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Volumn 9781118489932, Issue , 2014, Pages 341-353

Drug Transport in the Placenta

Author keywords

ATP binding cassette (ABC) transporters; Human placenta; Solute carrier (SLC) transporters; Transplacental drug transport

Indexed keywords

GLYCOPROTEINS;

EID: 84927131467     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118705308.ch17     Document Type: Chapter
Times cited : (5)

References (103)
  • 2
    • 0038743344 scopus 로고    scopus 로고
    • Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population
    • Glover DD, Amonkar M, Rybeck BF, Tracy TS. Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population. Am J Obstet Gynecol 2003;188 (4):1039-1045.
    • (2003) Am J Obstet Gynecol , vol.188 , Issue.4 , pp. 1039-1045
    • Glover, D.D.1    Amonkar, M.2    Rybeck, B.F.3    Tracy, T.S.4
  • 6
    • 35648954071 scopus 로고    scopus 로고
    • The human placenta-an alternative for studying foetal exposure
    • Myren M, Mose T, Mathiesen L, Knudsen LE. The human placenta-an alternative for studying foetal exposure. Toxicol In Vitro 2007;21 (7):1332-1340.
    • (2007) Toxicol In Vitro , vol.21 , Issue.7 , pp. 1332-1340
    • Myren, M.1    Mose, T.2    Mathiesen, L.3    Knudsen, L.E.4
  • 7
    • 79953803082 scopus 로고    scopus 로고
    • ATP-binding cassette efflux transporters in human placenta
    • Ni Z, Mao Q. ATP-binding cassette efflux transporters in human placenta. Curr Pharm Biotechnol 2011;12 (4):674-685.
    • (2011) Curr Pharm Biotechnol , vol.12 , Issue.4 , pp. 674-685
    • Ni, Z.1    Mao, Q.2
  • 9
    • 0033943307 scopus 로고    scopus 로고
    • Placental transporters relevant to drug distribution across the maternal-fetal interface
    • Ganapathy V, Prasad PD, Ganapathy ME, Leibach FH. Placental transporters relevant to drug distribution across the maternal-fetal interface. J Pharmacol Exp Ther 2000;294 (2):413-420.
    • (2000) J Pharmacol Exp Ther , vol.294 , Issue.2 , pp. 413-420
    • Ganapathy, V.1    Prasad, P.D.2    Ganapathy, M.E.3    Leibach, F.H.4
  • 10
    • 70350053125 scopus 로고    scopus 로고
    • Drug transporters in the human blood-placental barrier
    • Vahakangas K, Myllynen P. Drug transporters in the human blood-placental barrier. Br J Pharmacol 2009;158 (3):665-678.
    • (2009) Br J Pharmacol , vol.158 , Issue.3 , pp. 665-678
    • Vahakangas, K.1    Myllynen, P.2
  • 11
    • 0028355922 scopus 로고
    • Stagespecific distribution of P-glycoprotein in first-trimester and full-term human placenta
    • MacFarland A, Abramovich DR, Ewen SW, Pearson CK. Stagespecific distribution of P-glycoprotein in first-trimester and full-term human placenta. Histochem J 1994;26 (5):417-423.
    • (1994) Histochem J , vol.26 , Issue.5 , pp. 417-423
    • MacFarland, A.1    Abramovich, D.R.2    Ewen, S.W.3    Pearson, C.K.4
  • 12
    • 33749488939 scopus 로고    scopus 로고
    • Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system
    • Sarkadi B, Homolya L, Szakacs G, Varadi A. Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiol Rev 2006;86 (4):1179-1236.
    • (2006) Physiol Rev , vol.86 , Issue.4 , pp. 1179-1236
    • Sarkadi, B.1    Homolya, L.2    Szakacs, G.3    Varadi, A.4
  • 14
    • 0032129118 scopus 로고    scopus 로고
    • Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice
    • Lankas GR, Wise LD, Cartwright ME, Pippert T, Umbenhauer DR. Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. Reprod Toxicol 1998;12 (4):457-463.
    • (1998) Reprod Toxicol , vol.12 , Issue.4 , pp. 457-463
    • Lankas, G.R.1    Wise, L.D.2    Cartwright, M.E.3    Pippert, T.4    Umbenhauer, D.R.5
  • 15
    • 0032701128 scopus 로고    scopus 로고
    • Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure
    • Smit JW, Huisman MT, van Tellingen O, Wiltshire HR, Schinkel AH. Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. J Clin Invest 1999;104 (10):1441-1447.
