Podophyllotoxin acetate enhances γ-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathway

Biomedicine and Pharmacotherapy

Volumn 70, Issue C, 2015, Pages 111-118

  Choi, Jae Yeon ^a,c   Cho, Hyun Ji ^a   Hwang, Sang Gu ^a   Kim, Wun Jae ^b   Kim, Jong Il ^c   Um, Hong Duck ^a   Park, Jong Kuk ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

^c Seoul Women University   (South Korea)

Author keywords

Apoptosis; ERK; P38; Podophyllotoxin acetate; Radiosensitizer; Reactive oxygen species

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PODOPHYLLOTOXIN ACETATE; PODOPHYLLOTOXIN DERIVATIVE; PROPIDIUM IODIDE; RADIOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PODOPHYLLOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER SIZE; CELL COUNTING; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GAMMA RADIATION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG CANCER CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIZATION; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR CLONING; NON SMALL CELL LUNG CANCER; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL LINE, TUMOR; CLONING, MOLECULAR; GAMMA RAYS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PODOPHYLLOTOXIN; REACTIVE OXYGEN SPECIES;

EID: 84927558913     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2014.12.038     Document Type: Article

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