Depletion of intracellular Ca2+ stores, phosphorylation of eIF2α, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 14, 1998, Pages 8280-8285

  Aktas, Huseyin ^a   Flückiger, Rudolf ^a   Acosta, Juan A ^a   Savage, Joyce M ^a   Palakurthi, Sangeetha S ^a   Halperin, José A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM; CLOTRIMAZOLE; INITIATION FACTOR 2; CALCIUM ION; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN E; CYCLINE; MESSENGER RNA; PROTEIN;

ANIMAL; ARTICLE; CELL DIVISION; CELL STRAIN 3T3; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSLATION INITIATION;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM; CELL DIVISION; CLOTRIMAZOLE; EUKARYOTIC INITIATION FACTOR-2; MICE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0032493199     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.14.8280     Document Type: Article

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