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Volumn 6, Issue MAR, 2015, Pages

A new scientific paradigm may be needed to finally develop an HIV vaccine

Author keywords

HIV 1 vaccines; Innovation; Non neutralizing antibodies; Paradigm shift; Vaccine efficacy trials

Indexed keywords

HEMAGGLUTININ; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A; NEUTRALIZING ANTIBODY; VIRUS GLYCOPROTEIN;

EID: 84926658121     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00124     Document Type: Review
Times cited : (19)

References (88)
  • 3
    • 84874136610 scopus 로고    scopus 로고
    • Louis pasteur, the father of immunology?
    • Smith KA. Louis pasteur, the father of immunology? Front Immunol (2012) 3:68. doi: 10.3389/fimmu.2012.00068.
    • (2012) Front Immunol , vol.3 , pp. 68
    • Smith, K.A.1
  • 4
    • 18144430652 scopus 로고    scopus 로고
    • The discovery of the first human retroviruses: HTLV-1 and HTLV-2
    • Gallo RC. The discovery of the first human retroviruses: HTLV-1 and HTLV-2. Retrovirology (2005) 2:17. doi:10.1186/1742-4690-2-S1-S17.
    • (2005) Retrovirology , vol.2 , pp. 17
    • Gallo, R.C.1
  • 5
    • 0019254359 scopus 로고
    • Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomas
    • Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomas. Proc Nat Acad Sci U S A (1980) 77:7415-9. doi:10.1073/pnas.77.12.7415.
    • (1980) Proc Nat Acad Sci U S A , vol.77 , pp. 7415-7419
    • Poiesz, B.J.1    Ruscetti, F.W.2    Gazdar, A.F.3    Bunn, P.A.4    Minna, J.D.5    Gallo, R.C.6
  • 6
    • 0036728553 scopus 로고    scopus 로고
    • A perspective on the war on cancer
    • DeVita VT. A perspective on the war on cancer. Cancer J (2002) 5:352-6. doi:10.1097/00130404-200209000-00002.
    • (2002) Cancer J , vol.5 , pp. 352-356
    • DeVita, V.T.1
  • 8
    • 0032610181 scopus 로고    scopus 로고
    • The post-Loeffler-Frosch era: contribution of German virologists
    • Calisher CH, Horzinek MC, editors. Vienna: Springer
    • Rott R. The post-Loeffler-Frosch era: contribution of German virologists. In: Calisher CH, Horzinek MC, editors. 100 Years of Virology: The Birth and Growth of a Discipline. Vienna: Springer (1999). p. 43-61.
    • (1999) 100 Years of Virology: The Birth and Growth of a Discipline , pp. 43-61
    • Rott, R.1
  • 9
    • 29544436200 scopus 로고
    • Structure of some animal viruses and significance of their components
    • Schäfer W. Structure of some animal viruses and significance of their components. Bacteriol Rev (1963) 27:1-17.
    • (1963) Bacteriol Rev , vol.27 , pp. 1-17
    • Schäfer, W.1
  • 10
    • 0017201916 scopus 로고
    • Characterization of the immune response to the major glycoprotein (gp 71) of Friend leukemia virus. I. Response in BALB/c mice
    • Ihle JN, Collins JJ, Lee JC, Fischinger PJ, Moenning V, Schäfer W, et al. Characterization of the immune response to the major glycoprotein (gp 71) of Friend leukemia virus. I. Response in BALB/c mice. Virology (1976) 75:74-87. doi:10.1016/0042-6822(76)90008-8.
    • (1976) Virology , vol.75 , pp. 74-87
    • Ihle, J.N.1    Collins, J.J.2    Lee, J.C.3    Fischinger, P.J.4    Moenning, V.5    Schäfer, W.6
  • 11
    • 0022351176 scopus 로고
    • Prospects for treatment of human retrovirus-associated diseases
    • Bolognesi DP, Fischinger PJ. Prospects for treatment of human retrovirus-associated diseases. Cancer Res (1985) 45:470s-5s.
    • (1985) Cancer Res , vol.45 , pp. 470s-475s
    • Bolognesi, D.P.1    Fischinger, P.J.2
  • 12
    • 0022920194 scopus 로고
    • Toward a vaccine against AIDS: rationale and current progress
    • Fischinger PJ, Gallo RC, Bolognesi DP. Toward a vaccine against AIDS: rationale and current progress. Mt Sinai J Med (1986) 53:639-47.
