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Volumn 21, Issue 2, 2015, Pages 70-74

Metformin, an old drug, brings a new era to cancer therapy

Author keywords

cancer therapy; diabetes; Metformin

Indexed keywords

METFORMIN; ANTIDIABETIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE;

EID: 84926662707     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0000000000000103     Document Type: Review
Times cited : (49)

References (53)
  • 1
    • 84905757105 scopus 로고    scopus 로고
    • Metformin-mode of action and clinical implications for diabetes and cancer
    • Pernicova I, Korbonits M. Metformin-mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol. 2014;10:143-156.
    • (2014) Nat Rev Endocrinol. , vol.10 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 2
    • 77949462458 scopus 로고
    • AMPK as a metabolic tumor suppressor: Control of metabolism and cell growth
    • Luo Z, Zang M, Guo W. AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol. 1956;6:457-470.
    • (1956) Future Oncol. , vol.6 , pp. 457-470
    • Luo, Z.1    Zang, M.2    Guo, W.3
  • 3
    • 85027929687 scopus 로고    scopus 로고
    • Cancer as a metabolic disease
    • Hainaut P, Plymoth A. Cancer as a metabolic disease. Curr Opin Oncol. 2012;24:56-57.
    • (2012) Curr Opin Oncol. , vol.24 , pp. 56-57
    • Hainaut, P.1    Plymoth, A.2
  • 4
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science. 1956;123:309-314.
    • (1956) Science. , vol.123 , pp. 309-314
    • Warburg, O.1
  • 5
    • 84890159876 scopus 로고    scopus 로고
    • Cancer cell metabolism: Implications for therapeutic targets
    • Jang M, Kim SS, Lee J. Cancer cell metabolism: implications for therapeutic targets. Exp Mol Med. 2013;45:e45.
    • (2013) Exp Mol Med. , vol.45 , pp. e45
    • Jang, M.1    Kim, S.S.2    Lee, J.3
  • 6
    • 12844281251 scopus 로고    scopus 로고
    • AMPK, the metabolic syndrome and cancer
    • Luo Z, Saha AK, Xiang X, et al. AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci. 2005;26:69-76.
    • (2005) Trends Pharmacol Sci. , vol.26 , pp. 69-76
    • Luo, Z.1    Saha, A.K.2    Xiang, X.3
  • 7
    • 20444461067 scopus 로고    scopus 로고
    • Metformin and reduced risk of cancer in diabetic patients
    • Evans JM, Donnelly LA, Emslie-Smith AM, et al. Metformin and reduced risk of cancer in diabetic patients. BMJ. 2005;330:1304-1305.
    • (2005) BMJ. , vol.330 , pp. 1304-1305
    • Evans, J.M.1    Donnelly, L.A.2    Emslie-Smith, A.M.3
  • 8
    • 84912030559 scopus 로고    scopus 로고
    • Diabetes and cancer: Epidemiology and potential mechanisms
    • Joost HG. Diabetes and cancer: epidemiology and potential mechanisms. Diab Vasc Dis Res. 2014;11:390-394.
    • (2014) Diab Vasc Dis Res. , vol.11 , pp. 390-394
    • Joost, H.G.1
  • 10
  • 11
    • 7744242807 scopus 로고    scopus 로고
    • Avandamet: Combined metformin-rosiglitazone treatment for insulin resistance in type 2 diabetes
    • Bailey CJ, Day C. Avandamet: combined metformin-rosiglitazone treatment for insulin resistance in type 2 diabetes. Int J Clin Pract. 2004;58: 867-876.
    • (2004) Int J Clin Pract. , vol.58 , pp. 867-876
    • Bailey, C.J.1    Day, C.2
  • 12
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its antidiabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • OwenMR, Doran E, Halestrap AP. Evidence that metformin exerts its antidiabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000;348(pt 3):607-614.
