Sensitization of cisplatin therapy by a naphthalimide based organoselenium compound through modulation of antioxidant enzymes and p53 mediated apoptosis

Free Radical Research

Volumn 49, Issue 4, 2015, Pages 453-471

  Ghosh, P ^a   Singha Roy, S ^a   Basu, A ^a   Bhattacharjee, A ^a   Bhattacharya, S ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

Author keywords

Anti cancer drug; Antioxidant; Apoptosis; Oxidative stress; Selenium

Indexed keywords

2 (5 SELENOCYANATO PENTYL) BENZO[DE]ISOQUINOLINE 1,3 DIONE; ANTIOXIDANT; CATALASE; CISPLATIN; CREATININE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEMOGLOBIN; NAPHTHALIMIDE DERIVATIVE; NITRIC OXIDE; ORGANOSELENIUM DERIVATIVE; PROTEIN P53; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; 2-(5-SELENOCYANATOPENTYL)BENZO(DE)ISOQUINOLINE-1,3-DIONE; ANTINEOPLASTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHROMOSOME ABERRATION; COMET ASSAY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DNA DAMAGE; DRUG EFFICACY; DRUG SENSITIZATION; EHRLICH ASCITES TUMOR; EHRLICH ASCITES TUMOR CELL; ENZYME ACTIVITY; FEMALE; GENOTOXICITY; LIPID PEROXIDATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; UREA NITROGEN BLOOD LEVEL; ANIMAL; CARCINOMA, EHRLICH TUMOR; DRUG EFFECTS; ENZYMOLOGY; KIDNEY; METABOLISM;

ANIMALIA; MUS;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANTIOXIDANTS; APOPTOSIS; CARCINOMA, EHRLICH TUMOR; CHROMOSOME ABERRATIONS; CISPLATIN; DNA DAMAGE; FEMALE; KIDNEY; MICE; NAPHTHALIMIDES; ORGANOSELENIUM COMPOUNDS; OXIDATIVE STRESS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84927648757     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2015.1012079     Document Type: Article

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