Electrophoretic mobility as a tool to separate immune adjuvant saponins from Quillaja saponaria Molina

International Journal of Pharmaceutics

Volumn 487, Issue 1-2, 2015, Pages 39-48

  Gilabert Oriol, Roger ^a   Weng, Alexander ^a   Von Mallinckrodt, Benedicta ^a   Stöshel, Anja ^a   Nissi, Linda ^a   Melzig, Matthias F ^b   Fuchs, Hendrik ^a   Thakur, Mayank ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Cytotoxicity; Electrophoresis; Hemolysis; Immune adjuvant; Quillaja saponins

Indexed keywords

AGAROSE; CYTOTOXIC AGENT; HEMOLYTIC AGENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2B; QS 21; QUILLAJA SAPONIN; IMMUNOLOGICAL ADJUVANT;

ADJUVANT THERAPY; AGAR GEL ELECTROPHORESIS; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CANCER CELL LINE; CELL MIGRATION; CHEMICAL ANALYSIS; CLINICAL EVALUATION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; ELECTROPHORETIC MOBILITY; ERYTHROCYTE; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PHASE SEPARATION; PRIORITY JOURNAL; QUALITY CONTROL; QUILLAJA SAPONARIA; SAPONARIA; SEPARATION TECHNIQUE; SPLEEN CELL; THIN LAYER CHROMATOGRAPHY; VACCINATION; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GEL MOBILITY SHIFT ASSAY; IN VITRO STUDY; ISOLATION AND PURIFICATION; QUILLAJA; SPLEEN; TUMOR CELL LINE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEMOLYSIS; HUMANS; IN VITRO TECHNIQUES; MICE; MICE, INBRED BALB C; QUILLAJA; QUILLAJA SAPONINS; SPLEEN;

EID: 84927646058     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.03.063     Document Type: Article

References (39)