    • (2000) Biochem J. , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 13
    • 34547114475 scopus 로고    scopus 로고
    • Metformin and phenformin activate AMPactivated protein kinase in the heart by increasing cytosolic AMP concentration
    • Zhang L, He H, Balschi JA. Metformin and phenformin activate AMPactivated protein kinase in the heart by increasing cytosolic AMP concentration. Am J Physiol Heart Circ Physiol. 2007;293:H457-H466.
    • (2007) Am J Physiol Heart Circ Physiol. , vol.293 , pp. H457-H466
    • Zhang, L.1    He, H.2    Balschi, J.A.3
  • 14
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • Foretz M, Hebrard S, Leclerc J, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest. 2010;120:2355-2369.
    • (2010) J Clin Invest. , vol.120 , pp. 2355-2369
    • Foretz, M.1    Hebrard, S.2    Leclerc, J.3
  • 16
    • 0020040832 scopus 로고
    • Metabolic immunodepression andmetabolic immunotherapy: An attempt of improvement in immunologic response in breast cancer patients by correction of metabolic disturbances
    • Dilman VM, Berstein LM, OstroumovaMN, et al.Metabolic immunodepression andmetabolic immunotherapy: an attempt of improvement in immunologic response in breast cancer patients by correction of metabolic disturbances. Oncology. 1982;39:13-19.
    • (1982) Oncology. , vol.39 , pp. 13-19
    • Dilman, V.M.1    Berstein, L.M.2    Ostroumova, M.N.3
  • 17
    • 0023917551 scopus 로고
    • Preliminary evidence on metabolic rehabilitation of cancer patients
    • Dilman VM, Berstein LM, Yevtushenko TP, et al. Preliminary evidence on metabolic rehabilitation of cancer patients. Arch Geschwulstforsch. 1988; 58:175-183.
    • (1988) Arch Geschwulstforsch. , vol.58 , pp. 175-183
    • Dilman, V.M.1    Berstein, L.M.2    Yevtushenko, T.P.3
  • 18
    • 0017843134 scopus 로고
    • Inhibition of DMBAinduced carcinogenesis by phenformin in the mammary gland of rats
    • Dilman VM, Berstein LM, Zabezhinski MA, et al. Inhibition of DMBAinduced carcinogenesis by phenformin in the mammary gland of rats. Arch Geschwulstforsch. 1978;48:1-8.
    • (1978) Arch Geschwulstforsch. , vol.48 , pp. 1-8
    • Dilman, V.M.1    Berstein, L.M.2    Zabezhinski, M.A.3
  • 19
    • 24644475793 scopus 로고    scopus 로고
    • Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/ neu transgenic mice
    • Anisimov VN, Berstein LM, Egormin PA, et al. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/ neu transgenic mice. Exp Gerontol. 2005;40:685-693.
    • (2005) Exp Gerontol. , vol.40 , pp. 685-693
    • Anisimov, V.N.1    Berstein, L.M.2    Egormin, P.A.3
  • 20
    • 84921405225 scopus 로고    scopus 로고
    • Metformin in cancer treatment and prevention
    • Morales DR, Morris AD. Metformin in cancer treatment and prevention. Annu Rev Med. 2015;66:17-29.
    • (2015) Annu Rev Med. , vol.66 , pp. 17-29
    • Morales, D.R.1    Morris, A.D.2
  • 21
    • 84907701160 scopus 로고    scopus 로고
    • Exploring the role ofmetformin in anticancer treatments: A systematic review
    • Miranda VC, Barroso-Sousa R, Glasberg J, et al. Exploring the role ofmetformin in anticancer treatments: a systematic review. Drugs Today (Barc). 2014;50:623-640.
    • (2014) Drugs Today (Barc). , vol.50 , pp. 623-640
    • Miranda, V.C.1    Barroso-Sousa, R.2    Glasberg, J.3
  • 22
    • 84880974660 scopus 로고    scopus 로고
    • Metformin therapy and risk of cancer in patients with type 2 diabetes: Systematic review
    • Franciosi M, Lucisano G, Lapice E, et al. Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLoS One. 2013;8:e71583.
