Protective effect of a lignan-containing flaxseed extract against CCl 4-induced hepatic injury

Journal of Veterinary Medical Science

Volumn 64, Issue 9, 2002, Pages 761-765

  Endoh, Daiji ^a   Okui, Toyo ^b   Ozawa, Shuji ^a   Yamato, Osamu ^c   Kon, Yasuhiro ^c   Arikawa, Jiro ^d   Hayashi, Masanobu ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Carbon tetrachloride induced liver injury; Comet assay; Flaxseed extract; Glutathione; Lignan

Indexed keywords

CARBON TETRACHLORIDE; GLUTATHIONE; LIGNAN; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DNA DAMAGE; DRUG ADMINISTRATION; DRUG ANTAGONISM; DRUG EFFECT; FLAX; GENETICS; LIVER; LIVER DISEASE; METABOLISM; NECROSIS; PATHOLOGY; RAT; RAT STRAIN;

ANIMALS; CARBON TETRACHLORIDE; DNA DAMAGE; DRUG ADMINISTRATION SCHEDULE; FLAX; GLUTATHIONE; LIGNANS; LIVER; LIVER DISEASES; NECROSIS; PLANT EXTRACTS; RATS; RATS, INBRED STRAINS;

EID: 0036715953     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.64.761     Document Type: Article

References (32)