1. C.R. Alving, K.K. Peachman, M. Rao, and S.G. Reed Adjuvants for human vaccines Curr. Opin. Immunol. 24 2012 310 315
2. J. Bankefors, S. Broberg, L.I. Nord, and L. Kenne Electrospray ionization ion-trap multiple-stage mass spectrometry of Quillaja saponins J. Mass Spectrom. 46 2011 658 665
3. J. Bankefors, L.I. Nord, and L. Kenne Structural classification of acyl-substituted Quillaja saponins by electrospray ionisation ion trap multiple-stage mass spectrometry in combination with multivariate analysis Rapid Commun. Mass Spectrom. 22 2008 3851 3860
4. C. Barnier Quer, A. Elsharkawy, S. Romeijn, A. Kros, and W. Jiskoot Cationic liposomes as adjuvants for influenza hemagglutinin: more than charge alone Eur. J. Pharm. Biopharm. 81 2012 294 302
5. I.G. Barr, A. Sjölander, and J.C. Cox ISCOMs and other saponin based adjuvants Adv. Drug Deliv. Rev. 32 1998 247 271
6. A. Bermudez, C. Reyes, F. Guzman, M. Vanegas, J. Rosas, R. Amador, R. Rodriguez, M.A. Patarroyo, and M.E. Patarroyo Synthetic vaccine update: applying lessons learned from recent SPf66 malarial vaccine physicochemical, structural and immunological characterization Vaccine 25 2007 4487 4501
7. D. Chen, and D. Zehrung Desirable attributes of vaccines for deployment in low-resource settings J. Pharm. Sci. 102 2013 29 33
8. M.L. Chen, W. Hu, C. Zhang, and Y. Fang Capillary electrophoresis method for the determination of flavonoids Acta Pharm. Sin. 46 2011 883 889
9. Dalsgaard A study of the isolation and characterization of the saponin Quil A. Evaluation of its adjuvant activity, with a special reference to the application in the vaccination of cattle against foot-and-mouth disease Acta Vet. Scand. Suppl. 1978 7 40
10. F. de Costa, A.C. Yendo, J.D. Fleck, G. Gosmann, and A.G. Fett-Neto Immunoadjuvant and anti-inflammatory plant saponins: characteristics and biotechnological approaches towards sustainable production Mini Rev. Med. Chem. 11 2011 857 880
11. T.C. Do, T.D. Nguyen, H. Tran, H. Stuppner, and M. Ganzera Analysis of alkaloids in Lotus (Nelumbo nucifera Gaertn.) leaves by non-aqueous capillary electrophoresis using ultraviolet and mass spectrometric detection J. Chromatogr. A 2013
12. D.R. Flower Systematic identification of small molecule adjuvants Expert Opin. Drug Discov. 7 2012 807 817
13. H. Fuchs, D. Bachran, H. Panjideh, N. Schellmann, A. Weng, M.F. Melzig, M. Sutherland, and C. Bachran Saponins as tool for improved targeted tumor therapies Curr. Drug Targets 10 2009 140 151
14. R. Gevrenova, L. Voutquenne-Nazabadioko, D. Harakat, E. Prost, and M. Henry Complete 1H- and 13C NMR assignments of saponins from roots of Gypsophila trichotoma Wend Magn. Reson. Chem. 44 2006 686 691
15. R. Gilabert-Oriol, K. Mergel, M. Thakur, B. von Mallinckrodt, M.F. Melzig, H. Fuchs, and A. Weng Real-time analysis of membrane permeabilizing effects of oleanane saponins Bioorg. Med. Chem. 21 2013 2387 2395
16. M.P. Godoy-Caballero, M.I. Acedo-Valenzuela, I. Duran-Meras, and T. Galeano-Diaz Development of a non-aqueous capillary electrophoresis method with UV-visible and fluorescence detection for phenolics compounds in olive oil Anal. Bioanal. Chem. 403 2012 279 290
17. K. Hollo, T.T. Glant, M. Garzo, A. Finnegan, K. Mikecz, and E. Buzas Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis Clin. Exp. Immunol. 120 2000 167 173
18. H.J. Issaq Capillary electrophoresis of natural products-II Electrophoresis 20 1999 3190 3202
19. C.R. Kensil, U. Patel, M. Lennick, and D. Marciani Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex J. Immunol. 146 1991 431 437
20. C.R. Kensil Saponins as vaccine adjuvants Crit. Rev. Ther. Drug Carrier Syst. 13 1996 1 55
21. Y.J. Kim, P. Wang, M. Navarro-Villalobos, B.D. Rohde, J. Derryberry, and D.Y. Gin Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi J. Am. Chem. Soc. 128 2006 11906 11915
22. M.A. Lacaille-Dubois Bioactive saponins with cancer related and immunomodulatory activity: recent developments Stud. Nat. Prod. Chem. 32 2005 209 246
23. Y. Ma, Y. Zhuang, X. Xie, C. Wang, F. Wang, D. Zhou, J. Zeng, and L. Cai The role of surface charge density in cationic liposome-promoted dendritic cell maturation and vaccine-induced immune responses Nanoscale 3 2011 2307 2314
24. M.L. Mbow, E. De Gregorio, N.M. Valiante, and R. Rappuoli New adjuvants for human vaccines Curr. Opin. Immunol. 22 2010 411 416
25. M.J. Newman, J.Y. Wu, B.H. Gardner, C.A. Anderson, C.R. Kensil, J. Recchia, R.T. Coughlin, and M.F. Powell Induction of cross-reactive cytotoxic T-lymphocyte responses specific for HIV-1 gp120 using saponin adjuvant (QS-21) supplemented subunit vaccine formulations Vaccine 15 1997 1001 1007
26. L.I. Nord, L. Kenne, and S.P. Jacobsson Multivariate analysis of 1H NMR spectra for saponins from Quillaja saponaria Molina Anal. Chim. Acta 446 2000 197 207
27. D.T. O'Hagan, and E. De Gregorio The path to a successful vaccine adjuvant - 'the long and winding road' Drug Discov. Today 14 2009 541 551
28. J.B. Press, R.C. Reynolds, R.D. May, and D. Marciani Structure/function relationships of immunostimulating saponins Stud. Nat. Prod. Chem. 24 2000 131 174
29. J. Rhodes Evidence for an intercellular covalent reaction essential in antigen-specific T cell activation J. Immunol. 143 1989 1482 1489
30. R. San Martín, and R. Briones Quality control of commercial quillaja (Quillaja saponaria Molina) extracts by reverse phase HPLC J. Sci. Food Agric. 80 2000 2063 2068
31. C.D. Skene, and P. Sutton Saponin-adjuvanted particulate vaccines for clinical use Methods 40 2006 53 59
32. S. Soltysik, J.Y. Wu, J. Recchia, D.A. Wheeler, M.J. Newman, R.T. Coughlin, and C.R. Kensil Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function Vaccine 13 1995 1403 1410
33. S.G. Sparg, M.E. Light, and J. van Staden Biological activities and distribution of plant saponins J. Ethnopharmacol. 94 2004 219 243
34. D.M. Strong, A.A. Ahmed, G.B. Thurman, and K.W. Sell In vitro stimulation of murine spleen cells using a microculture system and a multiple automated sample harvester J. Immunol. Methods 2 1973 279 291
35. Y. Sun, H. Tong, M. Li, Y. Li, S. Guan, and J. Liu Immunological adjuvant effect of Japanese ginseng saponins (JGS) on specific antibody and cellular response to ovalbumin and its haemolytic activities Vaccine 26 2008 5911 5917
36. H.X. Sun, Y. Xie, and Y.P. Ye Advances in saponin-based adjuvants Vaccine 27 2009 1787 1796
37. M. Thakur, A. Weng, D. Bachran, S.B. Riese, S. Bottger, M.F. Melzig, and H. Fuchs Electrophoretic isolation of saponin fractions from Saponinum album and their evaluation in synergistically enhancing the receptor-specific cytotoxicity of targeted toxins Electrophoresis 32 2011 3085 3089
38. V.C. Trenerry The application of capillary electrophoresis to the analysis of vitamins in food and beverages Electrophoresis 22 2001 1468 1478
39. P. Vandepapeliere, Y. Horsmans, P. Moris, M. Van Mechelen, M. Janssens, M. Koutsoukos, P. Van Belle, F. Clement, E. Hanon, M. Wettendorff, N. Garcon, and G. Leroux-Roels Vaccine adjuvant systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers Vaccine 26 2008 1375 1386