Depletion of eIF2×GTP×Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

Oncotarget

Volumn 6, Issue 9, 2015, Pages 6902-6914

  Aktas, Bertal H ^a,b   Bordelois, Paula ^b   Peker, Selen ^a,c   Merajver, Sophia ^d   Halperin, Jose A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ANKARA UNIVERSITY   (Turkey)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

BRCA1; EIF2 GTP Met tRNAi; EPA; Fish oil; UORF

Indexed keywords

BRCA1 PROTEIN; FISH OIL; GUANOSINE TRIPHOSPHATE; ICOSAPENTAENOIC ACID; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; MESSENGER RNA; METHIONINE TRANSFER RNA; MRNAB; UNCLASSIFIED DRUG; 5' UNTRANSLATED REGION; BRCA1 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN TERTIARY STRUCTURE; TRANSLATION INITIATION; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; BREAST TUMOR; CANCER TRANSPLANTATION; CHEMISTRY; GENETICS; MCF-7 CELL LINE; METABOLISM; NUDE MOUSE; OPEN READING FRAME; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; TUMOR CELL LINE;

5' UNTRANSLATED REGIONS; ANIMALS; BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; EICOSAPENTAENOIC ACID; EUKARYOTIC INITIATION FACTOR-2; FEMALE; FISH OILS; GUANOSINE TRIPHOSPHATE; HUMANS; MCF-7 CELLS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OPEN READING FRAMES; PHOSPHORYLATION; RNA INTERFERENCE; RNA, MESSENGER; RNA, TRANSFER, MET;

EID: 84927142811     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3125     Document Type: Article

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