    • (1999) J Clin Invest , vol.104 , Issue.10 , pp. 1441-1447
    • Smit, J.W.1    Huisman, M.T.2    van Tellingen, O.3    Wiltshire, H.R.4    Schinkel, A.H.5
  • 16
    • 84874884710 scopus 로고    scopus 로고
    • Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition
    • Ke AB, Eyal S, Chung FS, Link JM, Mankoff DA, Muzi M, Unadkat JD. Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition. J Nucl Med 2013;54:437-446.
    • (2013) J Nucl Med , vol.54 , pp. 437-446
    • Ke, A.B.1    Eyal, S.2    Chung, F.S.3    Link, J.M.4    Mankoff, D.A.5    Muzi, M.6    Unadkat, J.D.7
  • 20
    • 25844485913 scopus 로고    scopus 로고
    • P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages
    • Mathias AA, Hitti J, Unadkat JD. P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages. Am J Physiol Regul Integr Comp Physiol 2005;289 (4):R963-R969.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289 , Issue.4 , pp. R963-R969
    • Mathias, A.A.1    Hitti, J.2    Unadkat, J.D.3
  • 21
    • 0032499771 scopus 로고    scopus 로고
    • The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspasedependent apoptosis
    • Smyth MJ, Krasovskis E, Sutton VR, Johnstone RW. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspasedependent apoptosis. Proc Natl Acad Sci U S A 1998;95 (12):7024-7029.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.12 , pp. 7024-7029
    • Smyth, M.J.1    Krasovskis, E.2    Sutton, V.R.3    Johnstone, R.W.4
  • 22
    • 74849123222 scopus 로고    scopus 로고
    • Multidrug resistance phosphoglycoprotein (ABCB1) expression in the guinea pig placenta: developmental changes and regulation by betamethasone
    • Kalabis GM, Petropoulos S, Gibb W, Matthews SG. Multidrug resistance phosphoglycoprotein (ABCB1) expression in the guinea pig placenta: developmental changes and regulation by betamethasone. Can J Physiol Pharmacol 2009;87 (11):973-978.
    • (2009) Can J Physiol Pharmacol , vol.87 , Issue.11 , pp. 973-978
    • Kalabis, G.M.1    Petropoulos, S.2    Gibb, W.3    Matthews, S.G.4
  • 24
    • 77958025244 scopus 로고    scopus 로고
    • Structure and function of the human breast cancer resistance protein (BCRP/ ABCG2)
    • Ni Z, Bikadi Z, Rosenberg MF, Mao Q. Structure and function of the human breast cancer resistance protein (BCRP/ ABCG2). Curr Drug Metab 2010;11 (7):603-617.
    • (2010) Curr Drug Metab , vol.11 , Issue.7 , pp. 603-617
    • Ni, Z.1    Bikadi, Z.2    Rosenberg, M.F.3    Mao, Q.4
  • 26
    • 36348932850 scopus 로고    scopus 로고
    • Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse
    • Zhang Y, Wang H, Unadkat JD, Mao Q. Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouse. Drug Metab Dispos 2007;35 (12):2154-2158.
    • (2007) Drug Metab Dispos , vol.35 , Issue.12 , pp. 2154-2158
    • Zhang, Y.1    Wang, H.2    Unadkat, J.D.3    Mao, Q.4
  • 27
    • 40849097788 scopus 로고    scopus 로고
    • The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study
    • Zhou L, Naraharisetti SB, Wang H, Unadkat JD, Hebert MF, Mao Q. The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study. Mol Pharmacol 2008;73 (3):949-959.
    • (2008) Mol Pharmacol , vol.73 , Issue.3 , pp. 949-959
    • Zhou, L.1    Naraharisetti, S.B.2    Wang, H.3    Unadkat, J.D.4    Hebert, M.F.5    Mao, Q.6
  • 28
    • 33845383376 scopus 로고    scopus 로고
    • Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors
    • Wang H, Wu X, Hudkins K, Mikheev A, Zhang H, Gupta A, Unadkat JD, Mao Q. Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors. Am J Physiol Endocrinol Metab 2006;291 (6):E1295-E1304.
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , Issue.6 , pp. E1295-E1304
    • Wang, H.1    Wu, X.2    Hudkins, K.3    Mikheev, A.4    Zhang, H.5    Gupta, A.6    Unadkat, J.D.7    Mao, Q.8
  • 29
    • 43049156332 scopus 로고    scopus 로고
    • Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat
    • Cygalova L, Ceckova M, Pavek P, Staud F. Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat. Toxicol Lett 2008;178 (3):176-180.
    • (2008) Toxicol Lett , vol.178 , Issue.3 , pp. 176-180
    • Cygalova, L.1    Ceckova, M.2    Pavek, P.3    Staud, F.4
  • 31
    • 34248186154 scopus 로고    scopus 로고
    • Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor
    • Yeboah D, Sun M, Kingdom J, Baczyk D, Lye SJ, Matthews SG, Gibb W. Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor. Can J Physiol Pharmacol 2006;84 (12):1251-1258.
