Water extract of Cinnamomum cassia suppresses angiogenesis through inhibition of VEGF receptor 2 phosphorylation

Bioscience, Biotechnology and Biochemistry

Volumn 79, Issue 4, 2015, Pages 617-624

  Kim, Eok Cheon ^a   Kim, Hye Jin ^a   Kim, Tack Joong ^a  

^a Yonsei University Wonju   (South Korea)

Author keywords

Angiogenesis; Cinnamomum cassia; Vascular endothelial growth factor (VEGF); VEGFR2 phosphorylation angiogenesis

Indexed keywords

BLOOD VESSELS; CELL SIGNALING; DISEASES; ENZYME ACTIVITY; EXTRACTION; PHOSPHORYLATION;

ANGIOGENESIS; CINNAMOMUM CASSIAS; HERBAL MEDICINES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; INTRACELLULAR SIGNALING; MATRIX METALLOPROTEINASES; POTENTIAL TARGETS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

ENDOTHELIAL CELLS;

CINNAMOMUM AROMATICUM; RATTUS;

ANGIOGENESIS INHIBITOR; MAPK1 PROTEIN, HUMAN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PLANT EXTRACT; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; VEGFA PROTEIN, HUMAN; WATER;

ANGIOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; CINNAMOMUM CASSIA; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MALE; METABOLISM; PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; CELL MOVEMENT; CELL PROLIFERATION; CINNAMOMUM AROMATICUM; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOVASCULARIZATION, PHYSIOLOGIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; WATER;

EID: 84927589868     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1080/09168451.2014.993917     Document Type: Article

References (55)

