Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions

Expert Review of Neurotherapeutics

Volumn 12, Issue 5, 2012, Pages 577-585

  Staud, Roland ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

central sensitization; chronic pain; facilitation; fibromyalgia; inhibition; osteoarthritis; pain modulation

Indexed keywords

DEXTROMETHORPHAN;

AMPUTATION; ANALGESIA; ARTHROPLASTY; BONE PAIN; BREAST CANCER; CANCER SURGERY; CHOLECYSTECTOMY; CHRONIC FATIGUE SYNDROME; CHRONIC PAIN; CINGULATE GYRUS; FIBROMYALGIA; HEADACHE; HERNIORRHAPHY; HERPES ZOSTER; HIP OSTEOARTHRITIS; HUMAN; IRRITABLE COLON; MESENCEPHALON; NEUROIMAGING; PAIN; PERIAQUEDUCTAL GRAY MATTER; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PAIN; REVIEW; SPINAL CORD INJURY; TEMPOROMANDIBULAR JOINT DISORDER; THORACOTOMY;

CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM SENSITIZATION; CHRONIC PAIN; HUMANS; INDIVIDUALITY; PAIN THRESHOLD;

EID: 84860600115     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.12.41     Document Type: Review

References (146)

1. Sharif-Naeini R, Basbaum AI. Targeting pain where it resides .. in the brain. Sci. Transl. Med. 3(65), 65ps1 (2011)
2. Latremoliere A, Woolf CJ. Central sensitization: A generator of pain hypersensitivity by central neural plasticity. J. Pain 10, 895-926 (2009)
3. Kroenke K, Krebs EE, Bair MJ. Pharmacotherapy of chronic pain: A synthesis of recommendations from systematic reviews. Gen. Hosp. Psychiatry 31, 206-219 (2009)
4. Johannes CB, Le TK, Zhou XL, Johnston JA, Dworkin RH. The prevalence of chronic pain in United States adults results of an internet-based survey. J. Pain 11, 1230-1239 (2010)
5. Andersson HI. The course of non-malignant chronic pain: A 12 year follow-up of a cohort from the general population. Eur. J. Pain 8, 47-53 (2004)
6. Elliott AM, Smith BH, Hannaford PC, Smith WC, Chambers WA. The course of chronic pain in the community: Results of a 4 year follow-up study. Pain 99, 299-307 (2002)
7. Thomsen AB, Sorensen J, Sjogren P, Eriksen J. Chronic non-malignant pain patients and health economic consequences. Eur. J. Pain 6, 341-352 (2002)
8. Turk DC. Chronic non-malignant pain patients and health economic consequences. Eur. J. Pain 6, 353-355 (2002)
9. Andersson HI. Increased mortality among individuals with chronic widespread pain relates to lifestyle factors: A prospective population-based study. Disabil. Rehabil. 21, 1-8 (2009)
10. Torrance N, Elliott AM, Lee AJ, Smith BH. Severe chronic pain is associated with increased 10 year mortality. A cohort record linkage study. Eur. J. Pain 14, 380-386 (2010)
11. Macfarlane GJ, McBeth J, Silman AJ. Widespread body pain and mortality: Prospective population based study. BMJ 323, 662-665 (2001)
12. Linton SJ. Cognitive behavioral therapy in the prevention of musculoskeletal pain: Description of a program. In: New Avenues for the Prevention of Chronic Musculoskeletal Pain and Disability. Linton SJ (Ed.). Elsevier, Amsterdam, The Netherlands 269-276 (2002)
13. Muir WW 3rd, Woolf CJ. Mechanisms of pain and their therapeutic implications. J. Am. Vet. Med. Assoc. 219, 1346-1356 (2001)
14. Woolf CJ, Max MB. Mechanism-based pain diagnosis: Issues for analgesic drug development. Anesthesiology 95, 241-249 (2001)
15. Howard FM. Endometriosis and mechanisms of pelvic pain. J. Minim. Invasive Gynecol. 16, 540-550 (2009)
16. Szebenyi B, Hollander AP, Dieppe P et al. Associations between pain, function, and radiographic features in osteoarthritis of the knee. Arthritis Rheum. 54, 230-235 (2006)
17. Porpora MG, Koninckx PR, Piazze J, Natili M, Colagrande S, Cosmi EV. Correlation between endometriosis and pelvic pain. J. Am. Assoc. Gynecol. Laparosc. 6, 429-434 (1999)
18. Muraki S, Oka H, Akune T et al. Prevalence of radiographic lumbar spondylosis and its association with low back pain in elderly subjects of population-based cohorts: The ROAD study. Ann. Rheum. Dis. 68, 1401-1406 (2009)