    • (2013) PLoS One. , vol.8 , pp. e71583
    • Franciosi, M.1    Lucisano, G.2    Lapice, E.3
  • 23
    • 84876334434 scopus 로고    scopus 로고
    • Association of metformin use with cancer incidence and mortality: A meta-analysis
    • Zhang P, Li H, Tan X, et al. Association of metformin use with cancer incidence and mortality: a meta-analysis. Cancer Epidemiol. 2013;37: 207-218.
    • (2013) Cancer Epidemiol. , vol.37 , pp. 207-218
    • Zhang, P.1    Li, H.2    Tan, X.3
  • 24
    • 67749144226 scopus 로고    scopus 로고
    • Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
    • Jiralerspong S, Palla SL, Giordano SH, et al. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol. 2009;27:3297-3302.
    • (2009) J Clin Oncol. , vol.27 , pp. 3297-3302
    • Jiralerspong, S.1    Palla, S.L.2    Giordano, S.H.3
  • 25
    • 84857372409 scopus 로고    scopus 로고
    • Effect ofmetformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer
    • Bayraktar S, Hernadez-Aya LF, Lei X, et al. Effect ofmetformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer. Cancer. 2012;118:1202-1211.
    • (2012) Cancer. , vol.118 , pp. 1202-1211
    • Bayraktar, S.1    Hernadez-Aya, L.F.2    Lei, X.3
  • 26
    • 84879325892 scopus 로고    scopus 로고
    • Clinical pathological characteristics and prognostic analysis of 1,013 breast cancer patients with diabetes
    • Hou G, Zhang S, Zhang X, et al. Clinical pathological characteristics and prognostic analysis of 1,013 breast cancer patients with diabetes. Breast Cancer Res Treat. 2013;137:807-816.
    • (2013) Breast Cancer Res Treat. , vol.137 , pp. 807-816
    • Hou, G.1    Zhang, S.2    Zhang, X.3
  • 27
    • 84859029647 scopus 로고    scopus 로고
    • Mortality after incident cancer in people with and without type 2 diabetes: Impact of metformin on survival
    • Currie CJ, Poole CD, Jenkins-Jones S, et al. Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival. Diabetes Care. 2012;35:299-304.
    • (2012) Diabetes Care. , vol.35 , pp. 299-304
    • Currie, C.J.1    Poole, C.D.2    Jenkins-Jones, S.3
  • 28
    • 79954478103 scopus 로고    scopus 로고
    • Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation
    • Chen TM, Lin CC, Huang PT, et al.Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation. J Gastroenterol Hepatol. 2011;26:858-865.
    • (2011) J Gastroenterol Hepatol. , vol.26 , pp. 858-865
    • Chen, T.M.1    Lin, C.C.2    Huang, P.T.3
  • 29
    • 80555126838 scopus 로고    scopus 로고
    • Prognostic influence of metformin as firstline chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes
    • Tan BX, Yao WX, Ge J, et al. Prognostic influence of metformin as firstline chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes. Cancer. 2011;117:5103-5111.
    • (2011) Cancer. , vol.117 , pp. 5103-5111
    • Tan, B.X.1    Yao, W.X.2    Ge, J.3
  • 30
    • 84867404716 scopus 로고    scopus 로고
    • Metformin does not alter the risk of lung cancer: A case-control analysis
    • Bodmer M, Becker C, Jick SS, et al. Metformin does not alter the risk of lung cancer: a case-control analysis. Lung Cancer. 2012;78:133-137.
    • (2012) Lung Cancer. , vol.78 , pp. 133-137
    • Bodmer, M.1    Becker, C.2    Jick, S.S.3
  • 31
    • 84872019209 scopus 로고    scopus 로고
    • The use of metformin and the incidence of lung cancer in patients with type 2 diabetes
    • Smiechowski BB, Azoulay L, Yin H, et al. The use of metformin and the incidence of lung cancer in patients with type 2 diabetes. Diabetes Care. 2013;36:124-129.
