Central sensitization in humans: Assessment and pharmacology

Handbook of Experimental Pharmacology

Volumn 227, Issue , 2015, Pages 79-102

  Arendt Nielsen, Lars ^a  

^a AALBORG UNIVERSITY   (Denmark)

Author keywords

Pain assessment; Quantitative sensory testing; Spreading sensitization

Indexed keywords

MINOCYCLINE; PREGABALIN; TETRACYCLINE;

ALLODYNIA; ARTICLE; CENTRAL NERVOUS SYSTEM SENSITIZATION; CHRONIC PAIN; DISEASE DURATION; DISEASE PREDISPOSITION; DRUG EFFICACY; ELECTROSTIMULATION; FACE PAIN; HUMAN; HYPERALGESIA; KNEE OSTEOARTHRITIS; LOW BACK PAIN; MECHANICAL STIMULATION; MIGRAINE; NECK PAIN; NEUROPATHIC PAIN; PAIN INTENSITY; PATHOGENESIS; POSTHERPETIC NEURALGIA; PRIORITY JOURNAL; RISK FACTOR; SHOULDER PAIN; SYMPTOMATOLOGY; THERMAL STIMULATION; TREATMENT RESPONSE; ANALGESIA; DRUG EFFECTS; PATHOPHYSIOLOGY; PHYSIOLOGY;

CENTRAL NERVOUS SYSTEM SENSITIZATION; CHRONIC PAIN; HUMANS; PAIN MANAGEMENT;

EID: 84927649504     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-662-46450-2_5     Document Type: Article

References (161)

1. Andersen OK, Sonnenborg FA, Arendt-Nielsen L (2001) Reflex receptive fields for human withdrawal reflexes elicited by non-painful and painful electrical stimulation of the foot sole. Clin Neurophysiol 112(4):641-649
2. Andersen OK, Finnerup NB, Spaich EG, Jensen TS, Arendt-Nielsen L (2004) Expansion of nociceptive withdrawal reflex receptive fields in spinal cord injured humans. Clin Neurophysiol 115(12):2798-2810
3. Arendt-Nielsen L (1997) Induction and assessment of experimental pain from human skin, muscle and viscera. In: Jensen TS, Turner JA, Wiesenfeld-Hallin Z (eds) Proceedings of the 8th World Congress on pain, Vancouver, Canada, August 17-22: progress in pain research and management, vol 8. IASP Press, Seattle, pp 393-425
4. Arendt-Nielsen L, Curatolo M (2013) Mechanistic, translational, quantitative pain assessment tools in profiling of pain patients and for development of new analgesic compounds. Scand J Pain 4(4):226-230
5. Arendt-Nielsen L, Hoeck HC (2011) Optimizing the early phase development of new analgesics by human pain biomarkers. Expert Rev Neurother 11(11):1631-1651
6. Arendt-Nielsen L, Yarnitsky D (2009) Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera. J Pain 10(6):556-572
7. Arendt-Nielsen L, Brennum J, Sindrup SH, Bak P (1994) Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system. Eur J Appl Physiol Occup Physiol 68:266-273
8. Arendt-Nielsen L, Drewes AM, Hansen JB, Tage-Jensen U (1997a) Gut pain reactions in man: an experimental investigation using short and long duration transmucosal electrical stimulation. Pain 69(3):255-262
9. Arendt-Nielsen L, Graven-Nielsen T, Svensson P, Jensen TS (1997b) Temporal summation in muscles and referred pain areas: an experimental human study. Muscle Nerve 20(10):1311-1313
10. Arendt-Nielsen L, Frokjaer JB, Staahl C, Graven-Nielsen T, Huggins JP, Smart TS, Drewes AM(2007) Effects of gabapentin on experimental somatic pain and temporal summation. Reg Anesth Pain Med 2(5):382-388
11. Arendt-Nielsen L, Graven-Nielsen T (2008) Muscle pain: sensory implications and interaction with motor control. Clin J Pain 24(4):291-298
12. Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T (2010) Sensitization in patients with painful knee osteoarthritis. Pain 149(3):573-581.
13. Arendt-Nielsen L, Andresen T, Malver LP, Oksche A, Mansikka H, Drewes AM (2012a) A double-blind, placebo-controlled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. Clin J Pain 28(7):623-627.
