메뉴 건너뛰기




Volumn 82, Issue 4, 2015, Pages 305-314

mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; S PHASE KINASE ASSOCIATED PROTEIN 2; CYCLIN D1; CYCLIN E; PRIMER DNA; S PHASE KINASE ASSOCIATED PROTEIN; TARGET OF RAPAMYCIN KINASE;

EID: 84927581510     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.22473     Document Type: Article
Times cited : (23)

References (68)
  • 1
    • 84861203286 scopus 로고    scopus 로고
    • Mammary cancer promotion by ovarian hormones involves IGFR/AKT/mTOR signaling
    • Arumugam A, Parada J, Rajkumar L. 2012. Mammary cancer promotion by ovarian hormones involves IGFR/AKT/mTOR signaling. Steroids 77:791-797.
    • (2012) Steroids , vol.77 , pp. 791-797
    • Arumugam, A.1    Parada, J.2    Rajkumar, L.3
  • 2
    • 38349178697 scopus 로고    scopus 로고
    • A reciprocal relationship between Rb and Skp2: Implications for restriction point control, signal transduction to the cell cycle and cancer
    • Assoian RK, Yung Y. 2008. A reciprocal relationship between Rb and Skp2: Implications for restriction point control, signal transduction to the cell cycle and cancer. Cell Cycle 7:24-27.
    • (2008) Cell Cycle , vol.7 , pp. 24-27
    • Assoian, R.K.1    Yung, Y.2
  • 3
    • 33746435317 scopus 로고    scopus 로고
    • Reducing estrogen synthesis in developing boars increases testis size and total sperm production
    • At-Taras EE, Berger T, McCarthy MJ, Conley AJ, Nitta-Oda BJ, Roser JF. 2006a. Reducing estrogen synthesis in developing boars increases testis size and total sperm production. J Androl 27:552-559.
    • (2006) J Androl , vol.27 , pp. 552-559
    • At-Taras, E.E.1    Berger, T.2    McCarthy, M.J.3    Conley, A.J.4    Nitta-Oda, B.J.5    Roser, J.F.6
  • 4
    • 33746435317 scopus 로고    scopus 로고
    • Reducing estrogen synthesis in developing boars increases testis size and total sperm production
    • At-Taras EE, Berger T, McCarthy MJ, Conley AJ, Nitta-Oda BJ, Roser JF. 2006b. Reducing estrogen synthesis in developing boars increases testis size and total sperm production. J Androl 27:552-559.
    • (2006) J Androl , vol.27 , pp. 552-559
    • At-Taras, E.E.1    Berger, T.2    McCarthy, M.J.3    Conley, A.J.4    Nitta-Oda, B.J.5    Roser, J.F.6
  • 6
    • 0034522252 scopus 로고    scopus 로고
    • Expression of cyclin-dependent kinase inhibitors in epiphyseal chondrocytes induced to terminally differentiate with thyroid hormone
    • Ballock RT, Zhou X, Mink LM, Chen DH, Mita BC, Stewart MC. 2000. Expression of cyclin-dependent kinase inhibitors in epiphyseal chondrocytes induced to terminally differentiate with thyroid hormone. Endocrinology 141:4552-4557.
    • (2000) Endocrinology , vol.141 , pp. 4552-4557
    • Ballock, R.T.1    Zhou, X.2    Mink, L.M.3    Chen, D.H.4    Mita, B.C.5    Stewart, M.C.6
  • 7
    • 1642378661 scopus 로고    scopus 로고
    • Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase
    • Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M. 2004. Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428:190-193.
    • (2004) Nature , vol.428 , pp. 190-193
    • Bashir, T.1    Dorrello, N.V.2    Amador, V.3    Guardavaccaro, D.4    Pagano, M.5
  • 8
    • 84860475014 scopus 로고    scopus 로고
    • Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression
    • Belin S, Kaya F, Duisit G, Giacometti S, Ciccolini J, Fontes M. 2009. Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression. PLoS ONE 4:e4409.
    • (2009) PLoS ONE , vol.4 , pp. e4409
    • Belin, S.1    Kaya, F.2    Duisit, G.3    Giacometti, S.4    Ciccolini, J.5    Fontes, M.6
  • 9
    • 0036936848 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha inhibits glutathione S-transferase-alpha expression in cultured porcine Sertoli cells
    • Benbrahim-Tallaa L, Boussouar F, Rey C, Benahmed M. 2002. Tumor necrosis factor-alpha inhibits glutathione S-transferase-alpha expression in cultured porcine Sertoli cells. J Endocrinol 175:803-812.