    • (2006) Can J Physiol Pharmacol , vol.84 , Issue.12 , pp. 1251-1258
    • Yeboah, D.1    Sun, M.2    Kingdom, J.3    Baczyk, D.4    Lye, S.J.5    Matthews, S.G.6    Gibb, W.7
  • 32
    • 40849142349 scopus 로고    scopus 로고
    • Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells
    • Wang H, Lee EW, Zhou L, Leung PC, Ross DD, Unadkat JD, Mao Q. Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells. Mol Pharmacol 2008;73 (3):845-854.
    • (2008) Mol Pharmacol , vol.73 , Issue.3 , pp. 845-854
    • Wang, H.1    Lee, E.W.2    Zhou, L.3    Leung, P.C.4    Ross, D.D.5    Unadkat, J.D.6    Mao, Q.7
  • 33
    • 34047162390 scopus 로고    scopus 로고
    • Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors
    • Evseenko DA, Paxton JW, Keelan JA. Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors. Drug Metab Dispos 2007;35 (4):595-601.
    • (2007) Drug Metab Dispos , vol.35 , Issue.4 , pp. 595-601
    • Evseenko, D.A.1    Paxton, J.W.2    Keelan, J.A.3
  • 34
    • 1242293680 scopus 로고    scopus 로고
    • Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene
    • Ee PL, Kamalakaran S, Tonetti D, He X, Ross DD, Beck WT. Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene. Cancer Res 2004;64 (4):1247-1251.
    • (2004) Cancer Res , vol.64 , Issue.4 , pp. 1247-1251
    • Ee, P.L.1    Kamalakaran, S.2    Tonetti, D.3    He, X.4    Ross, D.D.5    Beck, W.T.6
  • 35
    • 12544251673 scopus 로고    scopus 로고
    • Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2
    • Imai Y, Ishikawa E, Asada S, Sugimoto Y. Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2. Cancer Res 2005;65 (2):596-604.
    • (2005) Cancer Res , vol.65 , Issue.2 , pp. 596-604
    • Imai, Y.1    Ishikawa, E.2    Asada, S.3    Sugimoto, Y.4
  • 36
    • 39149109608 scopus 로고    scopus 로고
    • Hormonal regulation of BCRP expression in human placental BeWo cells
    • Wang H, Unadkat JD, Mao Q. Hormonal regulation of BCRP expression in human placental BeWo cells. Pharm Res 2008;25 (2):444-452.
    • (2008) Pharm Res , vol.25 , Issue.2 , pp. 444-452
    • Wang, H.1    Unadkat, J.D.2    Mao, Q.3
  • 37
    • 33745835398 scopus 로고    scopus 로고
    • Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    • Deeley RG, Westlake C, Cole SP. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 2006;86 (3):849-899.
    • (2006) Physiol Rev , vol.86 , Issue.3 , pp. 849-899
    • Deeley, R.G.1    Westlake, C.2    Cole, S.P.3
  • 40
    • 68649117490 scopus 로고    scopus 로고
    • Formation and efflux of ATP- binding cassette transporter substrate 2,4-dinitrophenyl-S-glutathione from cultured human term placental villous tissue fragments
    • Vaidya SS, Walsh SW, Gerk PM. Formation and efflux of ATP- binding cassette transporter substrate 2,4-dinitrophenyl-S-glutathione from cultured human term placental villous tissue fragments. Mol Pharm 2009;6 (6):1689-1702.
    • (2009) Mol Pharm , vol.6 , Issue.6 , pp. 1689-1702
    • Vaidya, S.S.1    Walsh, S.W.2    Gerk, P.M.3
  • 41
    • 41549096850 scopus 로고    scopus 로고
    • Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta
    • May K, Minarikova V, Linnemann K, Zygmunt M, Kroemer HK, Fusch C, Siegmund W. Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta. Drug Metab Dispos 2008;36 (4):740-744.
    • (2008) Drug Metab Dispos , vol.36 , Issue.4 , pp. 740-744
    • May, K.1    Minarikova, V.2    Linnemann, K.3    Zygmunt, M.4    Kroemer, H.K.5    Fusch, C.6    Siegmund, W.7
  • 43
    • 11144223752 scopus 로고    scopus 로고
    • Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation
    • Meyer zu Schwabedissen HE, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK, Jedlitschky G. Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. Am J Pathol 2005;166 (1):39-48.