19. Nielsen CS, Staud R, Price DD. Individual differences in pain sensitivity: Measurement, causation, and consequences. J. Pain 10, 231-237 (2009)
20. Siddall PJ, Cousins MJ. Persistent pain as a disease entity: Implications for clinical management. Anesth. Analg. 99, 510-520 (2004)
21. Staud R, Rodriguez ME. Mechanisms of disease: Pain in fibromyalgia syndrome. Nat. Rev. Rheumatol. 2, 90-98 (2006)
22. Hurtig IM, Raak RI, Kendall SA, Gerdle B, Wahren LK. Quantitative sensory testing in fibromyalgia patients and in healthy subjects: Identification of subgroups. Clin. J. Pain 17, 316-322 (2001)
23. Dyck PJ, Dyck PJ, Larson TS, O'Brien PC, Velosa JA. Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: A study of three cohorts. Nerve growth factor study group. Diabetes Care 23, 510-517 (2000)
24. Sommer C. Painful neuropathies. Curr. Opin. Neurol. 16, 623-628 (2003)
25. Calcutt NA, Backonja MM. Pathogenesis of pain in peripheral diabetic neuropathy. Curr. Diab. Rep. 7, 429-434 (2007)
26. Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron 55, 377-391 (2007)
27. Aaron LA, Burke MM, Buchwald D. Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder. Arch. Intern. Med. 160, 221-227 (2000)
28. Kong J, Gollub RL, Rosman IS et al. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J. Neurosci. 26, 381-388 (2006)
29. Mason P. Ventromedial medulla: Pain modulation and beyond. J. Comp. Neurol. 493, 2-8 (2005)
30. Dubner R, Ren K. Endogenous mechanisms of sensory modulation. Pain Suppl. 6, S45-S53 (1999)
31. Ren K, Dubner R. Descending modulation in persistent pain: An update. Pain 100, 1-6 (2002)
32. van Wijk G, Veldhuijzen DS. Perspective on diffuse noxious inhibitory controls as a model of endogenous pain modulation in clinical pain syndromes. J. Pain 11, 408-419 (2010)
33. Edwards RR, Fillingim RB. Effects of age on temporal summation and habituation of thermal pain: Clinical relevance in healthy older and younger adults. J. Pain 2, 307-317 (2001)
34. Tracey I, Dunckley P. Importance of anti- and pro-nociceptive mechanisms in human disease. Gut 53, 1553-1555 (2004)
35. Staud R, Vierck CJ, Cannon RL, Mauderli AP, Price DD. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain 91, 165-175 (2001)
36. Staud R, Cannon RC, Mauderli AP, Robinson ME, Price DD, Vierck CJ. Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome. Pain 102, 87-95 (2003)
37. Kosek E, Ordeberg G. Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain 88, 69-78 (2000)
38. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell 139, 267-284 (2009)
39. Staud R, Vierck CJ, Robinson ME, Price DD. Effects of the NDMA receptor antagonist dextromethorphan on temporal summation of pain are similar in fibromyalgia patients and normal controls. J. Pain 6, 323-332 (2005)
40. Arendt-Nielsen L, Mansikka H, Staahl C et al. A translational study of the effects of ketamine and pregabalin on temporal summation of experimental pain. Reg. Anesth. Pain Med. 36, 585-591 (2011)
41. Rabben T, Skjelbred P, Oye I. Prolonged analgesic effect of ketamine, an N-methyl-d-Aspartate receptor inhibitor, in patients with chronic pain. J. Pharmacol. Exp. Ther. 289, 1060-1066 (1999)
42. Chizh BA, Headley PM, Tzschentke TM. NMDA receptor antagonists as analgesics: Focus on the NR2B subtype. Trends Pharmacol. Sci. 22, 636-642 (2001)
43. Sherrington CS, Sowton SC. Observations on reflex responses to single break-shots. J. Physiol. 49, 331-348 (1915)
44. Bernard C. Lecons sur le physiologie et la pathologie du systeme nerveaux. Baillere, Paris, France (1858)
45. Sillery E, Bittar RG, Robson MD et al. Connectivity of the human periventricular-periaqueductal gray region. J. Neurosurg. 103, 1030-1034 (2005)
46. Millan MJ. Descending control of pain. Prog. Neurobiol. 66, 355-474 (2002)
47. Mayer DJ, Wolfle TL, Akil H, Carder B, Liebeskind JC. Analgesia from electrical stimulation in the brainstem of the rat. Science 174, 1351-1354 (1971)
48. Hosobuchi Y, Adams JE, Linchitz R. Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. Science 197, 183-186 (1977)