    • (2002) J Endocrinol , vol.175 , pp. 803-812
    • Benbrahim-Tallaa, L.1    Boussouar, F.2    Rey, C.3    Benahmed, M.4
  • 11
    • 84860437677 scopus 로고    scopus 로고
    • Stimulation of Sertoli cell proliferation: defining the response interval to an inhibitor of estrogen synthesis in the boar
    • Berger T, Kentfield L, Roser JF, Conley A. 2012. Stimulation of Sertoli cell proliferation: defining the response interval to an inhibitor of estrogen synthesis in the boar. Reproduction 143:523-529.
    • (2012) Reproduction , vol.143 , pp. 523-529
    • Berger, T.1    Kentfield, L.2    Roser, J.F.3    Conley, A.4
  • 12
    • 54149114751 scopus 로고    scopus 로고
    • Reducing endogenous estrogens during the neonatal and juvenile periods affects reproductive tract development and sperm production in postpuberal boars
    • Berger T, McCarthy M, Pearl CA, At-Taras E, Roser JF, Conley A. 2008. Reducing endogenous estrogens during the neonatal and juvenile periods affects reproductive tract development and sperm production in postpuberal boars. Anim Reprod Sci 109:218-235.
    • (2008) Anim Reprod Sci , vol.109 , pp. 218-235
    • Berger, T.1    McCarthy, M.2    Pearl, C.A.3    At-Taras, E.4    Roser, J.F.5    Conley, A.6
  • 18
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 20
    • 0033721628 scopus 로고    scopus 로고
    • Cell proliferation and hormonal changes during postnatal development of the testis in the pig
    • Franca LR, Silva VA, Chiarini-Garcia H, Garcia SK, Debeljuk L. 2000a. Cell proliferation and hormonal changes during postnatal development of the testis in the pig. Biol of Reprod 63:1629-1636.
    • (2000) Biol of Reprod , vol.63 , pp. 1629-1636
    • Franca, L.R.1    Silva, V.A.2    Chiarini-Garcia, H.3    Garcia, S.K.4    Debeljuk, L.5
  • 21
    • 0033721628 scopus 로고    scopus 로고
    • Cell proliferation and hormonal changes during postnatal development of the testis in the pig
    • Franca LR, Silva VA, Chiarini-Garcia H, Garcia SK, Debeljuk L. 2000b. Cell proliferation and hormonal changes during postnatal development of the testis in the pig. Biol Reprod 63:1629-1636.
    • (2000) Biol Reprod , vol.63 , pp. 1629-1636
    • Franca, L.R.1    Silva, V.A.2    Chiarini-Garcia, H.3    Garcia, S.K.4    Debeljuk, L.5
  • 23
    • 84927572316 scopus 로고    scopus 로고
    • Activation of G protein coupled estrogen receptor (GPER) promotes the migration of renal cell carcinoma via the PI3K/AKT/MMP-9 Signals
    • [Epub ahead of print].
    • Guan BZ, Yan RL, Huang JW, Li FL, Zhong YX, Chen Y, Liu FN, Hu B, Huang SB, Yin LH. 2015. Activation of G protein coupled estrogen receptor (GPER) promotes the migration of renal cell carcinoma via the PI3K/AKT/MMP-9 Signals. Cell Adh Migr [Epub ahead of print].
    • (2015) Cell Adh Migr
    • Guan, B.Z.1    Yan, R.L.2    Huang, J.W.3    Li, F.L.4    Zhong, Y.X.5    Chen, Y.6    Liu, F.N.7    Hu, B.8    Huang, S.B.9    Yin, L.H.10
  • 24
    • 59249091238 scopus 로고    scopus 로고
    • Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells
    • Guan S, Ge D, Liu TQ, Ma XH, Cui ZF. 2009. Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells. Toxicol In Vitro 23:201-208.
    • (2009) Toxicol In Vitro , vol.23 , pp. 201-208
    • Guan, S.1    Ge, D.2    Liu, T.Q.3    Ma, X.H.4    Cui, Z.F.5
  • 25
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo M, Rowinsky EK. 2000. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19:6680-6686.