    • (2005) Am J Pathol , vol.166 , Issue.1 , pp. 39-48
    • Meyer zu Schwabedissen, H.E.1    Grube, M.2    Heydrich, B.3    Linnemann, K.4    Fusch, C.5    Kroemer, H.K.6    Jedlitschky, G.7
  • 45
    • 0027499643 scopus 로고
    • Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast
    • Ramamoorthy S, Prasad PD, Kulanthaivel P, Leibach FH, Blakely RD, Ganapathy V. Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast. Biochemistry 1993;32 (5):1346-1353.
    • (1993) Biochemistry , vol.32 , Issue.5 , pp. 1346-1353
    • Ramamoorthy, S.1    Prasad, P.D.2    Kulanthaivel, P.3    Leibach, F.H.4    Blakely, R.D.5    Ganapathy, V.6
  • 46
    • 0030011143 scopus 로고    scopus 로고
    • Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells
    • Prasad PD, Hoffmans BJ, Moe AJ, Smith CH, Leibach FH, Ganapathy V. Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells. Placenta 1996;17 (4):201-207.
    • (1996) Placenta , vol.17 , Issue.4 , pp. 201-207
    • Prasad, P.D.1    Hoffmans, B.J.2    Moe, A.J.3    Smith, C.H.4    Leibach, F.H.5    Ganapathy, V.6
  • 47
    • 79956203502 scopus 로고    scopus 로고
    • Drugs of abuse and human placenta
    • Ganapathy V. Drugs of abuse and human placenta. Life Sci 2011;88 (21-22):926-930.
    • (2011) Life Sci , vol.88 , Issue.21-22 , pp. 926-930
    • Ganapathy, V.1
  • 49
    • 84872171001 scopus 로고    scopus 로고
    • Antidepressant use in pregnancy: a critical review focused on risks and controversies
    • Byatt N, Deligiannidis KM, Freeman MP. Antidepressant use in pregnancy: a critical review focused on risks and controversies. Acta Psychiatr Scand 2013;127:94-114.
    • (2013) Acta Psychiatr Scand , vol.127 , pp. 94-114
    • Byatt, N.1    Deligiannidis, K.M.2    Freeman, M.P.3
  • 50
    • 0028214888 scopus 로고
    • Human placenta as a target organ for cocaine action: interaction of cocaine with the placental serotonin transporter
    • Prasad PD, Leibach FH, Mahesh VB, Ganapathy V. Human placenta as a target organ for cocaine action: interaction of cocaine with the placental serotonin transporter. Placenta 1994;15 (3):267-278.
    • (1994) Placenta , vol.15 , Issue.3 , pp. 267-278
    • Prasad, P.D.1    Leibach, F.H.2    Mahesh, V.B.3    Ganapathy, V.4
  • 52
    • 0026410145 scopus 로고
    • Cocaine and the pregnant woman
    • Nair BS, Watson RR. Cocaine and the pregnant woman. J Reprod Med 1991;36 (12):862-867.
    • (1991) J Reprod Med , vol.36 , Issue.12 , pp. 862-867
    • Nair, B.S.1    Watson, R.R.2
  • 54
    • 0038131135 scopus 로고    scopus 로고
    • Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine
    • Martel F, Keating E. Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. Placenta 2003;24 (4):361-369.
    • (2003) Placenta , vol.24 , Issue.4 , pp. 361-369
    • Martel, F.1    Keating, E.2
  • 55
    • 21444458653 scopus 로고    scopus 로고
    • Substrate binding stoichiometry and kinetics of the norepinephrine transporter
    • Schwartz JW, Novarino G, Piston DW, DeFelice LJ. Substrate binding stoichiometry and kinetics of the norepinephrine transporter. J Biol Chem 2005;280 (19):19177-19184.
    • (2005) J Biol Chem , vol.280 , Issue.19 , pp. 19177-19184
    • Schwartz, J.W.1    Novarino, G.2    Piston, D.W.3    DeFelice, L.J.4
  • 56
    • 84856480886 scopus 로고    scopus 로고
    • The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine
    • Sommerauer C, Rebernik P, Reither H, Nanoff C, Pifl C. The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine. Neuropharmacology 2012;62 (4):1708-1716.
    • (2012) Neuropharmacology , vol.62 , Issue.4 , pp. 1708-1716
    • Sommerauer, C.1    Rebernik, P.2    Reither, H.3    Nanoff, C.4    Pifl, C.5
  • 57
    • 0032857273 scopus 로고    scopus 로고
    • Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta
    • Kenney SP, Kekuda R, Prasad PD, Leibach FH, Devoe LD, Ganapathy V. Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta. Am J Obstet Gynecol 1999;181 (2):491-497.
