Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus

Microbial Cell Factories

Volumn 14, Issue 1, 2015, Pages

  Yin, Shouliang ^a   Wang, Weishan ^b   Wang, Xuefeng ^c   Zhu, Yaxin ^b   Jia, Xiaole ^c   Li, Shanshan ^b   Yuan, Fang ^c   Zhang, Yuxiu ^a   Yang, Keqian ^b  

^a CHINA UNIVERSITY OF MINING AND TECHNOLOGY   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c Shengxue Dacheng Pharmaceutical Co Ltd   (China)

Author keywords

Activator; Oxytetracycline; Rational engineering; SARP; Streptomyces rimosus

Indexed keywords

GREEN FLUORESCENT PROTEIN; OXYTETRACYCLINE; REGULATOR PROTEIN; STREPTOMYCES ANTIBIOTIC REGULATORY PROTEIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; PROTEIN BINDING;

ARTICLE; BACTERIAL STRAIN; CONSENSUS SEQUENCE; DRUG SYNTHESIS; GENE CLUSTER; GENE DELETION; GENE OVEREXPRESSION; GENETIC COMPLEMENTATION; GENETIC ENGINEERING; GENETIC MANIPULATION; MUTATIONAL ANALYSIS; NONHUMAN; OTCR GENE; OTRB GENE; OXY GENE; PROMOTER REGION; REGULATOR GENE; STREPTOMYCES RIMOSUS; TRANSCRIPTION INITIATION; AMINO ACID SEQUENCE; BINDING SITE; BIOSYNTHESIS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; MUTATION; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY;

STREPTOMYCES; STREPTOMYCES RIMOSUS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTATION; OXYTETRACYCLINE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES RIMOSUS; TRANSCRIPTION, GENETIC;

EID: 84926656970     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-015-0231-7     Document Type: Article

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