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 26
    • 0042529298 scopus 로고    scopus 로고
    • Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells
    • Holsberger DR, Jirawatnotai S, Kiyokawa H, Cooke PS. 2003. Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells. Endocrinology 144:3732-3738.
    • (2003) Endocrinology , vol.144 , pp. 3732-3738
    • Holsberger, D.R.1    Jirawatnotai, S.2    Kiyokawa, H.3    Cooke, P.S.4
  • 27
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang J, Manning BD. 2009. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37:217-222.
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 28
    • 84872527628 scopus 로고    scopus 로고
    • MTOR is a key modulator of ageing and age-related disease
    • Johnson SC, Rabinovitch PS, Kaeberlein M. 2013. MTOR is a key modulator of ageing and age-related disease. Nature 493:338-345.
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 29
    • 84869082147 scopus 로고    scopus 로고
    • Role for endogenous estrogen in prepubertal Sertoli cell maturation
    • Kao E, Villalon R, Ribeiro S, RBerger T. 2012. Role for endogenous estrogen in prepubertal Sertoli cell maturation. Anim Reprod Sci 135:106-112.
    • (2012) Anim Reprod Sci , vol.135 , pp. 106-112
    • Kao, E.1    Villalon, R.2    Ribeiro, S.3    RBerger, T.4
  • 30
    • 1842634486 scopus 로고    scopus 로고
    • Crashing waves of destruction: The cell cycle and APC(Cdh1) regulation of SCF(Skp2)
    • Kurland JF, Tansey WP. 2004. Crashing waves of destruction: The cell cycle and APC(Cdh1) regulation of SCF(Skp2). Cancer Cell 5:305-306.
    • (2004) Cancer Cell , vol.5 , pp. 305-306
    • Kurland, J.F.1    Tansey, W.P.2
  • 31
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. 2012. MTOR signaling in growth control and disease. Cell 149:274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 32
    • 84885476531 scopus 로고    scopus 로고
    • Phloridzin isolated from Acanthopanax senticosus promotes proliferation of alpha6 integrin (CD 49f) and beta1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway
    • Lee J, Jung E, Kim YS, Park D, Toyama K, Date A. 2013. Phloridzin isolated from Acanthopanax senticosus promotes proliferation of alpha6 integrin (CD 49f) and beta1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway. Arch Dermatol Res 305:747-754.
    • (2013) Arch Dermatol Res , vol.305 , pp. 747-754
    • Lee, J.1    Jung, E.2    Kim, Y.S.3    Park, D.4    Toyama, K.5    Date, A.6
  • 33
    • 22244456033 scopus 로고    scopus 로고
    • Transactivation of cyclin E gene by EWS-Fli1 and antitumor effects of cyclin dependent kinase inhibitor on Ewing's family tumor cells
    • Li X, Tanaka K, Nakatani F, Matsunobu T, Sakimura R, Hanada M, Okada T, Nakamura T, Iwamoto Y. 2005. Transactivation of cyclin E gene by EWS-Fli1 and antitumor effects of cyclin dependent kinase inhibitor on Ewing's family tumor cells. Int J Cancer 116:385-394.
    • (2005) Int J Cancer , vol.116 , pp. 385-394
    • Li, X.1    Tanaka, K.2    Nakatani, F.3    Matsunobu, T.4    Sakimura, R.5    Hanada, M.6    Okada, T.7    Nakamura, T.8    Iwamoto, Y.9
  • 34
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 35
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
    • LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA. 2008. Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 11:32-50.
    • (2008) Drug Resist Updat , vol.11 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 36
    • 84868237217 scopus 로고    scopus 로고
    • Mammalian target of rapamycin as a rational therapeutic target for breast cancer treatment
    • LoRusso PM. 2013. Mammalian target of rapamycin as a rational therapeutic target for breast cancer treatment. Oncology 84:43-56.
    • (2013) Oncology , vol.84 , pp. 43-56
    • LoRusso, P.M.1
  • 37
    • 38149120809 scopus 로고    scopus 로고
    • 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells
    • Lucas TF, Siu ER, Esteves CA, Monteiro HP, Oliveira CA, Porto CS, Lazari MF. 2008. 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells. Biol Reprod 78:101-114.