14. Arendt-Nielsen L, Graven-Nielsen T, Petrini L (2012b) Experimental human models and assessment of pain in non-pain conditions. In: Giamberardino MA, Jensen TS (eds) Pain comorbidities: understanding and treating the complex patient. IASP Press, Seattle, Chapter 3.
15. Atzeni F, Cazzola M, Benucci M, Di Franco M, Salaffi F, Sarzi-Puttini P (2011) Chronic widespread pain in the spectrum of rheumatological diseases. Best Pract Res Clin Rheumatol25(2):165-171
16. Aykanat V, Gentgall M, Briggs N, Williams D, Yap S, Rolan P (2012) Intradermal capsaicin as a neuropathic pain model in patients with unilateral sciatica. Br J Clin Pharmacol 73(1):37-45.
17. Baba Y, Kohase H, Oono Y, Fujii-Abe K, Arendt-Nielsen L (2012) Effects of dexmedetomidine on conditioned pain modulation in humans. Eur J Pain 16(8):1137-1147.
18. Bajaj P, Bajaj P, Graven-Nielsen T, Arendt-Nielsen L (2001a) Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain 93(2):107-114.
19. Bajaj P, Graven-Nielsen T, Arendt-Nielsen L (2001b) Trigger points in patients with lower limb osteoarthritis. J Musculoskelet Pain 9:17-33
20. Bajaj P, Bajaj P, Madsen H, Arendt-Nielsen L (2003) Endometriosis is associated with central sensitization: a psychophysical controlled study. J Pain 4(7):372-380.
21. Balasubramaniam R, de Leeuw R, Zhu H, Nickerson RB, Okeson JP, Carlson CR (2007)Prevalence of temporomandibular disorders in fibromyalgia and failed back syndrome patients: a blinded prospective comparison study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod104:204-216
22. Banic B, Petersen-Felix S, Andersen OK, Radanov BP, Villiger PM, Arendt-Nielsen L, Curatolo M (2004) Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain 107:7-15
23. Baron R, Saguer M (1994) Axon-reflex reactions in affected and homologous contralateral skin after unilateral peripheral injury of thoracic segmental nerves in humans. Neurosci Lett 165(1-2):97-100
24. Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139:267-284
25. Benson S, Kattoor J, Wegner A, Hammes F, Reidick D, Grigoleit JS, Engler H, Oberbeck R, Schedlowski M, Elsenbruch S (2012) Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans. Pain 153(4):794-799.
26. Biurrun Manresa JA, Neziri AY, Curatolo M, Arendt-Nielsen L, Andersen OK (2013) Reflex receptive fields are enlarged in patients with musculoskeletal low back and neck pain. Pain 154(8):1318-1324
27. Bouhassira D, Gall O, Chitour D, Le Bars D (1995) Dorsal horn convergent neurones: negative feedback triggered by spatial summation of nociceptive afferents. Pain 62(2):195-200.
28. Bragdon EE, Light KC, Costello NL, Sigurdsson A, Bunting S, Bhalang K, Maixner W (2002)Group differences in pain modulation: pain-free women compared to pain-free men and to women with TMD. Pain 96:227-237
29. Burstein R, Yarnitsky D, Goor-Aryeh I et al (2000) An association between migraine and cutaneous allodynia. Ann Neurol 47:614-624
30. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D (2010) Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol 68(1):81-91
31. Carli G, Suman AL, Biasi G, Marcolongo R (2002) Reactivity to superficial and deep stimuli in patients with chronic musculoskeletal pain. Pain 100:259-269
32. Cavallone LF, Frey K, Montana MC, Joyal J, Regina KJ, Petersen KL, Gereau RW IV (2013) Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers. J Pain Res6:771-784
33. Christidis N, Ioannidou K, Milosevic M, Segerdahl M, Ernberg M (2008) Changes of hypertonic saline-induced masseter muscle pain characteristics, by an infusion of the serotonin receptor type 3 antagonist granisetron. J Pain 9(10):892-901.