    • (1986) Mt Sinai J Med , vol.53 , pp. 639-647
    • Fischinger, P.J.1    Gallo, R.C.2    Bolognesi, D.P.3
  • 13
    • 0022465945 scopus 로고
    • Prospects for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody
    • Robey WG, Arthur LO, Matthews TJ, Langlois A, Copeland TD, Lerche NW, et al. Prospects for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody. Proc Natl Acad Sci U S A (1986) 83:7023-7. doi:10.1073/pnas.83.18.7023.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 7023-7027
    • Robey, W.G.1    Arthur, L.O.2    Matthews, T.J.3    Langlois, A.4    Copeland, T.D.5    Lerche, N.W.6
  • 14
    • 0019985965 scopus 로고
    • Synthesis and assembly of hepatitis B virus surface antigen particles in yeast
    • Valenzuela P, Medina A, Rutter WJ, Ammerer G, Hall BD. Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature (1982) 298:347-50. doi:10.1038/298347a0.
    • (1982) Nature , vol.298 , pp. 347-350
    • Valenzuela, P.1    Medina, A.2    Rutter, W.J.3    Ammerer, G.4    Hall, B.D.5
  • 16
    • 0022348880 scopus 로고
    • Current status and strategies for vaccines against diseases induced by human T-cell lymphotropic retroviruses (HTLV-I,-II,-III)
    • Fischinger PJ, Robey WG, Koprowsky H, Gallo RC, Bolognesi D. Current status and strategies for vaccines against diseases induced by human T-cell lymphotropic retroviruses (HTLV-I,-II,-III). Cancer Res (1985) 45(9 Suppl):4694s-9s.
    • (1985) Cancer Res , vol.45 , Issue.9 , pp. 4694s-4699s
    • Fischinger, P.J.1    Robey, W.G.2    Koprowsky, H.3    Gallo, R.C.4    Bolognesi, D.5
  • 17
    • 84880714310 scopus 로고    scopus 로고
    • A brief history of the global effort to develop a preventive HIV vaccine
    • Esparza J. A brief history of the global effort to develop a preventive HIV vaccine. Vaccine (2013) 31:3502-18. doi:10.1016/j.vaccine.2013.05.018.
    • (2013) Vaccine , vol.31 , pp. 3502-3518
    • Esparza, J.1
  • 18
    • 84880746422 scopus 로고    scopus 로고
    • The long road to an HIV vaccine
    • Kleinman DL, Delbourne J, Cloud-Hansen KA, Handelsman J, editors. (Vol. 3), New York, NY: Mary Ann Liebert Inc Publishers
    • Esparza J, Russell N, McCutchan F. The long road to an HIV vaccine. In: Kleinman DL, Delbourne J, Cloud-Hansen KA, Handelsman J, editors. Controversies in Science and Technology. (Vol. 3), New York, NY: Mary Ann Liebert Inc Publishers (2010). p. 44-76.
    • (2010) Controversies in Science and Technology , pp. 44-76
    • Esparza, J.1    Russell, N.2    McCutchan, F.3
  • 19
    • 84914695671 scopus 로고    scopus 로고
    • Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development
    • Lewis GK, DeVico AL, Gallo RC. Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development. Proc Natl Acad Sci U S A (2014) 111:15614-21. doi:10.1073/pnas.1413550111.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 15614-15621
    • Lewis, G.K.1    DeVico, A.L.2    Gallo, R.C.3
  • 20
    • 84920972934 scopus 로고    scopus 로고
    • Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques
    • Carnathan DG, Wetzel KS, Yu J, Lee ST, Johnson BA, Paiardini M, et al. Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques. Proc Natl Acad Sci U S A (2015) 112:518-23. doi:10.1073/pnas.1407466112.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 518-523
    • Carnathan, D.G.1    Wetzel, K.S.2    Yu, J.3    Lee, S.T.4    Johnson, B.A.5    Paiardini, M.6
  • 21
    • 84924092302 scopus 로고    scopus 로고
    • Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection
    • Fouts TR, Bagley K, Prado IJ, Bobb KL, Schwartz JA, Xu R, et al. Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection. Proc Natl Acad Sci U S A (2015) 112(9):E992-9. doi:10.1073/pnas.1423669112.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.9 , pp. E992-E999
    • Fouts, T.R.1    Bagley, K.2    Prado, I.J.3    Bobb, K.L.4    Schwartz, J.A.5    Xu, R.6
  • 22
    • 84898917118 scopus 로고    scopus 로고
    • What has 30 years of HIV vaccine research taught us?
    • Esparza J. What has 30 years of HIV vaccine research taught us? Vaccines (2013) 1:513-26. doi:10.3390/vaccines1040513.