    • (2008) Biol Reprod , vol.78 , pp. 101-114
    • Lucas, T.F.1    Siu, E.R.2    Esteves, C.A.3    Monteiro, H.P.4    Oliveira, C.A.5    Porto, C.S.6    Lazari, M.F.7
  • 38
    • 84055178474 scopus 로고    scopus 로고
    • Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
    • Magnuson B, Ekim B, Fingar DC. 2012. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J 441:1-21.
    • (2012) Biochem J , vol.441 , pp. 1-21
    • Magnuson, B.1    Ekim, B.2    Fingar, D.C.3
  • 39
    • 79958026380 scopus 로고    scopus 로고
    • The Ras-ERK and PI3K-mTOR pathways: Cross-talk and compensation
    • Mendoza MC, Er EE, Blenis J. 2011. The Ras-ERK and PI3K-mTOR pathways: Cross-talk and compensation. Trends Biochem Sci 36:320-328.
    • (2011) Trends Biochem Sci , vol.36 , pp. 320-328
    • Mendoza, M.C.1    Er, E.E.2    Blenis, J.3
  • 40
    • 0035964367 scopus 로고    scopus 로고
    • Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
    • Mills GB, Lu Y, Kohn EC. 2001. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci USA 98:10031-10033.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10031-10033
    • Mills, G.B.1    Lu, Y.2    Kohn, E.C.3
  • 41
    • 3242879161 scopus 로고    scopus 로고
    • Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis
    • Mruk DD, Cheng CY. 2004. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev 25:747-806.
    • (2004) Endocr Rev , vol.25 , pp. 747-806
    • Mruk, D.D.1    Cheng, C.Y.2
  • 42
    • 84859150660 scopus 로고    scopus 로고
    • MRNA-selective translation induced by FSH in primary Sertoli cells
    • Musnier A, Leon K, Morales J. et al. 2012. MRNA-selective translation induced by FSH in primary Sertoli cells. Mol Endocrinol 26:669-680.
    • (2012) Mol Endocrinol , vol.26 , pp. 669-680
    • Musnier, A.1    Leon, K.2    Morales, J.3
  • 43
    • 17044370346 scopus 로고    scopus 로고
    • Regulation of the cell cycle by SCF-type ubiquitin ligases
    • Nakayama KI, Nakayama K. 2005. Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol 16:323-333.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 323-333
    • Nakayama, K.I.1    Nakayama, K.2
  • 44
    • 0029317904 scopus 로고
    • Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle
    • Nigg EA. 1995. Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle. Bioessays 17:471-480.
    • (1995) Bioessays , vol.17 , pp. 471-480
    • Nigg, E.A.1
  • 45
    • 84916215148 scopus 로고    scopus 로고
    • Activation of the mTOR signaling pathway in breast cancer MCF7 cells by a peptide derived from Porphyra yezoensis
    • Park SJ, Ryu J, Kim IH, Choi YH, Nam TJ. 2014. Activation of the mTOR signaling pathway in breast cancer MCF7 cells by a peptide derived from Porphyra yezoensis. Oncol Rep 33:19-24.
    • (2014) Oncol Rep , vol.33 , pp. 19-24
    • Park, S.J.1    Ryu, J.2    Kim, I.H.3    Choi, Y.H.4    Nam, T.J.5
  • 46
    • 84873284974 scopus 로고    scopus 로고
    • ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation
    • Parrales A, Lopez E, Lee-Rivera I, Lopez-Colome AM. 2013. ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation. Cell Signal 25:829-838.
    • (2013) Cell Signal , vol.25 , pp. 829-838
    • Parrales, A.1    Lopez, E.2    Lee-Rivera, I.3    Lopez-Colome, A.M.4
  • 47
    • 0034043572 scopus 로고    scopus 로고
    • Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs
    • Pelletier G, Labrie C, Labrie F. 2000. Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs. J Endocrinol 165:359-370.
    • (2000) J Endocrinol , vol.165 , pp. 359-370
    • Pelletier, G.1    Labrie, C.2    Labrie, F.3
  • 48
    • 0033582430 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor p27(Kip1) is involved in thyroid hormone-mediated neuronal differentiation
    • Perez-Juste G, Aranda A. 1999. The cyclin-dependent kinase inhibitor p27(Kip1) is involved in thyroid hormone-mediated neuronal differentiation. J Biol Chem 274:5026-5031.