34. Crow M, Denk F, McMahon SB (2013) Genes and epigenetic processes as prospective pain targets. Genome Med 5(2):12
35. Daenen L, Nijs J, Cras P, Wouters K, Roussel N (2014) Changes in pain modulation occur soon after whiplash trauma but are not related to altered perception of distorted visual feedback. Pain Pract 14(7):588-598
36. Davis MA, Ettinger WH, Neuhaus JM, Barclay JD, Segal MR (1992) Correlates of knee pain among US adults with and without radiographic knee osteoarthritis. J Rheumatol 19(12):1943-1949
37. de Goeij M, van Eijk LT, Vanelderen P, Wilder-Smith OH, Vissers KC, van der Hoeven JG, Kox M, Scheffer GJ, Pickkers P (2013) Systemic inflammation decreases pain threshold in humans in vivo. PLoS One 8(12):e84159
38. Dimcevski G, Staahl C, Andersen SD, Thorsgaard N, Funch-Jensen P, Arendt-Nielsen L et al (2007) Assessment of experimental pain from skin, muscle, and esophagus in patients with chronic pancreatitis. Pancreas 35(1):22-29
39. Drewes AM, Petersen P, Qvist P, Nielsen J, Arendt-Nielsen L (1999) An experimental pain model based on electric stimulations of the colon mucosa. Scand J Gastroenterol 34(8):765-771.
40. Eide PK, J0rum E, Stubhaug A, Bremnes J, Breivik H (1994) Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine. A doubleblind, cross-over comparison with morphine and placebo. Pain 58:347-354.
41. Eisenberg E, Kleiser A, Dortort A, Haim T, Yarnitsky D (1998) The NMDA (N-methyl-D-aspartate) receptor antagonist memantine in the treatment of postherpetic neuralgia: a double-blind, placebo-controlled study. Eur J Pain 2(4):321-327.
42. Fernandez Carnero J, Fernandezdelas Pehas C, Sterling M, Souvlis T, Arendt-Nielsen L, Vicenzino B (2009a) Exploration of the extent of somato-sensory impairment in patients with unilateral lateral epicondylalgia. J Pain 10(11):1179-1185.
43. Fernandez Carnero J, Fernandez-de-las, Peüas C, De La Llave, Rincon AI, Ge HY, Arendt-Nielsen L (2009b) Widespread mechanical pain hyper-sensitivity as sign of central sensitization in unilateral lateral epicondylalgia: a blinded, controlled study. Clin J Pain 2(7):555-561.
44. Femandez-de-las, Peiras C, Ge HY, Cuadrado ML, Madeleine P, Pareja JA, Arendt-Nielsen L (2008) Bilateral pressure pain sensitivity mapping of the temporalis muscle in chronic tension type headache. Headache 48(8):1067-1075
45. Femandez-de-las, Peiras C, Galan del Río F, Fernandez Carnero J, Pesquera J, Arendt-Nielsen L, Svensson P (2009) Bilateral widespread mechanical pain sensitivity in myofascial temporomandibular disorder: evidence of impairment in central nociceptive processing. J Pain 10(11):1170-1178
46. Femandez-de-las, Peiias C, Galan-del-Rio F, Ortega-Santiago R, Jimenez-Garcia R, ArendtNielsen L, Svensson P (2010) Bilateral thermal hyperalgesia in trigeminal and extra-trigeminal regions in patients with myofascial temporomandibular disorders. Exp Brain Res 202:171-179.
47. Fillingim RB, Fillingim LA, Hollins M, Sigurdsson A, Maixner W (1998) Generalized vibrotactile allodynia in a patient with temporomandibular disorder. Pain 78:75-78.
48. Finnerup NB, Sindrup SH, Bach FW, Johannesen IL, Jensen TS (2002) Lamotrigine in spinal cord injury pain: a randomized controlled trial. Pain 96(3):375-383.
49. Foster DC, Dworkin RH, Wood RW (2005) Effects of intradermal foot and forearm capsaicin injections in normal and vulvodynia-afflicted women. Pain 117:128-136.
50. Geber C, Klein T, Azad S, Birklein F, Gierthmühlen J, Huge V, Lauchart M, Nitzsche D,Stengel M, Valet M, Baron R, Maier C, Tolle T, Treede RD (2011) Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study. Pain 152(3):548-556.