    • (2013) Vaccines , vol.1 , pp. 513-526
    • Esparza, J.1
  • 23
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn NM, Forthal DN, Harro CD, Judson FN, Mayer KH, Para MF, et al. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis (2005) 191:654-65. doi:10.1086/428404.
    • (2005) J Infect Dis , vol.191 , pp. 654-665
    • Flynn, N.M.1    Forthal, D.N.2    Harro, C.D.3    Judson, F.N.4    Mayer, K.H.5    Para, M.F.6
  • 24
    • 33845433434 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    • Pitisuttithum P, Gilbert P, Gurwith M, Heyward W, Martin M, van Griensven F. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis (2006) 194:1661-71. doi:10.1086/508748.
    • (2006) J Infect Dis , vol.194 , pp. 1661-1671
    • Pitisuttithum, P.1    Gilbert, P.2    Gurwith, M.3    Heyward, W.4    Martin, M.5    van Griensven, F.6
  • 25
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder SP, Mehrotra DV, Duerr A, Fitzgerald DW, Mogg R, Li D, et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet (2008) 372:1881-93. doi:10.1016/S0140-6736(08)61591-3.
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3    Fitzgerald, D.W.4    Mogg, R.5    Li, D.6
  • 27
    • 0032509888 scopus 로고    scopus 로고
    • HIV vaccines viral envelope fails to deliver?
    • Bolognesi DP, Matthews TJ. HIV vaccines viral envelope fails to deliver? Nature (1999) 391:638-9. doi:10.1038/35504.
    • (1999) Nature , vol.391 , pp. 638-639
    • Bolognesi, D.P.1    Matthews, T.J.2
  • 29
    • 84908379850 scopus 로고    scopus 로고
    • Characterization and immunogenicity of a novel mosaic M HIV-1 gp140 trimer
    • Nkolola JP, Bricault CA, Cheung A, Shields J, Perry J, Kovacs JM, et al. Characterization and immunogenicity of a novel mosaic M HIV-1 gp140 trimer. J Virol (2014) 88:9538-52. doi:10.1128/JVI.01739-14.
    • (2014) J Virol , vol.88 , pp. 9538-9552
    • Nkolola, J.P.1    Bricault, C.A.2    Cheung, A.3    Shields, J.4    Perry, J.5    Kovacs, J.M.6
  • 30
    • 84903173697 scopus 로고    scopus 로고
    • Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
    • Yasmeen A, Ringe R, Derking R, Cupo A, Julien JP, Burton DR, et al. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits. Retrovirology (2014) 11:41. doi:10.1186/1742-4690-11-41.
    • (2014) Retrovirology , vol.11 , pp. 41
    • Yasmeen, A.1    Ringe, R.2    Derking, R.3    Cupo, A.4    Julien, J.P.5    Burton, D.R.6
  • 32
    • 9844256104 scopus 로고    scopus 로고
    • International clinical trials of HIV vaccines: II. Phase I trial of an HIV-1 synthetic peptide vaccine evaluating an accelerated immunization schedule in Yunnan, China
    • Li D, Forrest BD, Li Z, Xue P, Hanson CV, Duan S, et al. International clinical trials of HIV vaccines: II. Phase I trial of an HIV-1 synthetic peptide vaccine evaluating an accelerated immunization schedule in Yunnan, China. Asian Pac J Allergy Immunol (1997) 15:105-13.
    • (1997) Asian Pac J Allergy Immunol , vol.15 , pp. 105-113
    • Li, D.1    Forrest, B.D.2    Li, Z.3    Xue, P.4    Hanson, C.V.5    Duan, S.6
  • 33
    • 0026044947 scopus 로고
    • Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to gp120
    • Steimer KS, Scandella CJ, Skiles PV, Haigwood NL. Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to gp120. Science (1991) 254:105-8. doi:10.1126/science.1718036.
    • (1991) Science , vol.254 , pp. 105-108
    • Steimer, K.S.1    Scandella, C.J.2    Skiles, P.V.3    Haigwood, N.L.4
  • 34
    • 82955241840 scopus 로고    scopus 로고
    • Rational design of vaccines to elicit broadly neutralizing antibodies to HV-1
    • Kwong PD, Mascola JR, Nabel GJ. Rational design of vaccines to elicit broadly neutralizing antibodies to HV-1. Cold Spring Harb Perspect Med (2011) 1(1):a007278. doi:10.1101/cshperspect.a007278.