    • (1999) J Biol Chem , vol.274 , pp. 5026-5031
    • Perez-Juste, G.1    Aranda, A.2
  • 49
    • 34748915685 scopus 로고    scopus 로고
    • The immunophilin ligands cyclosporin A and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and -independent mechanisms
    • Periyasamy S, Warrier M, Tillekeratne MP, Shou W, Sanchez ER. 2007. The immunophilin ligands cyclosporin A and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and -independent mechanisms. Endocrinology 148:4716-4726.
    • (2007) Endocrinology , vol.148 , pp. 4716-4726
    • Periyasamy, S.1    Warrier, M.2    Tillekeratne, M.P.3    Shou, W.4    Sanchez, E.R.5
  • 50
    • 23944466418 scopus 로고    scopus 로고
    • Role of connexin-based gap junction channels in testis
    • Pointis G, Segretain D. 2005. Role of connexin-based gap junction channels in testis. Trends Endocrinol Metab 16:300-306.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 300-306
    • Pointis, G.1    Segretain, D.2
  • 51
    • 67349105361 scopus 로고    scopus 로고
    • Mechanisms of estrogen signaling and gene expression via GPR30
    • Prossnitz ER, Maggiolini M. 2009. Mechanisms of estrogen signaling and gene expression via GPR30. Mol Cell Endocrinol 308:32-38.
    • (2009) Mol Cell Endocrinol , vol.308 , pp. 32-38
    • Prossnitz, E.R.1    Maggiolini, M.2
  • 52
    • 84887065790 scopus 로고    scopus 로고
    • Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo
    • Renshaw J, Taylor KR, Bishop R. et al. 2013. Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo. Clin Cancer Res 19:5940-5951.
    • (2013) Clin Cancer Res , vol.19 , pp. 5940-5951
    • Renshaw, J.1    Taylor, K.R.2    Bishop, R.3
  • 54
    • 84864025146 scopus 로고    scopus 로고
    • 17Beta-estradiol signaling and regulation of proliferation and apoptosis of rat Sertoli cells
    • Royer C, Lucas TF, Lazari MF, Porto CS. 2012. 17Beta-estradiol signaling and regulation of proliferation and apoptosis of rat Sertoli cells. Biol Reprod 86:1-13.
    • (2012) Biol Reprod , vol.86 , pp. 1-13
    • Royer, C.1    Lucas, T.F.2    Lazari, M.F.3    Porto, C.S.4
  • 55
    • 84922041782 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin signaling pathway decreases retinoic acid stimulated gene 8 expression in adult mouse testis
    • Sahin P, Sahin Z, Gungor-Ordueri NE, Donmez BO, Celik-Ozenci C. 2014. Inhibition of mammalian target of rapamycin signaling pathway decreases retinoic acid stimulated gene 8 expression in adult mouse testis. Fertil Steril 102:1428-1490.
    • (2014) Fertil Steril , vol.102 , pp. 1428-1490
    • Sahin, P.1    Sahin, Z.2    Gungor-Ordueri, N.E.3    Donmez, B.O.4    Celik-Ozenci, C.5
  • 57
    • 84867112902 scopus 로고    scopus 로고
    • Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis
    • Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM. 2012. Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis. Hum Mol Genet 21:4394-4405.
    • (2012) Hum Mol Genet , vol.21 , pp. 4394-4405
    • Tanwar, P.S.1    Kaneko-Tarui, T.2    Zhang, L.3    Teixeira, J.M.4
  • 58
    • 46749087424 scopus 로고    scopus 로고
    • Estrogen facilitates both phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons
    • Titolo D, Mayer CM, Dhillon SS, Cai F, Belsham DD. 2008. Estrogen facilitates both phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons. J Neurosci 28:6473-6482.
    • (2008) J Neurosci , vol.28 , pp. 6473-6482
    • Titolo, D.1    Mayer, C.M.2    Dhillon, S.S.3    Cai, F.4    Belsham, D.D.5
  • 59
    • 34249670193 scopus 로고    scopus 로고
    • Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells
    • Wakayama T, Sai Y, Ito A, Kato Y, Kurobo M, Murakami Y, Nakashima E, Tsuji A, Kitamura Y, Iseki S. 2007. Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells. Biol Reprod 76:1081-1090.