51. Giamberardino MA (2003) Referred muscle pain/hyperalgesia and central sensitisation. J Rehabil Med 41(Suppl):85-88
52. Giamberardino MA, de Bigontina P, Martegiani C, Vecchiet L (1994) Effects of extracorporeal shock-wave lithotripsy on referred hyperalgesia from renal/ureteral calculosis. Pain 56(1):77-83
53. Giamberardino MA, Costantini R, Affaitati G, Fabrizio A, Lapenna D, Tafuri E, Mezzetti A (2010) Viscero-visceral hyperalgesia: characterization in different clinical models. Pain 151(2):307-322
54. Gottrup H, Kristensen AD, Bach FW, Jensen TS (2003) Aftersensations in experimental and clinical hypersensitivity. Pain 103(1-2):57-64
55. Graven-Nielsen T, Aspegren Kendall S, Henriksson KG, Bengtsson M, Sorensen J, Johnson A, Gerdle B, Arendt-Nielsen L (2000) Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients. Pain 85(3):483-491.
56. Graven-Nielsen T, Wodehouse T, Langford RM, Arendt-Nielsen L, Kidd BL (2012) Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum 64(9):2907-2916.
57. Grill JD, Coghill RC (2002) Transient analgesia evoked by noxious stimulus offset. J Neurophysiol 87:2205-2208
58. Haanpaa M (2011) Are neuropathic pain screening tools useful for patients with spinal cord injury? Pain 152:715-716
59. Hannan MT, Felson DT, Pincus T (2000) Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol 27(6):1513-1517.
60. Harris J, Clarke RW (2003) Organisation of sensitisation of hind limb withdrawal reflexes from acute noxious stimuli in the rabbit. J Physiol 546:251-265.
61. Hayes AG, Arendt-Nielsen L, Tate S (2014) Multiple mechanisms have been tested in pain-how can we improve the chances of success? Curr Opin Pharmacol 14:11-17.
62. Herren-Gerber R, Weiss S, Arendt-Nielsen L, Petersen-Felix S, Di Stefano G, Radanov BP, Curatolo M (2004) Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. Pain Med 5(4):366-376.
63. Holm LW, Carroll LJ, Cassidy JD, Skillgate E, Ahlbom A (2007) Widespread pain following whiplash-associated disorders: incidence, course, and risk factors. J Rheumatol 34:193-200.
64. Holst H, Arendt-Nielsen L, Mosbech H, Elberling J (2011) Increased capsaicin-induced secondary hyperalgesia in patients with multiple chemical sensitivity. Clin J Pain 27(2):156-162.
65. Honigman L, Yarnitsky D, Sprecher E, Weissman-Fogel I (2013) Psychophysical testing of spatial and temporal dimensions of endogenous analgesia: conditioned pain modulation and offset analgesia. Exp Brain Res 228(4):493-501
66. Hutchinson MR, Buijs M, Tuke J, Kwok YH, Gentgall M, Williams D, Rolan P (2013) Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection. Brain Behav Immun 30:3-11
67. Jensen TS, Baron R (2002) Translation of symptoms and signs into mechanisms in neuropathic pain: topical review. Pain 102:1-8
68. Jespersen A, Amris K, Graven-Nielsen T, Arendt-Nielsen L, Bartels EM, Torp-Pedersen S, Bliddal H, Danneskiold-Samsoe B (2013) Assessment of pressure-pain thresholds and central sensitization of pain in lateral epicondylalgia. Pain Med 14(2):297-304.
69. John MT, Miglioretti DL, LeResche L, Von Korff M, Critchlow CW (2003) Widespread pain as a risk factor for dysfunctional temporomandibular disorder pain. Pain 102:257-263.
70. Koelbaek Johansen M, Graven-Nielsen T, Olesen AS, Arendt-Nielsen L (1999) Generalised muscular hyperalgesia in chronic whiplash syndrome. Pain 83(2):229-234.
71. Kong JT, Johnson KA, Balise RR, Mackey S (2013) Test-retest reliability of thermal temporal summation using an individualized protocol. J Pain 14(1):79-88
72. Konopka KH, Harbers M, Houghton A, Kortekaas R, van Vliet A, Timmerman W, den Boer JA, Strnys MM, van Wijhe M (2012) Bilateral sensory abnormalities in patients with unilateral neuropathic pain: a quantitative sensory testing (QST) study. PLoS One 7(5):e37524.
73. Kosek E, Hansson P (1997) Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain 70:41-51
74. Kosek E, Ordeberg G (2000) Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain 88:69-78
75. Kozin F, McCarty SJ, Sims J, Genant H (1976) The reflex sympathetic dystrophy syndrome. Am J Med 60:320-337
76. Lapossy E, Maleitzke R, Hrycaj P, Mennet W, Muller W (1995) The frequency of transition of chronic low back pain to fibromyalgia. Scand J Rheumatol 24:29-33.