1. Pepper MS. Manipulating angiogenesis: from basic science to the bedside. Arterioscler. Thromb. Vasc. Biol. 1997;17:605-619.
2. Senan S, Smit EF. Design of clinical trials of radiation combined with antiangiogenic therapy. Oncologist. 2007;12:465-477.
3. Borek C. Dietary antioxidants and human cancer. Integr. Cancer Ther. 2004;3:333-341.
4. Li XW, Li J, Werff H. "Cinnamomum cassia". Flora of China; St. Louis (MO): Missouri Botanical Garden, Cambridge (MA): Harvard University Herbaria; p. 186 (2013).
5. Wijesekera RO. Historical overview of the cinnamon industry. Crit. Rev. Food Sci. Nutr. 1978;10:1-30.
6. Nohara T, Kashiwada Y, Nishioka I. Cinncassiol E, a diterpene from the bark of Cinnamomum cassia. Phytochemistry. 1985;24:1849-1850.
7. Lin RJ, Cheng MJ, Huang JC, Lo WL, Yeh YT, Yen CM, Lu CM, Chen CY. Cytotoxic compounds from the stems of Cinnamomum tenuifolium. J. Nat. Prod. 2009;72:1816-1824.
8. Ngoc TM, Lee I, Ha DT, Kim H, Min B, Bae K. Tyrosinaseinhibitory constituents from the twigs of Cinnamomum cassia. J. Nat. Prod. 2009;72:1205-1208.
9. Prasad KN, Yang B, Dong X, Jiang G, Zhang H, Xie H, Jiang Y. Flavonoid contents and antioxidant activities from Cinnamomum species. Innov. Food Sci. Emerg. Technol. 2009;10: 627-632.
10. Miyamura M, Nohara T, Tomimatsu T, Nishiokat I. Seven aromatic compounds from bark of Cinnamomum cassia. Phytochemistry. 1983;22:215-218.
11. Ooi LS, Li Y, Kam SL, Wang H, Wong EY, Ooi VE. Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia blume. Am. J. Chin. Med. 2006;34:511-522.
12. Matan N, Rimkeeree H, Mawson AJ, Chompreeda P, Haruthaithanasan V, Parker M. Antimicrobial activity of cinnamon and clove oils under modified atmosphere conditions. Int. J. Food Microbiol. 2006;107:180-185.
13. Lin CC, Wu SJ, Chang CH, Ng LT. Antioxidant activity of Cinnamomum cassia. Phytother. Res. 2003;17:726-730.
14. Lee JS, Jeon SM, Park EM, Huh TL, Kwon OS, Lee MK, Choi MS. Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J. Med. Food. 2003;6:183-191.
15. Shiraga Y, Okano K, Akira T, Fukaya C, Yokoyama K, Tanaka S, Fukui H, Tabata M. Structures of potent antiulcerogenic compounds from Cinnamomum cassia. Tetrahedron. 1988;44: 4703-4711.
16. Verspohl EJ, Bauer K, Neddermann E. Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro. Phytother. Res. 2005;19:203-206.
17. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003;26:3215-3218.
18. Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J. Ethnopharmacol. 2006;104:119-123.
19. Nagai H, Shimazawa T, Matsuura N, Koda A. Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq). I. Anti-allergic action. Jpn. J. Pharmacol. 1982;32:813-822.
20. Kamei T, Kumano H, Iwata K, Nariai Y, Matsumoto T. The effect of a traditional Chinese prescription for a case of lung carcinoma. J. Altern. Complement. Med. 2000;6:557-559.
21. Schoene NW, Kelly MA, Polansky MM, Anderson RA. Watersoluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines. Cancer Lett. 2005;230:134-140.
22. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, Kozlowski JM, McEwan RN. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 1987;47:3239-3245.
23. Hanemaaijer R, Koolwijk P, Le Clercq L, De Vree WJ, Van Hinsbergh VWM. Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Biochem. J. 1993;296:803-809.
24. Lee OH, Kim YM, Lee YM, Moon EJ, Lee DJ, Kim JH, Kim KW, Kwon YG. Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 1999;264:743-750.
25. Brown KJ, Maynes SF, Bezos A, Maguire DJ, Ford MD, Parish CR. A novel in vitro assay for human angiogenesis. Lab. Invest. 1996;75:539-555.
26. Gordaliza M. Natural products as leads to anticancer drugs. Clin. Transl. Oncol. 2007;9:767-776.
27. Miller JL, Binns HJ, Brickman WJ. Complementary and alternative medicine use in children with type 1 diabetes: a pilot survey of parents. Explore (NY). 2008;4:311-314.
28. Ernst E. Complementary/alternative medicine for disease prevention: The good, the bad and the ugly. Prev. Med. 2009;49:77.
29. Ji HF, Li XJ, Zhang HY. Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fi ght against cancer and dementia? EMBO Rep. 2009;10:194-200.
30. Zhao J, Jiang P, Zhang WD. Molecular networks for the study of TCM pharmacology. Brief Bioinform. 2009;11:417-430.
31. Kwon HK, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, Jeon WK, Ko BS, Im CR, Lee SH, Park ZY, Im SH. Cinnamon extract induces tumor cell death through inhibition of NFêB and AP1. BMC Cancer. 2010;10:392.
32. Ngoc TM, Nhiem NX, Khoi NM, Son DC, Hung TV, Van Kiem P. A new coumarin and cytotoxic activities of constituents from Cinnamomum cassia. Nat. Prod. Commun. 2014;9:487-488.
33. Yu C, Liu SL, Qi MH, Zou X. Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer. Mol. Med. Rep. 2014;9:669-676.
34. Chen TH, Huang YH, Lin JJ, Liau BC, Wang SY, Wu YC, Jong TT. Cytotoxic lignan esters from Cinnamomum osmophloeum. Planta Med. 2010;76:613-619.
35. Choi DY, Baek YH, Huh JE, Ko JM, Woo H, Lee JD, Park DS. Stimulatory effect of Cinnamomum cassia and cinnamic acid on angiogenesis through up-regulation of VEGF and Flk-1/KDR expression. Int. Immunopharmacol. 2009;9:959-967.
36. Song F, Li H, Sun J, Wang S. Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats. J. Ethnopharmacol. 2013;150:125-130.
37. Liao JC, Deng JS, Chiu CS, Hou WC, Huang SS, Shie PH, Huang GJ. Anti-inflammatory activities of Cinnamomum cassia constituents in vitro and in vivo. Evid. Based Complement. Alternat. Med. 2012;2012:1-12.
38. Yeh CF, Chang JS, Wang KC, Shieh DE, Chiang LC. Water extract of Cinnamomum cassia Blume inhibited human respiratory syncytial virus by preventing viral attachment, internalization, and syncytium formation. J. Ethnopharmacol. 2013; 147:321-326.
39. Zeng J, Xue Y, Shu P, Qian H, Sa R, Xiang M, Li XN, Luo Z, Yao G, Zhang Y. Diterpenoids with immunosuppressive activities from Cinnamomum cassia. J. Nat. Prod. 2014; 77: 1948-1954.
40. Sung YY, Yoon T, Jang JY, Park SJ, Jeong GH, Kim HK. Inhibitory effects of Cinnamomum cassia extract on atopic der-matitis-like skin lesions induced by mite antigen in NC/Nga mice. J. Ethnopharmacol. 2011;133:621-628.
41. Bandara T, Uluwaduge I, Jansz ER. Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review. Int. J. Food Sci. Nutr. 2012;63:380-386.
42. Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp. Cell Res. 2006;312:549-560.
43. Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M. Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Nat. Acad. Sci. USA. 2005;102:1076-1081.
44. Oshikawa J, Kim SJ, Furuta E, Caliceti C, Chen GF, McKinney RD, Kuhr F, Levitan I, Fukai T, Ushio-Fukai M. Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 2012;302: H724-H732.
45. 38 signaling pathways. Mol. Nutr. Food Res. 2012;56:889-899.
46. Zhang L, Ji Q, Liu X, Chen X, Chen Z, Qiu Y, Sun J, Cai J, Zhu H, Li Q. Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways. Cancer Sci. 2013;104:604-610.
47. Bode AM, Ma WY, Surh YJ, Dong Z. Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res. 2001;61: 850-853.
48. 38 MAP kinase and NF-κB in phorbol esterstimulated mouse skin. Oncogene. 2005;24:2558-2567.
49. Hagemann T, Wilson J, Kulbe H, Li NF, Leinster DA, Charles K, Klemm F, Pukrop T, Binder C, Balkwill FR. Macrtophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J. Immunol. 2005;175:1197-1205.
50. Bachelor MA, Bowden GT. UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin. Cancer Biol. 2004;14:131-138.
51. Ock J, Hong SH, Han YM, Kwon BM, Lee WH, Lee MS, Suk K. 2?-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation. J. Neuroimmunol. 2011;230:52-64.
52. Lee CW, Lee SH, Lee JW, Ban JO, Lee SY, Yoo HS, Jung JK, Moon DC, Oh KW, Hong JT. 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation. J. Pharmacol. Sci. 2007;104:19-28.
53. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ. Res. 2003;92:827-839.
54. Galardy RE, Grobelny D, Foellmer HG, Femandez LA. Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R- 2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide. Cancer Res. 1994;54:4715-4718.
55. Doyle JL, Haas TL. Differential role of β-catenin in VEGF and histamine-induced MMP-2 production in microvascular endothelial cells. J. Cell Biochem. 2009;107:272-283.