    • (2007) Biol Reprod , vol.76 , pp. 1081-1090
    • Wakayama, T.1    Sai, Y.2    Ito, A.3    Kato, Y.4    Kurobo, M.5    Murakami, Y.6    Nakashima, E.7    Tsuji, A.8    Kitamura, Y.9    Iseki, S.10
  • 60
    • 77956409780 scopus 로고    scopus 로고
    • 17 beta-estradiol regulates cultured immature boar sertoli cell proliferation via the cAMP-ERK1/2 pathway and the estrogen receptor beta
    • Wang X-z, Zhao B-c, Zhou Y-l, Zhou Y-t, Ma K-g, Zhang J-h. 2010. 17 beta-estradiol regulates cultured immature boar sertoli cell proliferation via the cAMP-ERK1/2 pathway and the estrogen receptor beta. Agricultural Sciences in China 9:1201-1210.
    • (2010) Agricultural Sciences in China , vol.9 , pp. 1201-1210
    • Wang, X.-z.1    Zhao, B.-c.2    Zhou, Y.-l.3    Zhou, Y.-t.4    Ma, K.-g.5    Zhang, J.-h.6
  • 61
    • 0034675922 scopus 로고    scopus 로고
    • The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts
    • Wirbelauer C, Sutterluty H, Blondel M, Gstaiger M, Peter M, Reymond F, Krek W. 2000. The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J 19:5362-5375.
    • (2000) EMBO J , vol.19 , pp. 5362-5375
    • Wirbelauer, C.1    Sutterluty, H.2    Blondel, M.3    Gstaiger, M.4    Peter, M.5    Reymond, F.6    Krek, W.7
  • 62
    • 69949159612 scopus 로고    scopus 로고
    • Testicular dysgenesis syndrome: foetal origin of adult reproductive problems
    • Wohlfahrt-Veje C, Main KM, Skakkebaek NE. 2009. Testicular dysgenesis syndrome: foetal origin of adult reproductive problems. Clin Endocrinol (Oxf) 71:459-465.
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 459-465
    • Wohlfahrt-Veje, C.1    Main, K.M.2    Skakkebaek, N.E.3
  • 63
    • 58149492943 scopus 로고    scopus 로고
    • USF1/2 transcription factor DNA-binding activity is induced during rat Sertoli cell differentiation
    • Wood MA, Walker WH. 2009. USF1/2 transcription factor DNA-binding activity is induced during rat Sertoli cell differentiation. Biol Reprod 80:24-33.
    • (2009) Biol Reprod , vol.80 , pp. 24-33
    • Wood, M.A.1    Walker, W.H.2
  • 64
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. 2006. TOR signaling in growth and metabolism. Cell 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 65
    • 84886410536 scopus 로고    scopus 로고
    • Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway
    • Yang YH, Chen K, Li B, Chen JW, Zheng XF, Wang YR, Jiang SD, Jiang LS. 2013. Estradiol inhibits osteoblast apoptosis via promotion of autophagy through the ER-ERK-mTOR pathway. Apoptosis 18:1363-1375.
    • (2013) Apoptosis , vol.18 , pp. 1363-1375
    • Yang, Y.H.1    Chen, K.2    Li, B.3    Chen, J.W.4    Zheng, X.F.5    Wang, Y.R.6    Jiang, S.D.7    Jiang, L.S.8
  • 66
    • 84859914883 scopus 로고    scopus 로고
    • Cross talk between estradiol and mTOR kinase in the regulation of ovarian granulosa proliferation
    • Yu J, Thomson TC, Johnson J. 2012. Cross talk between estradiol and mTOR kinase in the regulation of ovarian granulosa proliferation. Reprod Sci 19:143-151.
    • (2012) Reprod Sci , vol.19 , pp. 143-151
    • Yu, J.1    Thomson, T.C.2    Johnson, J.3
  • 67
    • 84873469666 scopus 로고    scopus 로고
    • Nutrient sensing, metabolism, and cell growth control
    • Yuan HX, Xiong Y, Guan KL. 2013. Nutrient sensing, metabolism, and cell growth control. Mol Cell 49:379-387.
    • (2013) Mol Cell , vol.49 , pp. 379-387
    • Yuan, H.X.1    Xiong, Y.2    Guan, K.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.