    • (1999) Am J Obstet Gynecol , vol.181 , Issue.2 , pp. 491-497
    • Kenney, S.P.1    Kekuda, R.2    Prasad, P.D.3    Leibach, F.H.4    Devoe, L.D.5    Ganapathy, V.6
  • 58
    • 0033432876 scopus 로고    scopus 로고
    • Cocaine up-regulates norepinephrine transporter binding in the rat placenta
    • Shearman LP, Meyer JS. Cocaine up-regulates norepinephrine transporter binding in the rat placenta. Eur J Pharmacol 1999;386 (1):1-6.
    • (1999) Eur J Pharmacol , vol.386 , Issue.1 , pp. 1-6
    • Shearman, L.P.1    Meyer, J.S.2
  • 59
    • 0041589210 scopus 로고    scopus 로고
    • An update on the extraneuronal monoamine transporter (EMT): characteristics, distribution and regulation
    • Martel F, Azevedo I. An update on the extraneuronal monoamine transporter (EMT): characteristics, distribution and regulation. Curr Drug Metab 2003;4 (4):313-318.
    • (2003) Curr Drug Metab , vol.4 , Issue.4 , pp. 313-318
    • Martel, F.1    Azevedo, I.2
  • 61
    • 0032484146 scopus 로고    scopus 로고
    • Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain
    • Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V. Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem 1998;273 (49):32776-32786.
    • (1998) J Biol Chem , vol.273 , Issue.49 , pp. 32776-32786
    • Wu, X.1    Kekuda, R.2    Huang, W.3    Fei, Y.J.4    Leibach, F.H.5    Chen, J.6    Conway, S.J.7    Ganapathy, V.8
  • 62
    • 0034975789 scopus 로고    scopus 로고
    • Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice
    • Zwart R, Verhaagh S, Buitelaar M, Popp-Snijders C, Barlow DP. Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice. Mol Cell Biol 2001;21 (13):4188-4196.
    • (2001) Mol Cell Biol , vol.21 , Issue.13 , pp. 4188-4196
    • Zwart, R.1    Verhaagh, S.2    Buitelaar, M.3    Popp-snijders, C.4    Barlow, D.P.5
  • 63
    • 84865396291 scopus 로고    scopus 로고
    • Synchronized activity of organic cation transporter 3 (Oct3/ Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat
    • Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Ceckova M, Micuda S, Staud F. Synchronized activity of organic cation transporter 3 (Oct3/ Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat. Toxicol Sci 2012;128 (2):471-481.
    • (2012) Toxicol Sci , vol.128 , Issue.2 , pp. 471-481
    • Ahmadimoghaddam, D.1    Hofman, J.2    Zemankova, L.3    Nachtigal, P.4    Dolezelova, E.5    Cerveny, L.6    Ceckova, M.7    Micuda, S.8    Staud, F.9
  • 64
    • 0023877034 scopus 로고
    • Evidence for an organic cation-proton antiport system in brush-border membranes isolated from the human term placenta
    • Ganapathy V, Ganapathy ME, Nair CN, Mahesh VB, Leibach FH. Evidence for an organic cation-proton antiport system in brush-border membranes isolated from the human term placenta. J Biol Chem 1988;263 (10):4561-4568.
    • (1988) J Biol Chem , vol.263 , Issue.10 , pp. 4561-4568
    • Ganapathy, V.1    Ganapathy, M.E.2    Nair, C.N.3    Mahesh, V.B.4    Leibach, F.H.5
  • 66
    • 0000518648 scopus 로고    scopus 로고
    • Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    • Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 2000;275 (6):4507-4512.
    • (2000) J Biol Chem , vol.275 , Issue.6 , pp. 4507-4512
    • Cha, S.H.1    Sekine, T.2    Kusuhara, H.3    Yu, E.4    Kim, J.Y.5    Kim, D.K.6    Sugiyama, Y.7    Kanai, Y.8    Endou, H.9
  • 69
    • 0033524933 scopus 로고    scopus 로고
    • Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter
    • Kekuda R, Wang H, Huang W, Pajor AM, Leibach FH, Devoe LD, Prasad PD, Ganapathy V. Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter. J Biol Chem 1999;274 (6):3422-3429.
    • (1999) J Biol Chem , vol.274 , Issue.6 , pp. 3422-3429
    • Kekuda, R.1    Wang, H.2    Huang, W.3    Pajor, A.M.4    Leibach, F.H.5    Devoe, L.D.6    Prasad, P.D.7    Ganapathy, V.8
  • 70
    • 84872688669 scopus 로고    scopus 로고
    • Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)
    • Tamai I. Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21). Biopharm Drug Dispos 2013;34:29-44.