    • (2013) Diabetes Care. , vol.36 , pp. 124-129
    • Smiechowski, B.B.1    Azoulay, L.2    Yin, H.3
  • 32
    • 84866156935 scopus 로고    scopus 로고
    • The effect of metformin and thiazolidinedione use on lung cancer in diabetics
    • Mazzone PJ, Rai H, Beukemann M, et al. The effect of metformin and thiazolidinedione use on lung cancer in diabetics. BMC Cancer. 2012; 12:410.
    • (2012) BMC Cancer. , vol.12 , pp. 410
    • Mazzone, P.J.1    Rai, H.2    Beukemann, M.3
  • 33
    • 60549102941 scopus 로고    scopus 로고
    • Insulin-lowering effects of metformin in women with early breast cancer
    • Goodwin PJ, Pritchard KI, Ennis M, et al. Insulin-lowering effects of metformin in women with early breast cancer. Clin Breast Cancer. 2008;8: 501-505.
    • (2008) Clin Breast Cancer. , vol.8 , pp. 501-505
    • Goodwin, P.J.1    Pritchard, K.I.2    Ennis, M.3
  • 34
    • 79960845901 scopus 로고    scopus 로고
    • Evidence for biological effects of metformin in operable breast cancer: A pre-operative, window-of-opportunity, randomized trial
    • Hadad S, Iwamoto T, Jordan L, et al. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat. 2011;128:783-794.
    • (2011) Breast Cancer Res Treat. , vol.128 , pp. 783-794
    • Hadad, S.1    Iwamoto, T.2    Jordan, L.3
  • 35
    • 77956411030 scopus 로고    scopus 로고
    • Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial
    • Hosono K, Endo H, Takahashi H, et al. Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila). 2010;3:1077-1083.
    • (2010) Cancer Prev Res (Phila). , vol.3 , pp. 1077-1083
    • Hosono, K.1    Endo, H.2    Takahashi, H.3
  • 36
    • 77955287742 scopus 로고    scopus 로고
    • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
    • Kalender A, Selvaraj A, Kim SY, et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab. 2010; 11:390-401.
    • (2010) Cell Metab. , vol.11 , pp. 390-401
    • Kalender, A.1    Selvaraj, A.2    Kim, S.Y.3
  • 37
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in dietinduced insulin-resistant mice
    • Li Y, Xu S, Mihaylova MM, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in dietinduced insulin-resistant mice. Cell Metab. 2011;13:376-388.
    • (2011) Cell Metab. , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3
  • 38
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001;108:1167-1174.
    • (2001) J Clin Invest. , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 39
    • 84906893446 scopus 로고    scopus 로고
    • Combined cancer therapy with non-conventional drugs: All roads lead to AMPK
    • Chen S, Zhu X, Lai X, et al. Combined cancer therapy with non-conventional drugs: all roads lead to AMPK. Mini Rev Med Chem. 2014;14:642-654.
    • (2014) Mini Rev Med Chem. , vol.14 , pp. 642-654
    • Chen, S.1    Zhu, X.2    Lai, X.3
  • 40
    • 84861222690 scopus 로고    scopus 로고
    • The ancient drug salicylate directly activates AMP-activated protein kinase
    • Hawley SA, Fullerton MD, Ross FA, et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 2012;336:918-922.
    • (2012) Science. , vol.336 , pp. 918-922
    • Hawley, S.A.1    Fullerton, M.D.2    Ross, F.A.3
  • 41
    • 84861648941 scopus 로고    scopus 로고
    • Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
    • Din FV, Valanciute A, Houde VP, et al. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology. 2012;142:1504.e3-1515.e3.
    • (2012) Gastroenterology. , vol.142 , pp. 1504e3-1515e3
    • Din, F.V.1    Valanciute, A.2    Houde, V.P.3
  • 42
    • 84961386372 scopus 로고    scopus 로고
    • Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
    • Groenendijk FH,MellemaWW, van der Burg E, et al. Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation. Int J Cancer. 2015;136:1434-1444.