77. Laursen BS, Bajaj P, Olesen AS, Delmar C, Arendt-Nielsen L (2005) Health related quality of life and quantitative pain measurement in females with chronic non-malignant pain. Eur J Pain9:267-275
78. Leblebici B, Pektas ZO, Ortancil O, Hurcan EC, Bagis S, Akman MN (2007) Coexistence of fibromyalgia, temporomandibular disorder, and masticatory myofascial pain syndromes. Rheumatol Int 7:541-544
79. Lecybyl R, Acosta J, Ghoshdastidar J, Stringfellow K, Hanna M (2010) Validation, reproducibility and safety of trans dermal electrical stimulation in chronic pain patients and healthy volunteers. BMC Neurol 10:5
80. Lee J, Ellis B, Price C, Baranowski AP (2014) Chronic widespread pain, including fibromyalgia: a pathway for care developed by the British Pain Society. Br J Anaesth 112(1):16-24.
81. Lemming D, Graven-Nielsen T, Sorensen J, Arendt-Nielsen L, Gerdle B (2012) Widespread pain hypersensitivity and facilitated temporal summation of deep tissue pain in whiplash associated disorder: an explorative study of women. J Rehabil Med 44(8):648-657.
82. Macfarlane GJ (1999) Generalized pain, fibromyalgia and regional pain: an epidemiological view.Baillieres Best Pract Res Clin Rheumatol 13:403-414.
83. Magerl W, Krumova EK, Baron R, Tolle T, Treede RD, Maier C (2010) Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data. Pain 151(3):598-605.
84. Maier C, Baron R, Tolle TR, Binder A, Birbaumer N, Birklein F, Gierthmühlen J, Flor H, Geber C,Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihofner C, Richter H, Rolke R,Scherens A, Schwarz A, Sommer C, Tronnier V, Uceyler N, Valet M, Wasner G, Treede R D(2010) Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain 150(3):439-450
85. Malan TP, Ossipov MH, Gardell LR, Ibrahim M, Bian D, Lai J, Porreca F (2000) Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain 86(1-2):185-194
86. Martucci KT, Eisenach JC, Tong C, Coghill RC (2012a) Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information. Pain 153(6):1232-1243
87. Martucci KT, Yelle MD, Coghill RC (2012b) Differential effects of experimental central sensitization on the time-course and magnitude of offset analgesia. Pain 153(2):463-472.
88. Milligan ED, Watkins LR (2009) Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10:23-36
89. Miranda A, Peles S, Rudolph C, Shaker R, Sengupta JN (2004) Altered visceral sensation in response to somatic pain in the rat. Gastroenterology 126(4):1082-1089
90. Morris VH, Crnwys SC, Kidd BL (1997) Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis. Pain 71:179-186
91. Morris V, Cruwys S, Kidd B (1998) Increased capsaicin-induced secondary hyperalgesia as a marker of abnormal sensory activity in patients with fibromyalgia. Neurosci Lett 250(3):205-207
92. Mourao AF, Blyth FM, Branco JC (2010) Generalised musculoskeletal pain syndromes. Best Pract Res Clin Rheumatol 24(6):829-840
93. Naugle KM, Cruz-Almeida Y, Fillingim RB, Riley JL III (2013) Offset analgesia is reduced in older adults. Pain 154(11):2381-2387
94. Neogi T, Felson D, Niu J, Nevitt M, Lewis CE, Aliabadi P, Sack B, Torner J, Bradley L, Zhang Y(2009) Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies. BMJ 339:b2844
95. Ness TJ, Lloyd LK, Fillingim RB (2014) An endogenous pain control system is altered in subjects with interstitial cystitis. J Urol 191(2):364-370
96. Neziri AY, Haesler S, Petersen-Felix S, Muller M, Arendt-Nielsen L, Manresa JB, Andersen OK, Curatolo M (2010) Generalized expansion of nociceptive reflex receptive fields in chronic pain patients. Pain 151(3):798-805
97. Neziri AY, Scaramozzino P, Andersen OK, Dickenson AH, Arendt-Nielsen L, Curatolo M (2011) Reference values of mechanical and thermal pain tests in a pain-free population. Eur J Pain 15(4):376-383
98. Neziri AY, Dickenmann M, Scaramozzino P, Andersen OK, Arendt-Nielsen L, Dickenson AH, Curatolo M (2012) Effect of intravenous tropisetron on modulation of pain and central hypersensitivity in chronic low back pain patients. Pain 153(2):311-318.