    • (2013) Biopharm Drug Dispos , vol.34 , pp. 29-44
    • Tamai, I.1
  • 71
    • 0034212998 scopus 로고    scopus 로고
    • Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta
    • Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V. Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta 2000;1466 (1-2):315-327.
    • (2000) Biochim Biophys Acta , vol.1466 , Issue.1-2 , pp. 315-327
    • Wu, X.1    George, R.L.2    Huang, W.3    Wang, H.4    Conway, S.J.5    Leibach, F.H.6    Ganapathy, V.7
  • 74
    • 4344611974 scopus 로고    scopus 로고
    • Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice
    • Shekhawat PS, Yang HS, Bennett MJ, Carter AL, Matern D, Tamai I, Ganapathy V. Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice. Pediatr Res 2004;56 (3):323-328.
    • (2004) Pediatr Res , vol.56 , Issue.3 , pp. 323-328
    • Shekhawat, P.S.1    Yang, H.S.2    Bennett, M.J.3    Carter, A.L.4    Matern, D.5    Tamai, I.6    Ganapathy, V.7
  • 75
    • 84855869661 scopus 로고    scopus 로고
    • The expression and function of organic anion transporting polypeptides in normal tissues and in cancer
    • Obaidat A, Roth M, Hagenbuch B. The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu Rev Pharmacol Toxicol 2012;52:135-151.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 135-151
    • Obaidat, A.1    Roth, M.2    Hagenbuch, B.3
  • 76
    • 33845930051 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta
    • Grube M, Reuther S, Meyer zu Schwabedissen HE, Kock K, Draber K, Ritter CA, Fusch C, Jedlitschky G, Kroemer HK. Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. Drug Metab Dispos 2007;35 (1):30-35.
    • (2007) Drug Metab Dispos , vol.35 , Issue.1 , pp. 30-35
    • Grube, M.1    Reuther, S.2    Meyer zu Schwabedissen, H.E.3    Kock, K.4    Draber, K.5    Ritter, C.A.6    Fusch, C.7    Jedlitschky, G.8    Kroemer, H.K.9
  • 77
    • 0023767376 scopus 로고
    • A proton gradient is the driving force for uphill transport of lactate in human placental brush-border membrane vesicles
    • Balkovetz DF, Leibach FH, Mahesh VB, Ganapathy V. A proton gradient is the driving force for uphill transport of lactate in human placental brush-border membrane vesicles. J Biol Chem 1988;263 (27):13823-13830.
    • (1988) J Biol Chem , vol.263 , Issue.27 , pp. 13823-13830
    • Balkovetz, D.F.1    Leibach, F.H.2    Mahesh, V.B.3    Ganapathy, V.4
  • 78
  • 79
    • 0043212093 scopus 로고    scopus 로고
    • Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery
    • Enerson BE, Drewes LR. Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J Pharm Sci 2003;92 (8):1531-1544.
    • (2003) J Pharm Sci , vol.92 , Issue.8 , pp. 1531-1544
    • Enerson, B.E.1    Drewes, L.R.2
  • 80
    • 34347379290 scopus 로고    scopus 로고
    • H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
    • Thwaites DT, Anderson CM. H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol 2007;92 (4):603-619.
    • (2007) Exp Physiol , vol.92 , Issue.4 , pp. 603-619
    • Thwaites, D.T.1    Anderson, C.M.2
  • 81
    • 0028048398 scopus 로고
    • Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells
    • Prasad PD, Ramamoorthy S, Moe AJ, Smith CH, Leibach FH, Ganapathy V. Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Biochim Biophys Acta 1994;1223 (1):71-75.
    • (1994) Biochim Biophys Acta , vol.1223 , Issue.1 , pp. 71-75
    • Prasad, P.D.1    Ramamoorthy, S.2    Moe, A.J.3    Smith, C.H.4    Leibach, F.H.5    Ganapathy, V.6
  • 82
    • 0028580540 scopus 로고
    • Human placenta: a direct target for cocaine action
    • Ganapathy V, Leibach FH. Human placenta: a direct target for cocaine action. Placenta 1994;15 (8):785-795.
    • (1994) Placenta , vol.15 , Issue.8 , pp. 785-795
    • Ganapathy, V.1    Leibach, F.H.2
  • 83
    • 75049083781 scopus 로고    scopus 로고
    • Expression of folate transporters in human placenta and implications for homocysteine metabolism
    • Solanky N, Requena Jimenez A, D'Souza SW, Sibley CP, Glazier JD. Expression of folate transporters in human placenta and implications for homocysteine metabolism. Placenta 2010;31 (2):134-143.
