scopus 로고
    • Long-term outcome of anemic lower-risk myelodysplastic syndromes without 5q deletion refractory to or relapsing after erythropoiesis-stimulating agents
    • Kelaidi C., Park S., Sapena R., Beyne-Rauzy O., Coiteux V., Vey N., et al. Long-term outcome of anemic lower-risk myelodysplastic syndromes without 5q deletion refractory to or relapsing after erythropoiesis-stimulating agents. Leukemia 2013, 27:1283-1290.
    • (2013) Leukemia , vol.27 , pp. 1283-1290
    • Kelaidi, C.1    Park, S.2    Sapena, R.3    Beyne-Rauzy, O.4    Coiteux, V.5    Vey, N.6
  • 26
    • 0037457012 scopus 로고    scopus 로고
    • Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene
    • Nasr A.F., Nutini M., Palombo B., Guerra E., Alberti S. Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene. Oncogene 2003, 22:1668-1677.
    • (2003) Oncogene , vol.22 , pp. 1668-1677
    • Nasr, A.F.1    Nutini, M.2    Palombo, B.3    Guerra, E.4    Alberti, S.5
  • 27
    • 0035057219 scopus 로고    scopus 로고
    • Activation of the P53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine
    • Karpf A.R., Moore B.C., Ririe T.O., Jones D.A. Activation of the P53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine. Mol Pharmacol 2001, 59:751-757.
    • (2001) Mol Pharmacol , vol.59 , pp. 751-757
    • Karpf, A.R.1    Moore, B.C.2    Ririe, T.O.3    Jones, D.A.4
  • 28
    • 84860827822 scopus 로고    scopus 로고
    • 5-Azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand
    • Ghanim V., Herrmann H., Heller G., Peter B., Hadzijusufovic E., Blatt K., et al. 5-Azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand. Blood 2012, 119:4242-4252.
    • (2012) Blood , vol.119 , pp. 4242-4252
    • Ghanim, V.1    Herrmann, H.2    Heller, G.3    Peter, B.4    Hadzijusufovic, E.5    Blatt, K.6
  • 29
    • 78650710470 scopus 로고    scopus 로고
    • Sustained exposure to the DNA demethylating agent, 2'-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy
    • Schnekenburger M., Grandjenette C., Ghelfi J., Karius T., Foliguet B., Dicato M., et al. Sustained exposure to the DNA demethylating agent, 2'-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy. Biochem Pharmacol 2011, 81:364-378.
    • (2011) Biochem Pharmacol , vol.81 , pp. 364-378
    • Schnekenburger, M.1    Grandjenette, C.2    Ghelfi, J.3    Karius, T.4    Foliguet, B.5    Dicato, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.