    • (2015) Int J Cancer. , vol.136 , pp. 1434-1444
    • Groenendijk, F.H.1    Mellema, W.W.2    Van Der Burg, E.3
  • 43
    • 84922632590 scopus 로고    scopus 로고
    • Synergism between metformin and statins in modifying the risk of biochemical recurrence following radical prostatectomy in men with diabetes
    • DanzigMR, Kotamarti S, Ghandour RA, et al. Synergism between metformin and statins in modifying the risk of biochemical recurrence following radical prostatectomy in men with diabetes. Prostate Cancer Prostatic Dis. 2015;18:63-68.
    • (2015) Prostate Cancer Prostatic Dis. , vol.18 , pp. 63-68
    • Danzig, M.R.1    Kotamarti, S.2    Ghandour, R.A.3
  • 44
    • 0028158709 scopus 로고
    • Accumulation ofmetformin by tissues of the normal and diabetic mouse
    • Wilcock C, Bailey CJ. Accumulation ofmetformin by tissues of the normal and diabetic mouse. Xenobiotica. 1994;24:49-57.
    • (1994) Xenobiotica. , vol.24 , pp. 49-57
    • Wilcock, C.1    Bailey, C.J.2
  • 45
    • 84873584845 scopus 로고    scopus 로고
    • LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
    • Shackelford DB, Abt E, Gerken L, et al. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell. 2013;23:143-158.
    • (2013) Cancer Cell. , vol.23 , pp. 143-158
    • Shackelford, D.B.1    Abt, E.2    Gerken, L.3
  • 46
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
    • BuzzaiM, Jones RG, Amaravadi RK, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res. 2007;67:6745-6752.
    • (2007) Cancer Res. , vol.67 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3
  • 47
    • 84897537717 scopus 로고    scopus 로고
    • Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
    • Birsoy K, Possemato R, Lorbeer FK, et al. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 2014;508: 108-112.
    • (2014) Nature. , vol.508 , pp. 108-112
    • Birsoy, K.1    Possemato, R.2    Lorbeer, F.K.3
  • 49
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch HA, Iliopoulos D, Tsichlis PN, et al. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009;69: 7507-7511.
    • (2009) Cancer Res. , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3
  • 50
    • 84899733576 scopus 로고    scopus 로고
    • Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis
    • Zhao Z, Cheng X, Wang Y, et al. Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis. PLoS One. 2014;9:e95884.
    • (2014) PLoS One. , vol.9 , pp. e95884
    • Zhao, Z.1    Cheng, X.2    Wang, Y.3
  • 51
    • 84907479337 scopus 로고    scopus 로고
    • Metformin inhibits epithelial-mesenchymal transition in prostate cancer cells: Involvement of the tumor suppressor miR30a and its target gene SOX4
    • Zhang J, Shen C,Wang L, et al.Metformin inhibits epithelial-mesenchymal transition in prostate cancer cells: involvement of the tumor suppressor miR30a and its target gene SOX4. Biochem Biophys Res Commun. 2014; 452:746-752.
    • (2014) Biochem Biophys Res Commun. , vol.452 , pp. 746-752
    • Zhang, J.1    Shen, C.2    Wang, L.3
  • 52
    • 84907048181 scopus 로고    scopus 로고
    • AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis
    • Chou CC, Lee KH, Lai IL, et al. AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. Cancer Res. 2014;74:4783-4795.
    • (2014) Cancer Res. , vol.74 , pp. 4783-4795
    • Chou, C.C.1    Lee, K.H.2    Lai, I.L.3
  • 53
    • 85015475971 scopus 로고    scopus 로고
    • Metformin may function as anti-cancer agent via targeting cancer stem cells: The potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers
    • Bao B, Azmi AS, Ali S, et al.Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers. Ann Transl Med. 2014;2:59.
    • (2014) Ann Transl Med. , vol.2 , pp. 59
    • Bao, B.1    Azmi, A.S.2    Ali, S.3


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