    • (2010) Placenta , vol.31 , Issue.2 , pp. 134-143
    • Solanky, N.1    Requena Jimenez, A.2    D'Souza, S.W.3    Sibley, C.P.4    Glazier, J.D.5
  • 85
    • 79952738916 scopus 로고    scopus 로고
    • The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs
    • Goldman ID, Chattopadhyay S, Zhao R, Moran R. The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs. Curr Opin Investig Drugs 2010;11 (12):1409-1423.
    • (2010) Curr Opin Investig Drugs , vol.11 , Issue.12 , pp. 1409-1423
    • Goldman, I.D.1    Chattopadhyay, S.2    Zhao, R.3    Moran, R.4
  • 86
    • 0028797263 scopus 로고
    • Immunolocalisation of nucleoside transporters in human placental trophoblast and endothelial cells: evidence for multiple transporter isoforms
    • Barros LF, Yudilevich DL, Jarvis SM, Beaumont N, Young JD, Baldwin SA. Immunolocalisation of nucleoside transporters in human placental trophoblast and endothelial cells: evidence for multiple transporter isoforms. Pflugers Arch 1995;429 (3):394-399.
    • (1995) Pflugers Arch , vol.429 , Issue.3 , pp. 394-399
    • Barros, L.F.1    Yudilevich, D.L.2    Jarvis, S.M.3    Beaumont, N.4    Young, J.D.5    Baldwin, S.A.6
  • 88
    • 0031439882 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta
    • Griffiths M, Yao SY, Abidi F, Phillips SE, Cass CE, Young JD, Baldwin SA. Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochem J 1997; 328 (Pt 3):739-743.
    • (1997) Biochem J , vol.328 , Issue.PART 3 , pp. 739-743
    • Griffiths, M.1    Yao, S.Y.2    Abidi, F.3    Phillips, S.E.4    Cass, C.E.5    Young, J.D.6    Baldwin, S.A.7
  • 90
    • 33846373423 scopus 로고    scopus 로고
    • Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters
    • Yamamoto T, Kuniki K, Takekuma Y, Hirano T, Iseki K, Sugawara M. Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters. Eur J Pharmacol 2007;557 (1):1-8.
    • (2007) Eur J Pharmacol , vol.557 , Issue.1 , pp. 1-8
    • Yamamoto, T.1    Kuniki, K.2    Takekuma, Y.3    Hirano, T.4    Iseki, K.5    Sugawara, M.6
  • 91
    • 59849101790 scopus 로고    scopus 로고
    • Influx mechanism of 2',3'-dideoxyinosine and uridine at the blood-placenta barrier
    • Sato K, Sai Y, Nishimura T, Chishu T, Shimpo S, Kose N, Nakashima E. Influx mechanism of 2',3'-dideoxyinosine and uridine at the blood-placenta barrier. Placenta 2009;30 (3):263-269.
    • (2009) Placenta , vol.30 , Issue.3 , pp. 263-269
    • Sato, K.1    Sai, Y.2    Nishimura, T.3    Chishu, T.4    Shimpo, S.5    Kose, N.6    Nakashima, E.7
  • 92
    • 79960136319 scopus 로고    scopus 로고
    • 6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs
    • Lee NY, Sai Y, Nakashima E, Ohtsuki S, Kang YS. 6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs. J Pharm Sci 2011;100 (9):3773-3782.
    • (2011) J Pharm Sci , vol.100 , Issue.9 , pp. 3773-3782
    • Lee, N.Y.1    Sai, Y.2    Nakashima, E.3    Ohtsuki, S.4    Kang, Y.S.5
  • 93
    • 80054784669 scopus 로고    scopus 로고
    • Expression and distribution of nucleoside transporter proteins in the human syncytiotrophoblast
    • Errasti-Murugarren E, Diaz P, Godoy V, Riquelme G, Pastor-Anglada M. Expression and distribution of nucleoside transporter proteins in the human syncytiotrophoblast. Mol Pharmacol 2011;80 (5):809-817.
    • (2011) Mol Pharmacol , vol.80 , Issue.5 , pp. 809-817
    • Errasti-murugarren, E.1    Diaz, P.2    Godoy, V.3    Riquelme, G.4    Pastor-anglada, M.5
  • 94
    • 84857691265 scopus 로고    scopus 로고
    • Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition
    • Cano-Soldado P, Pastor-Anglada M. Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition. Med Res Rev 2012;32 (2):428-457.
    • (2012) Med Res Rev , vol.32 , Issue.2 , pp. 428-457
    • Cano-soldado, P.1    Pastor-anglada, M.2
  • 95
    • 0344435242 scopus 로고    scopus 로고
    • Techniques to study human placental transport
    • Sastry BV. Techniques to study human placental transport. Adv Drug Deliv Rev 1999;38 (1):17-39.