99. Nie H, Graven-Nielsen T, Arendt-Nielsen L (2009) Spatial and temporal summation of pain evoked by mechanical pressure stimulation. Eur J Pain 13(6):592-599
100. Nielsen J, Arendt-Nielsen L (1997) Spatial summation of heat induced pain within and between dermatomes. Somatosens Mot Res 14(2):119-125.
101. Niesters M, Hoitsma E, Sarton E, Aarts L, Dahan A (2011a) Offset analgesia in neuropathic pain patients and effect of treatment with morphine and ketamine. Anesthesiology 115(5):1063-1071
102. Niesters M, Dahan A, Swartjes M, Noppers I, Fillingim RB, Aarts L, Sarton EY (2011b) Effect of ketamine on endogenous pain modulation in healthy volunteers. Pain 152(3):656-663.
103. Nikolajsen L, Hansen CL, Nielsen J, Keller J, Arendt-Nielsen L, Jensen TS (1996) The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input. Pain67(1):69-77
104. Nikolajsen L, Gottrup H, Kristensen AG, Jensen TS (2000) Memantine (a N-methyl-D-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized, double-blinded, cross-over study. Anesth Analg 91(4):960-966.
105. Nilsson M, Piasco A, Nissen TD, Graversen C, Gazerani P, Lucas MF, Dahan A, Drewes AM, Brock C (2013) Reproducibility of psychophysics and electroencephalography during offset analgesia. Eur J Pain 18(6):824-834
106. Nishimura I, Thakor D, Lin A, Ruangsri S, Spigelman I (2010) Molecular strategies for therapeutic targeting of primary sensory neurons in chronic pain syndromes. In: Kruger L, Light AR (eds) Translational pain research: from mouse to man. CRC, Boca Raton, Chapter 6.
107. O’Neill S, Manniche C, Graven-Nielsen T, Arendt-Nielsen L (2007) Generalized deep-tissue hyperalgesia in patients with chronic low-back pain. Eur J Pain 11(4):415-420.
108. Oertel BG, Lotsch J (2013) Clinical pharmacology of analgesics assessed with human experimental pain models: bridging basic and clinical research. Br J Pharmacol 168(3):534-553
109. Peters ML, Schmidt AJ, Van den Hout MA, Koopmans R, Sluijter ME (1992) Chronic back pain, acute postoperative pain and the activation of diffuse noxious inhibitory controls (DNIC). Pain50:177-187
110. Petersen KL, Fields HL, Brennum J, Sandroni P, Rowbotham MC (2000) Capsaicin evoked pain and allodynia in post-herpetic neuralgia. Pain 88:125-133.
111. Piche M, Arsenault M, Poitras P, Rainville P, Bouin M (2010) Widespread hypersensitivity is related to altered pain inhibition processes in irritable bowel syndrome. Pain 148(1):49-58.
112. Polianskis R, Graven-Nielsen T, Arendt-Nielsen L (2002) Spatial and temporal aspects of deep tissue pain assessed by cuff algometry. Pain 100:19-26.
113. Porreca F, Ossipov MH, Gebhart GF (2002) Chronic pain and medullary descending facilitation. Trends Neurosci 25:319-325
114. Price DD, Hayes RL, Ruda M, Dubner R (1978) Neural representation of cutaneous aftersensations by spinothalamic tract neurons. Fed Proc 37(9):2237-2239.
115. Pud D, Eisenberg E, Spitzer A, Adler R, Fried G, Yarnitsky D (1998) The NMDA receptor antagonist amantadine reduces surgical neuropathic pain in cancer patients: a double blind, randomized, placebo controlled trial. Pain 75:349-354.
116. Rasmussen PV, Sindrup SH, Jensen TS, Bach FW (2004) Therapeutic outcome in neuropathic pain: relationship to evidence of nervous system lesion. Eur J Neurol 11(8):545-553.