49. Mantyh PW. Connections of midbrain periaqueductal gray in the monkey. II. Descending efferent projections. J. Neurophysiol. 49, 582-594 (1983)
50. Mantyh PW. Connections of midbrain periaqueductal gray in the monkey. I. Ascending efferent projections. J. Neurophysiol. 49, 567-581 (1983)
51. Swett JE, McMahon SB, Wall PD. Long ascending projections to the midbrain from cells of lamina I and nucleus of the dorsolateral funiculus of the rat spinal cord. J. Comp. Neurol. 238, 401-416 (1985)
52. Yelle MD, Rogers JM, Coghill RC. Offset analgesia: A temporal contrast mechanism for nociceptive information. Pain 134, 174-186 (2008)
53. Yelle MD, Oshiro Y, Kraft RA, Coghill RC. Temporal filtering of nociceptive information by dynamic activation of endogenous pain modulatory systems. J. Neurosci. 29, 10264-10271 (2009)
54. Rennefeld C, Wiech K, Schoell ED, Lorenz J, Bingel U. Habituation to pain: Further support for a central component. Pain 148, 503-508 (2010)
55. Roby-Brami A, Bussel B, Willer JC, Le Bars D. An electrophysiological investigation into the pain-relieving effects of heterotopic nociceptive stimuli. Probable involvement of a supraspinal loop. Brain 110, 1497-1508 (1987)
56. Bouhassira D, Villanueva L, Bing Z, Le Bars D. Involvement of the subnucleus reticularis dorsalis in diffuse noxious inhibitory controls in the rat. Brain Res. 595, 353-357 (1992)
57. Villanueva L, Bouhassira D, Le Bars D. The medullary subnucleus reticularis dorsalis (SRD) as a key link in both the transmission and modulation of pain signals. Pain 67, 231-240 (1996)
58. Desbois C, Villanueva L. The organization of lateral ventromedial thalamic connections in the rat: A link for the distribution of nociceptive signals to widespread cortical regions. Neuroscience 102, 885-898 (2001)
59. Desbois C, Le Bars D, Villanueva L. Organization of cortical projections to the medullary subnucleus reticularis dorsalis: A retrograde and anterograde tracing study in the rat. J. Comp. Neurol. 410, 178-196 (1999)
60. Goffaux P, Redmond WJ, Rainville P, Marchand S. Descending analgesia - when the spine echoes what the brain expects. Pain 130, 137-143 (2007)
61. Wilder-Smith CH, Schindler D, Lovblad K, Redmond SM, Nirkko A. Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls. Gut 53, 1595-1601 (2004)
62. Shyu BC, Sikes RW, Vogt LJ, Vogt BA. Nociceptive processing by anterior cingulate pyramidal neurons. J. Neurophysiol. 103, 3287-3301 (2010)
63. Edwards RR, Ness TJ, Weigent DA, Fillingim RB. Individual differences in diffuse noxious inhibitory controls (DNIC): Association with clinical variables. Pain 106, 427-437 (2003)
64. Yarnitsky D, Sprecher E, Zaslansky R, Hemli JA. Heat pain thresholds: Normative data and repeatability. Pain 60, 329-332 (1995)
65. Gracely RH, Grant MAB, Giesecke T. Evoked pain measures in fibromyalgia. Best Pract. Res. Clin. Rheumatol. 17, 593-609 (2003)
66. Coghill RC, McHaffie JG, Yen YF. Neural correlates of interindividual differences in the subjective experience of pain. Proc. Natl Acad. Sci. USA 100, 8538-8542 (2003)
67. Flores CM, Mogil JS. The pharmacogenetics of analgesia: Toward a genetically-based approach to pain management. Pharmacogenomics 2, 177-194 (2001)
68. Lariviere WR, Wilson SG, Laughlin TM et al. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity. Pain 97, 75-86 (2002)
69. Wilson SG, Smith SB, Chesler EJ et al. The heritability of antinociception: Common pharmacogenetic mediation of five neurochemically distinct analgesics. J. Pharmacol. Exp. Ther. 304, 547-559 (2003)
70. Diatchenko L, Anderson AD, Slade GD et al. Three major haplotypes of the beta 2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141B, 449-462 (2006)
71. Kim H, Neubert JK, San MA et al. Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain 109, 488-496 (2004)
72. Smith SB, Maixner DW, Fillingim RB et al. Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia. Arthritis Rheum. 64(2), 584-593 (2012)