    • (2011) Cold Spring Harb Perspect Med , vol.1 , Issue.1
    • Kwong, P.D.1    Mascola, J.R.2    Nabel, G.J.3
  • 36
    • 79958059341 scopus 로고    scopus 로고
    • Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus
    • McLellan JS, Correia BE, Chen M, Yang Y, Graham BS, Schief WR, et al. Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus. J Mol Biol (2011) 409:853-66. doi:10.1016/j.jmb.2011.04.044.
    • (2011) J Mol Biol , vol.409 , pp. 853-866
    • McLellan, J.S.1    Correia, B.E.2    Chen, M.3    Yang, Y.4    Graham, B.S.5    Schief, W.R.6
  • 37
    • 84871403286 scopus 로고    scopus 로고
    • Basic research in HIV vaccinology is hampered by reductionist thinking
    • Van Regenmortel MH. Basic research in HIV vaccinology is hampered by reductionist thinking. Front Immunol (2012) 3:194. doi:10.3389/fimmu.2012.00194.
    • (2012) Front Immunol , vol.3 , pp. 194
    • Van Regenmortel, M.H.1
  • 38
    • 84919443137 scopus 로고    scopus 로고
    • An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine
    • Van Regenmortel MH. An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine. Front Immunol (2014) 5:593. doi:10.3389/fimmu.2014.00593.
    • (2014) Front Immunol , vol.5 , pp. 593
    • Van Regenmortel, M.H.1
  • 39
    • 84879302728 scopus 로고    scopus 로고
    • HIV-1 neutralizing antibodies: understanding nature's pathways
    • Mascola JR, Haynes BF. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol Rev (2013) 254:225-44. doi:10.1111/imr.12075.
    • (2013) Immunol Rev , vol.254 , pp. 225-244
    • Mascola, J.R.1    Haynes, B.F.2
  • 40
    • 84860759632 scopus 로고    scopus 로고
    • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
    • Haynes BF, Kelsoe G, Harrison SC, Kepler TB. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol (2012) 30:423-33. doi:10.1038/nbt.2197.
    • (2012) Nat Biotechnol , vol.30 , pp. 423-433
    • Haynes, B.F.1    Kelsoe, G.2    Harrison, S.C.3    Kepler, T.B.4
  • 41
    • 84899063052 scopus 로고    scopus 로고
    • All eyes on the next generation of HIV vaccines: strategies for inducing a broadly neutralizing antibody response
    • Ahlers JD. All eyes on the next generation of HIV vaccines: strategies for inducing a broadly neutralizing antibody response. Discov Med (2014) 17:187-99.
    • (2014) Discov Med , vol.17 , pp. 187-199
    • Ahlers, J.D.1
  • 42
    • 84919420520 scopus 로고    scopus 로고
    • The antibody germline/maturation hypothesis, elicitation of broadly neutralizing antibodies against HIV-1 and cord blood IgM repertoires
    • Prabakaran P, Chen W, Dimitrov DS. The antibody germline/maturation hypothesis, elicitation of broadly neutralizing antibodies against HIV-1 and cord blood IgM repertoires. Front Immunol (2014) 5:398. doi:10.3389/fimmu.2014.00398.
    • (2014) Front Immunol , vol.5 , pp. 398
    • Prabakaran, P.1    Chen, W.2    Dimitrov, D.S.3
  • 43
    • 84879290459 scopus 로고    scopus 로고
    • A global approach to HIV-1 vaccine development
    • Stephenson KE, Barouch DH. A global approach to HIV-1 vaccine development. Immunol Rev (2013) 254:295-304. doi:10.1111/imr.12073.
    • (2013) Immunol Rev , vol.254 , pp. 295-304
    • Stephenson, K.E.1    Barouch, D.H.2
  • 44
    • 84886778874 scopus 로고    scopus 로고
    • Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys
    • Barouch DH, Stephenson KE, Borducchi EN, Smith K, Stanley K, McNally AG, et al. Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys. Cell (2013) 155:531-9. doi:10.1016/j.cell.2013.09.061.
    • (2013) Cell , vol.155 , pp. 531-539
    • Barouch, D.H.1    Stephenson, K.E.2    Borducchi, E.N.3    Smith, K.4    Stanley, K.5    McNally, A.G.6
  • 45
    • 84922480581 scopus 로고    scopus 로고
    • Novel vaccine vectors for HIV-1
    • Barouch DH, Picker LJ. Novel vaccine vectors for HIV-1. Nat Rev Microbiol (2014) 12:765-71. doi:10.1038/nrmicro3360.