117. Richards N, McMahon SB (2013) Targeting novel peripheral mediators for the treatment of chronic pain. Br J Anaesth 111(1):46-51
118. Robinson ME, Bialosky JE, Bishop MD, Price DD, George SZ (2010) Supra-threshold scaling, temporal summation, and after-sensation: relationships to each other and anxiety/fear. J Pain Res 3:25-32
119. Rolke R, Baron R, Maier C, Tolle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Botefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihofner C,Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B (2006a) Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 123(3):231-243.
120. Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, Birklein F, Treede RD (2006b)Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 10(1):77-88
121. Sandkuhler J (2009) Models and mechanisms of hyperalgesia and allodynia. Physiol Rev 89(2):707-758
122. Sandrini G, Rossi P, Milanov I, Serrao M, Cecchini AP, Nappi G (2006) Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients. Cephalalgia 26:782-789
123. Sarzi-Puttini P, Atzeni F, Mease PJ (2011) Chronic widespread pain: from peripheral to central evolution. Best Pract Res Clin Rheumatol 25(2):133-139.
124. Sato H, Saisu H, Muraoka W, Nakagawa T, Svensson P, Wajima K (2012) Lack of temporal summation but distinct aftersensations to thermal stimulation in patients with combined tension-type headache and myofascial temporomandibular disorder. J Orofac Pain 26(4):288-295
125. Schliessbach J, Siegenthaler A, Streitberger K, Eichenberger U, Niiesch E, Jiini P, ArendtNielsen L, Curatolo M (2013) The prevalence of widespread central hypersensitivity in chronic pain patients. Eur J Pain 17(10):1502-1510
126. Schneider GM, Smith AD, Hooper A, Stratford P, Schneider KJ, Westaway MD, Frizzell B, Olson L (2010) Minimizing the source of nociception and its concurrent effect on sensory hypersensitivity: an exploratory study in chronic whiplash patients. BMC Musculoskelet Disord 11:29.
127. Schomberg D, Olson JK (2012) Immune responses of microglia in the spinal cord: contribution to pain states. Exp Neurol 234:262-270
128. Schouenborg J, Weng HR, Holmberg H (1994) Modular organization of spinal reflexes: a new hypothesis. NIPS 9:261-265
129. Schouenborg J, Weng H-R, Kalliomaki J, Holmberg H (1995) A survey of spinal dorsal horn neurones encoding the spinal organization of withdrawal reflexes in the rat. Exp Brain Res106:19-27
130. Schulte H, Segerdahl M, Graven-Nielsen T, Grass S (2006) Reduction of human experimental muscle pain by alfentanil and morphine. Eur J Pain 10(8):733-741.
131. Scott D, Jull G, Sterling M (2005) Widespread sensory hypersensitivity is a feature of chronic whiplash-associated disorder but not chronic idiopathic neck pain. Clin J Pain 21:175-181.
132. Shimada A, Cairns BE, Vad N, Ulriksen K, Pedersen AM, Svensson P, Baad-Hansen L (2013)Headache and mechanical sensitization of human pericranial muscles after repeated intake of monosodium glutamate (MSG). J Headache Pain 14(1):2.
133. Skou ST, Graven-Nielsen T, Rasmussen S, Simonsen OH, Laursen MB, Arendt-Nielsen L (2013)Widespread sensitization in patients with chronic pain after revision total knee arthroplasty. Pain 154(9):1588-1594
134. Smith SB, Maixner DW, Greenspan JD, Dubner R, Fillingim RB, Ohrbach R, Knott C, Slade GD, Bair E, Gibson DG, Zaykin DV, Weir BS, Maixner W, Diatchenko L (2011) Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study. J Pain12(11 Suppl):T92-T101
135. Smith SB, Maixner DW, Fillingim RB, Slade G, Gracely RH, Ambrose K, Zaykin DV, Hyde C, John S, Tan K, Maixner W, Diatchenko L (2012) Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia. Arthritis Rheum 64(2):584-593
136. Sorensen J, Graven-Nielsen T, Henriksson KG, Bengtsson M, Arendt-Nielsen L (1998) Hyperexcitability in fibromyalgia. J Rheumatol 25(1):152-155.
137. Staud R (2011) Peripheral pain mechanisms in chronic widespread pain. Best Pract Res Clin Rheumatol 25(2):155-164
138. Staud R (2012) Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother 12(5):577-585.
139. Staud R, Cannon RC, Mauderli AP, Robinson ME, Price DD, Vierck CJ Jr (2003) Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome. Pain 102(1-2):87-95.