73. Reimann F, Cox JJ, Belfer I et al. Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc. Natl Acad. Sci. USA 107, 5148-5153 (2010)
74. Zubieta JK, Heitzeg MM, Smith YR et al. COMT val158met genotype affects μ-opioid neurotransmitter responses to a pain stressor. Science 299, 1240-1243 (2003)
75. Taddio A, Katz J, Ilersich AL, Koren G. Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet 349, 599-603 (1997)
76. Taddio A, Shah V, Gilbert-MacLeod C, Katz J. Conditioning and hyperalgesia in newborns exposed to repeated heel lances. JAMA 288, 857-861 (2002)
77. Scarinci IC, McDonald-Haile J, Bradley LA, Richter JE. Altered pain perception and psychosocial features among women with gastrointestinal disorders and history of abuse: A preliminary model. Am. J. Med. 97, 108-118 (1994)
78. Fillingim RB, Wilkinson CS, Powell T. Self-reported abuse history and pain complaints among young adults. Clin. J. Pain 15, 85-91 (1999)
79. Lampe A, Doering S, Rumpold G et al. Chronic pain syndromes and their relation to childhood abuse and stressful life events. J. Psychosom. Res. 54, 361-367 (2003)
80. Goldberg RT, Goldstein R. A comparison of chronic pain patients and controls on traumatic events in childhood. Disabil Rehabil. 22, 756-763 (2000)
81. Sullivan MJL, Thorn B, Haythornthwaite JA et al. Theoretical perspectives on the relation between catastrophizing and pain. Clin. J. Pain 17, 52-64 (2001)
82. Gracely RH, Geisser ME, Giesecke T et al. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain 127, 835-843 (2004)
83. Chitour D, Dickenson AH, Le Bars D. Pharmacological evidence for the involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC). Brain Res. 236, 329-337 (1982)
84. Kraus E, Besson JM, Le Bars D. Behavioral model for diffuse noxious inhibitory controls (DNIC): Potentiation by 5-hydroxytryptophan. Brain Res. 231, 461-465 (1982)
85. Rudnick G, Clark J. From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters. Biochim. Biophys. Acta 1144, 249-263 (1993)
86. Lesch KP, Balling U, Gross J et al. Organization of the human serotonin transporter gene. J. Neural Transm. Gen. Sect. 95, 157-162 (1994)
87. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am. J. Psychiatry 167, 509-527 (2010)
88. Szilagyi A, Boor K, Orosz I et al. Contribution of serotonin transporter gene polymorphisms to pediatric migraine. Headache 46, 478-485 (2006)
89. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol. Psychiatry 15, 18-22 (2010)
90. Offenbacher M, Bondy B, de-Jonge S et al. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum. 42, 2482-2488 (1999)
91. Cohen H, Buskila D, Neumann L, Ebstein RP. Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum. 46, 845-847 (2002)
92. Lindstedt F, Berrebi J, Greayer E et al. Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. PLoS ONE 6, e18252 (2011)
93. Potvin S, Larouche A, Normand E et al. No relationship between the ins del polymorphism of the serotonin transporter promoter and pain perception in fibromyalgia patients and healthy controls. Eur. J. Pain 14, 742-746 (2010)
94. Werner MU, Mjobo HN, Nielsen PR, Rudin A. Prediction of postoperative pain: A systematic review of predictive experimental pain studies. Anesthesiology 112, 1494-1502 (2010)
95. Nikolajsen L, Ilkjaer S, Jensen TS. Relationship between mechanical sensitivity and postamputation pain: A prospective study. Eur. J. Pain 4, 327-334 (2000)
96. Sng BL, Sia AT, Quek K, Woo D, Lim Y. Incidence and risk factors for chronic pain after caesarean section under spinal anaesthesia. Anaesth. Intensive Care 37, 748-752 (2009)
97. Granot M, Lowenstein L, Yarnitsky D, Tamir A, Zimmer EZ. Postcesarean section pain prediction by preoperative experimental pain assessment. Anesthesiology 98, 1422-1426 (2003)
98. Werner MU, Duun P, Kehlet H. Prediction of postoperative pain by preoperative nociceptive reponses to heat stimulation. Anesthesiology 100, 115-119 (2004)
99. Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Characteristics and prediction of early pain after laparoscopic cholecystectomy. Pain 90, 261-269 (2001)
100. Nielsen PR, Norgaard L, Rasmussen LS, Kehlet H. Prediction of postoperative pain by an electrical pain stimulus. Acta Anaesthesiol. Scand. 51, 582-586 (2007)
101. Landau R, Cardoso M, Lavand'homme P, Granot M, Kraft JC. A multicenter study on the prediction of postoperative pain (PPOP) after cesarian section. Anesthesiology A1282 (2010)
102. Mogil JS, Sternberg WF, Marek P, Sadowski B, Belknap JK, Liebeskind JC. The genetics of pain and pain inhibition. Proc. Natl Acad. Sci. USA 93, 3048-3055 (1996)
103. Mogil JS, Wilson SG, Bon K et al. Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain 80, 83-93 (1999)
104. Mogil JS, Wilson SG, Bon K et al. Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80, 67-82 (1999)
105. Elmer GI, Pieper JO, Negus SS, Woods JH. Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests. Pain 75, 129-140 (1998)
106. Mason P. Contributions of the medullary raphe and ventromedial reticular region to pain modulation and other homeostatic functions. Annu. Rev. Neurosci. 24, 737-777 (2001)
107. Nikolajsen L, Sorensen HC, Jensen TS, Kehlet H. Chronic pain following Caesarean section. Acta Anaesthesiol. Scand. 48, 111-116 (2004)
108. Lundblad H, Kreicbergs A, Jansson KA. Prediction of persistent pain after total knee replacement for osteoarthritis. J. Bone Joint Surg. Br. 90, 166-171 (2008)
109. Mikkelsen T, Werner MU, Lassen B, Kehlet H. Pain and sensory dysfunction 6 to 12 months after inguinal herniotomy. Anesth. Analg. 99, 146-151 (2004)
110. Macdonald L, Bruce J, Scott NW, Smith WC, Chambers WA. Long-term follow-up of breast cancer survivors with post-mastectomy pain syndrome. Br. J. Cancer 92, 225-230 (2005)
111. Senturk M, Ozcan PE, Talu GK et al. The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth. Analg. 94, 11 (2002)
112. Slade GD, Bair E, By K et al. Study methods, recruitment, sociodemographic findings, and demographic representativeness in the OPPERA study. J. Pain 12, T12-T26 (2011)
113. Roth ML, Tripp DA, Harrison MH, Sullivan M, Carson P. Demographic and psychosocial predictors of acute perioperative pain for total knee arthroplasty. Pain Res. Manag. 12, 185-194 (2007)
114. Katz J, Poleshuck EL, Andrus CH et al. Risk factors for acute pain and its persistence following breast cancer surgery. Pain 119, 16-25 (2005)
115. Perkins FM, Kehlet H. Chronic pain as an outcome of surgery. A review of predictive factors. Anesthesiology 93, 1123-1133 (2000)
116. Putzke JD, Richards JS, Hicken BL, Devivo MJ. Interference due to pain following spinal cord injury: Important predictors and impact on quality of life. Pain 100, 231-242 (2002)
117. Stammberger U, Steinacher C, Hillinger S, Schmid RA, Kinsbergen T, Weder W. Early and long-term complaints following video-Assisted thoracoscopic surgery: Evaluation in 173 patients. Eur. J. Cardiothorac. Surg. 18, 7-11 (2000)
118. Haythornthwaite JA, Raja SN, Fisher B, Frank SM, Brendler CB, Shir Y. Pain and quality of life following radical retropubic prostatectomy. J. Urol. 160, 1761-1764 (1998)
119. Gartner R, Jensen MB, Nielsen J, Ewertz M, Kroman N, Kehlet H. Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA 302, 1985-1992 (2009)
120. Opstelten W, Zuithoff NP, van Essen GA et al. Predicting postherpetic neuralgia in elderly primary care patients with herpes zoster: Prospective prognostic study. Pain 132, S52-S59 (2007)
121. Drolet M, Brisson M, Schmader K et al. Predictors of postherpetic neuralgia among patients with herpes zoster: A prospective study. J. Pain 11, 1211-1221 (2010)
122. Jung BF, Johnson RW, Griffin DR, Dworkin RH. Risk factors for postherpetic neuralgia in patients with herpes zoster. Neurology 62, 1545-1551 (2004)
123. Yunus MB. Central sensitivity syndromes: A new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. Semin. Arthritis Rheum. 37, 339-352 (2008)