    • (2014) Nat Rev Microbiol , vol.12 , pp. 765-771
    • Barouch, D.H.1    Picker, L.J.2
  • 46
    • 84892450553 scopus 로고    scopus 로고
    • The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys
    • Teigler JE, Phogat S, Franchini G, Hirsch VM, Michael NL, Barouch DH. The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys. J Virol (2014) 88:1809-14. doi:10.1128/JVI.02386-13.
    • (2014) J Virol , vol.88 , pp. 1809-1814
    • Teigler, J.E.1    Phogat, S.2    Franchini, G.3    Hirsch, V.M.4    Michael, N.L.5    Barouch, D.H.6
  • 47
    • 84920855652 scopus 로고    scopus 로고
    • Virological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as VLPs
    • Perdiguero B, Gómez CE, Cepeda V, Sánchez-Sampedro L, García-Arriaza J, Mejías-Pérez E, et al. Virological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as VLPs. J Virol (2014) 89(2):970-88. doi:10.1128/JVI.02469-14.
    • (2014) J Virol , vol.89 , Issue.2 , pp. 970-988
    • Perdiguero, B.1    Gómez, C.E.2    Cepeda, V.3    Sánchez-Sampedro, L.4    García-Arriaza, J.5    Mejías-Pérez, E.6
  • 48
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature (2011) 473:523-7. doi:10.1038/nature10003.
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1    Ford, J.C.2    Lewis, M.S.3    Ventura, A.B.4    Hughes, C.M.5    Coyne-Johnson, L.6
  • 49
    • 84877957880 scopus 로고    scopus 로고
    • Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms
    • 1237874
    • Hansen SG, Sacha JB, Hughes CM, Ford JC, Burwitz BJ, Scholz I, et al. Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science (2013) 340:1237874. doi:10.1126/science.1237874.
    • (2013) Science , vol.340
    • Hansen, S.G.1    Sacha, J.B.2    Hughes, C.M.3    Ford, J.C.4    Burwitz, B.J.5    Scholz, I.6
  • 50
    • 84855913888 scopus 로고    scopus 로고
    • New paradigms for HIV/AIDS vaccine development
    • Picker LJ, Hansen SG, Lifson JD. New paradigms for HIV/AIDS vaccine development. Annu Rev Med (2012) 63:95-111. doi:10.1146/annurev-med-042010-085643.
    • (2012) Annu Rev Med , vol.63 , pp. 95-111
    • Picker, L.J.1    Hansen, S.G.2    Lifson, J.D.3
  • 51
    • 84905368819 scopus 로고    scopus 로고
    • Are effector memory T cells the key to an effective HIV/AIDS vaccine?
    • Picker LJ. Are effector memory T cells the key to an effective HIV/AIDS vaccine? EMBO Rep (2014) 15:820-1. doi:10.15252/embr.201439052.
    • (2014) EMBO Rep , vol.15 , pp. 820-821
    • Picker, L.J.1
  • 52
    • 84926634007 scopus 로고    scopus 로고
    • Ending the global HIV/AIDS pandemic: the critical role of an HIV vaccine
    • Fauci AS, Folkers GK, Marston HD. Ending the global HIV/AIDS pandemic: the critical role of an HIV vaccine. Clin Infect Dis (2014) 59(Suppl 2):S80-4. doi:10.1093/cid/ciu420.
    • (2014) Clin Infect Dis , vol.59 , pp. S80-S84
    • Fauci, A.S.1    Folkers, G.K.2    Marston, H.D.3
  • 53
    • 1342332108 scopus 로고    scopus 로고
    • Public health. A sound rationale needed for phase III HIV-1 vaccine trials
    • Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, et al. Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science (2004) 303:316. doi:10.1126/science.1094620.
    • (2004) Science , vol.303 , pp. 316
    • Burton, D.R.1    Desrosiers, R.C.2    Doms, R.W.3    Feinberg, M.B.4    Gallo, R.C.5    Hahn, B.6
  • 55
    • 84899087118 scopus 로고    scopus 로고
    • Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination
    • Yates NL, Liao HX, Fong Y, deCamp A, Vandergrift NA, Williams WT, et al. Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination. Sci Transl Med (2014) 6:228ra39. doi:10.1126/scitranslmed.3007730.
    • (2014) Sci Transl Med , vol.6
    • Yates, N.L.1    Liao, H.X.2    Fong, Y.3    deCamp, A.4    Vandergrift, N.A.5    Williams, W.T.6
  • 56
    • 84896702279 scopus 로고    scopus 로고
    • Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity
    • Veillette M, Désormeaux A, Medjahed H, Gharsallah NE, Coutu M, Baalwa J, et al. Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity. J Virol (2014) 88:2633-44. doi:10.1128/JVI.03230-13.