140. Staud R, Vierck CJ, Robinson ME, Price DD (2004) Spatial summation of heat pain within and across dermatomes in fibromyalgia patients and pain-free subjects. Pain 111(3):342-350.
141. Staud R, Koo E, Robinson ME, Price DD (2007) Spatial summation of mechanically evoked muscle pain and painful aftersensations in normal subjects and fibromyalgia patients. Pain 130(1-2):177-187
142. Stawowy M, Rossel P, Bluhme C, Funch-Jensen P, Arendt-Nielsen L, Drewes AM (2002) Somatosensory changes in the referred pain area following acute inflammation of the appendix. Eur J Gastroenterol Hepatol 14(10):1079-1084
143. Stawowy M, Funch-Jensen P, Arendt-Nielsen L, Drewes AM (2005) Somatosensory changes in the referred pain area in patients with cholecystolithiasis. Eur J Gastroenterol Hepatol 17(8):865-870
144. Stiasny-Kolster K, Pfau DB, Oertel WH, Treede RD, Magerl W (2013) Hyperalgesia and functional sensory loss in restless legs syndrome. Pain 154(8):1457-1463.
145. Stubhaug A, Breivik H, Eide PK, Kreunen M, Foss A (1997) Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 41:1124-1132.
146. Sumracki NM, Hutchinson MR, Gentgall M, Briggs N, Williams DB, Rolan P (2012) The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. PLoS One 7(6):e3852.
147. Suzan E, Midbari A, Treister R, Haddad M, Pud D, Eisenberg E (2013) Oxycodone alters temporal summation but not conditioned pain modulation: preclinical findings and possible relations to mechanisms of opioid analgesia. Pain 154(8):1413-1418
148. Suzuki R, Rygh LJ, Dickenson AH (2004) Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci 25(12):613-617.
149. Swarbrick ET, Hegarty JE, Bat L, Williams CB, Dawson AM (1980) Site of pain from the irritable bowel. Lancet 2(8192):443-446
150. Thompson LR, Boudreau R, Newman AB, Hannon MJ, Chu CR, Nevitt MC, Kent Kwoh C, OAI Investigators (2010) The association of osteoarthritis risk factors with localized, regional and diffuse knee pain. Osteoarthritis Cartilage 18(10):1244-1249.
151. Treister R, Pud D, Eisenberg E (2013) The dopamine agonist apomorphine enhances conditioned pain modulation in healthy humans. Neurosci Lett 548:115-119.
152. van Rijn MA, Marinus J, Putter H, Bosselaar SR, Moseley GL, van Hilten JJ (2011) Spreading of complex regional pain syndrome: not a random process. J Neural Transm 118(9):1301-1309.
153. Veldman PH, Goris RJ (1996) Multiple reflex sympathetic dystrophy. Which patients are at risk for developing a recurrence of reflex sympathetic dystrophy in the same or another limb. Pain64:463-466
154. Werner MU, Petersen KL, Rowbotham MC, Dahl JB (2013) Healthy volunteers can be phenotyped using cutaneous sensitization pain models. PLoS One 8(5):62733.
155. Xu YM, Ge HY, Arendt-Nielsen L (2010) Sustained nociceptive mechanical stimulation of latent myofascial trigger point induces central sensitization in healthy subjects. J Pain 11(12):1348-1355
156. Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M, Hansson P, Lautenbacher S, Marchand S, Wilder-Smith O (2010) Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain 14(4):339.
157. Yarnitsky D, Granot M, Nahman-Averbuch H, Khamaisi M, Granovsky Y (2012) Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy. Pain 153(6):1193-1198
158. Yelle MD, Rogers JM, Coghill RC (2008) Offset analgesia: a temporal contrast mechanism for nociceptive information. Pain 134:174-186
159. You HJ, Colpaert FC, Arendt-Nielsen L (2005) The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes. Exp Neurol 191(1):174-183.
160. You HJ, Lei J, Sui MY, Huang L, Tan YX, Tj0lsen A, Arendt-Nielsen L (2010) Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception. J Physiol 588(Pt 21):4177-4188.
161. Zakrzewska JM (2013) Multi-dimensionality of chronic pain of the oral cavity and face. J Headache Pain 14:37-46