124. Neogi T, Felson D, Niu JB et al. Association between radiographic features of knee osteoarthritis and pain: Results from two cohort studies. BMJ 339, b2844 (2009)
125. Kalichman L, Kim DH, Li L, Guermazi A, Hunter DJ. Computed tomography-evaluated features of spinal degeneration: Prevalence, intercorrelation, and association with self-reported low back pain. Spine J. 10, 200-208 (2010)
126. Jacobs JW, Rasker JJ, van-der-Heide A et al. Lack of correlation between the mean tender point score and self-reported pain in fibromyalgia. Arthritis Care Res. 9, 105-111 (1996)
127. Price DD, Staud R, Robinson ME, Mauderli AP, Cannon RL, Vierck CJ. Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients. Pain 99, 49-59 (2002)
128. Lautenbacher S, Rollman GB. Possible deficiencies of pain modulation in fibromyalgia. Clin. J. Pain 13, 189-196 (1997)
129. Kosek E, Ekholm J. Modulation of pressure pain thresholds during and following isometric contraction. Pain 61, 481-486 (1995)
130. Staud R, Robinson ME, Price DD. Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared with normal controls. Pain 118, 176-184 (2005)
131. King CD, Wong F, Currie T, Mauderli AP, Fillingim RB, Riley JL. Deficiency in endogenous modulation of prolonged heat pain in patients with irritable bowel syndrome and temporomandibular disorder. Pain 143, 172-178 (2009)
132. Smith BW, Tooley EM, Montague EQ, Robinson AE, Cosper CJ, Mullins PG. Habituation and sensitization to heat and cold pain in women with fibromyalgia and healthy controls. Pain 140, 420-428 (2008)
133. De Tommaso M, Federici A, Santostasi R et al. Laser-evoked potentials habituation in fibromyalgia. J. Pain 12, 116-124 (2011)
134. Staud R, Vierck CJ, Robinson ME, Price DD. Spatial summation of heat pain within and across dermatomes in fibromyalgia patients and pain-free subjects. Pain 111, 342-350 (2004)
135. Staud R, Koo E, Robinson ME, Price DD. Spatial summation of mechanically evoked muscle pain and painful aftersensations in normal subject and fibromyalgia patients. Pain 130, 177-187 (2007)
136. Goffaux P, De Souza JB, Potvin S, Marchand S. Pain relief through expectation supersedes descending inhibitory deficits in fibromyalgia patients. Pain 145, 18-23 (2009)
137. Arendt-Nielsen L, Nie H, Laursen MB et al. Sensitization in patients with painful knee osteoarthritis. Pain 149, 573-581 (2010)
138. Price DD. Characterizing central mechanisms of pathological pain states by sensory testing and neurophysiological analysis. In: Pain and Central Nervous System Disease: Mechanisms and Assessment. Casey KL (Ed.). Raven Press, NY, USA 103-115 (1991)
139. Cook AJ, Woolf CJ, Wall PD. Prolonged C-fibre mediated facilitation of the flexion reflex in the rat is not due to changes in afferent terminal or motoneurone excitability. Neurosci. Lett. 70, 91-96 (1986)
140. Dubner R. Neuronal plasticity and pain following peripheral tissue inflammation or nerve injury. In: Proceedings of Vth World Congress on Pain. Bond M, Charlton E, Woolf CJ (Eds). Elsevier, Amsterdam, The Netherlands 263-276 (1991)
141. Woolf CJ. Windup and central sensitization are not equivalent. Pain 66, 105-108 (1996)
142. Kosek E, Ordeberg G. Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment. Eur. J. Pain 4, 229-238 (2000)
143. Gwilym SE, Keltner JR, Warnaby CE et al. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum. 61, 1226-1234 (2009)
144. Gwilym SE, Fillipini N, Douaud G, Carr AJ, Tracey I. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty; a longitudinal voxel-based morphometric study. Arthritis Rheum. 62, 2930-2940 (2010)
145. Kehlet H. Effect of postoperative pain treatment on outcome - Current status and future strategies. Langenbecks Arch. Surg. 389, 244-249 (2004)
146. Linton SJ, Ryberg M. A cognitive- behavioral group intervention as prevention for persistent neck and back pain in a non-patient population: A randomized controlled trial. Pain 90, 83-90 (2001)