    • (2014) J Virol , vol.88 , pp. 2633-2644
    • Veillette, M.1    Désormeaux, A.2    Medjahed, H.3    Gharsallah, N.E.4    Coutu, M.5    Baalwa, J.6
  • 57
    • 84867902474 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    • Bonsignori M, Pollara J, Moody MA, Alpert MD, Chen X, Hwang KK, et al. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol (2012) 86:11521-32. doi:10.1128/JVI.01023-12.
    • (2012) J Virol , vol.86 , pp. 11521-11532
    • Bonsignori, M.1    Pollara, J.2    Moody, M.A.3    Alpert, M.D.4    Chen, X.5    Hwang, K.K.6
  • 58
    • 36849031146 scopus 로고    scopus 로고
    • Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens
    • DeVico A, Fouts T, Lewis GK, Gallo RC, Godfrey K, Charurat M, et al. Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens. Proc Natl Acad Sci U S A (2007) 104:17477-82. doi:10.1073/pnas.0707399104.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17477-17482
    • DeVico, A.1    Fouts, T.2    Lewis, G.K.3    Gallo, R.C.4    Godfrey, K.5    Charurat, M.6
  • 59
    • 84871960572 scopus 로고    scopus 로고
    • Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding
    • Guan Y, Pazgier M, Sajadi MM, Kamin-Lewis R, Al-Darmarki S, Flinko R, et al. Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding. Proc Natl Acad Sci U S A (2013) 110:E69-78. doi:10.1073/pnas.1217609110.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E69-E78
    • Guan, Y.1    Pazgier, M.2    Sajadi, M.M.3    Kamin-Lewis, R.4    Al-Darmarki, S.5    Flinko, R.6
  • 60
    • 13544277161 scopus 로고    scopus 로고
    • Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251
    • Gómez-Román VR, Patterson LJ, Venzon D, Liewehr D, Aldrich K, Florese R, et al. Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251. J Immunol (2005) 174:2185-9. doi:10.4049/jimmunol.174.4.2185.
    • (2005) J Immunol , vol.174 , pp. 2185-2189
    • Gómez-Román, V.R.1    Patterson, L.J.2    Venzon, D.3    Liewehr, D.4    Aldrich, K.5    Florese, R.6
  • 61
    • 80055020243 scopus 로고    scopus 로고
    • A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fc? receptors to define the role of effector functions in protection against HIV
    • Moldt B, Schultz N, Dunlop DC, Alpert MD, Harvey JD, Evans DT, et al. A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fc? receptors to define the role of effector functions in protection against HIV. J Virol (2011) 85:10572-81. doi:10.1128/JVI.05541-11.
    • (2011) J Virol , vol.85 , pp. 10572-10581
    • Moldt, B.1    Schultz, N.2    Dunlop, D.C.3    Alpert, M.D.4    Harvey, J.D.5    Evans, D.T.6
  • 62
    • 84905663895 scopus 로고    scopus 로고
    • Nonneutralizing functional antibodies: a new "old" paradigm for HIV vaccines
    • Excler JL, Ake J, Robb ML, Kim JH, Plotkin SA. Nonneutralizing functional antibodies: a new "old" paradigm for HIV vaccines. Clin Vaccine Immunol (2014) 21:1023-36. doi:10.1128/CVI.00230-14.
    • (2014) Clin Vaccine Immunol , vol.21 , pp. 1023-1036
    • Excler, J.L.1    Ake, J.2    Robb, M.L.3    Kim, J.H.4    Plotkin, S.A.5
  • 64
    • 84926619980 scopus 로고    scopus 로고
    • P5 Partnership. Available from: http://www.vaccineenterprise.org/content/P5Partnership (2014).
    • (2014) P5 Partnership
  • 65
    • 84862764447 scopus 로고    scopus 로고
    • Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144
    • Robb ML, Rerks-Ngarm S, Nitayaphan S, Pitisuttithum P, Kaewkungwal J, Kunasol P, et al. Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144. Lancet Infect Dis (2012) 12:531-7. doi:10.1016/S1473-3099(12)70088-9.
    • (2012) Lancet Infect Dis , vol.12 , pp. 531-537
    • Robb, M.L.1    Rerks-Ngarm, S.2    Nitayaphan, S.3    Pitisuttithum, P.4    Kaewkungwal, J.5    Kunasol, P.6
  • 66
    • 84862765973 scopus 로고    scopus 로고
    • Understanding the efficacy variables of an HIV vaccine trial
    • Esparza J. Understanding the efficacy variables of an HIV vaccine trial. Lancet Infect Dis (2012) 12:499-500. doi:10.1016/S1473-3099(12)70117-2.
