Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes

Enzyme and Microbial Technology

Volumn 50, Issue 6-7, 2012, Pages 318-324

  Yu, Lan ^a,b   Cao, Nan ^a   Wang, Long ^a   Xiao, Ciying ^a   Guo, Meijin ^a   Chu, Ju ^a   Zhuang, Yingping ^a   Zhang, Siliang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUZHOU UNIVERSITY   (China)

Author keywords

Minimal PKS genes; Morphology; Overexpression; Oxytetracycline

Indexed keywords

BIOSYNTHESIS PATHWAYS; CARBON FLUXES; GENE TRANSCRIPTIONS; MALONYL-COA; OVER-EXPRESSION; OXYTETRACYCLINES (OTC); POLYKETIDE SYNTHASES; POLYKETIDES; QUANTITATIVE REAL TIME PCR; REVERSE TRANSCRIPTION; STREPTOMYCES RIMOSUS; TYPE II;

BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CELL GROWTH; GENES; GROWTH KINETICS; KETONES; MORPHOLOGY; POLYMERASE CHAIN REACTION;

TRANSCRIPTION;

MALONYL COENZYME A; OXYTETRACYCLINE; POLYKETIDE SYNTHASE;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CELL GROWTH; DRUG SYNTHESIS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; OXYA GENE; OXYB GENE; OXYC GENE; POLYMERIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES; STREPTOMYCES RIMOSUS;

BACTERIAL PROTEINS; BIOTECHNOLOGY; GENE DUPLICATION; GENES, BACTERIAL; GENETIC ENGINEERING; OXYTETRACYCLINE; POLYKETIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOMYCES; UP-REGULATION;

OXYA; STREPTOMYCES RIMOSUS;

EID: 84859772747     PISSN: 01410229     EISSN: 18790909     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2012.03.001     Document Type: Article

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