1. Adlercreutz, C. H., Goldin, B. R., Gorbach, S. L., Hockerstedt, K. A., Watanabe, S., Hamalainen, E. K., Markkanen, M. H., Makela, T. H., Wahala, K. T. and Adlercreutz, T. 1995. Soybean phytoestrogen intake and cancer risk. J. Nutr. 125: 757S-770S.
2. Ahmad, F. F., Cowan, D. L. and Sun, A. Y. 1987. Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil. Life Sci. 41: 2469-2475.
3. Campo, G. M., Squadrito, F., Ceccarelli, S., Calo, M., Avenoso, A., Campo, S., Squadrito, G. and Altavilla, D. 2001. Reduction of carbon tetrachloride-induced rat liver injury by IRFI 042, a novel dual vitamin E-like antioxidant. Free Radic. Res. 34: 379-393.
4. 4-induced hepatotoxicity in rats: effect of astilbin. Prostaglandins Leukot. Essent. Fatty Acids 56: 331-334.
5. 4 in the perfused rat liver and in vivo. J. Biol. Chem. 261: 4542-4548.
6. Cotelle, S. and Ferard, J. F. 1999. Comet assay in genetic ecotoxicology: a review. Environ. Mol. Mutagen. 34: 246-255.
7. Frank, H., Thiel, D. and MacLeod, J. 1989. Mass spectrometric detection of cross-linked fatty acids formed during radical-induced lesion of lipid membranes. Biochem. J. 260: 873-878.
8. Kitts, D. D., Yuan, Y. V., Wijewickreme, A. N. and Thompson, L. U. 1999. Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol. Cell Biochem. 202: 91-100.
9. Ko, K. M., Ip, S. P., Poon, M. K., Wu, S. S., Che, C. T., Ng, K. H. and Kong, Y. C. 1995. Effect of a lignan-enriched fructus schisandrae extract on hepatic glutathione status in rats: protection against carbon tetrachloride toxicity. Planta Med. 61: 134-137.
10. Ko, K. M., Mak, D. H., Li, P. C., Poon, M. K. and Ip, S. P. 1995. Enhancement of hepatic glutathione regeneration capacity by a lignan- enriched extract of fructus schisandrae in rats. Jpn. J. Pharmacol. 69: 439-442.
11. Lacagnin, L. B., Connor, H. D., Mason, R. P. and Thurman, R. G. 1988. The carbon dioxide anion radical adduct in the perfused rat liver: relationship to halocarbon-induced toxicity. Mol. Pharmacol. 33: 351-357.
12. Li, D., Yee, J. A., Thompson, L. U. and Yan, L. 1999. Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice. Cancer Lett. 142: 91-96.
13. Mansuy, D., Sassi, A., Dansette, P. M. and Plat, M. 1986. A new potent inhibitor of lipid peroxidation in vitro and in vivo, the hepatoprotective drug anisyldithiolthione. Biochem. Biophys. Res. Commun. 135: 1015-1021.
14. McKelvey-Martin, V. J., Green, M. H., Schmezer, P., Pool-Zobel, B. L., De Meo, M. P. and Collins, A. 1993. The single cell gel electrophoresis assay (comet assay): a European review. Mutat. Res. 288: 47-63.
15. Meagher, L. P., Beecher, G. R., Flanagan, V. P. and Li, B. W. 1999. Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal. J. Agric. Food Chem. 47: 3173-3180.
16. Mitchelmore, C. L. and Chipman, J. K. 1998. DNA strand breakage in aquatic organisms and the potential value of the comet assay in environmental monitoring. Mutat. Res. 399: 135-147.
17. Muir, A. D. and Westcott, N. D. 2000. Quantitation of the lignan secoisolariciresinol diglucoside in baked goods containing flax seed or flax meal. J. Agric. Food Chem. 48: 4048-4052.
18. Pool-Zobel, B. L., Adlercreutz, H., Glei, M., Liegibel, U. M., Sittlingon, J., Rowland, I., Wahala, K. and Rechkemmer, G. 2000. Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells. Carcinogenesis 21: 1247-1252.
19. Prasad, K. 1997. Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed. Mol. Cell Biochem. 168: 117-123.
20. Prasad, K. 1999. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 99: 1355-1362.
21. Prasad, K. 2001. Secoisolariciresinol diglucoside from flax-seed delays the development of type II diabetes in Zucker rat. J. Lab. Clin. Med. 138: 32-39.
22. Prasad, K., Mantha, S. V., Muir, A. D. and Westcott, N. D. 2000. Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism. Mol. Cell Biochem. 206: 141-149.
23. Sasaki, Y. F., Saga, A., Akasaka, M., Ishibashi, S., Yoshida, K., Su, Y. Q., Matsusaka, N. and Tsuda, S. 1998. Detection of in vivo genotoxicity of haloalkanes and haloalkenes carcinogenic to rodents by the alkaline single cell gel electrophoresis (comet) assay in multiple mouse organs. Mutat. Res. 419: 13-20.
24. Shibuya, K., Sasai, K., Xie, X., Utsumi, H., Shibata, T. and Hiraoka, M. 1999. Detection of hypoxic cells in murine tumors using the comet assay: comparison with a conventional radiobiological assay. Jpn. J. Cancer Res. 90: 880-886.
25. Singh, N. P., McCoy, M. T., Tice, R. R. and Schneider, E. L. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175: 184-191.
26. 4-induced toxicity in primary cultures of rat hepatocytes. Biol. Pharm. Bull. 23: 666-668.
27. Tafazoli, M., Baeten, A., Geerlings, P. and Kirsch-Volders, M. 1998. In vitro mutagenicity and genotoxicity study of a number of short-chain chlorinated hydrocarbons using the micronucleus test and the alkaline single cell gel electrophoresis technique (Comet assay) in human lymphocytes: a structure-activity relationship (QSAR) analysis of the genotoxic and cytotoxic potential. Mutagenesis 13: 115-126.
28. Taylor, S. L. and Tappel, A. L. 1976. Effect of dietary antioxidants and phenobarbital pretreatment on microsomal lipid peroxidation and activation by carbon tetrachloride. Life Sci. 19: 1151-1160.
29. Thompson, L. U. 1994. Antioxidants and hormone-mediated health benefits of whole grains. Crit Rev. Food Sci. Nutr. 34: 473-497.
30. Tietze, F. 1969. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Analytical Biochem. 27: 502-522.
31. 4-injured primary cultures of rat hepatocytes. J. Pharm. Pharmacol. 52: 1163-1169.
32. 4 intoxication model. J. Ethnopharmacol. 67: 61-68.