    • (2012) Lancet Infect Dis , vol.12 , pp. 499-500
    • Esparza, J.1
  • 67
    • 80052435641 scopus 로고    scopus 로고
    • Accelerating vaccine development and deployment: report of a Royal Society satellite meeting
    • Bregu M, Draper SJ, Hill AV, Greenwood BM. Accelerating vaccine development and deployment: report of a Royal Society satellite meeting. Philos Trans R Soc Lond B Biol Sci (2011) 366:2841-9. doi:10.1098/rstb.2011.0100.
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , pp. 2841-2849
    • Bregu, M.1    Draper, S.J.2    Hill, A.V.3    Greenwood, B.M.4
  • 68
    • 0033840552 scopus 로고    scopus 로고
    • Biological considerations in the development of a human immunodeficiency virus vaccine
    • Nathanson N, Mathieson BJ. Biological considerations in the development of a human immunodeficiency virus vaccine. J Infect Dis (2000) 182:579-89. doi:10.1086/315707.
    • (2000) J Infect Dis , vol.182 , pp. 579-589
    • Nathanson, N.1    Mathieson, B.J.2
  • 70
    • 66349121165 scopus 로고    scopus 로고
    • A brief history of HIV vaccine research: stepping back to the drawing board?
    • Miedema F. A brief history of HIV vaccine research: stepping back to the drawing board? AIDS (2008) 22:1699-703. doi:10.1097/QAD.0b013e3283021a61.
    • (2008) AIDS , vol.22 , pp. 1699-1703
    • Miedema, F.1
  • 71
    • 33846797919 scopus 로고    scopus 로고
    • Point: statistical analysis in NIH peer review-identifying innovation
    • Kaplan D. Point: statistical analysis in NIH peer review-identifying innovation. FASEB J (2007) 21:305-8. doi:10.1096/fj.07-0204ufm.
    • (2007) FASEB J , vol.21 , pp. 305-308
    • Kaplan, D.1
  • 72
    • 50649108777 scopus 로고    scopus 로고
    • Sample size and precision in NIH peer review
    • Kaplan D, Lacetera N, Kaplan C. Sample size and precision in NIH peer review. PLoS One (2008) 3:e2761. doi:10.1371/journal.pone.0002761.
    • (2008) PLoS One , vol.3
    • Kaplan, D.1    Lacetera, N.2    Kaplan, C.3
  • 73
    • 0031267455 scopus 로고    scopus 로고
    • First grants for innovative AIDS vaccine research awarded
    • Parrott C. First grants for innovative AIDS vaccine research awarded. NIAID AIDS Agenda (1997):5-7.
    • (1997) NIAID AIDS Agenda , pp. 5-7
    • Parrott, C.1
  • 74
    • 0030663995 scopus 로고    scopus 로고
    • "Innovation" in AIDS vaccines
    • Culliton BJ. "Innovation" in AIDS vaccines. Nat Med (1997) 3:1181. doi:10.1038/nm1097-1057a.
    • (1997) Nat Med , vol.3 , pp. 1181
    • Culliton, B.J.1
  • 76
    • 77950358649 scopus 로고    scopus 로고
    • The AIDS vaccine field considers ways to encourage innovation and recruit new minds to the effort
    • McEnery R. The AIDS vaccine field considers ways to encourage innovation and recruit new minds to the effort. IAVI Rep (2009) 13:9-13.
    • (2009) IAVI Rep , vol.13 , pp. 9-13
    • McEnery, R.1
  • 78
    • 84871718854 scopus 로고    scopus 로고
    • Induction of CD8+ regulatory T cells protects macaques against SIV challenge
    • Lu W, Chen S, Lai C, Guo W, Fu L, Andrieu JM. Induction of CD8+ regulatory T cells protects macaques against SIV challenge. Cell Rep (2012) 2:1736-46. doi:10.1016/j.celrep.2012.11.016.
    • (2012) Cell Rep , vol.2 , pp. 1736-1746
    • Lu, W.1    Chen, S.2    Lai, C.3    Guo, W.4    Fu, L.5    Andrieu, J.M.6
  • 79
    • 84905669844 scopus 로고    scopus 로고
    • Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8(+) T-regulatory cells that suppress SIV-positive CD4(+) T-cell activation and prevent SIV infection in the macaque model
    • Andrieu JM, Chen S, Lai C, Guo W, Lu W. Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8(+) T-regulatory cells that suppress SIV-positive CD4(+) T-cell activation and prevent SIV infection in the macaque model. Front Immunol (2014) 5:297. doi:10.3389/fimmu.2014.00297.
