The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Sumracki, Nicole M ^a   Hutchinson, Mark R ^a   Gentgall, Melanie ^a   Briggs, Nancy ^a   Williams, Desmond B ^b   Rolan, Paul ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; MINOCYCLINE; PLACEBO; PREGABALIN;

ADULT; ALLODYNIA; ANALGESIC ACTIVITY; ARTICLE; ATTENTION DISTURBANCE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE EXACERBATION; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; HANDEDNESS; HUMAN; HYPERALGESIA; ISCHIALGIA; LEG PAIN; MALE; NAUSEA; OUTCOME ASSESSMENT; PAIN; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SINGLE DRUG DOSE; SPONTANEOUS PAIN;

ADULT; ANALYSIS OF VARIANCE; CAPSAICIN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; HYPERALGESIA; INJECTIONS, INTRADERMAL; MALE; MIDDLE AGED; MINOCYCLINE; PAIN; SCIATICA; TIME FACTORS; TREATMENT OUTCOME;

EID: 84862001945     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038525     Document Type: Article

References (36)

1. Woolf CJ, (2010) Overcoming obstacles to developing new analgesics. Nature medicine 16: 1241-1247.
2. Milligan ED, Watkins LR, (2009) Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10: 23-36.
3. Nicotra L, Loram LC, Watkins LR, Hutchinson MR, (2012) Toll-like receptors in chronic pain. Experimental neurology 234: 316-329.
4. Grace PM, Rolan PE, Hutchinson MR, (2011) Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain, behavior, and immunity 25: 1322-1332.
5. Rolan P, Gibbons JA, He L, Chang E, Jones D, et al. (2008) Ibudilast in healthy volunteers: safety, tolerability and pharmacokinetics with single and multiple doses. Br J Clin Pharmacol 66: 792-801.
6. Younger J, Mackey S, (2009) Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain medicine 10: 663-672.
7. Landry RP, Jacobs VL, Romero-Sandoval EA, Deleo JA, (2012) Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages. Experimental neurology 234: 340-350.
8. Gelesko S, Long L, Faulk J, Phillips C, Dicus C, et al. (2011) Cryotherapy and topical minocycline as adjunctive measures to control pain after third molar surgery: an exploratory study. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 69: e324-332.
9. Gordon PH, Moore DH, Miller RG, Florence JM, Verheijde JL, et al. (2007) Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. Lancet neurology 6: 1045-1053.
10. Gordon PH, Cheung YK, Levin B, Andrews H, Doorish C, et al. (2008) A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS. Amyotrophic lateral sclerosis: official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 9: 212-222.
11. Khiat A, D'Amour M, Souchon F, Boulanger Y, (2010) MRS study of the effects of minocycline on markers of neuronal and microglial integrity in ALS. Magnetic resonance imaging 28: 1456-1460.
12. Ho EL, Spudich SS, Lee E, Fuchs D, Sinclair E, et al. (2011) Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study. AIDS research and therapy 8: 17.
13. Lampl Y, Boaz M, Gilad R, Lorberboym M, Dabby R, et al. (2007) Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology 69: 1404-1410.
14. Barkhof F, Hulst HE, Drulovic J, Uitdehaag BM, Matsuda K, et al. (2010) Ibudilast in relapsing-remitting multiple sclerosis: a neuroprotectant? Neurology 74: 1033-1040.
15. Paribello C, Tao L, Folino A, Berry-Kravis E, Tranfaglia M, et al. (2010) Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC neurology 10: 91.
16. Dworkin RH, Turk DC, Peirce-Sandner S, Baron R, Bellamy N, et al. (2010) Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations. Pain 149: 177-193.
17. Baron R, Freynhagen R, Tolle TR, Cloutier C, Leon T, et al. (2010) The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy. Pain 150: 420-427.
18. Ledeboer A, Sloane EM, Milligan ED, Frank MG, Mahony JH, et al. (2005) Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain 115: 71-83.
19. Smith K, Leyden J, (2005) Safety of Doxycycline and Minocycline: A Systematic Review. Clinical Therapeutics 27: 1329-1342.
20. Aronson AL, (1980) Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 176: 1061-1068.
21. Mika J, Osikowicz M, Makuch W, Przewlocka B, (2007) Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain. Eur J Pharmacol 560: 142-149.
22. Gustafsson H, Åkesson J, Lau CL, Williams D, Miller L, et al. (2009) A comparison of two formulations of intradermal capsaicin as models of neuropathic pain in healthy volunteers. British Journal of Clinical Pharmacology pp. 511-517.
23. Aykanat V, Gentgall M, Briggs N, Williams D, Yap S, et al. (2012) Intradermal capsaicin as a neuropathic pain model in patients with unilateral sciatica. British Journal of Clinical Pharmacology 73: 37-45.
24. Wang H, Bolognese J, Calder N, Baxendale J, Kehler A, et al. (2008) Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects. J Pain 9: 1088-1095.
25. Liu M, Max MB, Robinovitz E, Gracely RH, Bennett GJ, (1998) The human capsaicin model of allodynia and hyperalgesia: sources of variability and methods for reduction. J Pain Symptom Manage 16: 10-20.
26. LeVasseur SA, Gibson SJ, Helme RD, (1990) The measurement of capsaicin-sensitive sensory nerve fiber function in elderly patients with pain. Pain 41: 19-25.
27. Morris GC, Gibson SJ, Helme RD, (1995) Capsaicin-induced flare and vasodilatation in patients with post-herpetic neuralgia. Pain 63: 93-101.
28. Petersen KL, Fields HL, Brennum J, Sandroni P, Rowbotham MC, (2000) Capsaicin evoked pain and allodynia in post-herpetic neuralgia. Pain 88: 125-133.
29. Krishnan ST, Rayman G, (2004) The LDIflare: a novel test of C-fiber function demonstrates early neuropathy in type 2 diabetes. Diabetes Care 27: 2930-2935.
30. Foster DC, Dworkin RH, Wood RW, (2005) Effects of intradermal foot and forearm capsaicin injections in normal and vulvodynia-afflicted women. Pain 117: 128-136.
31. Shenker NG, Haigh RC, Mapp PI, Harris N, Blake DR, (2008) Contralateral hyperalgesia and allodynia following intradermal capsaicin injection in man. Rheumatology 47: 1417-1421.
32. Tan AM, Zhao P, Waxman SG, Hains BC, (2009) Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury. J Rehabil Res Dev 46: 123-133.
33. Jensen MP, Chen C, Brugger AM, (2003) Interpretation of visual analog scale ratings and change scores: a reanalysis of two clinical trials of postoperative pain. The journal of pain: official journal of the American Pain Society 4: 407-414.
34. Dworkin RH, O'Connor AB, Audette J, Baron R, Gourlay GK, et al. (2010) Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clinic proceedings Mayo Clinic 85: S3-14.
35. Moulin DE, Clark AJ, Gilron I, Ware MA, Watson CP, et al. (2007) Pharmacological management of chronic neuropathic pain- consensus statement and guidelines from the Canadian Pain Society. Pain research & management: the journal of the Canadian Pain Society = journal de la societe canadienne pour le traitement de la douleur 12: 13-21.
36. Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P, et al. (2010) EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. European journal of neurology: the official journal of the European Federation of Neurological Societies 17: 1113-e1188.