    • (1999) Adv Drug Deliv Rev , vol.38 , Issue.1 , pp. 17-39
    • Sastry, B.V.1
  • 96
    • 45349095283 scopus 로고    scopus 로고
    • An efficient optimized method for isolation of villous trophoblast cells from human early pregnancy placenta suitable for functional and molecular studies
    • Stenqvist AC, Chen T, Hedlund M, Dimova T, Nagaeva O, Kjellberg L, Innala E, Mincheva-Nilsson L. An efficient optimized method for isolation of villous trophoblast cells from human early pregnancy placenta suitable for functional and molecular studies. Am J Reprod Immunol 2008;60 (1):33-42.
    • (2008) Am J Reprod Immunol , vol.60 , Issue.1 , pp. 33-42
    • Stenqvist, A.C.1    Chen, T.2    Hedlund, M.3    Dimova, T.4    Nagaeva, O.5    Kjellberg, L.6    Innala, E.7    Mincheva-nilsson, L.8
  • 97
    • 0022527203 scopus 로고
    • Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae
    • Kliman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF III. Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 1986;118 (4):1567-1582.
    • (1986) Endocrinology , vol.118 , Issue.4 , pp. 1567-1582
    • Kliman, H.J.1    Nestler, J.E.2    Sermasi, E.3    Sanger, J.M.4    Strauss, J.F.5
  • 98
    • 0018240936 scopus 로고
    • Placental amino acid uptake. IV. Transport microvillous membrane vesicles
    • Ruzycki SM, Kelley LK, Smith CH. Placental amino acid uptake. IV. Transport microvillous membrane vesicles. Am J Physiol 1978;234 (1):C27-C35.
    • (1978) Am J Physiol , vol.234 , Issue.1 , pp. C27-C35
    • Ruzycki, S.M.1    Kelley, L.K.2    Smith, C.H.3
  • 99
    • 0032985121 scopus 로고    scopus 로고
    • In vitro models to predict the in vivo mechanism, rate, and extent of placental transfer of dideoxynucleoside drugs against human immunodeficiency virus
    • Tuntland T, Odinecs A, Pereira CM, Nosbisch C, Unadkat JD. In vitro models to predict the in vivo mechanism, rate, and extent of placental transfer of dideoxynucleoside drugs against human immunodeficiency virus. Am J Obstet Gynecol 1999;180 (1 Pt 1):198-206.
    • (1999) Am J Obstet Gynecol , vol.180 , Issue.1 PART 1 , pp. 198-206
    • Tuntland, T.1    Odinecs, A.2    Pereira, C.M.3    Nosbisch, C.4    Unadkat, J.D.5
  • 100
    • 33745253793 scopus 로고    scopus 로고
    • Perfusion studies of glyburide transfer across the human placenta: implications for fetal safety
    • Kraemer J, Klein J, Lubetsky A, Koren G. Perfusion studies of glyburide transfer across the human placenta: implications for fetal safety. Am J Obstet Gynecol 2006;195 (1):270-274.
    • (2006) Am J Obstet Gynecol , vol.195 , Issue.1 , pp. 270-274
    • Kraemer, J.1    Klein, J.2    Lubetsky, A.3    Koren, G.4
  • 101
    • 79951941382 scopus 로고    scopus 로고
    • Genetic polymorphisms in placental transporters: implications for fetal drug exposure to oral antidiabetic agents
    • Pollex EK, Hutson JR. Genetic polymorphisms in placental transporters: implications for fetal drug exposure to oral antidiabetic agents. Expert Opin Drug Metab Toxicol 2011;7 (3):325-339.
    • (2011) Expert Opin Drug Metab Toxicol , vol.7 , Issue.3 , pp. 325-339
    • Pollex, E.K.1    Hutson, J.R.2
  • 102
    • 84878129920 scopus 로고    scopus 로고
    • Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype
    • Prasad B, Lai Y, Lin Y, Unadkat JD. Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. J Pharm Sci 2013;102 (3):787-793.
    • (2013) J Pharm Sci , vol.102 , Issue.3 , pp. 787-793
    • Prasad, B.1    Lai, Y.2    Lin, Y.3    Unadkat, J.D.4
  • 103
    • 84859899906 scopus 로고    scopus 로고
    • Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry
    • Deo AK, Prasad B, Balogh L, Lai Y, Unadkat JD. Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry. Drug Metab Dispos 2012;40 (5):852-855.
    • (2012) Drug Metab Dispos , vol.40 , Issue.5 , pp. 852-855
    • Deo, A.K.1    Prasad, B.2    Balogh, L.3    Lai, Y.4    Unadkat, J.D.5


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