    • (2014) Front Immunol , vol.5 , pp. 297
    • Andrieu, J.M.1    Chen, S.2    Lai, C.3    Guo, W.4    Lu, W.5
  • 80
    • 79951754740 scopus 로고    scopus 로고
    • Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges
    • Bomsel M, Tudor D, Drillet AS, Alfsen A, Ganor Y, Roger MG, et al. Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges. Immunity (2011) 34:269-80. doi:10.1016/j.immuni.2011.01.015.
    • (2011) Immunity , vol.34 , pp. 269-280
    • Bomsel, M.1    Tudor, D.2    Drillet, A.S.3    Alfsen, A.4    Ganor, Y.5    Roger, M.G.6
  • 81
    • 84874274760 scopus 로고    scopus 로고
    • Randomized phase I: safety, immunogenicity and mucosal antiviral activity in young healthy women vaccinated with HIV-1 Gp41 P1 peptide on virosomes
    • Leroux-Roels G, Maes C, Clement F, van Engelenburg F, van den Dobbelsteen M, Adler M, et al. Randomized phase I: safety, immunogenicity and mucosal antiviral activity in young healthy women vaccinated with HIV-1 Gp41 P1 peptide on virosomes. PLoS One (2013) 8(2):e55438. doi:10.1371/journal.pone.0055438.
    • (2013) PLoS One , vol.8 , Issue.2
    • Leroux-Roels, G.1    Maes, C.2    Clement, F.3    van Engelenburg, F.4    van den Dobbelsteen, M.5    Adler, M.6
  • 82
    • 79951745043 scopus 로고    scopus 로고
    • Standing guard at the mucosa
    • McElrath MJ. Standing guard at the mucosa. Immunity (2011) 34:146-8. doi:10.1016/j.immuni.2011.02.014.
    • (2011) Immunity , vol.34 , pp. 146-148
    • McElrath, M.J.1
  • 83
    • 84924116817 scopus 로고    scopus 로고
    • Are anti-HIV IgAs good guys or bad guys?
    • Zhou M, Ruprecht RM. Are anti-HIV IgAs good guys or bad guys? Retrovirology (2014) 11:109. doi:10.1186/PREACCEPT-1729873135143527.
    • (2014) Retrovirology , vol.11 , pp. 109
    • Zhou, M.1    Ruprecht, R.M.2
  • 84
    • 23344448979 scopus 로고    scopus 로고
    • NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand
    • Vieillard V, Strominger JL, Debré P. NK cytotoxicity against CD4+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand. Proc Natl Acad Sci U S A (2005) 102:10981-6. doi:10.1073/pnas.0504315102.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10981-10986
    • Vieillard, V.1    Strominger, J.L.2    Debré, P.3
  • 86
    • 84926634395 scopus 로고    scopus 로고
    • Time for a systematic look at inactivated HIV vaccines
    • Sheppard HW, Dorman BP. Time for a systematic look at inactivated HIV vaccines. AIDS (2015) 29:125-7. doi:10.1097/QAD.0000000000000476.
    • (2015) AIDS , vol.29 , pp. 125-127
    • Sheppard, H.W.1    Dorman, B.P.2
  • 87
    • 84905665255 scopus 로고    scopus 로고
    • More surprises in the development of an HIV vaccine
    • Esparza J, Van Regenmortel MH. More surprises in the development of an HIV vaccine. Front Immunol (2014) 5:329. doi:10.3389/fimmu.2014.00329.
    • (2014) Front Immunol , vol.5 , pp. 329
    • Esparza, J.1    Van Regenmortel, M.H.2
  • 88
    • 84898876770 scopus 로고    scopus 로고
    • Paradigm changes and the future of HIV vaccines: a summary of a workshop held in Baltimore on 20 November 2013
    • Van Regenmortel MHV, Andrieu J-M, Dimitrov DS, Ensoli B, Hioe CE, Moog C, et al. Paradigm changes and the future of HIV vaccines: a summary of a workshop held in Baltimore on 20 November 2013. J AIDS Clin Res (2014) 5:281. doi:10.4172/2155-6113.1000281.
    • (2014) J AIDS Clin Res , vol.5 , pp. 281
    • Van Regenmortel, M.H.V.1    Andrieu, J.-M.2    Dimitrov, D.S.3    Ensoli, B.4    Hioe, C.E.5    Moog, C.6


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